Carpal Tunnel SyndromeNCT07724717
Effects of Whole Wrist Versus Specific Carpal Bone Mobilization in the Patients of Carpel Tunnel Syndrome
A study testing Specific Bone Mobilization, Whole Wrist Mobilization and Standardized Physiotherapy Treatment in people with Carpal Tunnel Syndrome, run by Riphah International University at 2 sites in Pakistan.
Trial summary
The study was conducted to compare the effectiveness of Whole Wrist Mobilization versus Specific Carpal Bone Mobilization in reducing symptoms and improving function in patients with Carpal Tunnel Syndrome (CTS). Read more about this study
- Who is it for?
- Ages 30 to 60 years
- Conditions the study is for
- Carpal Tunnel Syndrome
- What is being tested?
- Specific Bone Mobilization, Whole Wrist Mobilization and Standardized Physiotherapy Treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 2 sitesPakistan
- Study dates
- 1 Dec 2025to 30 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants aged 30 to 60 years old
- Both male and female participants
- CTS for at least 2 months
- Pain levels on the Numeric Pain Rating Scale (NPRS) between 3 and 7
- Limited range of motion and wrist pain
- Patient with positive PHALEN and TINEL test
Who cannot join
- Prior traumatic injury of wrist
- History of wrist surgery
- Diagnoses of polyneuropathy, cervical radiculopathy, myelopathy, inflammatory arthritis, diabetes, thyroid disease
- Presence of abnormal sensation in the wrist region
- Hemorrhagic tendency and/or current anticoagulation treatment
- History of whiplash injury
Trial locations and contacts
2 sites in 1 country.
Pakistan2 sites
Riphah Rehabilitation Clinic
Lahore, Punjab Province
Umaid Qaseem Hospital and Chest Clinic
Lahore, Punjab Province
About this study
The study was conducted to compare the effectiveness of Whole Wrist Mobilization versus Specific Carpal Bone Mobilization in reducing symptoms and improving function in patients with Carpal Tunnel Syndrome (CTS).
- Conditions
- Carpal Tunnel Syndrome
- Being tested
- Specific Bone Mobilization, Whole Wrist Mobilization, Standardized Physiotherapy Treatment
- Keywords
- Carpal Tunnel Syndrome, Manual Therapy, Range of Motion, Specific Carpal Bone Mobilization, Wrist Mobilization
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Specific Bone MobilizationOther
Scaphoid Mobilization: The therapist applied anterior-posterior mobilization on the scaphoid while the patient's wrist was in slight flexion. It was held for 5 seconds and repeated for 10 repetitions.
Lunate Mobilization: The therapist performed lateral and medial mobilization of the lunate while stabilizing the forearm. It was held for 5 seconds and repeated for 10 repetitions.
Triquetrum Mobilization: With the wrist in a neutral position, the therapist applied gentle mobilization to the triquetrum. It was held for 5 seconds and repeated for 10 repetitions.
Whole Wrist MobilizationOther
Distal Radioulnar Joint Mobilization: To perform mobilizations at the distal radioulnar joint, the therapist stabilized the patient's hand and radiocarpal region, then provided anteroposterior glide and medial and lateral rotary joint play movements of the distal ulna.
Radiocarpal Joint - Dorsal Palmar Glide:
The mobilization involved moving the row of carpal bones either dorsally to promote wrist extension or palmary to promote wrist flexion.
Radiocarpal Joint - Ulnar and Radial Glide: Ulnar glide was performed to increase radial deviation, while radial glide was performed to increase ulnar deviation of the wrist joint.
Mid-Carpal Joint Mobilization: The mobilization involved moving the row of carpal bones either dorsally to promote wrist extension or palmary to promote wrist flexion.
Standardized Physiotherapy TreatmentOther
Hot Pack: A hot pack was applied to the wrist and forearm for 10 minutes to help relax the muscles and improve circulation around the carpal tunnel.
Transcutaneous Electrical Nerve Stimulation: TENS was applied with a frequency of 2 Hz and a pulse duration of 200 µs for 10 minutes over the wrist area to reduce pain and discomfort.
Wrist Flexion and Extension: With the arm supported, the patient actively flexed and extended the wrist through a full range of motion. This was repeated for 10 repetitions.
Radial and Ulnar Deviation: With the arm supported, the patient actively moved the wrist side to side (radially and ulnarly).
Wrist Circles: The patient performed circular motions with the wrist in both clockwise and counterclockwise directions. This was repeated for 10 repetitions.
Wrist Flexor Stretch:
The arm was extended in front with the palm facing up, and the fingers were gently pulled back to stretch the wrist flexors. The stretch was held for 30 seconds and repeated 3 times.
| Study group | Role | What they receive |
|---|---|---|
| Specific Bone Mobilization | Experimental | Not described Receives: Other: Specific Bone Mobilization; Other: Standardized Physiotherapy Treatment |
| Whole Wrist Mobilization | Active comparator | Not described Receives: Other: Whole Wrist Mobilization; Other: Standardized Physiotherapy Treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale
The Numeric Pain Rating Scale (NPRS) was used to assess pain intensity, with participants rating their pain from 0 (no pain) to 10 (worst possible pain). It provided a quantitative measure to track pain changes over time.
Measured: From enrollment to the end of treatment at 4 weeks
Boston Carpal Tunnel Questionnaire
The Boston Carpal Tunnel Questionnaire (BCTQ) is a recommended tool for assessing the functional status and severity of symptoms in CTS patients.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Wrist Flexion
Changes in wrist flexion ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Wrist Extension
Changes in wrist extension ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Wrist Radial Deviation
Changes in wrist radial deviation ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Wrist Ulnar Deviation
Changes in wrist ulnar deviation ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start1 Dec 2025
- Primary completion30 May 2026
- Study completion30 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Carpal Tunnel SyndromeStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ali Raza, MS-OMPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07724717
- Sponsor's protocol ID
- REC/RCR & AHS/25/0149
- Status last verified
- Jul 2026
- First submitted
- 21 Jul 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Sault JD, Jayaseelan DJ, Mischke JJ, Post AA. The Utilization of Joint Mobilization As Part of a Comprehensive Program to Manage Carpal Tunnel Syndrome: A Systematic Review. J Manipulative Physiol Ther. 2020 May;43(4):356-370. doi: 10.1016/j.jmpt.2020.02.001. Epub 2020 Aug 26.
PubMed 32861521Liew BXW, de-la-Llave-Rincon AI, Scutari M, Arias-Buria JL, Cook CE, Cleland J, Fernandez-de-Las-Penas C. Do Short-Term Effects Predict Long-Term Improvements in Women Who Receive Manual Therapy or Surgery for Carpal Tunnel Syndrome? A Bayesian Network Analysis of a Randomized Clinical Trial. Phys Ther. 2022 Apr 1;102(4):pzac015. doi: 10.1093/ptj/pzac015.
PubMed 35194646Ceylan I, Buyukturan O, Aykanat O, Buyukturan B, Sas S, Ceylan MF. The effectiveness of mobilization with movement on patients with mild and moderate carpal tunnel syndrome: A single-blinded, randomized controlled study. J Hand Ther. 2023 Oct-Dec;36(4):773-785. doi: 10.1016/j.jht.2023.02.004. Epub 2023 Aug 11.
PubMed 37573157Dilvesi D, Jelaca B, Knezevic A, Zivanovic Z, Pantelic V, Golubovic J. Evolution of Carpal Tunnel Syndrome Treatment: A Narrative Review. NeuroSci. 2026 Jan 12;7(1):10. doi: 10.3390/neurosci7010010.
PubMed 41562834Masiero S, Arcuri P, Boccolari P, Zorzi E, Vio A, Fairplay T, Zanin D, Vita F, Donati D, Tedeschi R. Surgical Versus Conservative Management for Carpal Tunnel Syndrome: An Updated Systematic Review of Randomised Trials. Brain Sci. 2026 Apr 8;16(4):399. doi: 10.3390/brainsci16040399.
PubMed 42041808
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Whole Wrist Versus Specific Carpal Bone Mobilization in the Patients of Carpel Tunnel Syndrome
- ClinicalTrials.gov ID
- NCT07724717
- Acronym / sponsor ID
- REC/RCR & AHS/25/0149
- Conditions
- Carpal Tunnel Syndrome
- Keywords
- Carpal Tunnel Syndrome, Manual Therapy, Range of Motion, Specific Carpal Bone Mobilization, Wrist Mobilization
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 30 May 2026 (actual)
- Study completion
- 30 May 2026 (actual)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study was conducted to compare the effectiveness of Whole Wrist Mobilization versus Specific Carpal Bone Mobilization in reducing symptoms and improving function in patients with Carpal Tunnel Syndrome (CTS).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Specific Bone Mobilization | Experimental | Other: Specific Bone Mobilization, Other: Standardized Physiotherapy Treatment |
| Whole Wrist Mobilization | Active comparator | Other: Whole Wrist Mobilization, Other: Standardized Physiotherapy Treatment |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Participants aged 30 to 60 years old
- Both male and female participants
- CTS for at least 2 months
- Pain levels on the Numeric Pain Rating Scale (NPRS) between 3 and 7
- Limited range of motion and wrist pain
Key exclusion criteria (6 listed)
- Prior traumatic injury of wrist
- History of wrist surgery
- Diagnoses of polyneuropathy, cervical radiculopathy, myelopathy, inflammatory arthritis, diabetes, thyroid disease
- Presence of abnormal sensation in the wrist region
- Hemorrhagic tendency and/or current anticoagulation treatment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Specific Bone MobilizationScaphoid Mobilization: The therapist applied anterior-posterior mobilization on the scaphoid while the patient's wrist was in slight flexion. It was held for 5 seconds and repeated for 10 repetitions. Lunate Mobilization: The therapist performed lateral and medial mobilization of the lunate while stabilizing the forearm. It was held for 5 seconds and repeated for 10 repetitions. Triquetrum Mobilization: With the wrist in a neutral position, the therapist applied gentle mobilization to the triquetrum. It was held for 5 seconds and repeated for 10 repetitions. | Other | Specific Bone Mobilization |
| Whole Wrist MobilizationDistal Radioulnar Joint Mobilization: To perform mobilizations at the distal radioulnar joint, the therapist stabilized the patient's hand and radiocarpal region, then provided anteroposterior glide and medial and lateral rotary joint play movements of the distal ulna. Radiocarpal Joint - Dorsal Palmar Glide: The mobilization involved moving the row of carpal bones either dorsally to promote wrist extension or palmary to promote wrist flexion. Radiocarpal Joint - Ulnar and Radial Glide: Ulnar glide was performed to increase radial deviation, while radial glide was performed to increase ulnar deviation of the wrist joint. Mid-Carpal Joint Mobilization: The mobilization involved moving the row of carpal bones either dorsally to promote wrist extension or palmary to promote wrist flexion. | Other | Whole Wrist Mobilization |
| Standardized Physiotherapy TreatmentHot Pack: A hot pack was applied to the wrist and forearm for 10 minutes to help relax the muscles and improve circulation around the carpal tunnel. Transcutaneous Electrical Nerve Stimulation: TENS was applied with a frequency of 2 Hz and a pulse duration of 200 µs for 10 minutes over the wrist area to reduce pain and discomfort. Wrist Flexion and Extension: With the arm supported, the patient actively flexed and extended the wrist through a full range of motion. This was repeated for 10 repetitions. Radial and Ulnar Deviation: With the arm supported, the patient actively moved the wrist side to side (radially and ulnarly). Wrist Circles: The patient performed circular motions with the wrist in both clockwise and counterclockwise directions. This was repeated for 10 repetitions. Wrist Flexor Stretch: The arm was extended in front with the palm facing up, and the fingers were gently pulled back to stretch the wrist flexors. The stretch was held for 30 seconds and repeated 3 times. | Other | Specific Bone Mobilization, Whole Wrist Mobilization |
Primary outcome
Numeric Pain Rating Scale
Time frame: From enrollment to the end of treatment at 4 weeks
The Numeric Pain Rating Scale (NPRS) was used to assess pain intensity, with participants rating their pain from 0 (no pain) to 10 (worst possible pain). It provided a quantitative measure to track pain changes over time.
Boston Carpal Tunnel Questionnaire
Time frame: From enrollment to the end of treatment at 4 weeks
The Boston Carpal Tunnel Questionnaire (BCTQ) is a recommended tool for assessing the functional status and severity of symptoms in CTS patients.
ROM Wrist Flexion
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in wrist flexion ROM at baseline and 4th week of intervention was measured using goniometer.
ROM Wrist Extension
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in wrist extension ROM at baseline and 4th week of intervention was measured using goniometer.
ROM Wrist Radial Deviation
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in wrist radial deviation ROM at baseline and 4th week of intervention was measured using goniometer.
ROM Wrist Ulnar Deviation
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in wrist ulnar deviation ROM at baseline and 4th week of intervention was measured using goniometer.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Background: PubMed 32861521Sault JD, Jayaseelan DJ, Mischke JJ, Post AA. The Utilization of Joint Mobilization As Part of a Comprehensive Program to Manage Carpal Tunnel Syndrome: A Systematic Review. J Manipulative Physiol Ther. 2020 May;43(4):356-370. doi: 10.1016/j.jmpt.2020.02.001. Epub 2020 Aug 26.
- Background: PubMed 35194646Liew BXW, de-la-Llave-Rincon AI, Scutari M, Arias-Buria JL, Cook CE, Cleland J, Fernandez-de-Las-Penas C. Do Short-Term Effects Predict Long-Term Improvements in Women Who Receive Manual Therapy or Surgery for Carpal Tunnel Syndrome? A Bayesian Network Analysis of a Randomized Clinical Trial. Phys Ther. 2022 Apr 1;102(4):pzac015. doi: 10.1093/ptj/pzac015.
- Background: PubMed 37573157Ceylan I, Buyukturan O, Aykanat O, Buyukturan B, Sas S, Ceylan MF. The effectiveness of mobilization with movement on patients with mild and moderate carpal tunnel syndrome: A single-blinded, randomized controlled study. J Hand Ther. 2023 Oct-Dec;36(4):773-785. doi: 10.1016/j.jht.2023.02.004. Epub 2023 Aug 11.
- Background: PubMed 41562834Dilvesi D, Jelaca B, Knezevic A, Zivanovic Z, Pantelic V, Golubovic J. Evolution of Carpal Tunnel Syndrome Treatment: A Narrative Review. NeuroSci. 2026 Jan 12;7(1):10. doi: 10.3390/neurosci7010010.
- Background: PubMed 42041808Masiero S, Arcuri P, Boccolari P, Zorzi E, Vio A, Fairplay T, Zanin D, Vita F, Donati D, Tedeschi R. Surgical Versus Conservative Management for Carpal Tunnel Syndrome: An Updated Systematic Review of Randomised Trials. Brain Sci. 2026 Apr 8;16(4):399. doi: 10.3390/brainsci16040399.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ali Raza, MS-OMPT principal investigator
Riphah International University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Specific Bone Mobilization, Whole Wrist Mobilization and Standardized Physiotherapy Treatment in people with Carpal Tunnel Syndrome, run by Riphah International University at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (time frame: From enrollment to the end of treatment at 4 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07724717, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.