Violent Suicide Attempts in AdolescentsMENTACOG-TSNCT07688798
Mentalization and Social Cognition in Adolescents After Suicide Attempt
A study testing Test and Questionnaires in people with Violent Suicide Attempts in Adolescents, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
This study investigates the risk of violent suicide attempts in adolescents, with a particular focus on social cognition and sleep disturbances, to better understand the cognitive and behavioral mechanisms involved and to inform more targeted prevention strategies. Read more about this study
- Who is it for?
- Ages 12 to 16 years
- Conditions the study is for
- Violent Suicide Attempts in Adolescents
- What is being tested?
- Test and Questionnaires
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 82 participants
- Where
- 1 siteFrance
- Study dates
- Oct 2026to Apr 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 16 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Adolescents aged 12 to 16 years, inclusive
- Having made a violent or non-violent suicide attempt
- Hospitalized in the Department of Child and Adolescent Psychiatry at Necker Children's Hospital
- No intellectual disability (IQ > 70)
- Sufficient proficiency in French to complete the study assessments; at least one parent or legal guardian must also have sufficient proficiency in French
- Written informed consent obtained from the holders of parental authority and assent obtained from the adolescent
- Covered by a health insurance scheme
Who cannot join
- Current psychotic disorder or documented history of a psychotic disorder
- Current manic or hypomanic episode
- Severe neurological or medical condition likely to significantly affect cognitive performance
- Moderate-to-severe substance use disorder requiring specialized treatment
- Acute intoxication or withdrawal state at the time of assessment- Written informed consent obtained from parents or legal guardians and assent obtained from the adolescent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hélène Morel contact
France1 site
Hôpital Necker-Enfants Malades
Paris, 75015
Catherine Grosmaitre, PhD, 033144494561, catherine.grosmaitre@aphp.fr
About this study
This study investigates the risk of violent suicide attempts in adolescents, with a particular focus on social cognition and sleep disturbances, to better understand the cognitive and behavioral mechanisms involved and to inform more targeted prevention strategies.
Violent suicide attempts are defined as the use of methods with a high immediate lethal potential. They are associated with distinct clinical profiles and specific risk factors, including an increased risk of recurrence and completed suicide.
Read more
Although the association between suicidal behavior and psychiatric disorders is well established, evidence regarding the underlying neurocognitive factors remains inconsistent. In particular, little is known about the role of social cognition in suicidal risk among adolescents. Research in this area is limited, leaving an important gap in our understanding of the cognitive processes that may contribute to the emergence of suicidal thoughts and behaviors during adolescence.
In addition, studies conducted in community-based adolescent cohorts have shown that insufficient sleep duration is independently associated with increased suicidal ideation and suicidal behavior, even after accounting for depressive symptoms.
Read the detailed description
This research examines violent suicide risk in adolescents through the study of social cognition and sleep disturbances, with the aim of clarifying the cognitive and behavioral mechanisms involved and informing more targeted prevention strategies. Violent suicide attempts are defined as attempts involving methods associated with a high risk of fatal outcome. Such attempts have been associated with distinct clinical characteristics and risk profiles, including a greater risk of recurrence and completed suicide. Although the association between suicidal risk and psychiatric history is well documented, evidence regarding the neurocognitive factors involved remains limited and inconsistent. Social cognition refers to the cognitive processes involved in perceiving, interpreting, and responding to social information. Adolescence is a critical developmental period for social cognition, characterized both by ongoing maturation of socio-emotional and prefrontal brain networks and by increasing social demands, including greater reliance on peer relationships, heightened sensitivity to social evaluation, and the emergence of more complex interpersonal interactions. These developmental changes may influence how adolescents interpret and respond to interpersonal stressors associated with suicidal vulnerability. However, the relationship between social cognition and suicidal risk in adolescents remains poorly understood, and relatively few studies have specifically investigated the cognitive mechanisms that may contribute to the emergence of suicidal thoughts and behaviors in this population. Finally, studies conducted in community adolescent samples suggest that insufficient sleep duration is associated with increased suicidal ideation and suicidal behaviors, independently of depressive symptoms.
- Conditions
- Violent Suicide Attempts in Adolescents
- Being tested
- Test, Questionnaires
- Keywords
- Violent suicide attempts, Teenagers, Social cognition, Sleep Disturbance
- Medical subject headings
- Parasomnias
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
TestOther
Clinical Assessment of Social Cognition, including :
- PERSO: measurement of social reasoning, through the analysis and interpretation of social situations, the understanding of the emotions and intentions of others, as well as the adaptation of responses to the relational context;
- Movie for the Assessment of Social Cognition (MASC): video task measuring understanding of the mental states, intentions and emotions of others (theory of mind),
- Ambiguous Intentions Hostility Questionnaire (AIHQ): measurement of attribution biases and hostile interpretations in social interactions.
