Cerebrovascular Accident (Stroke)NCT07670728
Comparison of Open Vs Closed Kinetic Chain Exercises in Genu Recurvatum Among Stroke Patients
A study testing Open and closed kinetic chain exercises in people with Cerebrovascular Accident (Stroke) and Knee Hyperextension, run by Dow University of Health Sciences at 1 site in Pakistan.
Trial summary
Brief Summary The goal of this clinical trial is to learn which type of exercise is more effective for reducing knee hyperextension in people who have had a stroke. Knee hyperextension, also called genu recurvatum, occurs when the knee bends too far backward while standing or walking. Read more about this study
- Who is it for?
- Ages 30 to 65 weeks
- Conditions the study is for
- Cerebrovascular Accident (Stroke), Knee Hyperextension, Genu Recurvatum
- What is being tested?
- Open and closed kinetic chain exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 8 Jun 2026to 30 Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 65 weeks
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Male and female participants
- Age between 30 and 65 years
- Referred by a neurologist
- Diagnosed case of stroke with one-sided hemiparesis
- Functional ambulatory capacity (Functional Ambulation Category ≥ 2)
- Muscle strength of at least grade 3+ on the Manual Muscle Testing (MMT) scale in the affected lower limb
- No participation in other rehabilitation programs during the study period
Who cannot join
- Participants with any musculoskeletal condition such as osteoarthritis or ligament laxity
- Significant cognitive, communicative, perceptual, or sensory problems that hinder understanding and/or following verbal commands
- Pregnant individuals
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Dow University of Health Sciences Ojha Campus
Karachi, Sindh, 75280
About this study
Official title: Comparison of Open Vs Closed Kinetic Chain Exercises in Genu Recurvatum Among Stroke Patients: A Randomized Controlled Trial
Brief Summary The goal of this clinical trial is to learn which type of exercise is more effective for reducing knee hyperextension in people who have had a stroke. Knee hyperextension, also called genu recurvatum, occurs when the knee bends too far backward while standing or walking. This problem is common after a stroke and can make walking difficult, reduce balance, increase the risk of falls, and place extra stress on the knee joint. Over time, it may also lead to pain, joint damage, and reduced independence in daily activities.
Stroke is one of the leading causes of long-term disability. Many people who survive a stroke experience weakness, muscle stiffness, balance problems, and difficulty controlling movement on one side of the body. These changes can affect the way a person walks. One common walking problem after stroke is knee hyperextension during the part of walking when the foot is on the ground. This may happen because of muscle weakness, poor balance, reduced body awareness, or difficulty controlling movement. As a result, people may walk more slowly, feel less confident when moving, and have difficulty performing everyday tasks.
Read more
Physical therapy plays an important role in helping people recover after a stroke. Exercise programs are commonly used to improve strength, balance, walking ability, and overall function. Two types of exercises frequently used in rehabilitation are Open Kinetic Chain (OKC) exercises and Closed Kinetic Chain (CKC) exercises. However, there is limited research directly comparing these exercise approaches for treating knee hyperextension after stroke.
Open Kinetic Chain exercises involve moving the leg freely while the foot is not fixed to the ground. Examples include straight leg raises, knee extensions while sitting, hip abduction, hip adduction, and hamstring curls. These exercises are often used to strengthen specific muscles and improve movement control.
Closed Kinetic Chain exercises involve movements performed with the foot fixed on the ground or another stable surface. Examples include squats, lunges, step-ups, and side step exercises. These exercises require several joints and muscle groups to work together and may better reflect movements used in everyday activities such as standing, walking, and climbing stairs. They may also improve balance and body awareness.
The main questions this study aims to answer are:
- Does Closed Kinetic Chain exercise reduce knee hyperextension more effectively than Open Kinetic Chain exercise?
- Does Open Kinetic Chain exercise improve knee control and walking ability after stroke?
- Which exercise program leads to greater improvements in muscle strength, balance, mobility, and independence in daily activities?
