Frontal SinusitisNCT07748806
Radiological and Surgical Analysis of Frontal Recess Variations in Endoscopic Sinus Surgery
A study testing endosocpic sinus surgery in people with Frontal Sinusitis and Endoscopic Sinus Surgery, run by Al-Azhar University at 1 site in Egypt.
Trial summary
Introduction The frontal recess is a narrow and anatomically variable region that forms the frontal sinus drainage pathway. Variations in its anatomy, particularly those related to the agger nasi cell and other frontal recess cells, can impair frontal sinus drainage and contribute to the development of frontal sinus… Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Frontal Sinusitis, Endoscopic Sinus Surgery, Frontal Sinus Recess
- What is being tested?
- endosocpic sinus surgery
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Sep 2025to 1 Jul 2026
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age : (20 -60 years old ).
- Sex: both males and females.
- Patients were selected from the otorhinolaryngology outpatient clinic of Al-Azhar University Hospital in Assiut in a consecutive manner.
- All patients were generally well and fit for surgery.
Who cannot join
- Patients with massive inflammatory disease of specific in
- infections (e.g., rhinoscleroma).
- Malignancy.
- Severe nasal trauma.
- Foreign body.
- Previous nasal surgery.
- Atrophic diseases or systemic diseases and patients not fit for surgery.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Radiological and Surgical Analysis of Anatomical Variations of Frontal Sinus Recess and Its Surgical Importance in the Management of Frontal Sinus Disorders During Endoscopic Sinus Surgery
Introduction
The frontal recess is a narrow and anatomically variable region that forms the frontal sinus drainage pathway. Variations in its anatomy, particularly those related to the agger nasi cell and other frontal recess cells, can impair frontal sinus drainage and contribute to the development of frontal sinus disease. High-resolution computed tomography and endoscopic evaluation are essential for identifying these variations and planning endoscopic sinus surgery. A thorough understanding of frontal recess anatomy is crucial for achieving adequate frontal sinus drainage, improving surgical outcomes, and minimizing complications due to the close proximity of the orbit and skull base.
The Study aim to evaluate the anatomical variations of the frontal recess using radiological and surgical assessment and determine their significance in the management of frontal sinus disorders during endoscopic sinus surgery.
- Being tested
- endosocpic sinus surgery
- Medical subject headings
- Frontal Sinusitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
endosocpic sinus surgeryProcedure or surgery
Endoscopic sinus surgery to drain the frontal sinus and detect how easy it will be during surgery and its relation to anatomical variations
| Study group | Role | What they receive |
|---|---|---|
| patients presneted with chronic frontal sinusitis refreactory to medical treatment | Other | Patients who fulfill the inclusion criteria will undergo endoscopic sinus surgery and a CT scan to detect the anatomical variation of the frontal sinus, frontal recess, and the correlation of this viarations on surgical easiness Receives: Procedure: endosocpic sinus surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Size distribution of Agar nasi cells
Distribution of different sizes of agar nasi cells among the participants: small, medium, and large
Measured: Baseline
Prevalence of aggar nasi cell
The frequency of presence of aggar nasi cells on one side, bilateral, or absent
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2026
- Study start1 Sep 2025
- Primary completion1 Jul 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Frontal SinusitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Nabil Selim, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07748806
- Sponsor's protocol ID
- MSCAZASTENT0301024792025
- Status last verified
- Sep 2025
- First submitted
- 29 Jul 2026
- Last updated
- 6 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided