Periodontal DiseaseEarly Phase 1NCT07697963
Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers
A Early Phase 1 study testing Photodynamic therapy (PDT) in people with Periodontal Disease, run by University of Pristina.
Trial summary
Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontal Disease
- What is being tested?
- Photodynamic therapy (PDT)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 120 participants
- Where
- No sites listed yet
- Study dates
- 5 Jan 2015to 15 Dec 2015
- Phase
- Early Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- at least two teeth with periodontal pockets up to 4 mm
Who cannot join
- less than two teeth with periodontal pockets
About this study
Official title: Comparison of Photodynamic Therapy vs. Non-surgical Periodontal Treatment in Patients Who Smoke vs. Non-smokers
Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.
- Conditions
- Periodontal Disease
- Being tested
- Scaling and root planing plus placebo, Photodynamic therapy (PDT)
- Keywords
- photodynamic therapy
- Medical subject headings
- Periodontal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scaling and root planing plus placeboProcedure or surgery
Also called scaling and root planning
Non-surgical treatment of periodontal pockets
Photodynamic therapy (PDT)Combination product
Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy
| Study group | Role | What they receive |
|---|---|---|
| Scaling and root planning | Active comparator | Non-surgical treatment Receives: Procedure: Scaling and root planing plus placebo |
| Photodynamic therapy | Experimental | Application of photodynamic therapy as an adjunct to non-surgical therapy Receives: Combination Product: Photodynamic therapy (PDT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Periodontal pocket depth reduction
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jul 2026
- Study start5 Jan 2015
- Primary completion15 Oct 2015
- Study completion15 Dec 2015
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontal DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Early Phase 1
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Pristina
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kastriot Meqa, University of Pristina
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07697963
- Sponsor's protocol ID
- Ref. 2972, 05.05.2014
- Status last verified
- Oct 2015
- First submitted
- 6 Jul 2026
- Last updated
- 13 Jul 2026
- Results posted
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Photodynamic Therapy vs. Non-surgical Periodontal Treatment in Patients Who Smoke vs. Non-smokers
- ClinicalTrials.gov ID
- NCT07697963
- Acronym / sponsor ID
- Ref. 2972, 05.05.2014
- Conditions
- Periodontal Disease
- Keywords
- photodynamic therapy
- Phase
- Early Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- University of PristinaUniversity, hospital or other
- Study start
- 5 Jan 2015 (actual)
- Primary completion
- 15 Oct 2015 (actual)
- Study completion
- 15 Dec 2015 (actual)
- First posted
- 13 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Scaling and root planning | Active comparator | Procedure: Scaling and root planing plus placeboNon-surgical treatment |
| Photodynamic therapy | Experimental | Combination Product: Photodynamic therapy (PDT)Application of photodynamic therapy as an adjunct to non-surgical therapy |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- at least two teeth with periodontal pockets up to 4 mm
Key exclusion criteria (1 listed)
- less than two teeth with periodontal pockets
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scaling and root planing plus placeboAlso: scaling and root planningNon-surgical treatment of periodontal pockets | Procedure or surgery | Scaling and root planning |
| Photodynamic therapy (PDT)Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy | Combination product | Photodynamic therapy |
Primary outcome
Periodontal pocket depth reduction
Time frame: 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A Early Phase 1 study testing Photodynamic therapy (PDT) in people with Periodontal Disease, run by University of Pristina.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Early Phase 1 (sometimes called Phase 0) studies give a very small amount of a treatment to a few people, mainly to see how the body handles it.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Periodontal pocket depth reduction (time frame: 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jul 2026; AzTrials last refreshed its copy on 8 Nov 2026.