Teeth StainingPhase 1NCT07709286
Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion
A Phase 1 study testing (Antivet, MDC DENTAL, Zapopan Jalisco México), Opalustre and phosphoric acid 37% and aluminium oxid 50 microns in people with Teeth Staining, run by Misr University for Science and Technology at 1 site in Egypt.
Trial summary
This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth. Read more about this study
- Who is it for?
- Ages 16 to 50 years
- Conditions the study is for
- Teeth Staining
- What is being tested?
- (Antivet, MDC DENTAL, Zapopan Jalisco México), Opalustre and phosphoric acid 37% and aluminium oxid 50 microns
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Jan 2026to 1 Oct 2026
- Phase
- Phase 1
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 50 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients with moderate to mild stained teeth.
- 16-50 years.
- Males or Females.
- Co-operative patients approving to participate in the study.
- Anterior teeth.
- Mild to moderate intrinsic or extrinsic stains.
- Vital and non-sensitive anterior teeth.
Who cannot join
- High caries index with poor oral hygiene.
- Severe medical complications.
- Pregnancy.
- Xerostomia.
- Lack of compliance.
- Smokers
Show all 12Show fewer
- Eligibility Criteria of teeth:
- pitted enamel.
- carious teeth.
- Deep lesions.
- Severe periodontal problems.
- Previous treatment for the stained teeth
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Egyptian Russian University
Badr, Cairo Governorate, 11829
Esraa Esmeail Hussien EEH LECTURER, phd holder, +201111103836, dr.esraaism@gmail.com
About this study
Official title: Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion Technique for Treatment of Stained Teeth: Randomized Clinical Trial
This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.
Read the detailed description
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- 5 drops of Antivet will be placed in the plastic mixing well that comes with the kit.Apply the ANTIVET solution over the tooth's surface using a well condensed cotton pellet (approximately a 3 mm diameter), the cotton pellet will be holded with the pliers that were provided in the kit and the pellet will be rubbed onto the surface in a sweeping motion from cervical to incisal.
- When the cotton pellet is pigmented by the tooth's staining, a new one will be used, the pellet will be saturated with the solution and the procedure will be repeated, this process will be repeated until the stain is removed. This process may take about 1 to 5 minutes per tooth. It should take no longer than 15 minutes from the moment the solution contacts the tooth's surface.
- The tooth must not be dry at any given moment, otherwise the Antivet solution will not work properly.
- Before completing treatment, the last application will be applied with a new pellet and sweeping movements will be made from the distal surface towards the midline of the tooth.
- Once the tooth surface is free of stains, A dry cotton pellet or gauze will be used to remove any excess solution on the enamel.
- In a separate mixing well the NEUTRALIZING SOLUTION will be dispensed, the solution will be applied onto the tooth surface using a brush or microbrush and let it sit for 2 minutes. It is of utmost importance that the neutralizing solution will be applied completely up to the gingival margin.
- the dental dam will not removed until you the process has been completed with the neautralizing agent.
- The last step will be rinsing with water.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale. ►B. Comparator Group 1
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- Equal quantities from phosphoric acid 37% and aluminium oxid 50 micron will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications. At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
- Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.
- Comparator Group 2
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- Microabrasion will be conducted using Opalustre (Ultradent Products Inc, South Jordan, UT, USA) will be applied onto the stained areas of the teeth. The microabrasion technique will be performed according to the manufacturer's instructions.
- A fine-grit diamond abrasive bur will be used initially for 5 to 10 seconds on the stained areas of the tooth to help the microabrasion slurry penetrate into the enamel. This will be followed by drying of the teeth and application of the microabrasion slurry of approximately 1- to 3-mm thickness onto the stained regions of the teeth using rubber prophy cups (OpalCups, Ultradent Products Inc) for 60 seconds.
- The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.
- At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
- Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.
- Conditions
- Teeth Staining
- Being tested
- (Antivet, MDC DENTAL, Zapopan Jalisco México), Opalustre, phosphoric acid 37% and aluminium oxid 50 microns
- Keywords
- tooth discoloration, microabrasion, antivet
- Medical subject headings
- Tooth Discoloration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
(Antivet, MDC DENTAL, Zapopan Jalisco México)Drug
specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it
OpalustreDrug
technique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.
.
phosphoric acid 37% and aluminium oxid 50 micronsDrug
● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications.
| Study group | Role | What they receive |
|---|---|---|
| phosphoric acid 37% and aluminium oxid 50 microns | Active comparator | Microabrasion technique could be considered as the first treatment option when trying to improve the esthetics of teeth that present with mild or moderate intrinsic stains as it is a simple, safe, atraumatic, minimally invasive single visit procedure with high success rate Receives: Drug: phosphoric acid 37% and aluminium oxid 50 microns |
| Opalustre™ | Active comparator | a mixture of 37% phosphoric acid gel in extra fine grain pumice or 18% hydrochloric acid in pumice or 6.6% and 10% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities. Another advantage of microabrasion technique is that it leaves the treated enamel surface as highly polished which minimizes the cariogenic bacteria colonization and render it more resistant to demineralization Receives: Drug: Opalustre |
| Antivet | Experimental | The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be Receives: Drug: (Antivet, MDC DENTAL, Zapopan Jalisco México) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical performance
visual analog scale using scoring system
Measured: three months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2026
- Study start10 Jan 2026
- Primary completion10 Jul 2026 (estimated)
- Study completion1 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Teeth StainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \<3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Misr University for Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Esraa Esmeail Hussien, Misr University for Science and Technology
- Investigators
- Esraa Esmeail Hussien EEH Elhaddad, PHD, Study director, Misr University for Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07709286
- Sponsor's protocol ID
- 49
- Status last verified
- Jul 2026
- First submitted
- 10 Jul 2026
- Last updated
- 16 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No: will not be shared except with authors only
Publications
Blanchet I, Camoin A, Tardieu C, Jacquot B. Microabrasion in the management of enamel discolorations in paediatric dentistry: a systematic review. J Clin Pediatr Dent. 2023 Jan;47(1):17-26. doi: 10.22514/jocpd.2022.015. Epub 2023 Jan 3.
