Alopecia AreataPhase 2NCT07749716
Phase II Clinical Study of VC005 Tablets in Subjects With Severe Alopecia Areata
A Phase 2 study testing Drug: VC005 tablets and VC005 tablets in people with Alopecia Areata, run by Jiangsu vcare pharmaceutical technology co., LTD at 1 site in China.
Trial summary
This study is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the efficacy and safety of VC005 tablets in subjects with severe alopecia areata (AA). Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Alopecia Areata
- What is being tested?
- Drug: VC005 tablets and VC005 tablets
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 120 participants
- Where
- 1 siteChina
- Study dates
- 18 Aug 2026to 30 Dec 2028
- Phase
- Phase 2
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Subjects must fully understand the study, be willing and able to comply with all trial procedures, voluntarily participate in the clinical trial, and provide written informed consent by signing the informed consent form (ICF).
- Subjects must be aged between 18 and 65 years (inclusive) at the time of ICF signing, regardless of gender.
- Subjects must meet the diagnostic criteria for alopecia areata (AA) at both screening and baseline visits.
Who cannot join
- Women who are pregnant or breastfeeding, or subjects who plan to become pregnant or breastfeed during the study period.
- Subjects with a current diagnosis of acute diffuse alopecia areata (AA).
- Subjects with a current diagnosis of other types of alopecia that may interfere with the evaluation of AA, including but not limited to traction alopecia, cicatricial alopecia, telogen effluvium, androgenetic alopecia, syphilitic alopecia, anagen effluvium, folliculotropic mycosis fungoides, or alopecia caused by thyroid disease, etc.
- Subjects with other scalp diseases that may affect the assessment of AA, such as scalp psoriasis, dermatitis, tinea capitis, etc.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
The Peking University People's Hospital, Beijing, Beijng
Beijing, Beijing Municipality
Jianzhong Zhang, 010-88325471, rmzjz@126.com
About this study
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of VC005 Tablets in Subjects With Severe Alopecia Areata
This study is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the efficacy and safety of VC005 tablets in subjects with severe alopecia areata (AA).
- Conditions
- Alopecia Areata
- Being tested
- Drug: VC005 tablets, VC005 tablets, VC005 placebo tablets
- Medical subject headings
- Alopecia Areata
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Drug: VC005 tabletsDrug
VC005 repeat administration for 24 weeks
VC005 tabletsDrug
VC005 repeat administration for 24 weeks
VC005 placebo tabletsDrug
VC005 placebo repeat administration for 24 weeks
| Study group | Role | What they receive |
|---|---|---|
| VC005 Tablets Low Dose group | Experimental | Not described Receives: Drug: Drug: VC005 tablets |
| VC005 Tablets High Dose group | Experimental | Not described Receives: Drug: VC005 tablets |
| VC005 Tablets placebo group | Placebo comparator | Not described Receives: Drug: VC005 placebo tablets |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of subjects with a Severity of Alopecia Tool (SALT) score ≤ 20
Measured: at Week 24 (W24)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2026
- Study start18 Aug 2026
- Primary completion30 Dec 2028 (estimated)
- Study completion30 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alopecia AreataStudies of the same condition, open and under way.
- More trials run by Jiangsu vcare pharmaceutical technology co., LTDThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- jianzhong Zhang, Principal investigator, The Peking University People's Hospital, Beijing, Beijngcheng zhou, Principal investigator, The Peking University People's Hospital, Beijing, Beijng
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07749716
- Sponsor's protocol ID
- VC005-206
- Status last verified
- Aug 2026
- First submitted
- 3 Aug 2026
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of VC005 Tablets in Subjects With Severe Alopecia Areata
- ClinicalTrials.gov ID
- NCT07749716
- Acronym / sponsor ID
- VC005-206
- Conditions
- Alopecia Areata
- Phase
- Phase 2
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Jiangsu vcare pharmaceutical technology co., LTDIndustry (pharma, biotech, devices)
- Study start
- 18 Aug 2026 (actual)
- Primary completion
- 30 Dec 2028 (estimated)
- Study completion
- 30 Dec 2028 (estimated)
- First posted
- 6 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical study designed to evaluate the efficacy and safety of VC005 tablets in subjects with severe alopecia areata (AA).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| VC005 Tablets Low Dose group | Experimental | Drug: Drug: VC005 tablets |
| VC005 Tablets High Dose group | Experimental | Drug: VC005 tablets |
| VC005 Tablets placebo group | Placebo comparator | Drug: VC005 placebo tablets |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Subjects must fully understand the study, be willing and able to comply with all trial procedures, voluntarily participate in the clinical trial, and provide written informed consent by signing the informed consent form (ICF).
- Subjects must be aged between 18 and 65 years (inclusive) at the time of ICF signing, regardless of gender.
- Subjects must meet the diagnostic criteria for alopecia areata (AA) at both screening and baseline visits.
Key exclusion criteria (4 listed)
- Women who are pregnant or breastfeeding, or subjects who plan to become pregnant or breastfeed during the study period.
- Subjects with a current diagnosis of acute diffuse alopecia areata (AA).
- Subjects with a current diagnosis of other types of alopecia that may interfere with the evaluation of AA, including but not limited to traction alopecia, cicatricial alopecia, telogen effluvium, androgenetic alopecia, syphilitic alopecia, anagen effluvium, folliculotropic mycosis fungoides, or alopecia caused by thyroid disease, etc.
- Subjects with other scalp diseases that may affect the assessment of AA, such as scalp psoriasis, dermatitis, tinea capitis, etc.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Drug: VC005 tabletsVC005 repeat administration for 24 weeks | Drug | VC005 Tablets Low Dose group |
| VC005 tabletsVC005 repeat administration for 24 weeks | Drug | VC005 Tablets High Dose group |
| VC005 placebo tabletsVC005 placebo repeat administration for 24 weeks | Drug | VC005 Tablets placebo group |
Primary outcome
Proportion of subjects with a Severity of Alopecia Tool (SALT) score ≤ 20
Time frame: at Week 24 (W24)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
jianzhong Zhang principal investigator
The Peking University People's Hospital, Beijing, Beijng
cheng zhou principal investigator
The Peking University People's Hospital, Beijing, Beijng
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2 study testing Drug: VC005 tablets and VC005 tablets in people with Alopecia Areata, run by Jiangsu vcare pharmaceutical technology co., LTD at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact xiaojuan Lai (+8615358160458, lai_xiaojuan@vcarepharmatech.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of subjects with a Severity of Alopecia Tool (SALT) score ≤ 20 (time frame: at Week 24 (W24)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2026.