Knee SurgeriesNCT07700797
Adductor Canal Block With IPACK Versus 4-in-1 Block for Postoperative Analgesia in Knee Surgery
A study testing Adductor canal block with IPACK and 4 in 1 block in people with Knee Surgeries and Total Ankle Arthroplasty, run by Zagazig University at 1 site in Egypt.
Trial summary
This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee surgery. Twenty-four patients were randomly allocated into two equal groups. Read more about this study
- Who is it for?
- Ages 21 to 64 yearsHealthy volunteers can take part
- Conditions the study is for
- Knee Surgeries, Total Ankle Arthroplasty, Anterior Cruciate Ligament (ACL) Tear
- What is being tested?
- Adductor canal block with IPACK and 4 in 1 block
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 22 Jun 2026to 22 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 64 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 1. Patients or caregivers acceptance. 2. Age : 21 - 64 years 3. Sex : both ( males \& females). 4. Physical status: ASA І \& II. 5. BMI 18.5-30 kg/m2. 6. Type of operations : elective surgery. 7. Type of anesthesia: unilateral intrathecal anesthesia. 8. Patients undergoing elective knee surgery under unilateral spinal anesthesia 9. Duration of surgery within 2 hr.
Who cannot join
- Known history of allergy to study drug Coagulopathies or taking drugs affecting coagulation.. Contraindications for peripheral nerve block (PNB) and spinal anesthesia (SA) (coagulation defects, infection at the puncture site), bone degenerative disease and posttraumatic condition of the spine, dementia and severe visual or auditory disorder.
- Current severe psychiatric disease, alcoholism or drug dependence. Subjects with history previous knee surgery, osteoarthritis, malformation or tumors (including Baker's cyst), which could alter the normal anatomy of the popliteal fossa
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Medicine, Zagazig University Hospitals
Zagazig, Sharqia Province, 055
About this study
Official title: Effect of Adductor Canal Block With Infiltration of the Posterior Capsule of the Knee Versus 4-in-1 Block Technique for Postoperative Analgesia in Patients Undergoing Knee Surgeries
This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee surgery. Twenty-four patients were randomly allocated into two equal groups. The primary objective is to compare postoperative pain scores and analgesic requirements. Secondary outcomes include time to first rescue analgesia, total analgesic consumption, motor function preservation, and block-related complications.
Read the detailed description
Effective postoperative pain control following knee surgery is essential for early mobilization, rehabilitation, and patient satisfaction. Several regional anesthesia techniques have been developed to provide analgesia while preserving quadriceps muscle strength. Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) has been proposed as a motor-sparing technique that provides effective anterior and posterior knee analgesia. The 4-in-1 block is another ultrasound-guided regional anesthesia technique designed to provide comprehensive analgesia for knee surgery.
This prospective randomized interventional study enrolled 24 patients undergoing knee surgery. Participants were randomly assigned to receive either Adductor Canal Block with IPCAK or the 4-in-1 block. Postoperative pain scores, time to first rescue analgesia, total analgesic consumption, motor function, patient satisfaction, and complications were evaluated and compared between the two groups
- Conditions
- Knee Surgeries, Total Ankle Arthroplasty, Anterior Cruciate Ligament (ACL) Tear, Posterior Cruciate Ligament Tear
- Being tested
- Adductor canal block with IPACK, 4 in 1 block
- Keywords
- Adductor canal block, IPACK, 4 in 1 block, Knee surgeries, Postoperative analgesia, Regional anesthesia, Ultrasound guided nerve block
- Medical subject headings
- Lacerations
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adductor canal block with IPACKProcedure or surgery
Ultrasound-guided Adductor Canal Block combined with IPCAK block
4 in 1 blockProcedure or surgery
Ultrasound-guided 4-in-1 block technique.
