Dental Implant PlacementNCT07687680
Ozone Versus Conventional Socket Disinfection for Primary Dental Implant Stability
A study testing Ozone Implant Site Disinfection and Conventional Socket Disinfection in people with Dental Implant Placement and Ozone Therapy, run by Zeliha Başak Çakır Erdil at 1 site in Turkey (Türkiye).
Trial summary
This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Dental Implant Placement, Ozone Therapy
- What is being tested?
- Ozone Implant Site Disinfection and Conventional Socket Disinfection
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 51 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 18 Nov 2025to 20 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older.
- Systemically healthy individuals requiring at least two dental implants.
- Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
- Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
- Ability and willingness to provide written informed consent and comply with the study protocol.
Who cannot join
- Adults aged 18 years or older.
- Systemically healthy individuals requiring at least two dental implants.
- Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
- Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
- Ability and willingness to provide written informed consent and comply with the study protocol.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Faculty of Dentistry, Adıyaman University
Adıyaman, Merkez, 02030
About this study
Official title: Comparison of Ozone and Conventional Socket Disinfection in Dental Implant Placement in Terms of Primary Stability
This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.
Read the detailed description
Primary implant stability is a key determinant of successful osseointegration and long-term implant survival. Various implant site disinfection methods have been proposed to reduce the microbial load before implant placement. Ozone possesses antimicrobial and biostimulatory properties and may improve the biological environment for implant healing compared with conventional implant site disinfection.
The purpose of this randomized split-mouth controlled clinical trial is to compare ozone implant site disinfection with conventional implant site disinfection in terms of primary and early secondary implant stability.
Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will be enrolled. According to a randomized split-mouth design, one implant site will receive ozone disinfection before implant placement, whereas the paired implant site will receive conventional disinfection. This design allows each participant to serve as their own control, thereby minimizing inter-individual variability.
Primary implant stability will be assessed immediately after implant placement using insertion torque measurements and resonance frequency analysis (Implant Stability Quotient, ISQ). Secondary implant stability will be evaluated by resonance frequency analysis at the 3-month follow-up during healing abutment placement. All clinical procedures will be standardized and performed by experienced clinicians. The study aims to determine whether ozone implant site disinfection provides superior implant stability during the early osseointegration period compared with conventional implant site disinfection.
- Conditions
- Dental Implant Placement, Ozone Therapy
- Being tested
- Ozone Implant Site Disinfection, Conventional Socket Disinfection
- Keywords
- Ozone therapy, Primary implant stability, Insertion torque, Socket disinfection, Osseointegration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ozone Implant Site DisinfectionProcedure or surgery
Before dental implant placement, the implant site assigned to the experimental intervention is disinfected using ozone according to the study protocol. In this randomized split-mouth design, each participant receives ozone disinfection at one implant site, while the paired contralateral or symmetrical implant site receives conventional disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.
Conventional Socket DisinfectionProcedure or surgery
Before dental implant placement, the implant site assigned to the control intervention is disinfected using the conventional disinfection protocol. In this randomized split-mouth design, each participant receives conventional disinfection at one implant site, while the paired contralateral or symmetrical implant site receives ozone disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.
| Study group | Role | What they receive |
|---|---|---|
| Ozone Disinfection | Experimental | Implant sites assigned to the experimental intervention receive ozone disinfection before dental implant placement. Receives: Procedure: Ozone Implant Site Disinfection |
| Conventional Disinfection | Experimental | Implant sites assigned to the control intervention receive conventional implant site disinfection before dental implant placement. Receives: Procedure: Conventional Socket Disinfection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Primary Implant Stability (Insertion Torque)
Primary implant stability will be assessed immediately after implant placement by measuring insertion torque (Ncm).
Measured: Immediately after implant placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start18 Nov 2025
- Primary completion20 Jul 2026 (estimated)
- Study completion20 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental Implant PlacementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants are enrolled in a randomized split-mouth study design. Each participant receives both interventions at paired implant sites in symmetrical or contralateral edentulous areas. One implant site is assigned to ozone disinfection and the paired implant site to conventional disinfection before dental implant placement, allowing within-participant comparison.