- Can these exercise programs be safely used as part of stroke rehabilitation? Researchers will compare the effects of these two exercise programs in adults who have experienced a stroke and have weakness on one side of the body. Participants must be able to walk with at least minimal assistance and meet other study requirements. People with certain musculoskeletal conditions, severe communication or cognitive difficulties, or other conditions that may interfere with participation will not be eligible to take part.
A total of 60 participants will be enrolled in the study. Participants will be assigned by chance, similar to flipping a coin, to one of two treatment groups. Thirty participants will receive Closed Kinetic Chain exercises, and thirty participants will receive Open Kinetic Chain exercises. Neither participants nor researchers can choose which group a participant joins. Both groups will continue to receive standard rehabilitation care throughout the study.
Participants will:
- Attend supervised physical therapy sessions three times per week for four weeks.
- Complete a total of 12 treatment sessions.
- Perform exercises designed to improve lower limb strength and movement control.
- Receive either Open Kinetic Chain or Closed Kinetic Chain exercises based on random assignment.
- Continue their routine rehabilitation program alongside the study exercises.
- Complete assessments before starting treatment and again after completing the intervention period.
Participants assigned to the Open Kinetic Chain exercise group may perform activities such as:
- Straight leg raises while lying down.
- Knee extensions while sitting.
- Hip abduction exercises.
- Hip adduction exercises.
- Hamstring curl exercises.
Participants assigned to the Closed Kinetic Chain exercise group may perform activities such as:
- Lunges.
- Semi-squats.
- Forward step-up and step-down exercises.
- Side step-up and step-down exercises.
Researchers will measure several outcomes before and after the treatment period. These measurements will help determine whether either exercise program improves movement and function.
Read the detailed description
Background and Rationale
Stroke remains a leading cause of long-term disability worldwide, ranking among the top causes of death and accounting for a substantial proportion of disability-adjusted life years globally. Post-stroke gait abnormalities are common and vary according to the severity of sensorimotor impairment. One of the most frequently observed deviations in the paretic limb during the stance phase of gait is knee hyperextension, also known as genu recurvatum, which has been reported to affect approximately 40% to 68% of individuals with chronic hemiparetic stroke.
Knee hyperextension compromises joint stability, disrupts normal gait mechanics, and is associated with reduced walking speed and efficiency, as well as pain and an increased risk of long-term musculoskeletal complications such as joint degeneration. The condition is thought to arise from a combination of factors, including quadriceps weakness, plantar flexor spasticity, weak gluteal and hamstring muscles, limited ankle dorsiflexion, hip flexion contracture, and proprioceptive deficits. Because the underlying causes vary across individuals, rehabilitation strategies that fail to address the specific contributing impairments may be less effective.
Several intervention approaches have been described for managing post-stroke knee hyperextension, including functional electrical stimulation, electrogoniometric biofeedback, orthotic management, and surgical intervention; however, no consistently established best-practice rehabilitation protocol currently exists. Progressive resistance training (PRT) is widely used in stroke rehabilitation to increase muscle strength and improve functional outcomes, and is broadly categorized into open kinetic chain (OKC) and closed kinetic chain (CKC) exercise approaches.
OKC exercises involve movement of the distal limb segment in a non-weight-bearing position (for example, seated knee extension or straight leg raise) and are typically used to isolate and strengthen specific muscle groups, though they provide comparatively less joint stability and proprioceptive input. CKC exercises involve movement with the distal segment fixed against a surface in a weight-bearing position (for example, squats, step-ups, or lunges); these exercises are considered more functional, as they more closely replicate movement patterns used in walking and other activities of daily living, and are thought to enhance proprioception, joint stability, and coordinated multi-joint muscle activation.
While prior research has examined OKC and CKC exercises individually, or as components of broader lower-limb strengthening programs following stroke, direct comparative evidence regarding their relative effectiveness specifically for managing knee hyperextension remains limited. This study is designed to address that gap by directly comparing the effects of OKC and CKC exercise programs on knee hyperextension, joint stability, gait, functional mobility, and balance in individuals with chronic post-stroke hemiparesis.