| Study group | Role | What they receive |
|---|---|---|
| Adductor canal block+ IPACK | Experimental | Patients receive ultrasound-guided Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) for postoperative analgesia after knee surgery Receives: Procedure: Adductor canal block with IPACK |
| 4 in 1 block | Experimental | Patients receive ultrasound-guided 4-in-1 block for postoperative analgesia after knee surgery. Receives: Procedure: 4 in 1 block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative pain intensity measured by Visual Analog Scale (VAS)
Postoperative pain will be assessed using the Visual Analog Scale (VAS) at rest and during movement at predetermined postoperative time points
Measured: 24 hours after surgery
Secondary outcomes (3)
Total opioid consumption
Total rescue opioid analgesic consumption during the first 24 postoperative hours
Measured: First 24 hours after surgery
Time to first rescue analgesia
Time from completion of surgery to the first request for rescue analgesia
Measured: Within 24 hours after surgery
Patient satisfaction with postoperative analgesia
Patient satisfaction score regarding postoperative pain management
Measured: 24 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start22 Jun 2026
- Primary completion22 Jun 2026
- Study completion22 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee SurgeriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Zagazig University
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Abdalla Mohamed Goda, MD, Study chair, Faculty of Medicine, Zagazig UniversityYasser Mohamed Naser, MD, Study director, Faculty of Medicine, Zagazig University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07700797
- Sponsor's protocol ID
- 1763
- Status last verified
- Jul 2026
- First submitted
- 8 Jul 2026
- Last updated
- 17 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Adductor Canal Block With Infiltration of the Posterior Capsule of the Knee Versus 4-in-1 Block Technique for Postoperative Analgesia in Patients Undergoing Knee Surgeries
- ClinicalTrials.gov ID
- NCT07700797
- Acronym / sponsor ID
- 1763
- Conditions
- Knee Surgeries, Total Ankle Arthroplasty, Anterior Cruciate Ligament (ACL) Tear, Posterior Cruciate Ligament Tear
- Keywords
- Adductor canal block, IPACK, 4 in 1 block, Knee surgeries, Postoperative analgesia, Regional anesthesia, Ultrasound guided nerve block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Zagazig UniversityOther government
- Study start
- 22 Jun 2026 (actual)
- Primary completion
- 22 Jun 2026 (actual)
- Study completion
- 22 Jun 2026 (actual)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized interventional study compares the analgesic efficacy of Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) versus the 4-in-1 block technique in patients undergoing knee surgery. Twenty-four patients were randomly allocated into two equal groups. The primary objective is to compare postoperative pain scores and analgesic requirements. Secondary outcomes include time to first rescue analgesia, total analgesic consumption, motor function preservation, and block-related complications.
Detailed description
Effective postoperative pain control following knee surgery is essential for early mobilization, rehabilitation, and patient satisfaction. Several regional anesthesia techniques have been developed to provide analgesia while preserving quadriceps muscle strength. Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) has been proposed as a motor-sparing technique that provides effective anterior and posterior knee analgesia. The 4-in-1 block is another ultrasound-guided regional anesthesia technique designed to provide comprehensive analgesia for knee surgery.
This prospective randomized interventional study enrolled 24 patients undergoing knee surgery. Participants were randomly assigned to receive either Adductor Canal Block with IPCAK or the 4-in-1 block. Postoperative pain scores, time to first rescue analgesia, total analgesic consumption, motor function, patient satisfaction, and complications were evaluated and compared between the two groups
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adductor canal block+ IPACK | Experimental | Procedure: Adductor canal block with IPACKPatients receive ultrasound-guided Adductor Canal Block combined with Infiltration of the Posterior Capsule of the Knee (IPCAK) for postoperative analgesia after knee surgery |
| 4 in 1 block | Experimental | Procedure: 4 in 1 blockPatients receive ultrasound-guided 4-in-1 block for postoperative analgesia after knee surgery. |
Who may qualify
- Ages
- 21 to 64 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- 1. Patients or caregivers acceptance. 2. Age : 21 - 64 years 3. Sex : both ( males \& females). 4. Physical status: ASA І \& II. 5. BMI 18.5-30 kg/m2. 6. Type of operations : elective surgery. 7. Type of anesthesia: unilateral intrathecal anesthesia. 8. Patients undergoing elective knee surgery under unilateral spinal anesthesia 9. Duration of surgery within 2 hr.
Key exclusion criteria (2 listed)
- Known history of allergy to study drug Coagulopathies or taking drugs affecting coagulation.. Contraindications for peripheral nerve block (PNB) and spinal anesthesia (SA) (coagulation defects, infection at the puncture site), bone degenerative disease and posttraumatic condition of the spine, dementia and severe visual or auditory disorder.
- Current severe psychiatric disease, alcoholism or drug dependence. Subjects with history previous knee surgery, osteoarthritis, malformation or tumors (including Baker's cyst), which could alter the normal anatomy of the popliteal fossa
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adductor canal block with IPACKUltrasound-guided Adductor Canal Block combined with IPCAK block | Procedure or surgery | Adductor canal block+ IPACK |
| 4 in 1 blockUltrasound-guided 4-in-1 block technique. | Procedure or surgery | 4 in 1 block |
Primary outcome
Postoperative pain intensity measured by Visual Analog Scale (VAS)
Time frame: 24 hours after surgery
Postoperative pain will be assessed using the Visual Analog Scale (VAS) at rest and during movement at predetermined postoperative time points
3 secondary outcomes
Total opioid consumption
Time frame: First 24 hours after surgery
Time to first rescue analgesia
Time frame: Within 24 hours after surgery
Patient satisfaction with postoperative analgesia
Time frame: 24 hours after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Knee Surgeries
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Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Abdalla Mohamed Goda, MD study chair
Faculty of Medicine, Zagazig University
Yasser Mohamed Naser, MD study director
Faculty of Medicine, Zagazig University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adductor canal block with IPACK and 4 in 1 block in people with Knee Surgeries and Total Ankle Arthroplasty, run by Zagazig University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative pain intensity measured by Visual Analog Scale (VAS) (time frame: 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jul 2026.