Coronary Artery Bypass GraftingPNE-CABGNCT07783750
Preoperative Pain Neuroscience Education in Patients Undergoing CABG
A study testing Pain Neuroscience Education in people with Coronary Artery Bypass Grafting and Postoperative Pain, run by İsmail Palalı at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting (CABG). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Coronary Artery Bypass Grafting, Postoperative Pain
- What is being tested?
- Pain Neuroscience Education
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 76 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 23 Jun 2025to 4 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older Scheduled for elective coronary artery bypass grafting (CABG) through median sternotomy Able to understand and communicate sufficiently to participate in the education and outcome assessments Provided informed consent to participate in the study
Who cannot join
- Emergency CABG surgery Concomitant cardiac surgical procedures other than CABG Inability to understand or participate in the pain neuroscience education session Cognitive or communication impairment preventing completion of study assessments Postoperative clinical conditions preventing participation in the planned assessments
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Harran University Faculty of Medicine Training and Research Hospital
Sanliurfa, Şanlıurfa, 63000
About this study
Official title: Effect of Preoperative Pain Neuroscience Education on Chronic Postoperative Pain After Coronary Artery Bypass Grafting: A Randomized Controlled Trial
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting (CABG). Participants were randomly allocated to either a PNE group, which received a structured preoperative PNE session in addition to routine preoperative care, or a control group, which received routine preoperative information and care. Outcomes included pain intensity, pain catastrophizing, pain vigilance and awareness, and pressure pain threshold. Assessments were conducted preoperatively and at 24 hours, 1 month, and 3 months after surgery.
Read the detailed description
This study was designed as a prospective, two-arm, parallel-group randomized controlled trial involving patients scheduled for elective coronary artery bypass grafting (CABG). The study investigated whether preoperative pain neuroscience education could influence acute and persistent postoperative pain-related outcomes following CABG.
Participants were randomly allocated to an intervention group or a control group. Participants in the intervention group received a structured pain neuroscience education session before surgery in addition to routine preoperative care. The educational session addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors that may influence pain experiences, common misconceptions about pain, and strategies for understanding and coping with postoperative pain. Participants in the control group received routine preoperative information and care without structured pain neuroscience education.
Assessments were performed at baseline before surgery and at 24 hours, 1 month, and 3 months after surgery. Pain intensity was assessed using a visual analog scale (VAS). Pain-related cognitive and attentional factors were assessed using the Pain Catastrophizing Scale (PCS) and Pain Vigilance and Awareness Questionnaire (PVAQ). Pressure pain threshold (PPT) was assessed using a digital pressure algometer.
The study aimed to determine whether a brief preoperative educational intervention targeting pain-related knowledge and beliefs could improve postoperative pain and pain-related outcomes in patients undergoing CABG.
- Being tested
- Pain Neuroscience Education
- Keywords
- Pain Neuroscience Education, Coronary Artery Bypass Grafting, CABG, Postoperative Pain, Chronic Postoperative Pain, Pain Catastrophizing, Pain Vigilance, Pressure Pain Threshold
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pain Neuroscience EducationBehavioural
Participants received a structured pain neuroscience education session preoperatively in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing the pain experience, common pain-related misconceptions, and strategies for understanding and coping with postoperative pain.
| Study group | Role | What they receive |
|---|---|---|
| Preoperative Pain Neuroscience Education | Experimental | Participants received a structured preoperative pain neuroscience education (PNE) session in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing pain experiences, common misconceptions about pain, and strategies for understanding and coping with postoperative pain. Receives: Behavioral: Pain Neuroscience Education |
| Routine Preoperative Care | No intervention | Participants received routine preoperative information and standard care provided to patients undergoing elective coronary artery bypass grafting (CABG). No structured pain neuroscience education was provided to this group. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cough-Evoked Surgical-Site Pain Intensity at 3 Months
Cough-evoked pain intensity at the surgical site was assessed using a 0-10 pain rating scale, with higher scores indicating greater pain intensity.
Measured: 3 months after surgery
Secondary outcomes (6)
Cough-Evoked Surgical-Site Pain Intensity
Cough-evoked pain intensity at the surgical site was assessed using a 0-10 pain rating scale, with higher scores indicating greater pain intensity.
Measured: 24 hours and 1 month after surgery
Pain Catastrophizing
Pain catastrophizing was assessed using the Pain Catastrophizing Scale (PCS). The PCS consists of 13 items scored from 0 to 4, yielding a total score ranging from 0 to 52. Higher scores indicate greater pain catastrophizing.
Measured: Baseline, 1 month, and 3 months after surgery
Pain Vigilance and Awareness
Pain-related vigilance and attention were assessed using the Pain Vigilance and Awareness Questionnaire (PVAQ). The PVAQ consists of 16 items, with higher total scores indicating greater attention to and vigilance for pain.
Measured: Baseline, 1 month, and 3 months after surgery
Local Pressure Pain Threshold
Local mechanical pain sensitivity was assessed using pressure pain threshold (PPT) testing with a pressure algometer at a site adjacent to the sternotomy region. The pressure at which the sensation first became painful was recorded, with higher PPT values indicating lower mechanical pain sensitivity.
Measured: Baseline, 1 month, and 3 months after surgery
Remote Pressure Pain Threshold
Remote mechanical pain sensitivity was assessed using pressure pain threshold (PPT) testing with a pressure algometer at a site remote from the surgical area. The pressure at which the sensation first became painful was recorded, with higher PPT values indicating lower mechanical pain sensitivity
Measured: Baseline, 1 month, and 3 months after surgery
Chronic Postsurgical Pain
The presence of chronic postsurgical pain (CPSP) was assessed at 3 months after CABG based on the presence of persistent pain related to the surgical procedure.
