Gingival Recession, Mucogingival SurgeryNCT07706257
Gingival Unit Graft Versus Free Gingival Graft: 18-Month Digital Color Analysis
An observational study of Gingival Recession, Mucogingival Surgery and Keratinized Tissue Deficiency, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
Trial summary
The purpose of this retrospective clinical study is to compare the long-term aesthetic integration and clinical outcomes of two periodontal plastic surgery techniques: Gingival Unit Grafting (GUG) and Free Gingival Grafting (FGG). Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Gingival Recession, Mucogingival Surgery, Keratinized Tissue Deficiency
- What is being tested?
- Gingival Unit Grafting and Conventional Free Gingival Grafting
- Type of treatment
- Surgery or procedure
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2022to 31 Dec 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients seeking treatment for localized gingival recessions on mandibular incisors at a university faculty of dentistry.
Who may be able to join
- Systemically healthy individuals aged between 18 and 65 years
- No systemic diseases contraindicating periodontal surgery
- Not taking medications known to exert adverse effects on periodontal tissues
- Presenting with Cairo Type 2 (RT2) or Type 3 (RT3) localized gingival recessions on mandibular incisors
- Presence of ≤1 mm of attached gingiva resulting in difficulty maintaining plaque control
- Full-mouth plaque and gingival index scores ≤1
- Bleeding on probing (BOP) <10%
- No history of prior soft tissue surgery in the designated area
Who cannot join
- Individuals who are pregnant or lactating.
- Presenting with gingival recession or prosthetic restorations at the donor site (maxillary premolar palatal region).
- Cases demonstrating caries, abrasions, or restorations on the root surfaces of the related teeth.
- Individuals with known allergies to dental impression materials.
- Periodontal pocket depth greater than 3 mm.
- Tooth malposition.
- Endodontic complications.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Bezmialem Vakif University, Faculty of Dentistry
Istanbul, Fatih, 34093
About this study
Official title: Clinical Outcomes and Digital Color Stability of Gingival Unit Graft Versus Free Gingival Graft: An 18-Month Comparative Digital Photographic Color Analysis Study
The purpose of this retrospective clinical study is to compare the long-term aesthetic integration and clinical outcomes of two periodontal plastic surgery techniques: Gingival Unit Grafting (GUG) and Free Gingival Grafting (FGG). The study evaluates the effectiveness of these procedures in increasing keratinized tissue width and assesses the color integration of the grafted tissues with the surrounding gingiva over an 18-month follow-up period using objective digital color analysis based on CIE Lab and RGB parameters.
Read the detailed description
This single-center retrospective study included patients treated with either Gingival Unit Grafts (GUG) or Free Gingival Grafts (FGG) for the management of Cairo Type 2 and Type 3 gingival recessions between March 2022 and December 2022. Clinical and photographic records obtained at baseline and during follow-up visits up to 18 months were retrospectively analyzed. The primary outcome was the evaluation of color integration of the grafted tissues using objective digital color analysis based on CIE Lab and RGB parameters. Secondary outcomes included changes in keratinized tissue width. The aim of the study was to compare the long-term aesthetic integration and clinical performance of GUG and FGG and to determine which technique provides superior color matching with the surrounding tissues.
- Being tested
- Gingival Unit Grafting, Conventional Free Gingival Grafting
- Keywords
- Gingival Unit Graft, Free Gingival Graft, Aesthetics, Digital color analysis, Color matching
- Medical subject headings
- Gingival Recession
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Gingival Unit GraftingProcedure or surgery
Harvesting a gingival unit graft and transplanting it to the recipient area to increase keratinized tissue width and assess long-term aesthetic integration.
Conventional Free Gingival GraftingProcedure or surgery
Harvesting a conventional free gingival graft and transplanting it to the recipient area to increase keratinized tissue width and serve as a control group for aesthetic integration.
| Study group | Role | What they receive |
|---|---|---|
| Gingival Unit Graft (GUG) Group | Patients who underwent periodontal plastic surgery using Gingival Unit Grafts for keratinized tissue gain Receives: Procedure: Gingival Unit Grafting | |
| Conventional Free Gingival Graft (FGG) Group | Patients who underwent periodontal plastic surgery using Conventional Free Gingival Grafts for keratinized tissue gain Receives: Procedure: Conventional Free Gingival Grafting |
What is being measured
The primary outcome is the main question the study is designed to answer.
Aesthetic Integration (Color Evaluation)
Objective assessment of color integration between the grafted tissue and the surrounding gingiva using digital color analysis. Color parameters were evaluated based on the CIE Lab* color space system and RGB color channels obtained from standardized clinical photographs. The degree of color matching between grafted and adjacent tissues was assessed over the follow-up period.
Measured: Baseline and 18 months post-surgery
Secondary outcomes (1)
Keratinized Tissue Width (KTW)
The clinical measurement of the width of keratinized tissue in millimeters, evaluated from the gingival margin to the mucogingival junction using a standard periodontal probe to determine the amount of tissue gain.