Objectives
The primary objective is to compare the effects of open kinetic chain and closed kinetic chain exercises on knee hyperextension (genu recurvatum) in individuals with post-stroke hemiparesis. Secondary objectives are to determine which exercise approach is more effective in improving knee joint stability, muscle strength, gait and functional mobility, performance of activities of daily living, and dynamic balance.
Hypotheses
Null hypothesis (H0): There is no statistically significant difference between the effects of closed kinetic chain exercises and open kinetic chain exercises on knee hyperextension in stroke patients.
Alternative hypothesis (Ha): There is a statistically significant difference between the effects of closed kinetic chain exercises and open kinetic chain exercises on knee hyperextension in stroke patients.
Study Design and Setting This is a single-blind, randomized controlled trial. Participants will be recruited from the Physiotherapy Outpatient Department of Dow Ojha Hospital, the Department of Institute of Physical Medicine and Rehabilitation (DIPMR), Dow University of Health Sciences, and Health Icon, Karachi, Pakistan, following approval from the Institutional Review Board of Dow University of Health Sciences.
Population and Eligibility
A total of 60 participants will be enrolled and randomly allocated, using a computer-generated randomization sequence, into two equal groups of 30 participants each: Group A (closed kinetic chain exercise group) and Group B (open kinetic chain exercise group). The required sample size was calculated using OpenEpi statistical software, based on post-intervention means and standard deviations reported in prior literature (Group A: 78 ± 12.57; Group B: 87.44 ± 11.69), to achieve 95% power at a significance level (alpha) of 0.05.
Inclusion criteria: men and women aged between 30 and 65 years; referred by a neurologist with a diagnosed case of stroke and one-sided hemiparesis; minimal ambulatory capacity (Functional Ambulation Category ≥ 2); muscle strength of at least grade 3+ on Manual Muscle Testing in the affected lower limb; and no concurrent participation in any other rehabilitation program during the study period.
Exclusion criteria: presence of any musculoskeletal condition such as osteoarthritis or ligamentous laxity affecting the lower limb; significant cognitive, communicative, perceptual, or sensory impairment limiting the ability to understand or follow verbal instructions; and pregnancy.
Randomization and Blinding
Eligible participants will be screened and, upon meeting inclusion criteria, will provide written informed consent (available in English and Urdu) after the purpose, procedures, risks, and potential benefits of the study have been explained. Each participant will then be randomly assigned to Group A or Group B using a computer-generated randomization sheet. To reduce assessment bias, the outcome assessor will be blinded to each participant's group allocation; both groups will continue to receive standard physiotherapy care alongside their assigned study intervention.
Interventions
Group A (Closed Kinetic Chain Exercises): lunges; semi-squats; forward step-up and step-down; side step-up and step-down.
Group B (Open Kinetic Chain Exercises): straight leg raises in lying position; knee extension in sitting position; hip abduction in lying position; hip adduction in lying position; prone hamstring curls.
Both groups will begin with 10 repetitions per set, one set per exercise, performed three sessions per week for 4 weeks (12 sessions total), with each session lasting approximately 30 minutes. Progression will be individualized: participants who consistently report low discomfort (below 3 on the Visual Analogue Scale) will be progressed by increasing the number of sets, while repetitions per set remain constant.
Outcome Measures Primary outcome measures are knee hyperextension angle, assessed using a standard goniometer, and lower-limb muscle strength, assessed using an isokinetic dynamometer, regarded as the gold-standard tool for muscle strength testing and capable of evaluating both concentric and eccentric contraction.
Secondary outcome measures include gait and functional mobility (Dynamic Gait Index), activities of daily living (Barthel Index), and dynamic balance (Berg Balance Scale), a validated tool widely used in stroke rehabilitation research. All outcome measures will be recorded at baseline and again following completion of the 4-week intervention period.