QuestionnairesOther
To explore the associations between performance on the most discriminative social cognition measures (derived from the Clinical Assessment of Social Cognition [ClaCoS] battery) and several secondary variables that may influence socio-cognitive functioning or the characteristics of the suicide attempt, including:
- Suicidal intent, assessed using the Suicide Intent Scale (SIS)
- Anxiety symptoms, assessed using the Screen for Child Anxiety Related Emotional Disorders (SCARED)
- Depressive symptoms, assessed using the Major Depressive Disorder (MDD) module of the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS)
- Socioeconomic vulnerability, assessed using the EPICES deprivation score
- Attachment styles, assessed using the Adolescent Relationship Scale Questionnaire (ARSQ)
- Sleep characteristics, assessed using the Sleep Disturbance Scale for Children (SDSC) and the Disturbing Dreams and Nightmare Severity Index (DDNSI)
- Everyday social cognition skills, assessed us
| Study group | Role | What they receive |
|---|---|---|
| Adolescents who have attempted violent suicide | Experimental | Adolescents aged 12 to 16 inclusive who have attempted violent suicide and are hospitalized at Necker Children's Hospital :
* Hospitalization lasting more than 24 hours.
* One criterion among: treatment in a specialized department, surgery under general anesthesia, intensive medical treatment, attempted suicide by methods involving a high risk of mortality (hanging, firearm, etc.).
And their parents. Receives: Other: Test; Other: Questionnaires |
| Adolescents who have attempted nonviolent suicide | Experimental | Adolescents aged 12 to 16 inclusive who have attempted non-violent suicide (low or moderate lethality means) and are hospitalized at Necker Children's Hospital and matched with adolescents who have attempted violent suicide according to three control variables: gender, main psychiatric diagnosis, and socio-economic precariousness (binary score from a validated scale).
And their parents. Receives: Other: Test; Other: Questionnaires |
What is being measured
The primary outcome is the main question the study is designed to answer.
Level of performance in social cognition in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt
Social cognition will be assessed using three subtests from the Clinical Assessment of Social Cognition (ClaCoS) battery. The PERSO task evaluates social reasoning through the interpretation of social situations and yields a total score based on the number of correct responses. The MASC (Movie for the Assessment of Social Cognition) assesses theory of mind using a video-based task and provides a total score corresponding to the number of correctly inferred mental states. The AIHQ assesses attributional biases in ambiguous social situations and generates scores reflecting hostile and intentionality attribution biases. For all three measures, scores will be analysed as continuous variables, with higher scores indicating better social cognitive performance (PERSO, MASC) or stronger attributional biases (AIHQ).
Measured: 1 day
Secondary outcomes (8)
Severity of suicidal intention
Measurement of the severity of suicidal intention by the Suicide Intent Scale (SIS) rated by the service psychologist based on information collected in the clinical file in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt.
Measured: 1 day
Level of socio-economic precariousness
Level of precariousness and social vulnerability score using the EPICES questionnaire in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt.
Measured: 1 day
Level of anxiety
Level of anxiety assessed using the Screen for Child Anxiety Related Emotional Disorders (SCARED), a self-report questionnaire measuring specific and generalized anxiety symptoms in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt.
Measured: 1 day
Level of depressive disorder
Assessment of depression by the Major Depressive Disorder (MDD) section of the K-SADS (Kiddie Schedule for Affective Disorders and Schizophrenia), a semi-structured interview tool used to diagnose a major depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders criteria in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt.
Measured: 1 day
Evaluation of attachment styles
Evaluation of attachment styles, assessed by a self-reported questionnaire, the Adolescent Relationship Scale Questionnaire (ARSQ), in order to examine the quality of emotional bonds and perceived relational security in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt.
Measured: 1 day
Level of sleep disturbances
Sleep disturbances assessed using the Sleep Disturbance Scale for Children (SDSC), a 26-item caregiver-report questionnaire rated on a 5-point Likert scale. Total scores range from 26 to 130, with higher scores indicating greater sleep disturbance.
