Pain ManagementPhase 4NCT07712991
ORAL AND INTRA - LIGAMENTARY PIROXICAM for Post Endodontic Pain Management
A Phase 4 study testing intra-ligamentary in people with Pain Management and Post Endodontic Pain, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
Trial summary
the study find out the effect of oral and intra ligamentary piroxicam on the post endodontic pain . it tell us which one is better among both methods of using piroxicam Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Pain Management, Post Endodontic Pain
- What is being tested?
- intra-ligamentary
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 sitePakistan
- Study dates
- 27 May 2023to 27 Nov 2024
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Patient diagnosed with irreversible pulpitis
- Patient have Tooth pain before Root canal treatment
Who cannot join
- Patient already treated with root canal
- Necrotic Tooth
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of ORAL AND INTRA - LIGAMENTARY PIROXICAM for Post Endodontic Pain Management
the study find out the effect of oral and intra ligamentary piroxicam on the post endodontic pain . it tell us which one is better among both methods of using piroxicam
Read the detailed description
post endodontic pain is very common and it effect the quality of life of patients. piroxicam reduces the perception of pain . it is usually prescribe as oral medication but out study evaluate the effect of intra-ligamentary use of piroxicam to reduce post procedure pain.
- Conditions
- Pain Management, Post Endodontic Pain
- Being tested
- intra-ligamentary
- Keywords
- pain, endodontic
- Medical subject headings
- Agnosia, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
intra-ligamentaryOther
intra ligamentary mode of piroxicam use
| Study group | Role | What they receive |
|---|---|---|
| intra ligamentry | Experimental | intra ligamentary mode of administration Receives: Other: intra-ligamentary |
| oral | No intervention | oral use of piroxicam |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain intensity
Pain intensity will be measured by Visual Analogue scale(VAS). Patient will advised to rate there pain intensity from 0 to 10 after 12 hours, 24 and 48 hours. So both groups patient will record there pain in number and report to dentist in follow-up visit.
Measured: 12, 24,48 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jul 2026
- Study start27 May 2023
- Primary completion26 Nov 2024
- Study completion27 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Pain ManagementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pakistan Institute of Medical Sciences
- Sponsor type
- Other government
- Responsible party
- Principal investigator, nosheen sarwar, Pakistan Institute of Medical Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07712991
- Sponsor's protocol ID
- SZABMU386
- Status last verified
- Jul 2026
- First submitted
- 13 Jul 2026
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
. Comparing the efficacy of local intraligamentary injection of dexamethasone and piroxicam on postoperative pain in mandibular molars with symptomatic irreversible pulpitis
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of ORAL AND INTRA - LIGAMENTARY PIROXICAM for Post Endodontic Pain Management
- ClinicalTrials.gov ID
- NCT07712991
- Acronym / sponsor ID
- SZABMU386
- Conditions
- Pain Management, Post Endodontic Pain
- Keywords
- pain, endodontic
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Pakistan Institute of Medical SciencesOther government
- Study start
- 27 May 2023 (actual)
- Primary completion
- 26 Nov 2024 (actual)
- Study completion
- 27 Nov 2024 (actual)
- First posted
- 20 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the study find out the effect of oral and intra ligamentary piroxicam on the post endodontic pain . it tell us which one is better among both methods of using piroxicam
Detailed description
post endodontic pain is very common and it effect the quality of life of patients. piroxicam reduces the perception of pain . it is usually prescribe as oral medication but out study evaluate the effect of intra-ligamentary use of piroxicam to reduce post procedure pain.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| intra ligamentry | Experimental | Other: intra-ligamentaryintra ligamentary mode of administration |
| oral | No intervention | –oral use of piroxicam |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Patient diagnosed with irreversible pulpitis
- Patient have Tooth pain before Root canal treatment
Key exclusion criteria (2 listed)
- Patient already treated with root canal
- Necrotic Tooth
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| intra-ligamentaryintra ligamentary mode of piroxicam use | Other | intra ligamentry |
Primary outcome
pain intensity
Time frame: 12, 24,48 hours
Pain intensity will be measured by Visual Analogue scale(VAS). Patient will advised to rate there pain intensity from 0 to 10 after 12 hours, 24 and 48 hours. So both groups patient will record there pain in number and report to dentist in follow-up visit.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- Background. Comparing the efficacy of local intraligamentary injection of dexamethasone and piroxicam on postoperative pain in mandibular molars with symptomatic irreversible pulpitis
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing intra-ligamentary in people with Pain Management and Post Endodontic Pain, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain intensity (time frame: 12, 24,48 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07712991, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.