Premenstrual SyndromeNCT07754149
Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls
A study testing Progressive Resistance Training and Low-Intensity Resistance Training in people with Premenstrual Syndrome, run by Riphah International University at 2 sites in Pakistan.
Trial summary
This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. Read more about this study
- Who is it for?
- Ages 11 to 19 years, women only
- Conditions the study is for
- Premenstrual Syndrome
- What is being tested?
- Progressive Resistance Training and Low-Intensity Resistance Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 2 sitesPakistan
- Study dates
- 10 Aug 2026to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 11 to 19 years
- Women only
- No healthy volunteers
- Child, Adult
Who may be able to join
- Diagnosed with Premenstrual Syndrome (PMS) based on PSST screening tool.
- Not currently engaged in any structured resistance or exercise training program.
- Medically cleared to participate in moderate-intensity resistance training.
- Provided written informed consent for participation.
Who cannot join
- Current use of hormonal therapy or oral contraceptives.
- History of endocrine disorders (e.g., PCOS, thyroid dysfunction).
- Any musculoskeletal or cardiovascular condition limiting exercise participation.
- Ongoing psychiatric medication or diagnosed depression/anxiety disorder.
- Participation in a structured exercise or resistance training program within the last 3 months.
- Use of analgesics, anti-inflammatory, or hormonal medications during the study period.
Trial locations and contacts
2 sites in 1 country.
Pakistan2 sites
Kens college model town humak and community model town
Islamabad, Federal, 051
Kid city high school
Islamabad, Federal, 051
About this study
This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. While exercise is known to reduce symptoms, the optimal intensity of resistance training remains unclear. Using a randomized controlled trial design, participants are assigned to progressive or low-intensity training groups. PMS symptoms and quality of life are assessed over time. The study aims to determine whether higher exercise intensity leads to greater symptom reduction and improved overall well-being.
Read the detailed description
This study focuses on premenstrual syndrome (PMS), a common cyclical condition experienced by adolescent girls that includes physical, psychological, and behavioral symptoms such as pain, mood swings, anxiety, fatigue, and reduced concentration. These symptoms can negatively affect academic performance, social interactions, and overall quality of life. Exercise has been shown to improve hormonal balance, reduce stress, and enhance mood through the release of endorphins and serotonin. However, most existing research has focused on aerobic exercise, with limited attention given to resistance training. Resistance training, which involves strengthening muscles through weights or bodyweight exercises, may offer additional benefits, but its optimal intensity and effectiveness for PMS management remain unclear. This study addresses this gap by examining the dose-response relationship of resistance training.
- Conditions
- Premenstrual Syndrome
- Being tested
- Progressive Resistance Training, Low-Intensity Resistance Training
- Keywords
- Premenstrual Syndrome, Resistance Training, Dose-Response, Adolescent Girls, Exercise Therapy, Quality of Life, Randomized Controlled Trial
- Medical subject headings
- Premenstrual Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Progressive Resistance TrainingOther
A supervised progressive resistance training program delivered three sessions per week for six weeks. Exercise intensity is gradually increased using the Borg Rating of Perceived Exertion (RPE) scale.
A warm up session will be done before resistance training exercise and Cool down for 5-10 minutes will be done exercise.
Participants will follow the FITT prescription for their resistance exercises.
Week 1-2 (DOSE 1) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25-30 reps. Volume: High. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: moderate. Bodyweight or dumbbells (RPE 12-14/20). Sets \& Reps: 2 sets of 20-25 repetitions. Volume: Moderate. Focus on mastering technique. Week 5-6(DOSE 3) Intensity: high. Dumbbells (RPE 15-16/20). Sets \& Reps: 2 sets of 15-20 repetitions. Volume: Low.
Low-Intensity Resistance TrainingOther
Participants of this group will receive the same standardized exercises as the experimental group. Exercise intensity remains constant at low intensity throughout the intervention period without progressive increase.
Before exercise the participants will perform warm up and after exercise they will perform cool down, same as the experimental group.