Measured: 1 day
Evaluation of socio-developmental / social-cognition skills
Everyday socio-cognitive skills are assessed using the Socio-developmental Skills Questionnaire (SOCODEV), a 20-item parent-completed questionnaire evaluating mentalization, emotion recognition, social motivation, and prosocial behaviors. Each item is rated on a 5-point Likert scale ranging from 1 (never) to 5 (always). Total scores range from 20 to 100, with higher scores indicating better socio-developmental skills. SOCODEV total scores are compared between adolescents hospitalized following a violent versus a non-violent suicide attempt.
Measured: 1 day
Severity of nightmares
Nightmare severity assessed using the Disturbing Dreams and Nightmare Severity Index (DDNSI). Total scores range from 0 to 37, with higher scores indicating greater nightmare severity.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study startOct 2026 (estimated)
- Primary completionApr 2028 (estimated)
- Study completionApr 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (33)Papers the sponsor has linked to this study.
- Other trials for Violent Suicide Attempts in AdolescentsStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 82 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Responsible party
- Sponsor
- Investigators
- Catherine Grosmaitre, PhD, Principal investigator, Assistance Publique - Hôpitaux de ParisPauline MD, PhD Chaste, Study director, Assistance Publique - Hôpitaux de Paris
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07688798
- Sponsor's protocol ID
- APHP251891
- Other IDs
- 2025-A02756-43
- Acronym
- MENTACOG-TS
- Status last verified
- Sep 2026
- First submitted
- 22 Jun 2026
- Last updated
- 18 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Szeifert N, Balint L, Sebok B, Gonda X. Risk factors for violent suicide attempts: Hungarian cross-sectional study. Eur Psychiatry. 2025 Jun 11;68(1):e85. doi: 10.1192/j.eurpsy.2025.10042.
PubMed 40495519Sastre-Buades A, Alacreu-Crespo A, Courtet P, Baca-Garcia E, Barrigon ML. Decision-making in suicidal behavior: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2021 Dec;131:642-662. doi: 10.1016/j.neubiorev.2021.10.005. Epub 2021 Oct 5.
PubMed 34619171Pompili M, Innamorati M, Forte A, Longo L, Mazzetta C, Erbuto D, Ricci F, Palermo M, Stefani H, Seretti ME, Lamis DA, Perna G, Serafini G, Amore M, Girardi P. Insomnia as a predictor of high-lethality suicide attempts. Int J Clin Pract. 2013 Dec;67(12):1311-6. doi: 10.1111/ijcp.12211.
PubMed 24246209Perrain R, Dardennes R, Jollant F. Risky decision-making in suicide attempters, and the choice of a violent suicidal means: an updated meta-analysis. J Affect Disord. 2021 Feb 1;280(Pt A):241-249. doi: 10.1016/j.jad.2020.11.052. Epub 2020 Nov 12.
PubMed 33220560Parrish EM, Steenkamp L, Chalker SA, Moore RC, Pinkham A, Depp CA. Systematic Review of the Link Between Social Cognition and Suicidal Ideation and Behavior in People With Serious Mental Illness. Schizophr Bull Open. 2024 Mar 27;5(1):sgae007. doi: 10.1093/schizbullopen/sgae007. eCollection 2024 Jan.
PubMed 38617732Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008 Dec;9(12):947-57. doi: 10.1038/nrn2513. Epub 2008 Nov 12.
PubMed 19002191Mendle, J. (2014). Why Puberty Matters for Psychopathology. Child Development Perspectives, 8(4), 218-222. https://doi.org/10.1111/cdep.12092
Oliphant RYK, Smith EM, Grahame V. What is the Prevalence of Self-harming and Suicidal Behaviour in Under 18s with ASD, With or Without an Intellectual Disability? J Autism Dev Disord. 2020 Oct;50(10):3510-3524. doi: 10.1007/s10803-020-04422-6.
PubMed 32125568Mikami K, Inomata S, Hayakawa N, Ohnishi Y, Enseki Y, Ohya A, Haruki Y, Kishi Y, Shinohara Y, Ichimura A, Matsumoto H. Frequency and clinical features of pervasive developmental disorder in adolescent suicide attempts. Gen Hosp Psychiatry. 2009 Mar-Apr;31(2):163-6. doi: 10.1016/j.genhosppsych.2008.12.003. Epub 2009 Feb 1.
PubMed 19269537MacPherson HA, Kim KL, Seymour KE, Wolff J, Esposito-Smythers C, Spirito A, Dickstein DP. Cognitive Flexibility and Impulsivity Deficits in Suicidal Adolescents. Res Child Adolesc Psychopathol. 2022 Dec;50(12):1643-1656. doi: 10.1007/s10802-022-00952-y. Epub 2022 Jun 25.