- Masking
- None (open label)
- Enrolment
- 51 participants (actual)
Sponsor and investigators
- Lead sponsor
- Zeliha Başak Çakır Erdil
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Zeliha Başak Çakır Erdil, Adiyaman University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07687680
- Sponsor's protocol ID
- HRU-25.18.55
- Status last verified
- Jun 2026
- First submitted
- 30 Jun 2026
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available because of participant confidentiality and institutional data-sharing policies.
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Ozone and Conventional Socket Disinfection in Dental Implant Placement in Terms of Primary Stability
- ClinicalTrials.gov ID
- NCT07687680
- Acronym / sponsor ID
- HRU-25.18.55
- Conditions
- Dental Implant Placement, Ozone Therapy
- Keywords
- Ozone therapy, Primary implant stability, Insertion torque, Socket disinfection, Osseointegration
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 51 participants (actual)
- Lead sponsor
- Zeliha Başak Çakır ErdilUniversity, hospital or other
- Study start
- 18 Nov 2025 (actual)
- Primary completion
- 20 Jul 2026 (estimated)
- Study completion
- 20 Jul 2026 (estimated)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.
Detailed description
Primary implant stability is a key determinant of successful osseointegration and long-term implant survival. Various implant site disinfection methods have been proposed to reduce the microbial load before implant placement. Ozone possesses antimicrobial and biostimulatory properties and may improve the biological environment for implant healing compared with conventional implant site disinfection.
The purpose of this randomized split-mouth controlled clinical trial is to compare ozone implant site disinfection with conventional implant site disinfection in terms of primary and early secondary implant stability.
Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will be enrolled. According to a randomized split-mouth design, one implant site will receive ozone disinfection before implant placement, whereas the paired implant site will receive conventional disinfection. This design allows each participant to serve as their own control, thereby minimizing inter-individual variability.
Primary implant stability will be assessed immediately after implant placement using insertion torque measurements and resonance frequency analysis (Implant Stability Quotient, ISQ). Secondary implant stability will be evaluated by resonance frequency analysis at the 3-month follow-up during healing abutment placement. All clinical procedures will be standardized and performed by experienced clinicians. The study aims to determine whether ozone implant site disinfection provides superior implant stability during the early osseointegration period compared with conventional implant site disinfection.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants are enrolled in a randomized split-mouth study design. Each participant receives both interventions at paired implant sites in symmetrical or contralateral edentulous areas. One implant site is assigned to ozone disinfection and the paired implant site to conventional disinfection before dental implant placement, allowing within-participant comparison.
| Arm | Type | Receives |
|---|---|---|
| Ozone Disinfection | Experimental | Procedure: Ozone Implant Site DisinfectionImplant sites assigned to the experimental intervention receive ozone disinfection before dental implant placement. |
| Conventional Disinfection | Experimental | Procedure: Conventional Socket DisinfectionImplant sites assigned to the control intervention receive conventional implant site disinfection before dental implant placement. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults aged 18 years or older.
- Systemically healthy individuals requiring at least two dental implants.
- Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
- Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
- Ability and willingness to provide written informed consent and comply with the study protocol.
Key exclusion criteria (5 listed)
- Adults aged 18 years or older.
- Systemically healthy individuals requiring at least two dental implants.
- Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
- Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
- Ability and willingness to provide written informed consent and comply with the study protocol.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ozone Implant Site DisinfectionBefore dental implant placement, the implant site assigned to the experimental intervention is disinfected using ozone according to the study protocol. In this randomized split-mouth design, each participant receives ozone disinfection at one implant site, while the paired contralateral or symmetrical implant site receives conventional disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ. | Procedure or surgery | Ozone Disinfection |
| Conventional Socket DisinfectionBefore dental implant placement, the implant site assigned to the control intervention is disinfected using the conventional disinfection protocol. In this randomized split-mouth design, each participant receives conventional disinfection at one implant site, while the paired contralateral or symmetrical implant site receives ozone disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ. | Procedure or surgery | Conventional Disinfection |
Primary outcome
Primary Implant Stability (Insertion Torque)
Time frame: Immediately after implant placement
Primary implant stability will be assessed immediately after implant placement by measuring insertion torque (Ncm).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available because of participant confidentiality and institutional data-sharing policies.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ozone Implant Site Disinfection and Conventional Socket Disinfection in people with Dental Implant Placement and Ozone Therapy, run by Zeliha Başak Çakır Erdil at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Primary Implant Stability (Insertion Torque) (time frame: Immediately after implant placement). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.