AthletesNCT07756164
The Effects of a Multicomponent Sleep & Recovery Supplement on Muscle Fatigue and Sleep
A study testing magnesium-based sleep & recovery supplement in people with Athletes and Healthy, run by University of Exeter.
Trial summary
The goal of this clinical trial (randomised crossover study) is to learn if a multi-component sleep and exercise recovery supplement can improve sleep quality and enhance recovery following exercise in healthy, recreationally active adults aged 18-40. The main questions it aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- What is being tested?
- magnesium-based sleep & recovery supplement
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- Aug 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged between 18-40, healthy and non smokers
- Recreationally active, exercise at least 2 times a week
Who cannot join
- • Not have any injuries that would affect performance
- Not taking any medications that could affect drowsiness or energy levels
- Not taking any other dietary supplements high in magnesium
- Not be pregnant
- Not have any illness or medical condition that could make intense exercise unsafe
- Not be participating in other studies that could interfere with the outcomes of this study
- Not have any current sleep problems e.g. Insomnia
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: The Effects of a Multicomponent Sleep & Recovery Supplement on Exercise Performance and Recovery Following a Muscle Damaging Protocol
The goal of this clinical trial (randomised crossover study) is to learn if a multi-component sleep and exercise recovery supplement can improve sleep quality and enhance recovery following exercise in healthy, recreationally active adults aged 18-40.
The main questions it aims to answer are:
Read more
- Does the supplement reduce delayed onset muscle soreness (DOMS) following an intense exercise protocol?
- Does the supplement improve sleep quality?
Researchers will compare the supplement to a placebo (a look-alike tablet with no active ingredients) to see if the supplement improves exercise recovery and sleep quality. In this crossover design, all participants will receive both the supplement and the placebo in separate 2-week periods, with a 2-week washout period in between.
Participants will:
- Take the supplement during one 2-week period and the placebo during another (order randomised), 30 minutes before bed each day
- Complete an exercise protocol involving repeated leg extensions designed to induce muscle fatigue
- Attend six laboratory visits, including baseline testing and follow-up assessments at 24 and 48 hours post-exercise
- Complete daily sleep questionnaires during each supplementation period
- Record food intake prior to exercise trials and replicate it for consistency
- Perform muscle soreness assessments and single-leg jump tests before and after exercise, and during recovery
- Being tested
- magnesium-based sleep & recovery supplement, Placebo Supplementation
- Keywords
- Muscle Damage, Sleep, Supplementation, Recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
magnesium-based sleep & recovery supplementDietary supplement
magnesium-based sleep \& recovery supplement (2g/day for 2-weeks)
Placebo SupplementationDietary supplement
Placebo Supplementation (2g/day for 2-weeks)
| Study group | Role | What they receive |
|---|---|---|
| Magnesium-based sleep & recovery supplementation | Experimental | Supplementation of a magnesium-based sleep \& recovery supplement (2g/day for 2-weeks) Receives: Dietary Supplement: magnesium-based sleep & recovery supplement |
| Placebo Supplementation | Placebo comparator | Supplementation of placebo (2g/day for 2-weeks) Receives: Dietary Supplement: Placebo Supplementation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in total work done
Changes in total work done as measured by the Biodex
Measured: Following each 2-week supplementation period of either supplement
Changes in work done (Flexion)
Changes in work done (Flexion) as measured by the Biodex
Measured: Following each 2-week supplementation period of either supplement
Changes in work done (Extension)
Changes in work done (Extension) as measured by the Biodex
Measured: Following each 2-week supplementation period of either supplement
Changes in Single Leg jump height
Changes in Single Leg jump height (m)
Measured: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period
Changes in Single Leg Jump hang time
Changes in Single Leg Jump hang time (s)
Measured: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period
Secondary outcomes (6)
Changes in sleep quality
Changes in sleep quality as measured by the Groningen Sleep Quality questionnaire where a lower score indicates better sleep quality.
Measured: Following each 2-week supplementation period of either supplement.
Changes in perceived muscle soreness (Pain pressure threshold)
Changes in perceived muscle soreness (Pain pressure threshold in Newtons) as measured by the muscle algometer where a higher score means a better outcome
Measured: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol.
Change in Self-Reported Readiness to Train Score (5-Point Likert Scale)
Change in perceived readiness to train or compete assessed using a self-reported 5-point Likert scale, where 1 = not at all ready (extremely fatigued/sore) and 5 = completely ready (fresh, no limitations)
Measured: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Changes in Sleep Quality
Changes in Sleep Quality as measured by the Consensus Sleep Diary.
Measured: Following each 2-week supplementation period of either supplement.