PubMed 35751716Lubbert M, Bahlmann L, Sobanski T, Schulz A, Kastner UW, Walter M, Jollant F, Wagner G. Investigating the Clinical Profile of Suicide Attempters Who Used a Violent Suicidal Means. J Clin Med. 2022 Dec 2;11(23):7170. doi: 10.3390/jcm11237170.
PubMed 36498743Levi-Belz Y, Beautrais A. Serious Suicide Attempts. Crisis. 2016 Jul;37(4):299-309. doi: 10.1027/0227-5910/a000386. Epub 2016 Jun 1.
PubMed 27245812Levi-Belz Y, Gvion Y, Horesh N, Fischel T, Treves I, Or E, Stein-Reisner O, Weiser M, David HS, Apter A. Mental pain, communication difficulties, and medically serious suicide attempts: a case-control study. Arch Suicide Res. 2014;18(1):74-87. doi: 10.1080/13811118.2013.809041.
PubMed 24350568Larson T, Lundstrom S, Nilsson T, Selinus EN, Rastam M, Lichtenstein P, Gumpert CH, Anckarsater H, Kerekes N. Predictive properties of the A-TAC inventory when screening for childhood-onset neurodevelopmental problems in a population-based sample. BMC Psychiatry. 2013 Sep 25;13:233. doi: 10.1186/1471-244X-13-233.
PubMed 24066834Kwon SJ, Turpyn CC, Duell N, Telzer EH. Neural Underpinnings of Social Contextual Influences on Adolescent Risk-Taking. Curr Addict Rep. 2020 Sep;7(3):413-420. doi: 10.1007/s40429-020-00328-6. Epub 2020 Sep 1.
PubMed 36176898
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mentalization and Social Cognition in Adolescents After Suicide Attempt
- ClinicalTrials.gov ID
- NCT07688798
- Acronym / sponsor ID
- MENTACOG-TS / APHP251891
- Conditions
- Violent Suicide Attempts in Adolescents
- Keywords
- Violent suicide attempts, Teenagers, Social cognition, Sleep Disturbance
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 82 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Study start
- Oct 2026 (estimated)
- Primary completion
- Apr 2028 (estimated)
- Study completion
- Apr 2028 (estimated)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the risk of violent suicide attempts in adolescents, with a particular focus on social cognition and sleep disturbances, to better understand the cognitive and behavioral mechanisms involved and to inform more targeted prevention strategies.
Violent suicide attempts are defined as the use of methods with a high immediate lethal potential. They are associated with distinct clinical profiles and specific risk factors, including an increased risk of recurrence and completed suicide.
Although the association between suicidal behavior and psychiatric disorders is well established, evidence regarding the underlying neurocognitive factors remains inconsistent. In particular, little is known about the role of social cognition in suicidal risk among adolescents. Research in this area is limited, leaving an important gap in our understanding of the cognitive processes that may contribute to the emergence of suicidal thoughts and behaviors during adolescence.
In addition, studies conducted in community-based adolescent cohorts have shown that insufficient sleep duration is independently associated with increased suicidal ideation and suicidal behavior, even after accounting for depressive symptoms.
