Socket PreservationNCT07736053
Alveolar Ridge Preservation Using Acemannan Aloe Vera Versus Natural Socket Healing
A study testing Aloe vera extract and Normal Socket Healing in people with Socket Preservation, run by Cairo University at 1 site in Egypt.
Trial summary
The goal of this clinical trial is to evaluate the effectiveness of acemannan aloe vera powder extract in preserving the alveolar ridge following tooth extraction in healthy adult patients. It will also assess the healing process by radiographic and histomorphometric analyses. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Socket Preservation
- What is being tested?
- Aloe vera extract and Normal Socket Healing
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2024to 12 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Non-restorable tooth in maxillary or mandibular anterior esthetic region.
- Intact or minimally affected buccal plate of bone.
- Patients at least 18 years or older.
- Motivated patients, agree to sign the written informed consent and complete the follow-up period.
Who cannot join
- Infection at the extraction site.
- Smokers more than 10 cigarettes per day .
- Patients undergoing or having a history of radiotherapy, chemotherapy, or bisphosphonate therapy .
- Systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism) .
- Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy)
- Systemic diseases or medications that affect blood clotting
- Pregnant females or those planning to get pregnant during the study period (American Dental Association, 2011).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Radiographic And Histomorphometric Assessment Following Alveolar Ridge Preservation Using Acemannan Aloe Vera Powder Extract Versus Normal Socket Healing. A Randomized Clinical Trial
The goal of this clinical trial is to evaluate the effectiveness of acemannan aloe vera powder extract in preserving the alveolar ridge following tooth extraction in healthy adult patients. It will also assess the healing process by radiographic and histomorphometric analyses. The main questions it aims to answer are:
Does acemannan aloe vera powder extract improve alveolar ridge preservation compared with natural socket healing? Does the use of acemannan aloe vera powder extract enhance bone quality and new bone formation as assessed by radiographic and histomorphometric outcomes?
Read more
Researchers will compare sockets treated with acemannan aloe vera powder extract to sockets allowed to heal naturally to determine whether the intervention results in improved dimensional preservation of the alveolar ridge and enhanced bone regeneration.
Participants will:
Undergo tooth extraction according to the study protocol. Be randomly assigned to receive either acemannan aloe vera powder extract for alveolar ridge preservation or natural socket healing without grafting.
Attend scheduled follow-up visits for clinical and radiographic evaluations. Undergo radiographic assessment using cone-beam computed tomography (CBCT) to evaluate changes in alveolar ridge dimensions.
Provide a bone biopsy at the time of implant placement for histomorphometric analysis of new bone formation and tissue composition.
- Conditions
- Socket Preservation
- Being tested
- Aloe vera extract, Normal Socket Healing
- Keywords
- socket prservation, Ridge preservation, Acemannan aloe vera, normal socket healing, Tooth extraction, delayed dental implant
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aloe vera extractBiological
After atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase .
Normal Socket HealingOther
Control Group: Normal Socket Healing
- Tooth Extraction: Standard tooth extraction procedures will be followed, ensuring minimal trauma to the surrounding bone and soft tissues.
- Socket Cleaning: The extraction socket will be thoroughly cleaned and debrided to remove any debris and blood clots.
- Natural Healing: The socket will be allowed to heal naturally without any additional intervention. Standard post-extraction care will be provided.
| Study group | Role | What they receive |
|---|---|---|
| Socket Preservation with Acemannan Aloe Vera Extract Powder | Experimental | After atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase Receives: Biological: Aloe vera extract; Other: Normal Socket Healing |
| Control Group (Normal Socket Healing) | Active comparator | Following extraction, the sockets were carefully debrided to remove any debris and blood clots. The sockets were then left to heal naturally without the application of any adjunctive biomaterials. Receives: Biological: Aloe vera extract; Other: Normal Socket Healing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in radiographic horizontal ridge width at 4 mm below the most coronal aspect of the crest
The immediate postoperative scans served as the baseline and were evaluated after 6 months to assess horizontal ridge width. Employing the same software, standardized measurements were obtained at both time points using consistent anatomical landmarks. On each baseline and after 6 months images, the apical point of the extraction socket was identified, and a vertical line was drawn through the socket's midpoint. A horizontal reference line perpendicular to the vertical axis was then established at the apical point. Horizontal ridge width was measured at 4 mm below the crest, yielding the parameters HW-4
Measured: 6 months postoperatively
Secondary outcomes (3)
Horizontal ridge width was measured at 2 mm and 6 mm below the crest
The immediate postoperative scans served as the baseline and were evaluated after 6 months to assess horizontal ridge width. Employing the same software, standardized measurements were obtained at both time points using consistent anatomical landmarks. On each baseline and 6-month image, the apical point of the extraction socket was identified, and a vertical line was drawn through the socket's midpoint. A horizontal reference line perpendicular to the vertical axis was then established at the apical point. Horizontal ridge width was measured at 2 mm and 6 mm below the crest, yielding the parameters HW-2 and HW-6, respectively
Measured: 6 months postoperatively
Vertical ridge height
DICOM files of the Immediate Post-Operative scans were assessed as a baseline and 6 months postoperatively for measurements of Change in radiographic buccal \& palatal ridge height. DICOM files of the two post-operative scans were assessed using a specialized software program, OnDemand® Software for Secondary outcome measurements.Two reference lines were drawn. The vertical reference line was placed at the midpoint of the extraction socket, intersecting the apical reference point. The height of the alveolus was measured at the midbuccal aspect (BH) and midlingual aspect (LH).
