SarcopeniaNCT07726758
The Effectiveness of Squat Exercise for Improving Pre-Sarcopenia in Order Adults
A study testing Squat Exercise in people with Sarcopenia, run by Tzu Chi University at 1 site in Taiwan.
Trial summary
With the growing aging population, it has been reported that approximately 10-20% of older adults have pre-sarcopenia. Pre-sarcopenia is defined as a decline in either muscle mass or muscle strength. Read more about this study
- Who is it for?
- Ages 65 to 100 yearsHealthy volunteers can take part
- Conditions the study is for
- Sarcopenia
- What is being tested?
- Squat Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteTaiwan
- Study dates
- 6 Mar 2026to 31 Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 100 years
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Older adults aged 65 years and above who meet at least one criterion of pre-sarcopenia.
- Residents of Hualien.
- Able to read, have clear consciousness, and communicate in Mandarin.
- Willing to participate in this study.
Who cannot join
- Individuals with disability.
- Individuals with psychiatric disorders or other conditions affecting cognitive function.
- Individuals with injuries of the knee, hip, or lumbar spine that prevent participation in squat exercise.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
Hsiao-Chien,Tseng
Taipei
HSIAO-CHIEN TSENG, MASTER, 0910861224, qq572797@gmail.com
About this study
With the growing aging population, it has been reported that approximately 10-20% of older adults have pre-sarcopenia. Pre-sarcopenia is defined as a decline in either muscle mass or muscle strength. Previous studies have indicated that squat exercise has significant effects on improving lower-extremity muscle strength and physical performance. Early intervention through resistance exercise during the pre-sarcopenia stage may increase muscle mass, enhance physical performance, and prevent progression to sarcopenia. Therefore, the purpose of this study is to investigate the effects of squat exercise on improving pre-sarcopenia among older adults. It is expected that, following the squat exercise intervention, older adults will demonstrate significant improvements in muscle mass, lower-extremity muscle strength, physical performance, and body composition, thereby alleviating pre-sarcopenia.
- Conditions
- Sarcopenia
- Being tested
- Squat Exercise
- Keywords
- sarcopenia, Squat, muscle mass, Pre-sarcopenia, Aging
- Medical subject headings
- Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Squat ExerciseBehavioural
Squat exercise is an effective resistance training intervention that enhances lower-extremity muscle strength, physical performance, and functional ability, thereby helping prevent or delay sarcopenia in older adults.
| Study group | Role | What they receive |
|---|---|---|
| Squat Exercise | Experimental | The researcher first assists participants in completing the questionnaire and measures older adults' InBody composition, grip strength, and SPPB (Short Physical Performance Battery). A 12-week squat exercise intervention is then implemented. Post-intervention assessments are conducted at Week 6 and Week 12. Receives: Behavioral: Squat Exercise |
| Intervention: Usual Care | No intervention | No specific resistance training is performed, and participants maintain their usual daily activities. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Physical performance assessed by the Short Physical Performance Battery (SPPB)
Physical performance will be assessed using the Short Physical Performance Battery (SPPB). The SPPB consists of three components: balance test, gait speed test, and chair stand test. Total scores range from 0 to 12 points, with higher scores indicating better physical performance
Measured: Baseline, 6 weeks, and 12 weeks
Body composition assessed by bioelectrical impedance analysis (InBody)
Body composition will be assessed using bioelectrical impedance analysis (InBody).Measurements include skeletal muscle mass, body fat mass, and body fat percentage.
Measured: Baseline, 6 weeks, and 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start6 Mar 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SarcopeniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tzu Chi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, TSENG,HSIAO-CHIEN, Tzu Chi University
- Investigators
- HSIAO-CHIEN TSENG, MASTER, Study chair, STUDENT
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07726758
- Sponsor's protocol ID
- TZU
- Other IDs
- TCU
- Status last verified
- Jul 2026
- First submitted
- 27 Jun 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of Squat Exercise for Improving Pre-Sarcopenia in Order Adults
- ClinicalTrials.gov ID
- NCT07726758
- Acronym / sponsor ID
- TZU
- Conditions
- Sarcopenia
- Keywords
- sarcopenia, Squat, muscle mass, Pre-sarcopenia, Aging
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Tzu Chi UniversityUniversity, hospital or other
- Study start
- 6 Mar 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
With the growing aging population, it has been reported that approximately 10-20% of older adults have pre-sarcopenia. Pre-sarcopenia is defined as a decline in either muscle mass or muscle strength. Previous studies have indicated that squat exercise has significant effects on improving lower-extremity muscle strength and physical performance. Early intervention through resistance exercise during the pre-sarcopenia stage may increase muscle mass, enhance physical performance, and prevent progression to sarcopenia. Therefore, the purpose of this study is to investigate the effects of squat exercise on improving pre-sarcopenia among older adults. It is expected that, following the squat exercise intervention, older adults will demonstrate significant improvements in muscle mass, lower-extremity muscle strength, physical performance, and body composition, thereby alleviating pre-sarcopenia.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Squat Exercise | Experimental | Behavioral: Squat ExerciseThe researcher first assists participants in completing the questionnaire and measures older adults' InBody composition, grip strength, and SPPB (Short Physical Performance Battery). A 12-week squat exercise intervention is then implemented. Post-intervention assessments are conducted at Week 6 and Week 12. |
| Intervention: Usual Care | No intervention | –No specific resistance training is performed, and participants maintain their usual daily activities. |
Who may qualify
- Ages
- 65 to 100 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (4 listed)
- Older adults aged 65 years and above who meet at least one criterion of pre-sarcopenia.
- Residents of Hualien.
- Able to read, have clear consciousness, and communicate in Mandarin.
- Willing to participate in this study.
Key exclusion criteria (3 listed)
- Individuals with disability.
- Individuals with psychiatric disorders or other conditions affecting cognitive function.
- Individuals with injuries of the knee, hip, or lumbar spine that prevent participation in squat exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Squat ExerciseSquat exercise is an effective resistance training intervention that enhances lower-extremity muscle strength, physical performance, and functional ability, thereby helping prevent or delay sarcopenia in older adults. | Behavioural | Squat Exercise |
Primary outcome
Physical performance assessed by the Short Physical Performance Battery (SPPB)
Time frame: Baseline, 6 weeks, and 12 weeks
Physical performance will be assessed using the Short Physical Performance Battery (SPPB). The SPPB consists of three components: balance test, gait speed test, and chair stand test. Total scores range from 0 to 12 points, with higher scores indicating better physical performance
Body composition assessed by bioelectrical impedance analysis (InBody)
Time frame: Baseline, 6 weeks, and 12 weeks
Body composition will be assessed using bioelectrical impedance analysis (InBody).Measurements include skeletal muscle mass, body fat mass, and body fat percentage.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
HSIAO-CHIEN TSENG, MASTER study chair
STUDENT
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Squat Exercise in people with Sarcopenia, run by Tzu Chi University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact HSIAO-CHIEN TSENG, MASTER (0910861224, qq572797@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Physical performance assessed by the Short Physical Performance Battery (SPPB) (time frame: Baseline, 6 weeks, and 12 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.