Change in perceived recovery status (10-Point Likert Scale)
Change in perceived readiness to train or compete assessed using a self-reported 10-point Likert scale, where 0 = very poorly recovered and 10 = fully recovered
Measured: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Change in perceived overall muscle soreness (10-Point Likert Scale)
Change in perceived readiness to train or compete assessed using a self-reported 10-point Likert scale, where 0 = no soreness and 10 = worse soreness imaginable
Measured: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Aug 2026
- Study startAug 2026 (estimated)
- Primary completionOct 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AthletesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Exeter
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07756164
- Sponsor's protocol ID
- 8096200
- Status last verified
- Aug 2026
- First submitted
- 16 Apr 2026
- Last updated
- 10 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of a Multicomponent Sleep & Recovery Supplement on Exercise Performance and Recovery Following a Muscle Damaging Protocol
- ClinicalTrials.gov ID
- NCT07756164
- Acronym / sponsor ID
- 8096200
- Keywords
- Muscle Damage, Sleep, Supplementation, Recovery
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- University of ExeterUniversity, hospital or other
- Study start
- Aug 2026 (estimated)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 10 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial (randomised crossover study) is to learn if a multi-component sleep and exercise recovery supplement can improve sleep quality and enhance recovery following exercise in healthy, recreationally active adults aged 18-40.
The main questions it aims to answer are:
- Does the supplement reduce delayed onset muscle soreness (DOMS) following an intense exercise protocol?
- Does the supplement improve sleep quality?
Researchers will compare the supplement to a placebo (a look-alike tablet with no active ingredients) to see if the supplement improves exercise recovery and sleep quality. In this crossover design, all participants will receive both the supplement and the placebo in separate 2-week periods, with a 2-week washout period in between.
Participants will:
- Take the supplement during one 2-week period and the placebo during another (order randomised), 30 minutes before bed each day
- Complete an exercise protocol involving repeated leg extensions designed to induce muscle fatigue
- Attend six laboratory visits, including baseline testing and follow-up assessments at 24 and 48 hours post-exercise
- Complete daily sleep questionnaires during each supplementation period
- Record food intake prior to exercise trials and replicate it for consistency
- Perform muscle soreness assessments and single-leg jump tests before and after exercise, and during recovery
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Magnesium-based sleep & recovery supplementation | Experimental | Dietary Supplement: magnesium-based sleep & recovery supplementSupplementation of a magnesium-based sleep \& recovery supplement (2g/day for 2-weeks) |
| Placebo Supplementation | Placebo comparator | Dietary Supplement: Placebo SupplementationSupplementation of placebo (2g/day for 2-weeks) |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Aged between 18-40, healthy and non smokers
- Recreationally active, exercise at least 2 times a week
Key exclusion criteria (7 listed)
- • Not have any injuries that would affect performance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| magnesium-based sleep & recovery supplementmagnesium-based sleep \& recovery supplement (2g/day for 2-weeks) | Dietary supplement | Magnesium-based sleep & recovery supplementation |
| Placebo SupplementationPlacebo Supplementation (2g/day for 2-weeks) | Dietary supplement | Placebo Supplementation |
Primary outcome
Changes in total work done
Time frame: Following each 2-week supplementation period of either supplement
Changes in total work done as measured by the Biodex
Changes in work done (Flexion)
Time frame: Following each 2-week supplementation period of either supplement
Changes in work done (Flexion) as measured by the Biodex
Changes in work done (Extension)
Time frame: Following each 2-week supplementation period of either supplement
Changes in work done (Extension) as measured by the Biodex
Changes in Single Leg jump height
Time frame: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period
Changes in Single Leg jump height (m)
Changes in Single Leg Jump hang time
Time frame: Before and Immediately After Muscle Damaging Protocol at the End of Each 2-Week Supplementation Period
Changes in Single Leg Jump hang time (s)
6 secondary outcomes
Changes in sleep quality
Time frame: Following each 2-week supplementation period of either supplement.
Changes in perceived muscle soreness (Pain pressure threshold)
Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol.
Change in Self-Reported Readiness to Train Score (5-Point Likert Scale)
Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Changes in Sleep Quality
Time frame: Following each 2-week supplementation period of either supplement.
Change in perceived recovery status (10-Point Likert Scale)
Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Change in perceived overall muscle soreness (10-Point Likert Scale)
Time frame: Following each 2-week supplementation period of either supplement and 24hr and 48hr following the muscle damaging protocol
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing magnesium-based sleep & recovery supplement in people with Athletes and Healthy, run by University of Exeter.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tom G Gurney, PhD (+44 (0) 1326 370400, t.g.gurney@exeter.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in total work done (time frame: Following each 2-week supplementation period of either supplement). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.