Detailed description
This research examines violent suicide risk in adolescents through the study of social cognition and sleep disturbances, with the aim of clarifying the cognitive and behavioral mechanisms involved and informing more targeted prevention strategies. Violent suicide attempts are defined as attempts involving methods associated with a high risk of fatal outcome. Such attempts have been associated with distinct clinical characteristics and risk profiles, including a greater risk of recurrence and completed suicide. Although the association between suicidal risk and psychiatric history is well documented, evidence regarding the neurocognitive factors involved remains limited and inconsistent. Social cognition refers to the cognitive processes involved in perceiving, interpreting, and responding to social information. Adolescence is a critical developmental period for social cognition, characterized both by ongoing maturation of socio-emotional and prefrontal brain networks and by increasing social demands, including greater reliance on peer relationships, heightened sensitivity to social evaluation, and the emergence of more complex interpersonal interactions. These developmental changes may influence how adolescents interpret and respond to interpersonal stressors associated with suicidal vulnerability. However, the relationship between social cognition and suicidal risk in adolescents remains poorly understood, and relatively few studies have specifically investigated the cognitive mechanisms that may contribute to the emergence of suicidal thoughts and behaviors in this population. Finally, studies conducted in community adolescent samples suggest that insufficient sleep duration is associated with increased suicidal ideation and suicidal behaviors, independently of depressive symptoms.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adolescents who have attempted violent suicide | Experimental | Other: Test, Other: QuestionnairesAdolescents aged 12 to 16 inclusive who have attempted violent suicide and are hospitalized at Necker Children's Hospital : * Hospitalization lasting more than 24 hours. * One criterion among: treatment in a specialized department, surgery under general anesthesia, intensive medical treatment, attempted suicide by methods involving a high risk of mortality (hanging, firearm, etc.). And their parents. |
| Adolescents who have attempted nonviolent suicide | Experimental | Other: Test, Other: QuestionnairesAdolescents aged 12 to 16 inclusive who have attempted non-violent suicide (low or moderate lethality means) and are hospitalized at Necker Children's Hospital and matched with adolescents who have attempted violent suicide according to three control variables: gender, main psychiatric diagnosis, and socio-economic precariousness (binary score from a validated scale). And their parents. |
Who may qualify
- Ages
- 12 to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (7 listed)
- Adolescents aged 12 to 16 years, inclusive
- Having made a violent or non-violent suicide attempt
- Hospitalized in the Department of Child and Adolescent Psychiatry at Necker Children's Hospital
- No intellectual disability (IQ > 70)
- Sufficient proficiency in French to complete the study assessments; at least one parent or legal guardian must also have sufficient proficiency in French
Key exclusion criteria (5 listed)
- Current psychotic disorder or documented history of a psychotic disorder
- Current manic or hypomanic episode
- Severe neurological or medical condition likely to significantly affect cognitive performance
- Moderate-to-severe substance use disorder requiring specialized treatment
- Acute intoxication or withdrawal state at the time of assessment- Written informed consent obtained from parents or legal guardians and assent obtained from the adolescent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| TestClinical Assessment of Social Cognition, including : * PERSO: measurement of social reasoning, through the analysis and interpretation of social situations, the understanding of the emotions and intentions of others, as well as the adaptation of responses to the relational context; * Movie for the Assessment of Social Cognition (MASC): video task measuring understanding of the mental states, intentions and emotions of others (theory of mind), * Ambiguous Intentions Hostility Questionnaire (AIHQ): measurement of attribution biases and hostile interpretations in social interactions. | Other | Adolescents who have attempted nonviolent suicide, Adolescents who have attempted violent suicide |
| QuestionnairesTo explore the associations between performance on the most discriminative social cognition measures (derived from the Clinical Assessment of Social Cognition [ClaCoS] battery) and several secondary variables that may influence socio-cognitive functioning or the characteristics of the suicide attempt, including: * Suicidal intent, assessed using the Suicide Intent Scale (SIS) * Anxiety symptoms, assessed using the Screen for Child Anxiety Related Emotional Disorders (SCARED) * Depressive symptoms, assessed using the Major Depressive Disorder (MDD) module of the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) * Socioeconomic vulnerability, assessed using the EPICES deprivation score * Attachment styles, assessed using the Adolescent Relationship Scale Questionnaire (ARSQ) * Sleep characteristics, assessed using the Sleep Disturbance Scale for Children (SDSC) and the Disturbing Dreams and Nightmare Severity Index (DDNSI) * Everyday social cognition skills, assessed us | Other | Adolescents who have attempted nonviolent suicide, Adolescents who have attempted violent suicide |
Primary outcome
Level of performance in social cognition in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt
Time frame: 1 day
Social cognition will be assessed using three subtests from the Clinical Assessment of Social Cognition (ClaCoS) battery. The PERSO task evaluates social reasoning through the interpretation of social situations and yields a total score based on the number of correct responses. The MASC (Movie for the Assessment of Social Cognition) assesses theory of mind using a video-based task and provides a total score corresponding to the number of correctly inferred mental states. The AIHQ assesses attributional biases in ambiguous social situations and generates scores reflecting hostile and intentionality attribution biases. For all three measures, scores will be analysed as continuous variables, with higher scores indicating better social cognitive performance (PERSO, MASC) or stronger attributional biases (AIHQ).
8 secondary outcomes
Severity of suicidal intention
Time frame: 1 day
Level of socio-economic precariousness
Time frame: 1 day
Level of anxiety
Time frame: 1 day
Level of depressive disorder
Time frame: 1 day
Evaluation of attachment styles
Time frame: 1 day
Level of sleep disturbances
Time frame: 1 day
Evaluation of socio-developmental / social-cognition skills
Time frame: 1 day
Severity of nightmares
Time frame: 1 day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2026.
