Hypertension Disorders in PregnancyCPR_AUCR2026NCT07795320
Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in in Women With Hypertensive Disorders of Pregnancy.
An observational study of Hypertension Disorders in Pregnancy, run by Assiut University.
Trial summary
The primary aim of this study is to evaluate the predictive value of the Amniotic-Umbilical-to-Cerebral Ratio (AUCR) in predicting composite adverse perinatal outcomes in women with hypertensive disorders of pregnancy and to compare its predictive performance with the traditional Cerebroplacental Ratio (CPR) Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Hypertension Disorders in Pregnancy
- How many people
- 130 participants
- Where
- No sites listed yet
- Study dates
- 1 Nov 2026to 1 Apr 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Study population: pregnant women with hypertensive disorder
Who may be able to join
- Women aged 18-40 years, inclusive.
- Singleton viable pregnancy.
- Gestational age ≥32 weeks.
- Pregnancy complicated by a hypertensive disorder.
- Women who provide written informed consent.
Who cannot join
- Multiple gestation.
- Fetuses with known chromosomal or major congenital anomalies.
- Maternal diseases likely to independently affect fetal circulation or perinatal outcome, such as significant cardiac disease or other major systemic diseases.
- Inability to complete the required follow-up.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparison Between Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in Predicting of Adverse Perinatal Outcome in Women With Hypertensive Disorders of Pregnancy.
The primary aim of this study is to evaluate the predictive value of the Amniotic-Umbilical-to-Cerebral Ratio (AUCR) in predicting composite adverse perinatal outcomes in women with hypertensive disorders of pregnancy and to compare its predictive performance with the traditional Cerebroplacental Ratio (CPR)
Read the detailed description
A prospective cohort study will be conducted to compare the predictive accuracy of the cerebroplacental ratio (CPR) and the amniotic-umbilical-to-cerebral ratio (AUCR) for composite adverse perinatal outcomes among women with hypertensive disorders of pregnancy.
- Conditions
- Hypertension Disorders in Pregnancy
- Keywords
- Hypertension With Pregnancy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| obstetric doppler indices in hypertensive disorder with pregnancy | A prospective cohort study will be conducted to compare the predictive accuracy of the cerebroplacental ratio (CPR) and the amniotic-umbilical-to-cerebral ratio (AUCR) for composite adverse perinatal outcomes among women with hypertensive disorders of pregnancy.Fetal ultrasonographic measurements, including deepest vertical pocket (DVP) for amniotic fluid, and Doppler parameters including UtA systolic/diastolic (S/D) and pulsatility index (PI), MCA S/D and PI, and UA S/D and PI, will conducted following fetal biometry EFW was computed. CPR was determined using the ratio of MCA PI to UA PI.8 UCR will calculated as the inverse of CPR, the ratio of UA PI to MCA PI.11 CPUR was determined using the ratio of CPR to UtA PI.13 The DVP method will implemented to estimate the amniotic fluid volume.19 The AUCR will calculated as the ratio of DVP to UA PI/MCA PI |
What is being measured
The primary outcome is the main question the study is designed to answer.
number of cases with NICU admission
number of neonates admitted in neonatal care unit within 24 hours after delivery
Measured: 6 weeks
Secondary outcomes (1)
weight of birth
birth weight in grams after delivery
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Aug 2026
- Study start1 Nov 2026 (estimated)
- Primary completion1 Apr 2028 (estimated)
- Study completion1 Apr 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hypertension Disorders in PregnancyStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 130 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abdelrahman Mahmoud Mohammed, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07795320
- Sponsor's protocol ID
- assiutmed2032026
- Acronym
- CPR_AUCR2026
- Status last verified
- Aug 2026
- First submitted
- 23 Aug 2026
- Last updated
- 31 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in Predicting of Adverse Perinatal Outcome in Women With Hypertensive Disorders of Pregnancy.
- ClinicalTrials.gov ID
- NCT07795320
- Acronym / sponsor ID
- CPR_AUCR2026 / assiutmed2032026
- Conditions
- Hypertension Disorders in Pregnancy
- Keywords
- Hypertension With Pregnancy
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 130 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Nov 2026 (estimated)
- Primary completion
- 1 Apr 2028 (estimated)
- Study completion
- 1 Apr 2028 (estimated)
- First posted
- 31 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary aim of this study is to evaluate the predictive value of the Amniotic-Umbilical-to-Cerebral Ratio (AUCR) in predicting composite adverse perinatal outcomes in women with hypertensive disorders of pregnancy and to compare its predictive performance with the traditional Cerebroplacental Ratio (CPR)
Detailed description
A prospective cohort study will be conducted to compare the predictive accuracy of the cerebroplacental ratio (CPR) and the amniotic-umbilical-to-cerebral ratio (AUCR) for composite adverse perinatal outcomes among women with hypertensive disorders of pregnancy.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| obstetric doppler indices in hypertensive disorder with pregnancy | – | –A prospective cohort study will be conducted to compare the predictive accuracy of the cerebroplacental ratio (CPR) and the amniotic-umbilical-to-cerebral ratio (AUCR) for composite adverse perinatal outcomes among women with hypertensive disorders of pregnancy.Fetal ultrasonographic measurements, including deepest vertical pocket (DVP) for amniotic fluid, and Doppler parameters including UtA systolic/diastolic (S/D) and pulsatility index (PI), MCA S/D and PI, and UA S/D and PI, will conducted following fetal biometry EFW was computed. CPR was determined using the ratio of MCA PI to UA PI.8 UCR will calculated as the inverse of CPR, the ratio of UA PI to MCA PI.11 CPUR was determined using the ratio of CPR to UtA PI.13 The DVP method will implemented to estimate the amniotic fluid volume.19 The AUCR will calculated as the ratio of DVP to UA PI/MCA PI |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- pregnant women with hypertensive disorder
Key inclusion criteria (5 listed)
- Women aged 18-40 years, inclusive.
- Singleton viable pregnancy.
- Gestational age ≥32 weeks.
- Pregnancy complicated by a hypertensive disorder.
- Women who provide written informed consent.
Key exclusion criteria (4 listed)
- Multiple gestation.
- Fetuses with known chromosomal or major congenital anomalies.
- Maternal diseases likely to independently affect fetal circulation or perinatal outcome, such as significant cardiac disease or other major systemic diseases.
- Inability to complete the required follow-up.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
number of cases with NICU admission
Time frame: 6 weeks
number of neonates admitted in neonatal care unit within 24 hours after delivery
1 secondary outcome
weight of birth
Time frame: 1 day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Hypertension Disorders in Pregnancy, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 31 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abdelrahman Mahmoud, MD (08802089519, abdelrahman_mahmoud2@aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
number of cases with NICU admission (time frame: 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Aug 2026.