The FITT protocol for this group is as following:
Week 1-2 (DOSE1) Intensity: low Body weight. or Dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 15repetitions. Volume: Low. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 20 repetitions. Volume: Moderate. Focus on mastering technique Week 5-6(DOSE 3) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25 reps. Volume: High. Focus on mastering technique.
| Study group | Role | What they receive |
|---|---|---|
| Progressive Resistance Training Group | Experimental | Participants allocated to this arm will receive a supervised 6-week progressive resistance training program performed three times per week on non-consecutive days. Each session will last 45-60 minutes. Receives: Other: Progressive Resistance Training |
| Low-Intensity Resistance Training Group | Active comparator | Participants allocated to this arm will receive a supervised low-intensity resistance training program for six weeks. Sessions will be conducted three times per week, lasting 45-60 minutes each. Participants will perform the same standardized resistance exercises as the experimental group; however, exercise intensity will remain low throughout the intervention without progressive overload. Receives: Other: Low-Intensity Resistance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Premenstrual Symptoms Screening Tool (PSST)
The primary outcome of this study is the severity of premenstrual syndrome symptoms, measured using the Premenstrual Symptoms Screening Tool (PSST). The PSST is a self-reported questionnaire used to assess physical, psychological, and behavioral symptoms related to PMS, including mood swings, irritability, anxiety, fatigue, bloating, breast tenderness, and difficulty concentrating. It also evaluates how these symptoms affect daily activities, school performance, and social relationships. Each item is scored on a 4-point Likert scale ranging from "none" to "severe." Higher scores indicate greater PMS severity..
Measured: Assessments will be conducted at baseline, week 2, week 4, week 6, and at 3-month follow-up
Secondary outcomes (1)
Quality of Life (QoL)
Quality of life will be assessed using the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF). This questionnaire contains 26 items and evaluates four domains: physical health, psychological health, social relationships, and environmental well-being. Each item is rated on a 5-point Likert scale, with higher scores representing better quality of life. The WHOQOL-BREF is a reliable and valid tool commonly used in clinical and research settings to assess overall well-being.
Measured: Quality of life will be assessed at baseline, immediately after the 6-week intervention, and at 3-month follow-up using the WHOQOL-BREF questionnaire.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Aug 2026
- Study start10 Aug 2026
- Primary completionNov 2026 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Premenstrual SyndromeStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Rida Zafar, WHPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07754149
- Sponsor's protocol ID
- Amina Rizwan
- Status last verified
- Sep 2026
- First submitted
- 5 Aug 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD will not be shared to ensure participant confidentiality and data protection, particularly because the study involves adolescent girls, and data was collected for specific research purposes only."
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls
- ClinicalTrials.gov ID
- NCT07754149
- Acronym / sponsor ID
- Amina Rizwan
- Conditions
- Premenstrual Syndrome
- Keywords
- Premenstrual Syndrome, Resistance Training, Dose-Response, Adolescent Girls, Exercise Therapy, Quality of Life, Randomized Controlled Trial
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 10 Aug 2026 (actual)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 10 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. While exercise is known to reduce symptoms, the optimal intensity of resistance training remains unclear. Using a randomized controlled trial design, participants are assigned to progressive or low-intensity training groups. PMS symptoms and quality of life are assessed over time. The study aims to determine whether higher exercise intensity leads to greater symptom reduction and improved overall well-being.
Detailed description
This study focuses on premenstrual syndrome (PMS), a common cyclical condition experienced by adolescent girls that includes physical, psychological, and behavioral symptoms such as pain, mood swings, anxiety, fatigue, and reduced concentration. These symptoms can negatively affect academic performance, social interactions, and overall quality of life. Exercise has been shown to improve hormonal balance, reduce stress, and enhance mood through the release of endorphins and serotonin. However, most existing research has focused on aerobic exercise, with limited attention given to resistance training. Resistance training, which involves strengthening muscles through weights or bodyweight exercises, may offer additional benefits, but its optimal intensity and effectiveness for PMS management remain unclear. This study addresses this gap by examining the dose-response relationship of resistance training.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Progressive Resistance Training Group | Experimental | Other: Progressive Resistance TrainingParticipants allocated to this arm will receive a supervised 6-week progressive resistance training program performed three times per week on non-consecutive days. Each session will last 45-60 minutes. |
| Low-Intensity Resistance Training Group | Active comparator | Other: Low-Intensity Resistance TrainingParticipants allocated to this arm will receive a supervised low-intensity resistance training program for six weeks. Sessions will be conducted three times per week, lasting 45-60 minutes each. Participants will perform the same standardized resistance exercises as the experimental group; however, exercise intensity will remain low throughout the intervention without progressive overload. |
Who may qualify
- Ages
- 11 to 19 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Diagnosed with Premenstrual Syndrome (PMS) based on PSST screening tool.