Statistical Analysis
Data will be analyzed using SPSS version 27. Means and standard deviations will be computed for continuous variables such as age, while frequencies and percentages will be reported for categorical variables. Repeated-measures ANOVA will be used to evaluate within-group changes over time and between-group differences across all outcome measures. Independent variables include age and gender; dependent variables include knee hyperextension, functional mobility, activities of daily living, muscle strength, and balance. A p-value of less than 0.05 will be considered statistically significant.
Significance and Expected Outcomes
There is currently no consistently established best-practice exercise approach for managing knee hyperextension after stroke, and existing literature has rarely compared OKC and CKC exercises directly for this specific impairment. By generating direct comparative evidence, this trial is expected to help clinicians select more targeted, evidence-based exercise interventions, potentially improving knee joint stability, gait mechanics, balance, and independence in activities of daily living for stroke survivors, while reducing the risk of secondary musculoskeletal complications.
Anticipated Limitations
Anticipated limitations include possible participant dropout, whether voluntary or involuntary, and potential confounding effects from concurrent medication use among participants.
- Being tested
- Open and closed kinetic chain exercises
- Keywords
- Stroke, Genu Recurvatum, Knee Hyperextension, Open Kinetic Chain Exercises, Closed Kinetic Chain Exercises
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Open and closed kinetic chain exercisesOther
Open Kinetic Chain (OKC): The hand or foot is free to move. These exercises usually involve one joint and target specific muscles.
Examples: Leg extension, hamstring curl, biceps curl, straight leg raise. Closed Kinetic Chain (CKC): The hand or foot is fixed on a surface. These exercises involve multiple joints and muscle groups, improving stability and functional movement.
Examples: Squats, lunges, push-ups, step-ups.
| Study group | Role | What they receive |
|---|---|---|
| Open Kinetic Chain Exercises | Experimental | 1. Straight leg raising in lying position
2. Knee extension in sitting position
3. Hip abduction in lying position
4. Hip adduction in lying position
5. Prone Hamstring Curl Receives: Other: Open and closed kinetic chain exercises |
| Closed Kinetic Chain Exercises | Experimental | 1. Lunges
2. Semi Squat
3. Forward step up and down
4. Side step up and down Receives: Other: Open and closed kinetic chain exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knee hyperextension with Goniometer
Knee hyperextension is measured using a universal goniometer to determine the degree to which the knee extends beyond the neutral anatomical position (0°). The patient lies in a supine position with the lower limb fully supported. The fulcrum of the goniometer is placed over the lateral epicondyle of the femur, the stationary arm is aligned with the greater trochanter of the femur, and the movable arm is aligned with the lateral malleolus of the fibula. The patient actively or passively extends the knee to its maximum range. Any extension beyond 0° is recorded as hyperextension (e.g., 5°, 10°, or 15° hyperextension).
Measured: Assessment takes approximately 2-5 minutes per knee and may be performed at baseline and after the intervention period (e.g., 6-8 weeks) to evaluate changes in knee alignment and range of motion.
Muscle Strength with dynamometer
The dynamometer is an objective and reliable tool used to measure muscle strength by quantifying the force generated during a muscle contraction. During testing, the participant performs a maximal voluntary isometric contraction against the dynamometer.
Dynamometers are commonly used to assess the strength of various muscle groups, including the quadriceps, hamstrings, hip muscles, and upper limb muscles. Higher values indicate greater muscle strength. Dynamometry is widely used in clinical practice and research to evaluate baseline strength, monitor rehabilitation progress, and assess treatment outcomes.
Measured: The assessment requires approximately 5-10 minutes to complete and can be performed at baseline and after the intervention period (e.g., 6-8 weeks) to evaluate changes in muscle strength.
Secondary outcomes (3)
Barthel Index (BI)
The Barthel Index is a widely used functional assessment tool that measures a person's ability to perform Activities of Daily Living (ADLs) independently. It evaluates 10 areas: feeding, bathing, grooming, dressing, bowel control, bladder control, toilet use, transfers, mobility, and stair climbing. Scores range from 0 to 100, with higher scores indicating greater independence. It is commonly used in rehabilitation settings for patients with stroke, neurological disorders, musculoskeletal conditions, and older adults. The Barthel Index helps healthcare professionals assess functional status, monitor recovery, plan treatment, and evaluate rehabilitation outcomes. A score of 100 indicates complete independence, while lower scores reflect varying levels of dependence in daily activities.
