Upper Limb Overuse SyndromeNCT07703332
Elongation Longitudinal Decoaptation Ostéo-Articulaire Versus Active Isolated Stretching on Median Nerve Mobility and Pain in Patient With Upper Limb Overuse Syndrome
A study testing Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline and Active isolated stretching (AIS) in people with Upper Limb Overuse Syndrome, run by University of Faisalabad at 1 site in Pakistan.
Trial summary
Upper-limb overuse syndrome (ULOS) often arises from repetitive loading, altering cervical biomechanics and increased median-nerve mechano sensitivity. Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) at C5-C6 improves segmental decompression and neural sliding, while Active isolated stretching (AIS)… Read more about this study
- Who is it for?
- Ages 20 to 50 years
- Conditions the study is for
- Upper Limb Overuse Syndrome
- What is being tested?
- Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline and Active isolated stretching (AIS)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 1 sitePakistan
- Study dates
- 10 Jul 2026to 25 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- All adult age group (20-50 years) patients with clinical symptoms and signs of upper limb overuse syndrome with median nerve were included in the study (Latif et al., 2022).
- Participants included individuals engaged in repetitive upper-limb activities, such as office workers, manual laborers, athletes and students, who demonstrated median nerve involvement associated with repetitive task performance (Descatha et al., 2017).
- Persistent pain in the upper limb, pain intensity score from 3-7 on the Numeric pain rating scale (NPRS), discomfort and functional limitations in daily activities, occupational tasks or recreational activities were deemed to be indications of eligibility for participation in the study (Hawker et al., 2011).
- Participants with persistent nature symptoms (3 months or more than 3 months) are included in the study to secure homogenous study population (Nicholas et al., 2019).
- Willing to give their informed consent and take part.
Who cannot join
- Trauma, surgery, fracture or dislocation of the upper limb in the last six months or less were excluded to minimize the possibility of studying the acute tissue healing on the results of this study (Cools et al., 2021).
- Other neurological conditions (e.g., peripheral or central nervous system disorders, systemic neuropathies, cervical radiculopathy, or other neurological disorders) were excluded for participation (Padua et al., 2020).
- The potential effect of rheumatologic or inflammatory musculoskeletal disorders (rheumatoid arthritis, lupus, or other systemic inflammatory diseases) on pain and functional status was also a reason for exclusion (Smolen et al., 2020).
- No corticosteroid uses or prior physical therapy within 3 months to reduce the potentially confounding effect of prior therapeutic interventions on study outcomes (Kolasinski et al., 2020).
- Participants were excluded from the study if they had any contraindications to manual therapy treatment that could affect the safety of the intervention (e.g., vascular, severe osteoporosis, malignancy, acute infection, other conditions) (Puentedura et al., 2012).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Dr . Rubina Zulfqar
Faisalabad, Punjab Province, 38000
About this study
Upper-limb overuse syndrome (ULOS) often arises from repetitive loading, altering cervical biomechanics and increased median-nerve mechano sensitivity. Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) at C5-C6 improves segmental decompression and neural sliding, while Active isolated stretching (AIS) enhances soft tissue elasticity and neuro dynamic glide.
Currently no direct comparison exists between these two methods in literature. Study aims to compare ELDOA (C5-C6 specific) and AIS in patients with ULOS for checking effects on median nerve mobility and pain. This research will be conducted as a randomized clinical trial involving 84 participants (42 in each group). Adults aged 20-50 years with diagnosis of ULOS, symptom duration 3- months (12 weeks) will be included in the study. While Neurological or rheumatologic conditions, recent corticosteroid injections, recent cervical or major upper limb surgery, and ongoing neural mobilization-focused physical therapy are among the exclusions. After meeting the inclusion and exclusion criteria and obtaining written and verbal consent from the participants. Participants will be randomly assigned to either the AIS or ELDOA groups and will receive 3 sessions per week for 3 weeks with baseline hot pack. Group A will perform diaphragmatic breathing with ELDOA targeting C5-C6, whereas Group B will engage in AIS on muscles that cause median-nerve tension. Pain intensity, upper limb function and median nerve mobility are outcome measures that will be assessed using tools NPRS, QuickDASH and ULTT1. Data will be analyzed using the 2024 SPSS.
- Conditions
- Upper Limb Overuse Syndrome
- Being tested
- Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline, Active isolated stretching (AIS)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baselineProcedure or surgery
Common baseline treatment (both Groups) Prior to their designated intervention, both groups will receive the following standardized baseline treatment:
- Hot pack application
- Patient education
- Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly.
Active isolated stretching (AIS)Procedure or surgery
- Hot pack application
- Patient education.
- Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention.
| Study group | Role | What they receive |
|---|---|---|
| Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) | Experimental | 1. Hot pack application
• A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention.
2. Patient education
3. Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly. Receives: Procedure: Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline |
| Active isolated stretching (AIS) | Experimental | 1. Hot pack application
• A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention.
2. Patient education
3. Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention. Receives: Procedure: Active isolated stretching (AIS) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity
Pain intensity will be measured by using numeric pain rating scale
Measured: 3 weeks
Functional status/ Disability
Functional status/ Disability will be measured by using QuickDASH questionnaire, The lower the Quick DASH score, the better the upper limb function and fewer the activity limitations.
Measured: 3 weeks
Nerve mobility
Nerve mobility will be measured by using Upper Limb Tension Test (ULTT1), Better responses in the ULTT1 suggest better median nerve mobility and lower neural tension.