- Not currently engaged in any structured resistance or exercise training program.
- Medically cleared to participate in moderate-intensity resistance training.
- Provided written informed consent for participation.
Key exclusion criteria (6 listed)
- Current use of hormonal therapy or oral contraceptives.
- History of endocrine disorders (e.g., PCOS, thyroid dysfunction).
- Any musculoskeletal or cardiovascular condition limiting exercise participation.
- Ongoing psychiatric medication or diagnosed depression/anxiety disorder.
- Participation in a structured exercise or resistance training program within the last 3 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Progressive Resistance TrainingA supervised progressive resistance training program delivered three sessions per week for six weeks. Exercise intensity is gradually increased using the Borg Rating of Perceived Exertion (RPE) scale. A warm up session will be done before resistance training exercise and Cool down for 5-10 minutes will be done exercise. Participants will follow the FITT prescription for their resistance exercises. Week 1-2 (DOSE 1) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25-30 reps. Volume: High. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: moderate. Bodyweight or dumbbells (RPE 12-14/20). Sets \& Reps: 2 sets of 20-25 repetitions. Volume: Moderate. Focus on mastering technique. Week 5-6(DOSE 3) Intensity: high. Dumbbells (RPE 15-16/20). Sets \& Reps: 2 sets of 15-20 repetitions. Volume: Low. | Other | Progressive Resistance Training Group |
| Low-Intensity Resistance TrainingParticipants of this group will receive the same standardized exercises as the experimental group. Exercise intensity remains constant at low intensity throughout the intervention period without progressive increase. Before exercise the participants will perform warm up and after exercise they will perform cool down, same as the experimental group. The FITT protocol for this group is as following: Week 1-2 (DOSE1) Intensity: low Body weight. or Dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 15repetitions. Volume: Low. Focus on mastering technique. Week 3-4 (DOSE 2) Intensity: low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 20 repetitions. Volume: Moderate. Focus on mastering technique Week 5-6(DOSE 3) Intensity: Low. Bodyweight or dumbbells (RPE 7-11/20). Sets \& Reps: 2 sets of 25 reps. Volume: High. Focus on mastering technique. | Other | Low-Intensity Resistance Training Group |
Primary outcome
Premenstrual Symptoms Screening Tool (PSST)
Time frame: Assessments will be conducted at baseline, week 2, week 4, week 6, and at 3-month follow-up
The primary outcome of this study is the severity of premenstrual syndrome symptoms, measured using the Premenstrual Symptoms Screening Tool (PSST). The PSST is a self-reported questionnaire used to assess physical, psychological, and behavioral symptoms related to PMS, including mood swings, irritability, anxiety, fatigue, bloating, breast tenderness, and difficulty concentrating. It also evaluates how these symptoms affect daily activities, school performance, and social relationships. Each item is scored on a 4-point Likert scale ranging from "none" to "severe." Higher scores indicate greater PMS severity..
1 secondary outcome
Quality of Life (QoL)
Time frame: Quality of life will be assessed at baseline, immediately after the 6-week intervention, and at 3-month follow-up using the WHOQOL-BREF questionnaire.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
- Individual participant dataSharing planned: No. IPD will not be shared to ensure participant confidentiality and data protection, particularly because the study involves adolescent girls, and data was collected for specific research purposes only."
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Rida Zafar, WHPT principal investigator
Riphah International University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Progressive Resistance Training and Low-Intensity Resistance Training in people with Premenstrual Syndrome, run by Riphah International University at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Premenstrual Symptoms Screening Tool (PSST) (time frame: Assessments will be conducted at baseline, week 2, week 4, week 6, and at 3-month follow-up). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.