PubMed 36627216
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion Technique for Treatment of Stained Teeth: Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07709286
- Acronym / sponsor ID
- 49
- Conditions
- Teeth Staining
- Keywords
- tooth discoloration, microabrasion, antivet
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Misr University for Science and TechnologyUniversity, hospital or other
- Study start
- 10 Jan 2026 (actual)
- Primary completion
- 10 Jul 2026 (estimated)
- Study completion
- 1 Oct 2026 (estimated)
- First posted
- 16 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.
Detailed description
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- 5 drops of Antivet will be placed in the plastic mixing well that comes with the kit.Apply the ANTIVET solution over the tooth's surface using a well condensed cotton pellet (approximately a 3 mm diameter), the cotton pellet will be holded with the pliers that were provided in the kit and the pellet will be rubbed onto the surface in a sweeping motion from cervical to incisal.
- When the cotton pellet is pigmented by the tooth's staining, a new one will be used, the pellet will be saturated with the solution and the procedure will be repeated, this process will be repeated until the stain is removed. This process may take about 1 to 5 minutes per tooth. It should take no longer than 15 minutes from the moment the solution contacts the tooth's surface.
- The tooth must not be dry at any given moment, otherwise the Antivet solution will not work properly.
- Before completing treatment, the last application will be applied with a new pellet and sweeping movements will be made from the distal surface towards the midline of the tooth.
- Once the tooth surface is free of stains, A dry cotton pellet or gauze will be used to remove any excess solution on the enamel.
- In a separate mixing well the NEUTRALIZING SOLUTION will be dispensed, the solution will be applied onto the tooth surface using a brush or microbrush and let it sit for 2 minutes. It is of utmost importance that the neutralizing solution will be applied completely up to the gingival margin.
- the dental dam will not removed until you the process has been completed with the neautralizing agent.
- The last step will be rinsing with water.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale. ►B. Comparator Group 1
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- Equal quantities from phosphoric acid 37% and aluminium oxid 50 micron will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications. At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
- Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.
- Comparator Group 2
- Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
- tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
- patient will be seated at a 45 degree angle.
- Microabrasion will be conducted using Opalustre (Ultradent Products Inc, South Jordan, UT, USA) will be applied onto the stained areas of the teeth. The microabrasion technique will be performed according to the manufacturer's instructions.
- A fine-grit diamond abrasive bur will be used initially for 5 to 10 seconds on the stained areas of the tooth to help the microabrasion slurry penetrate into the enamel. This will be followed by drying of the teeth and application of the microabrasion slurry of approximately 1- to 3-mm thickness onto the stained regions of the teeth using rubber prophy cups (OpalCups, Ultradent Products Inc) for 60 seconds.
- The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.
- At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
- Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
- postoperative photographs will be taken after one hour with the same condition as mentioned above.
- Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be
| Arm | Type | Receives |
|---|---|---|
| phosphoric acid 37% and aluminium oxid 50 microns | Active comparator | Drug: phosphoric acid 37% and aluminium oxid 50 micronsMicroabrasion technique could be considered as the first treatment option when trying to improve the esthetics of teeth that present with mild or moderate intrinsic stains as it is a simple, safe, atraumatic, minimally invasive single visit procedure with high success rate |
| Opalustre™ | Active comparator | Drug: Opalustrea mixture of 37% phosphoric acid gel in extra fine grain pumice or 18% hydrochloric acid in pumice or 6.6% and 10% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities. Another advantage of microabrasion technique is that it leaves the treated enamel surface as highly polished which minimizes the cariogenic bacteria colonization and render it more resistant to demineralization |
| Antivet | Experimental | Drug: (Antivet, MDC DENTAL, Zapopan Jalisco México)The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be |
Who may qualify
- Ages
- 16 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (7 listed)
- Anterior teeth.
- Mild to moderate intrinsic or extrinsic stains.
- Vital and non-sensitive anterior teeth.
Key exclusion criteria (12 listed)
- Eligibility Criteria of teeth:
- pitted enamel.
- carious teeth.
- Deep lesions.
- Severe periodontal problems.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| (Antivet, MDC DENTAL, Zapopan Jalisco México)specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it | Drug | Antivet |
| Opalustretechnique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result. . | Drug | Opalustre™ |
| phosphoric acid 37% and aluminium oxid 50 microns● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications. | Drug | phosphoric acid 37% and aluminium oxid 50 microns |
Primary outcome
Clinical performance
Time frame: three months
visual analog scale using scoring system
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2026.
- Background: PubMed 36627216Blanchet I, Camoin A, Tardieu C, Jacquot B. Microabrasion in the management of enamel discolorations in paediatric dentistry: a systematic review. J Clin Pediatr Dent. 2023 Jan;47(1):17-26. doi: 10.22514/jocpd.2022.015. Epub 2023 Jan 3.
- Individual participant dataSharing planned: No. will not be shared except with authors only
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Esraa Esmeail Hussien EEH Elhaddad, PHD study director
Misr University for Science and Technology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing (Antivet, MDC DENTAL, Zapopan Jalisco México), Opalustre and phosphoric acid 37% and aluminium oxid 50 microns in people with Teeth Staining, run by Misr University for Science and Technology at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Esraa Esmeail Hussien EEH Lecturer, phd holder (0201111103836, dr.esraaism@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical performance (time frame: three months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07709286, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.