Measured: The Barthel Index will be assessed at baseline and after 4 weeks of intervention to measure changes in activities of daily living and functional independence
Gait Dynamic Index
The Dynamic Gait Index is a clinical outcome measure used to assess an individual's ability to modify balance while walking in response to changing task demands. It evaluates gait performance during eight functional activities, including walking at different speeds, walking with head turns, stepping over and around obstacles, pivot turning, and stair climbing. Each item is scored from 0 to 3, with a maximum total score of 24 points. Higher scores indicate better dynamic balance and gait function, while lower scores suggest an increased risk of falls. The DGI is commonly used in patients with neurological, vestibular, and balance disorders to assess mobility, monitor progress, and evaluate the effectiveness of rehabilitation interventions.
Measured: The Dynamic Gait Index takes approximately 10-15 minutes to administer and can be assessed at baseline and after the intervention period (4 weeks) to evaluate changes in dynamic balance and gait performance.
Berg Balance Scale
The Berg Balance Scale is a standardized clinical assessment tool used to evaluate static and dynamic balance abilities in individuals. It consists of 14 functional tasks, including sitting to standing, standing unsupported, reaching forward, turning, transferring, and standing on one foot. Each task is scored on a 5-point scale (0-4), with a maximum total score of 56 points. Higher scores indicate better balance and functional mobility, while lower scores suggest an increased risk of falls. The BBS is widely used in patients with neurological, geriatric, and musculoskeletal conditions to assess balance impairments, monitor progress, and evaluate the effectiveness of rehabilitation interventions.
Measured: he Berg Balance Scale takes approximately 15-20 minutes to administer and can be assessed at baseline and after the intervention period (4 weeks) to evaluate changes in balance performance
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2026
- Study start8 Jun 2026
- Primary completion8 Oct 2026 (estimated)
- Study completion30 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Cerebrovascular Accident (Stroke)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dow University of Health Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Syeda Areeba Asif, Dow University of Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07670728
- Sponsor's protocol ID
- 4536
- Status last verified
- Jun 2026
- First submitted
- 22 Jun 2026
- Last updated
- 2 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Lobo AA, Joshua AM, Nayak A, Mithra P P, Misri Z, Pai S. Effect of Compelled Body Weight Shift (CBWS) Therapy in Comparison to ProprioceptiveTraining on Functional Balance, Gait, andMuscle Strength Among Acute Stroke Subjects. Ann Neurosci. 2021 Jul;28(3-4):162-169. doi: 10.1177/09727531211063132. Epub 2022 Jan 28.
PubMed 35341230Ain QU, Imran M, Bashir A, Malik AN. Progressive resistance training improving gait performance and mobility in acute and chronic stroke patients. J Pak Med Assoc. 2021 Jan;71(1(A)):140-142. doi: 10.47391/JPMA.612.
PubMed 33484541Geerars M, Minnaar-van der Feen N, Huisstede BMA. Treatment of knee hyperextension in post-stroke gait. A systematic review. Gait Posture. 2022 Jan;91:137-148. doi: 10.1016/j.gaitpost.2021.08.016. Epub 2021 Aug 24.
PubMed 34695721Okada K, Haruyama K, Okuyama K, Tsuzuki K, Nakamura T, Kawakami M. Categorizing knee hyperextension patterns in hemiparetic gait and examining associated impairments in patients with chronic stroke. Gait Posture. 2024 Sep;113:18-25. doi: 10.1016/j.gaitpost.2024.05.025. Epub 2024 May 23.
PubMed 38820765Salaudeen MA, Bello N, Danraka RN, Ammani ML. Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones. Biomolecules. 2024 Mar 4;14(3):305. doi: 10.3390/biom14030305.