Measured: 3 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2026
- Study start23 Jun 2025
- Primary completion3 Aug 2026
- Study completion4 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery Bypass GraftingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants undergoing elective CABG were randomly allocated to either a preoperative pain neuroscience education group or a control group receiving routine preoperative care.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 76 participants (actual)
Sponsor and investigators
- Lead sponsor
- İsmail Palalı
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, İsmail Palalı, Harran University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07783750
- Sponsor's protocol ID
- HRU-PNE-CABG-2025-01
- Other IDs
- HRÜ/25.11.28
- Acronym
- PNE-CABG
- Status last verified
- Aug 2026
- First submitted
- 21 Aug 2026
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data are not planned to be publicly shared.
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Preoperative Pain Neuroscience Education on Chronic Postoperative Pain After Coronary Artery Bypass Grafting: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07783750
- Acronym / sponsor ID
- PNE-CABG / HRU-PNE-CABG-2025-01
- Keywords
- Pain Neuroscience Education, Coronary Artery Bypass Grafting, CABG, Postoperative Pain, Chronic Postoperative Pain, Pain Catastrophizing, Pain Vigilance, Pressure Pain Threshold
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 76 participants (actual)
- Lead sponsor
- İsmail PalalıUniversity, hospital or other
- Study start
- 23 Jun 2025 (actual)
- Primary completion
- 3 Aug 2026 (actual)
- Study completion
- 4 Aug 2026 (actual)
- First posted
- 25 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting (CABG). Participants were randomly allocated to either a PNE group, which received a structured preoperative PNE session in addition to routine preoperative care, or a control group, which received routine preoperative information and care. Outcomes included pain intensity, pain catastrophizing, pain vigilance and awareness, and pressure pain threshold. Assessments were conducted preoperatively and at 24 hours, 1 month, and 3 months after surgery.
Detailed description
This study was designed as a prospective, two-arm, parallel-group randomized controlled trial involving patients scheduled for elective coronary artery bypass grafting (CABG). The study investigated whether preoperative pain neuroscience education could influence acute and persistent postoperative pain-related outcomes following CABG.
Participants were randomly allocated to an intervention group or a control group. Participants in the intervention group received a structured pain neuroscience education session before surgery in addition to routine preoperative care. The educational session addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors that may influence pain experiences, common misconceptions about pain, and strategies for understanding and coping with postoperative pain. Participants in the control group received routine preoperative information and care without structured pain neuroscience education.
Assessments were performed at baseline before surgery and at 24 hours, 1 month, and 3 months after surgery. Pain intensity was assessed using a visual analog scale (VAS). Pain-related cognitive and attentional factors were assessed using the Pain Catastrophizing Scale (PCS) and Pain Vigilance and Awareness Questionnaire (PVAQ). Pressure pain threshold (PPT) was assessed using a digital pressure algometer.
The study aimed to determine whether a brief preoperative educational intervention targeting pain-related knowledge and beliefs could improve postoperative pain and pain-related outcomes in patients undergoing CABG.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants undergoing elective CABG were randomly allocated to either a preoperative pain neuroscience education group or a control group receiving routine preoperative care.
| Arm | Type | Receives |
|---|---|---|
| Preoperative Pain Neuroscience Education | Experimental | Behavioral: Pain Neuroscience EducationParticipants received a structured preoperative pain neuroscience education (PNE) session in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing pain experiences, common misconceptions about pain, and strategies for understanding and coping with postoperative pain. |
| Routine Preoperative Care | No intervention | –Participants received routine preoperative information and standard care provided to patients undergoing elective coronary artery bypass grafting (CABG). No structured pain neuroscience education was provided to this group. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adults aged 18 years or older Scheduled for elective coronary artery bypass grafting (CABG) through median sternotomy Able to understand and communicate sufficiently to participate in the education and outcome assessments Provided informed consent to participate in the study
Key exclusion criteria (1 listed)
- Emergency CABG surgery Concomitant cardiac surgical procedures other than CABG Inability to understand or participate in the pain neuroscience education session Cognitive or communication impairment preventing completion of study assessments Postoperative clinical conditions preventing participation in the planned assessments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pain Neuroscience EducationParticipants received a structured pain neuroscience education session preoperatively in addition to routine preoperative care. The education addressed the neurophysiology of pain, the role of the nervous system and brain in pain perception, factors influencing the pain experience, common pain-related misconceptions, and strategies for understanding and coping with postoperative pain. | Behavioural | Preoperative Pain Neuroscience Education |
Primary outcome
Cough-Evoked Surgical-Site Pain Intensity at 3 Months
Time frame: 3 months after surgery
Cough-evoked pain intensity at the surgical site was assessed using a 0-10 pain rating scale, with higher scores indicating greater pain intensity.
6 secondary outcomes
Cough-Evoked Surgical-Site Pain Intensity
Time frame: 24 hours and 1 month after surgery
Pain Catastrophizing
Time frame: Baseline, 1 month, and 3 months after surgery
Pain Vigilance and Awareness
Time frame: Baseline, 1 month, and 3 months after surgery
Local Pressure Pain Threshold
Time frame: Baseline, 1 month, and 3 months after surgery
Remote Pressure Pain Threshold
Time frame: Baseline, 1 month, and 3 months after surgery
Chronic Postsurgical Pain
Time frame: 3 months after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data are not planned to be publicly shared.
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Coronary Artery Bypass Graft (CABG)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pain Neuroscience Education in people with Coronary Artery Bypass Grafting and Postoperative Pain, run by İsmail Palalı at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cough-Evoked Surgical-Site Pain Intensity at 3 Months (time frame: 3 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2026.