Measured: Baseline and 18 months post-surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2026
- Study start1 Mar 2022
- Primary completion30 Jun 2024
- Study completion31 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Gingival Recession, Mucogingival SurgeryStudies of the same condition, open and under way.
- More trials run by Bezmialem Vakif UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bezmialem Vakif University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sanubar Shakiliyeva, Bezmialem Vakif University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07706257
- Sponsor's protocol ID
- No: 2024/304
- Status last verified
- Jul 2026
- First submitted
- 11 Jul 2026
- Last updated
- 16 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Outcomes and Digital Color Stability of Gingival Unit Graft Versus Free Gingival Graft: An 18-Month Comparative Digital Photographic Color Analysis Study
- ClinicalTrials.gov ID
- NCT07706257
- Acronym / sponsor ID
- No: 2024/304
- Keywords
- Gingival Unit Graft, Free Gingival Graft, Aesthetics, Digital color analysis, Color matching
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Bezmialem Vakif UniversityUniversity, hospital or other
- Study start
- 1 Mar 2022 (actual)
- Primary completion
- 30 Jun 2024 (actual)
- Study completion
- 31 Dec 2024 (actual)
- First posted
- 15 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this retrospective clinical study is to compare the long-term aesthetic integration and clinical outcomes of two periodontal plastic surgery techniques: Gingival Unit Grafting (GUG) and Free Gingival Grafting (FGG). The study evaluates the effectiveness of these procedures in increasing keratinized tissue width and assesses the color integration of the grafted tissues with the surrounding gingiva over an 18-month follow-up period using objective digital color analysis based on CIE Lab and RGB parameters.
Detailed description
This single-center retrospective study included patients treated with either Gingival Unit Grafts (GUG) or Free Gingival Grafts (FGG) for the management of Cairo Type 2 and Type 3 gingival recessions between March 2022 and December 2022. Clinical and photographic records obtained at baseline and during follow-up visits up to 18 months were retrospectively analyzed. The primary outcome was the evaluation of color integration of the grafted tissues using objective digital color analysis based on CIE Lab and RGB parameters. Secondary outcomes included changes in keratinized tissue width. The aim of the study was to compare the long-term aesthetic integration and clinical performance of GUG and FGG and to determine which technique provides superior color matching with the surrounding tissues.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Gingival Unit Graft (GUG) Group | – | Procedure: Gingival Unit GraftingPatients who underwent periodontal plastic surgery using Gingival Unit Grafts for keratinized tissue gain |
| Conventional Free Gingival Graft (FGG) Group | – | Procedure: Conventional Free Gingival GraftingPatients who underwent periodontal plastic surgery using Conventional Free Gingival Grafts for keratinized tissue gain |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients seeking treatment for localized gingival recessions on mandibular incisors at a university faculty of dentistry.
Key inclusion criteria (8 listed)
- Systemically healthy individuals aged between 18 and 65 years
- No systemic diseases contraindicating periodontal surgery
- Not taking medications known to exert adverse effects on periodontal tissues
- Presenting with Cairo Type 2 (RT2) or Type 3 (RT3) localized gingival recessions on mandibular incisors
- Presence of ≤1 mm of attached gingiva resulting in difficulty maintaining plaque control
Key exclusion criteria (7 listed)
- Individuals who are pregnant or lactating.
- Presenting with gingival recession or prosthetic restorations at the donor site (maxillary premolar palatal region).
- Cases demonstrating caries, abrasions, or restorations on the root surfaces of the related teeth.
- Individuals with known allergies to dental impression materials.
- Periodontal pocket depth greater than 3 mm.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Gingival Unit GraftingHarvesting a gingival unit graft and transplanting it to the recipient area to increase keratinized tissue width and assess long-term aesthetic integration. | Procedure or surgery | Gingival Unit Graft (GUG) Group |
| Conventional Free Gingival GraftingHarvesting a conventional free gingival graft and transplanting it to the recipient area to increase keratinized tissue width and serve as a control group for aesthetic integration. | Procedure or surgery | Conventional Free Gingival Graft (FGG) Group |
Primary outcome
Aesthetic Integration (Color Evaluation)
Time frame: Baseline and 18 months post-surgery
Objective assessment of color integration between the grafted tissue and the surrounding gingiva using digital color analysis. Color parameters were evaluated based on the CIE Lab* color space system and RGB color channels obtained from standardized clinical photographs. The degree of color matching between grafted and adjacent tissues was assessed over the follow-up period.
1 secondary outcome
Keratinized Tissue Width (KTW)
Time frame: Baseline and 18 months post-surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Gingival Recession, Mucogingival Surgery and Keratinized Tissue Deficiency, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Aesthetic Integration (Color Evaluation) (time frame: Baseline and 18 months post-surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.