PubMed 38540725
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Open Vs Closed Kinetic Chain Exercises in Genu Recurvatum Among Stroke Patients: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07670728
- Acronym / sponsor ID
- 4536
- Keywords
- Stroke, Genu Recurvatum, Knee Hyperextension, Open Kinetic Chain Exercises, Closed Kinetic Chain Exercises
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Dow University of Health SciencesUniversity, hospital or other
- Study start
- 8 Jun 2026 (actual)
- Primary completion
- 8 Oct 2026 (estimated)
- Study completion
- 30 Oct 2026 (estimated)
- First posted
- 26 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Brief Summary The goal of this clinical trial is to learn which type of exercise is more effective for reducing knee hyperextension in people who have had a stroke. Knee hyperextension, also called genu recurvatum, occurs when the knee bends too far backward while standing or walking. This problem is common after a stroke and can make walking difficult, reduce balance, increase the risk of falls, and place extra stress on the knee joint. Over time, it may also lead to pain, joint damage, and reduced independence in daily activities.
Stroke is one of the leading causes of long-term disability. Many people who survive a stroke experience weakness, muscle stiffness, balance problems, and difficulty controlling movement on one side of the body. These changes can affect the way a person walks. One common walking problem after stroke is knee hyperextension during the part of walking when the foot is on the ground. This may happen because of muscle weakness, poor balance, reduced body awareness, or difficulty controlling movement. As a result, people may walk more slowly, feel less confident when moving, and have difficulty performing everyday tasks.
Physical therapy plays an important role in helping people recover after a stroke. Exercise programs are commonly used to improve strength, balance, walking ability, and overall function. Two types of exercises frequently used in rehabilitation are Open Kinetic Chain (OKC) exercises and Closed Kinetic Chain (CKC) exercises. However, there is limited research directly comparing these exercise approaches for treating knee hyperextension after stroke.
Open Kinetic Chain exercises involve moving the leg freely while the foot is not fixed to the ground. Examples include straight leg raises, knee extensions while sitting, hip abduction, hip adduction, and hamstring curls. These exercises are often used to strengthen specific muscles and improve movement control.
Closed Kinetic Chain exercises involve movements performed with the foot fixed on the ground or another stable surface. Examples include squats, lunges, step-ups, and side step exercises. These exercises require several joints and muscle groups to work together and may better reflect movements used in everyday activities such as standing, walking, and climbing stairs. They may also improve balance and body awareness.
The main questions this study aims to answer are:
- Does Closed Kinetic Chain exercise reduce knee hyperextension more effectively than Open Kinetic Chain exercise?
- Does Open Kinetic Chain exercise improve knee control and walking ability after stroke?
- Which exercise program leads to greater improvements in muscle strength, balance, mobility, and independence in daily activities?
- Can these exercise programs be safely used as part of stroke rehabilitation? Researchers will compare the effects of these two exercise programs in adults who have experienced a stroke and have weakness on one side of the body. Participants must be able to walk with at least minimal assistance and meet other study requirements. People with certain musculoskeletal conditions, severe communication or cognitive difficulties, or other conditions that may interfere with participation will not be eligible to take part.
A total of 60 participants will be enrolled in the study. Participants will be assigned by chance, similar to flipping a coin, to one of two treatment groups. Thirty participants will receive Closed Kinetic Chain exercises, and thirty participants will receive Open Kinetic Chain exercises. Neither participants nor researchers can choose which group a participant joins. Both groups will continue to receive standard rehabilitation care throughout the study.
Participants will:
- Attend supervised physical therapy sessions three times per week for four weeks.
- Complete a total of 12 treatment sessions.
- Perform exercises designed to improve lower limb strength and movement control.
- Receive either Open Kinetic Chain or Closed Kinetic Chain exercises based on random assignment.
- Continue their routine rehabilitation program alongside the study exercises.
- Complete assessments before starting treatment and again after completing the intervention period.
Participants assigned to the Open Kinetic Chain exercise group may perform activities such as:
- Straight leg raises while lying down.
- Knee extensions while sitting.
- Hip abduction exercises.
- Hip adduction exercises.