Measured: 3 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start10 Jul 2026 (estimated)
- Primary completion20 Aug 2026 (estimated)
- Study completion25 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Upper Limb Overuse SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Faisalabad
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rubina Zulfqar, University of Faisalabad
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07703332
- Sponsor's protocol ID
- Tuf/EIRB/170/26
- Status last verified
- Jul 2026
- First submitted
- 8 Jun 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Elongation Longitudinal Decoaptation Ostéo-Articulaire Versus Active Isolated Stretching on Median Nerve Mobility and Pain in Patient With Upper Limb Overuse Syndrome
- ClinicalTrials.gov ID
- NCT07703332
- Acronym / sponsor ID
- Tuf/EIRB/170/26
- Conditions
- Upper Limb Overuse Syndrome
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- University of FaisalabadUniversity, hospital or other
- Study start
- 10 Jul 2026 (estimated)
- Primary completion
- 20 Aug 2026 (estimated)
- Study completion
- 25 Aug 2026 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Upper-limb overuse syndrome (ULOS) often arises from repetitive loading, altering cervical biomechanics and increased median-nerve mechano sensitivity. Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) at C5-C6 improves segmental decompression and neural sliding, while Active isolated stretching (AIS) enhances soft tissue elasticity and neuro dynamic glide.
Currently no direct comparison exists between these two methods in literature. Study aims to compare ELDOA (C5-C6 specific) and AIS in patients with ULOS for checking effects on median nerve mobility and pain. This research will be conducted as a randomized clinical trial involving 84 participants (42 in each group). Adults aged 20-50 years with diagnosis of ULOS, symptom duration 3- months (12 weeks) will be included in the study. While Neurological or rheumatologic conditions, recent corticosteroid injections, recent cervical or major upper limb surgery, and ongoing neural mobilization-focused physical therapy are among the exclusions. After meeting the inclusion and exclusion criteria and obtaining written and verbal consent from the participants. Participants will be randomly assigned to either the AIS or ELDOA groups and will receive 3 sessions per week for 3 weeks with baseline hot pack. Group A will perform diaphragmatic breathing with ELDOA targeting C5-C6, whereas Group B will engage in AIS on muscles that cause median-nerve tension. Pain intensity, upper limb function and median nerve mobility are outcome measures that will be assessed using tools NPRS, QuickDASH and ULTT1. Data will be analyzed using the 2024 SPSS.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) | Experimental | Procedure: Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline1. Hot pack application • A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention. 2. Patient education 3. Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly. |
| Active isolated stretching (AIS) | Experimental | Procedure: Active isolated stretching (AIS)1. Hot pack application • A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention. 2. Patient education 3. Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention. |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- All adult age group (20-50 years) patients with clinical symptoms and signs of upper limb overuse syndrome with median nerve were included in the study (Latif et al., 2022).
- Participants included individuals engaged in repetitive upper-limb activities, such as office workers, manual laborers, athletes and students, who demonstrated median nerve involvement associated with repetitive task performance (Descatha et al., 2017).
- Persistent pain in the upper limb, pain intensity score from 3-7 on the Numeric pain rating scale (NPRS), discomfort and functional limitations in daily activities, occupational tasks or recreational activities were deemed to be indications of eligibility for participation in the study (Hawker et al., 2011).
- Participants with persistent nature symptoms (3 months or more than 3 months) are included in the study to secure homogenous study population (Nicholas et al., 2019).
- Willing to give their informed consent and take part.
Key exclusion criteria (5 listed)
- Trauma, surgery, fracture or dislocation of the upper limb in the last six months or less were excluded to minimize the possibility of studying the acute tissue healing on the results of this study (Cools et al., 2021).
- Other neurological conditions (e.g., peripheral or central nervous system disorders, systemic neuropathies, cervical radiculopathy, or other neurological disorders) were excluded for participation (Padua et al., 2020).
- The potential effect of rheumatologic or inflammatory musculoskeletal disorders (rheumatoid arthritis, lupus, or other systemic inflammatory diseases) on pain and functional status was also a reason for exclusion (Smolen et al., 2020).
- No corticosteroid uses or prior physical therapy within 3 months to reduce the potentially confounding effect of prior therapeutic interventions on study outcomes (Kolasinski et al., 2020).
- Participants were excluded from the study if they had any contraindications to manual therapy treatment that could affect the safety of the intervention (e.g., vascular, severe osteoporosis, malignancy, acute infection, other conditions) (Puentedura et al., 2012).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baselineCommon baseline treatment (both Groups) Prior to their designated intervention, both groups will receive the following standardized baseline treatment: 1. Hot pack application 2. Patient education 3. Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly. | Procedure or surgery | Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) |
| Active isolated stretching (AIS)1. Hot pack application 2. Patient education. 3. Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention. | Procedure or surgery | Active isolated stretching (AIS) |
Primary outcome
Pain intensity
Time frame: 3 weeks
Pain intensity will be measured by using numeric pain rating scale
Functional status/ Disability
Time frame: 3 weeks
Functional status/ Disability will be measured by using QuickDASH questionnaire, The lower the Quick DASH score, the better the upper limb function and fewer the activity limitations.
Nerve mobility
Time frame: 3 weeks
Nerve mobility will be measured by using Upper Limb Tension Test (ULTT1), Better responses in the ULTT1 suggest better median nerve mobility and lower neural tension.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline and Active isolated stretching (AIS) in people with Upper Limb Overuse Syndrome, run by University of Faisalabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dr. Rubina Zulfqar (+923414291664, drubinazulfqar355@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity (time frame: 3 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.