- Background: PubMed 40495519Szeifert N, Balint L, Sebok B, Gonda X. Risk factors for violent suicide attempts: Hungarian cross-sectional study. Eur Psychiatry. 2025 Jun 11;68(1):e85. doi: 10.1192/j.eurpsy.2025.10042.
- Background: PubMed 34619171Sastre-Buades A, Alacreu-Crespo A, Courtet P, Baca-Garcia E, Barrigon ML. Decision-making in suicidal behavior: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2021 Dec;131:642-662. doi: 10.1016/j.neubiorev.2021.10.005. Epub 2021 Oct 5.
- Background: PubMed 24246209Pompili M, Innamorati M, Forte A, Longo L, Mazzetta C, Erbuto D, Ricci F, Palermo M, Stefani H, Seretti ME, Lamis DA, Perna G, Serafini G, Amore M, Girardi P. Insomnia as a predictor of high-lethality suicide attempts. Int J Clin Pract. 2013 Dec;67(12):1311-6. doi: 10.1111/ijcp.12211.
- Background: PubMed 33220560Perrain R, Dardennes R, Jollant F. Risky decision-making in suicide attempters, and the choice of a violent suicidal means: an updated meta-analysis. J Affect Disord. 2021 Feb 1;280(Pt A):241-249. doi: 10.1016/j.jad.2020.11.052. Epub 2020 Nov 12.
- Background: PubMed 38617732Parrish EM, Steenkamp L, Chalker SA, Moore RC, Pinkham A, Depp CA. Systematic Review of the Link Between Social Cognition and Suicidal Ideation and Behavior in People With Serious Mental Illness. Schizophr Bull Open. 2024 Mar 27;5(1):sgae007. doi: 10.1093/schizbullopen/sgae007. eCollection 2024 Jan.
- Background: PubMed 19002191Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008 Dec;9(12):947-57. doi: 10.1038/nrn2513. Epub 2008 Nov 12.
- BackgroundMendle, J. (2014). Why Puberty Matters for Psychopathology. Child Development Perspectives, 8(4), 218-222. https://doi.org/10.1111/cdep.12092
- Background: PubMed 32125568Oliphant RYK, Smith EM, Grahame V. What is the Prevalence of Self-harming and Suicidal Behaviour in Under 18s with ASD, With or Without an Intellectual Disability? J Autism Dev Disord. 2020 Oct;50(10):3510-3524. doi: 10.1007/s10803-020-04422-6.
- Background: PubMed 19269537Mikami K, Inomata S, Hayakawa N, Ohnishi Y, Enseki Y, Ohya A, Haruki Y, Kishi Y, Shinohara Y, Ichimura A, Matsumoto H. Frequency and clinical features of pervasive developmental disorder in adolescent suicide attempts. Gen Hosp Psychiatry. 2009 Mar-Apr;31(2):163-6. doi: 10.1016/j.genhosppsych.2008.12.003. Epub 2009 Feb 1.
- Background: PubMed 35751716MacPherson HA, Kim KL, Seymour KE, Wolff J, Esposito-Smythers C, Spirito A, Dickstein DP. Cognitive Flexibility and Impulsivity Deficits in Suicidal Adolescents. Res Child Adolesc Psychopathol. 2022 Dec;50(12):1643-1656. doi: 10.1007/s10802-022-00952-y. Epub 2022 Jun 25.
- Background: PubMed 36498743Lubbert M, Bahlmann L, Sobanski T, Schulz A, Kastner UW, Walter M, Jollant F, Wagner G. Investigating the Clinical Profile of Suicide Attempters Who Used a Violent Suicidal Means. J Clin Med. 2022 Dec 2;11(23):7170. doi: 10.3390/jcm11237170.
- Background: PubMed 27245812Levi-Belz Y, Beautrais A. Serious Suicide Attempts. Crisis. 2016 Jul;37(4):299-309. doi: 10.1027/0227-5910/a000386. Epub 2016 Jun 1.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hélène Morel contact
Catherine Grosmaitre, PhD principal investigator
Assistance Publique - Hôpitaux de Paris
Pauline MD, PhD Chaste study director
Assistance Publique - Hôpitaux de Paris
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Test and Questionnaires in people with Violent Suicide Attempts in Adolescents, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Catherine Grosmaitre, PhD (033144494561, catherine.grosmaitre@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Level of performance in social cognition in the two groups of adolescents hospitalized following a suicide attempt, distinguishing: adolescents who made a violent suicide attempt and those who made a non-violent suicide attempt (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07688798, which also lists 33 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2026.