- Hamstring curl exercises.
Participants assigned to the Closed Kinetic Chain exercise group may perform activities such as:
- Lunges.
- Semi-squats.
- Forward step-up and step-down exercises.
- Side step-up and step-down exercises.
Researchers will measure several outcomes before and after the treatment period. These measurements will help determine whether either exercise program improves movement and function.
Detailed description
Background and Rationale
Stroke remains a leading cause of long-term disability worldwide, ranking among the top causes of death and accounting for a substantial proportion of disability-adjusted life years globally. Post-stroke gait abnormalities are common and vary according to the severity of sensorimotor impairment. One of the most frequently observed deviations in the paretic limb during the stance phase of gait is knee hyperextension, also known as genu recurvatum, which has been reported to affect approximately 40% to 68% of individuals with chronic hemiparetic stroke.
Knee hyperextension compromises joint stability, disrupts normal gait mechanics, and is associated with reduced walking speed and efficiency, as well as pain and an increased risk of long-term musculoskeletal complications such as joint degeneration. The condition is thought to arise from a combination of factors, including quadriceps weakness, plantar flexor spasticity, weak gluteal and hamstring muscles, limited ankle dorsiflexion, hip flexion contracture, and proprioceptive deficits. Because the underlying causes vary across individuals, rehabilitation strategies that fail to address the specific contributing impairments may be less effective.
Several intervention approaches have been described for managing post-stroke knee hyperextension, including functional electrical stimulation, electrogoniometric biofeedback, orthotic management, and surgical intervention; however, no consistently established best-practice rehabilitation protocol currently exists. Progressive resistance training (PRT) is widely used in stroke rehabilitation to increase muscle strength and improve functional outcomes, and is broadly categorized into open kinetic chain (OKC) and closed kinetic chain (CKC) exercise approaches.
OKC exercises involve movement of the distal limb segment in a non-weight-bearing position (for example, seated knee extension or straight leg raise) and are typically used to isolate and strengthen specific muscle groups, though they provide comparatively less joint stability and proprioceptive input. CKC exercises involve movement with the distal segment fixed against a surface in a weight-bearing position (for example, squats, step-ups, or lunges); these exercises are considered more functional, as they more closely replicate movement patterns used in walking and other activities of daily living, and are thought to enhance proprioception, joint stability, and coordinated multi-joint muscle activation.
While prior research has examined OKC and CKC exercises individually, or as components of broader lower-limb strengthening programs following stroke, direct comparative evidence regarding their relative effectiveness specifically for managing knee hyperextension remains limited. This study is designed to address that gap by directly comparing the effects of OKC and CKC exercise programs on knee hyperextension, joint stability, gait, functional mobility, and balance in individuals with chronic post-stroke hemiparesis.
Objectives
The primary objective is to compare the effects of open kinetic chain and closed kinetic chain exercises on knee hyperextension (genu recurvatum) in individuals with post-stroke hemiparesis. Secondary objectives are to determine which exercise approach is more effective in improving knee joint stability, muscle strength, gait and functional mobility, performance of activities of daily living, and dynamic balance.
Hypotheses
Null hypothesis (H0): There is no statistically significant difference between the effects of closed kinetic chain exercises and open kinetic chain exercises on knee hyperextension in stroke patients.
Alternative hypothesis (Ha): There is a statistically significant difference between the effects of closed kinetic chain exercises and open kinetic chain exercises on knee hyperextension in stroke patients.
Study Design and Setting This is a single-blind, randomized controlled trial. Participants will be recruited from the Physiotherapy Outpatient Department of Dow Ojha Hospital, the Department of Institute of Physical Medicine and Rehabilitation (DIPMR), Dow University of Health Sciences, and Health Icon, Karachi, Pakistan, following approval from the Institutional Review Board of Dow University of Health Sciences.
Population and Eligibility
A total of 60 participants will be enrolled and randomly allocated, using a computer-generated randomization sequence, into two equal groups of 30 participants each: Group A (closed kinetic chain exercise group) and Group B (open kinetic chain exercise group). The required sample size was calculated using OpenEpi statistical software, based on post-intervention means and standard deviations reported in prior literature (Group A: 78 ± 12.57; Group B: 87.44 ± 11.69), to achieve 95% power at a significance level (alpha) of 0.05.
Inclusion criteria: men and women aged between 30 and 65 years; referred by a neurologist with a diagnosed case of stroke and one-sided hemiparesis; minimal ambulatory capacity (Functional Ambulation Category ≥ 2); muscle strength of at least grade 3+ on Manual Muscle Testing in the affected lower limb; and no concurrent participation in any other rehabilitation program during the study period.
Exclusion criteria: presence of any musculoskeletal condition such as osteoarthritis or ligamentous laxity affecting the lower limb; significant cognitive, communicative, perceptual, or sensory impairment limiting the ability to understand or follow verbal instructions; and pregnancy.
Randomization and Blinding
Eligible participants will be screened and, upon meeting inclusion criteria, will provide written informed consent (available in English and Urdu) after the purpose, procedures, risks, and potential benefits of the study have been explained. Each participant will then be randomly assigned to Group A or Group B using a computer-generated randomization sheet. To reduce assessment bias, the outcome assessor will be blinded to each participant's group allocation; both groups will continue to receive standard physiotherapy care alongside their assigned study intervention.
Interventions
Group A (Closed Kinetic Chain Exercises): lunges; semi-squats; forward step-up and step-down; side step-up and step-down.
Group B (Open Kinetic Chain Exercises): straight leg raises in lying position; knee extension in sitting position; hip abduction in lying position; hip adduction in lying position; prone hamstring curls.
Both groups will begin with 10 repetitions per set, one set per exercise, performed three sessions per week for 4 weeks (12 sessions total), with each session lasting approximately 30 minutes. Progression will be individualized: participants who consistently report low discomfort (below 3 on the Visual Analogue Scale) will be progressed by increasing the number of sets, while repetitions per set remain constant.
Outcome Measures Primary outcome measures are knee hyperextension angle, assessed using a standard goniometer, and lower-limb muscle strength, assessed using an isokinetic dynamometer, regarded as the gold-standard tool for muscle strength testing and capable of evaluating both concentric and eccentric contraction.
Secondary outcome measures include gait and functional mobility (Dynamic Gait Index), activities of daily living (Barthel Index), and dynamic balance (Berg Balance Scale), a validated tool widely used in stroke rehabilitation research. All outcome measures will be recorded at baseline and again following completion of the 4-week intervention period.
Statistical Analysis
Data will be analyzed using SPSS version 27. Means and standard deviations will be computed for continuous variables such as age, while frequencies and percentages will be reported for categorical variables. Repeated-measures ANOVA will be used to evaluate within-group changes over time and between-group differences across all outcome measures. Independent variables include age and gender; dependent variables include knee hyperextension, functional mobility, activities of daily living, muscle strength, and balance. A p-value of less than 0.05 will be considered statistically significant.
Significance and Expected Outcomes
There is currently no consistently established best-practice exercise approach for managing knee hyperextension after stroke, and existing literature has rarely compared OKC and CKC exercises directly for this specific impairment. By generating direct comparative evidence, this trial is expected to help clinicians select more targeted, evidence-based exercise interventions, potentially improving knee joint stability, gait mechanics, balance, and independence in activities of daily living for stroke survivors, while reducing the risk of secondary musculoskeletal complications.
Anticipated Limitations
Anticipated limitations include possible participant dropout, whether voluntary or involuntary, and potential confounding effects from concurrent medication use among participants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Open Kinetic Chain Exercises | Experimental | Other: Open and closed kinetic chain exercises1. Straight leg raising in lying position 2. Knee extension in sitting position 3. Hip abduction in lying position 4. Hip adduction in lying position 5. Prone Hamstring Curl |
| Closed Kinetic Chain Exercises | Experimental | Other: Open and closed kinetic chain exercises1. Lunges 2. Semi Squat 3. