Bowel ObstructionNCT07716709
Bowel Obstruction Post Open Versus Laparoscopic Appendectomy
A study testing Open appendectomy and Laparoscopic appendectomy in people with Bowel Obstruction, run by Sohag University at 1 site in Egypt.
Trial summary
Acute appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention, with appendectomy being the definitive treatment . Traditionally performed through an open approach, appendectomy has evolved significantly with the advent of minimally invasive surgery. Read more about this study
- Who is it for?
- Ages 12 years and older
- Conditions the study is for
- Bowel Obstruction
- What is being tested?
- Open appendectomy and Laparoscopic appendectomy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2025to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- both genders
- confirmed diagnosis of acute appendicitis
- patients undergo laparoscopic or open appendectomy
Who cannot join
- appendectomy performed as apart of another operation
- prior history of abdominal surgery
- patients show generalized peritonitis
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Study of Incidence of Bowel Obstruction Post Open Versus Laparoscopic Appendectomy
Acute appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention, with appendectomy being the definitive treatment . Traditionally performed through an open approach, appendectomy has evolved significantly with the advent of minimally invasive surgery. Since its introduction in the late 1980s, laparoscopic appendectomy has gained widespread acceptance and is now often preferred due to its well-documented advantages, including reduced postoperative pain, shorter hospital stay, quicker return to normal activity, and improved cosmetic outcomes . Despite these benefits, concerns remain regarding the long-term postoperative complications associated with both laparoscopic and open approaches, one of the most clinically significant being bowel obstruction
Read the detailed description
Postoperative bowel obstruction, often resulting from intra-abdominal adhesions, is a common and sometimes serious complication following abdominal surgeries. The pathogenesis of these adhesions can be influenced by several factors, including the extent of tissue handling, exposure of peritoneal surfaces, the degree of inflammation presents during surgery, and the surgical technique used .
Open surgery, by its nature, involves a larger incision and greater manipulation of intra-abdominal structures, which may predispose patients to more extensive adhesion formation and, subsequently, higher rates of bowel obstruction. On the other hand, laparoscopic surgery, with its minimal access approach, is associated with less tissue trauma and reduced adhesion formation in various abdominal procedures. However, it is not entirely devoid of risk, and rare but serious complications such as internal herniation and port site adhesions can also lead to bowel obstruction in laparoscopic cases .
The clinical presentation of postoperative bowel obstruction can vary widely, ranging from mild intermittent symptoms to complete mechanical obstruction requiring urgent reoperation. Understanding the relative risk and nature of bowel obstruction following laparoscopic versus open appendectomy is essential for both surgical decision-making and informed patient counseling. Moreover, identifying differences in the timing, severity, and management outcomes of this complication between the two surgical approaches may help refine perioperative strategies to minimize patient morbidity .
While several studies have attempted to compare postoperative outcomes between laparoscopic and open appendectomy, data specifically focusing on the incidence and characteristics of bowel obstruction are less abundant and sometimes conflicting . Some retrospective reviews suggest a lower incidence of bowel obstruction following laparoscopic appendectomy, while others report no significant difference. Variations in surgical technique, patient selection, underlying pathology, and follow-up duration may all contribute to these discrepancies .
- Conditions
- Bowel Obstruction
- Being tested
- Open appendectomy, Laparoscopic appendectomy
- Keywords
- post appendectomy bowel obstruction
- Medical subject headings
- Intestinal Obstruction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Open appendectomyProcedure or surgery
Open appendectomy For gruop A
Laparoscopic appendectomyProcedure or surgery
Laparoscopic appendectomy for group B
| Study group | Role | What they receive |
|---|---|---|
| Group A | Active comparator | Not described Receives: Procedure: Open appendectomy |
| Gruop B | Active comparator | Not described Receives: Procedure: Laparoscopic appendectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of bowel obstruction post laparoscopic versus open appendectomy
Measured: 6 months
Secondary outcomes (4)
• Operative time
Measured: : During operation (from incision to closure)
Analgesic requirement
Measured: From postoperative Day 0 through postoperative Day 7.
Postoperative pain
Postoperative pain assessed using the Visual Analog Scale (VAS; range 0-10, where 0 indicates no pain and 10 indicates the worst imaginable pain).
Measured: Postoperative Day 1.