Measured: 6-months post
Percentage of new vital bone formation
After 6 months healing a local anesthesia will be given, a full thickness mucoperiosteal flap will be detached in the augmented areas and a bone biopsy will be collected using a 2 mm trephine bur.
Measured: 6 months post
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2026
- Study start1 Oct 2024
- Primary completion1 Jul 2025
- Study completion12 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Socket PreservationStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nouf Saeed Ahmed Alamoudi, Cairo University
- Investigators
- Nouf Saeed Alamoudi, Bachelor, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07736053
- Sponsor's protocol ID
- 14924
- Status last verified
- Jul 2026
- First submitted
- 20 Jul 2026
- Last updated
- 30 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Radiographic And Histomorphometric Assessment Following Alveolar Ridge Preservation Using Acemannan Aloe Vera Powder Extract Versus Normal Socket Healing. A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07736053
- Acronym / sponsor ID
- 14924
- Conditions
- Socket Preservation
- Keywords
- socket prservation, Ridge preservation, Acemannan aloe vera, normal socket healing, Tooth extraction, delayed dental implant
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Oct 2024 (actual)
- Primary completion
- 1 Jul 2025 (actual)
- Study completion
- 12 Dec 2025 (actual)
- First posted
- 30 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the effectiveness of acemannan aloe vera powder extract in preserving the alveolar ridge following tooth extraction in healthy adult patients. It will also assess the healing process by radiographic and histomorphometric analyses. The main questions it aims to answer are:
Does acemannan aloe vera powder extract improve alveolar ridge preservation compared with natural socket healing? Does the use of acemannan aloe vera powder extract enhance bone quality and new bone formation as assessed by radiographic and histomorphometric outcomes?
Researchers will compare sockets treated with acemannan aloe vera powder extract to sockets allowed to heal naturally to determine whether the intervention results in improved dimensional preservation of the alveolar ridge and enhanced bone regeneration.
Participants will:
Undergo tooth extraction according to the study protocol. Be randomly assigned to receive either acemannan aloe vera powder extract for alveolar ridge preservation or natural socket healing without grafting.
Attend scheduled follow-up visits for clinical and radiographic evaluations. Undergo radiographic assessment using cone-beam computed tomography (CBCT) to evaluate changes in alveolar ridge dimensions.
Provide a bone biopsy at the time of implant placement for histomorphometric analysis of new bone formation and tissue composition.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Socket Preservation with Acemannan Aloe Vera Extract Powder | Experimental | Biological: Aloe vera extract, Other: Normal Socket HealingAfter atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase |
| Control Group (Normal Socket Healing) | Active comparator | Biological: Aloe vera extract, Other: Normal Socket HealingFollowing extraction, the sockets were carefully debrided to remove any debris and blood clots. The sockets were then left to heal naturally without the application of any adjunctive biomaterials. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Non-restorable tooth in maxillary or mandibular anterior esthetic region.
- Intact or minimally affected buccal plate of bone.
- Patients at least 18 years or older.
- Motivated patients, agree to sign the written informed consent and complete the follow-up period.
Key exclusion criteria (7 listed)
- Infection at the extraction site.
- Smokers more than 10 cigarettes per day .
- Patients undergoing or having a history of radiotherapy, chemotherapy, or bisphosphonate therapy .
- Systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism) .
- Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aloe vera extractAfter atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase . | Biological | Control Group (Normal Socket Healing), Socket Preservation with Acemannan Aloe Vera Extract Powder |
| Normal Socket HealingControl Group: Normal Socket Healing * Tooth Extraction: Standard tooth extraction procedures will be followed, ensuring minimal trauma to the surrounding bone and soft tissues. * Socket Cleaning: The extraction socket will be thoroughly cleaned and debrided to remove any debris and blood clots. * Natural Healing: The socket will be allowed to heal naturally without any additional intervention. Standard post-extraction care will be provided. | Other | Control Group (Normal Socket Healing), Socket Preservation with Acemannan Aloe Vera Extract Powder |
Primary outcome
Change in radiographic horizontal ridge width at 4 mm below the most coronal aspect of the crest
Time frame: 6 months postoperatively
The immediate postoperative scans served as the baseline and were evaluated after 6 months to assess horizontal ridge width. Employing the same software, standardized measurements were obtained at both time points using consistent anatomical landmarks. On each baseline and after 6 months images, the apical point of the extraction socket was identified, and a vertical line was drawn through the socket's midpoint. A horizontal reference line perpendicular to the vertical axis was then established at the apical point. Horizontal ridge width was measured at 4 mm below the crest, yielding the parameters HW-4
3 secondary outcomes
Horizontal ridge width was measured at 2 mm and 6 mm below the crest
Time frame: 6 months postoperatively
Vertical ridge height
Time frame: 6-months post
Percentage of new vital bone formation
Time frame: 6 months post
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Socket Preservation
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Vallomix Socket Preservation Study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nouf Saeed Alamoudi, Bachelor principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aloe vera extract and Normal Socket Healing in people with Socket Preservation, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in radiographic horizontal ridge width at 4 mm below the most coronal aspect of the crest (time frame: 6 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2026.