Thinned-out Lower Uterine Segment Scar Previous Cesarean SectionNCT07758959
Comparison of Purse String Suture vs Transverse Mattress Suture to Maintain Hemostasis in Thinned-out Caesarean Sections Scars
A study testing Purse-String Suture and Transverse Mattress Suture in people with Thinned-out Lower Uterine Segment Scar Previous Cesarean Section, run by Natasha Bushra at 1 site in Pakistan.
Trial summary
Brief Summary The goal of this clinical trial is to compare the effectiveness of purse-string suture versus transverse mattress suture for achieving hemostasis in women with thinned-out lower uterine segment scars undergoing repeat cesarean section. Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Thinned-out Lower Uterine Segment Scar Previous Cesarean Section
- What is being tested?
- Purse-String Suture and Transverse Mattress Suture
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 6 Aug 2026to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Females aged 18 to 40 years.
- Gestational age >37 weeks at the time of delivery.
- Parity <5.
- History of one or more previous cesarean sections.
- Intraoperative evidence of a thinned-out lower uterine segment scar during repeat cesarean section.
Who cannot join
- Preeclampsia (blood pressure ≥140/90 mmHg with proteinuria >+1 on dipstick).
- Gestational diabetes mellitus.
- Placental abnormalities, including placenta previa, placenta accreta spectrum (accreta/increta), or placental abruption.
- Previous uterine repair scar.
- Coagulation disorder (prothrombin time >15 seconds).
Trial locations and contacts
1 site in 1 country.
About this study
Brief Summary The goal of this clinical trial is to compare the effectiveness of purse-string suture versus transverse mattress suture for achieving hemostasis in women with thinned-out lower uterine segment scars undergoing repeat cesarean section. The study aims to determine whether the purse-string suture technique provides faster and more effective hemostasis than the transverse mattress suture technique.
The main questions it aims to answer are:
Read more
- Does the purse-string suture reduce the time required to achieve hemostasis compared with the transverse mattress suture?
- Does the purse-string suture reduce the number of additional sutures required to achieve adequate hemostasis? Researchers will compare purse-string suturing with transverse mattress suturing to determine which technique achieves hemostasis more efficiently in women with thinned-out cesarean section scars.
Participants will:
- Undergo repeat cesarean section under standard surgical care.
- Be randomly assigned to receive either purse-string suturing or transverse mattress suturing for repair of the thinned-out lower uterine segment after closure of the first uterine layer.
- Have the time required to achieve hemostasis and the number of sutures required recorded intraoperatively.
- Receive routine postoperative management according to institutional protocols. Suggested improvement
Although the thesis mentions only time to achieve hemostasis and number of sutures as outcomes, ClinicalTrials.gov prefers that the primary outcome be clearly identified. Since your sample size was calculated using time to achieve hemostasis, I recommend presenting it as:
- Primary outcome: Time to achieve hemostasis (minutes)
- Secondary outcomes: Number of sutures required for hemostasis; duration of cesarean section (minutes)
- Being tested
- Purse-String Suture, Transverse Mattress Suture
- Keywords
- Cesarean Section, Repeat Cesarean Section
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Purse-String SutureProcedure or surgery
Purse-string suturing of the thinned-out lower uterine segment during repeat cesarean section.
Transverse Mattress SutureProcedure or surgery
Transverse mattress suturing of the thinned-out lower uterine segment during repeat cesarean section.
| Study group | Role | What they receive |
|---|---|---|
| Arm 1 Arm Title: Purse-String Suture | Experimental | Participants undergoing repeat cesarean section with a thinned-out lower uterine segment scar underwent uterine repair using the purse-string suture technique to achieve hemostasis. Receives: Procedure: Purse-String Suture |
| Arm 2 Arm Title: Transverse Mattress Suture | Experimental | Participants undergoing repeat cesarean section with a thinned-out lower uterine segment scar underwent uterine repair using the transverse mattress suture technique to achieve hemostasis. Receives: Procedure: Transverse Mattress Suture |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to Achieve Hemostasis
Time (in minutes) required to achieve complete hemostasis of the thinned-out lower uterine segment following application of the assigned suturing technique during repeat cesarean section.
Measured: During the surgical procedure (intraoperative)
Time to Achieve Hemostasis
Time (in minutes) required to achieve complete hemostasis of the thinned-out lower uterine segment following application of the assigned suturing technique during repeat cesarean section.
Measured: Intraoperative (during cesarean section)
Secondary outcomes (1)
Number of Sutures Required to Achieve Hemostasis
Number of hemostatic sutures required to achieve complete hemostasis of the thinned-out lower uterine segment during repeat cesarean section.
Measured: Intraoperative (during cesarean section)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Aug 2026
- Study start6 Aug 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Thinned-out Lower Uterine Segment Scar Previous Cesarean SectionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Natasha Bushra
- Sponsor type
- Other government
- Collaborators
- Lahore General Hospital
- Responsible party
- Sponsor-investigator, Natasha Bushra, Lahore General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07758959
- Sponsor's protocol ID
- lahore general hospital
- Other IDs
- irb no 199/24
- Status last verified
- Aug 2026
- First submitted
- 6 Aug 2026
- Last updated
- 11 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to institutional and ethical restrictions and the absence of a predefined data-sharing plan.
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Purse String Suture vs Transverse Mattress Suture to Maintain Hemostasis in Thinned-out Caesarean Sections Scars
- ClinicalTrials.gov ID
- NCT07758959
- Acronym / sponsor ID
- lahore general hospital
- Keywords
- Cesarean Section, Repeat Cesarean Section
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Natasha BushraOther government
- Collaborators
- Lahore General Hospital
- Study start
- 6 Aug 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 11 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Brief Summary The goal of this clinical trial is to compare the effectiveness of purse-string suture versus transverse mattress suture for achieving hemostasis in women with thinned-out lower uterine segment scars undergoing repeat cesarean section. The study aims to determine whether the purse-string suture technique provides faster and more effective hemostasis than the transverse mattress suture technique.
The main questions it aims to answer are:
- Does the purse-string suture reduce the time required to achieve hemostasis compared with the transverse mattress suture?
- Does the purse-string suture reduce the number of additional sutures required to achieve adequate hemostasis? Researchers will compare purse-string suturing with transverse mattress suturing to determine which technique achieves hemostasis more efficiently in women with thinned-out cesarean section scars.
Participants will:
- Undergo repeat cesarean section under standard surgical care.
- Be randomly assigned to receive either purse-string suturing or transverse mattress suturing for repair of the thinned-out lower uterine segment after closure of the first uterine layer.
- Have the time required to achieve hemostasis and the number of sutures required recorded intraoperatively.
- Receive routine postoperative management according to institutional protocols. Suggested improvement
Although the thesis mentions only time to achieve hemostasis and number of sutures as outcomes, ClinicalTrials.gov prefers that the primary outcome be clearly identified. Since your sample size was calculated using time to achieve hemostasis, I recommend presenting it as:
- Primary outcome: Time to achieve hemostasis (minutes)
- Secondary outcomes: Number of sutures required for hemostasis; duration of cesarean section (minutes)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm 1 Arm Title: Purse-String Suture | Experimental | Procedure: Purse-String SutureParticipants undergoing repeat cesarean section with a thinned-out lower uterine segment scar underwent uterine repair using the purse-string suture technique to achieve hemostasis. |
| Arm 2 Arm Title: Transverse Mattress Suture | Experimental | Procedure: Transverse Mattress SutureParticipants undergoing repeat cesarean section with a thinned-out lower uterine segment scar underwent uterine repair using the transverse mattress suture technique to achieve hemostasis. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Females aged 18 to 40 years.
- Gestational age >37 weeks at the time of delivery.
- Parity <5.
- History of one or more previous cesarean sections.
- Intraoperative evidence of a thinned-out lower uterine segment scar during repeat cesarean section.
Key exclusion criteria (5 listed)
- Preeclampsia (blood pressure ≥140/90 mmHg with proteinuria >+1 on dipstick).
- Gestational diabetes mellitus.
- Placental abnormalities, including placenta previa, placenta accreta spectrum (accreta/increta), or placental abruption.
- Previous uterine repair scar.
- Coagulation disorder (prothrombin time >15 seconds).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Purse-String SuturePurse-string suturing of the thinned-out lower uterine segment during repeat cesarean section. | Procedure or surgery | Arm 1 Arm Title: Purse-String Suture |
| Transverse Mattress SutureTransverse mattress suturing of the thinned-out lower uterine segment during repeat cesarean section. | Procedure or surgery | Arm 2 Arm Title: Transverse Mattress Suture |
Primary outcome
Time to Achieve Hemostasis
Time frame: During the surgical procedure (intraoperative)
Time (in minutes) required to achieve complete hemostasis of the thinned-out lower uterine segment following application of the assigned suturing technique during repeat cesarean section.
Time to Achieve Hemostasis
Time frame: Intraoperative (during cesarean section)
Time (in minutes) required to achieve complete hemostasis of the thinned-out lower uterine segment following application of the assigned suturing technique during repeat cesarean section.
1 secondary outcome
Number of Sutures Required to Achieve Hemostasis
Time frame: Intraoperative (during cesarean section)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to institutional and ethical restrictions and the absence of a predefined data-sharing plan.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Purse-String Suture and Transverse Mattress Suture in people with Thinned-out Lower Uterine Segment Scar Previous Cesarean Section, run by Natasha Bushra at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 11 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to Achieve Hemostasis (time frame: During the surgical procedure (intraoperative)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2026; AzTrials last refreshed its copy on 7 Nov 2026.