Post operative hospital stay
Measured: From the day of surgery until hospital discharge (average of 2-5 days).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2026
- Study start1 Jul 2025
- Primary completion1 May 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Bowel ObstructionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nazeh Philip alabd, Sohag University
- Investigators
- osama abdlrahem oraby, professor, Study director, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07716709
- Sponsor's protocol ID
- Soh-Med--25-9-9MSSohagUH-DT-20
- Status last verified
- Sep 2025
- First submitted
- 24 Jun 2026
- Last updated
- 21 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 21 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study of Incidence of Bowel Obstruction Post Open Versus Laparoscopic Appendectomy
- ClinicalTrials.gov ID
- NCT07716709
- Acronym / sponsor ID
- Soh-Med--25-9-9MSSohagUH-DT-20
- Conditions
- Bowel Obstruction
- Keywords
- post appendectomy bowel obstruction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 1 May 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 21 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Acute appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention, with appendectomy being the definitive treatment . Traditionally performed through an open approach, appendectomy has evolved significantly with the advent of minimally invasive surgery. Since its introduction in the late 1980s, laparoscopic appendectomy has gained widespread acceptance and is now often preferred due to its well-documented advantages, including reduced postoperative pain, shorter hospital stay, quicker return to normal activity, and improved cosmetic outcomes . Despite these benefits, concerns remain regarding the long-term postoperative complications associated with both laparoscopic and open approaches, one of the most clinically significant being bowel obstruction
Detailed description
Postoperative bowel obstruction, often resulting from intra-abdominal adhesions, is a common and sometimes serious complication following abdominal surgeries. The pathogenesis of these adhesions can be influenced by several factors, including the extent of tissue handling, exposure of peritoneal surfaces, the degree of inflammation presents during surgery, and the surgical technique used .
Open surgery, by its nature, involves a larger incision and greater manipulation of intra-abdominal structures, which may predispose patients to more extensive adhesion formation and, subsequently, higher rates of bowel obstruction. On the other hand, laparoscopic surgery, with its minimal access approach, is associated with less tissue trauma and reduced adhesion formation in various abdominal procedures. However, it is not entirely devoid of risk, and rare but serious complications such as internal herniation and port site adhesions can also lead to bowel obstruction in laparoscopic cases .
The clinical presentation of postoperative bowel obstruction can vary widely, ranging from mild intermittent symptoms to complete mechanical obstruction requiring urgent reoperation. Understanding the relative risk and nature of bowel obstruction following laparoscopic versus open appendectomy is essential for both surgical decision-making and informed patient counseling. Moreover, identifying differences in the timing, severity, and management outcomes of this complication between the two surgical approaches may help refine perioperative strategies to minimize patient morbidity .
While several studies have attempted to compare postoperative outcomes between laparoscopic and open appendectomy, data specifically focusing on the incidence and characteristics of bowel obstruction are less abundant and sometimes conflicting . Some retrospective reviews suggest a lower incidence of bowel obstruction following laparoscopic appendectomy, while others report no significant difference. Variations in surgical technique, patient selection, underlying pathology, and follow-up duration may all contribute to these discrepancies .
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Active comparator | Procedure: Open appendectomy |
| Gruop B | Active comparator | Procedure: Laparoscopic appendectomy |
Who may qualify
- Ages
- 12 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- both genders
- confirmed diagnosis of acute appendicitis
- patients undergo laparoscopic or open appendectomy
Key exclusion criteria (3 listed)
- appendectomy performed as apart of another operation
- prior history of abdominal surgery
- patients show generalized peritonitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Open appendectomyOpen appendectomy For gruop A | Procedure or surgery | Group A |
| Laparoscopic appendectomyLaparoscopic appendectomy for group B | Procedure or surgery | Gruop B |
Primary outcome
Incidence of bowel obstruction post laparoscopic versus open appendectomy
Time frame: 6 months
4 secondary outcomes
• Operative time
Time frame: : During operation (from incision to closure)
Analgesic requirement
Time frame: From postoperative Day 0 through postoperative Day 7.
Postoperative pain
Time frame: Postoperative Day 1.
Post operative hospital stay
Time frame: From the day of surgery until hospital discharge (average of 2-5 days).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
osama abdlrahem oraby, professor study director
Sohag University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Open appendectomy and Laparoscopic appendectomy in people with Bowel Obstruction, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of bowel obstruction post laparoscopic versus open appendectomy (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jul 2026.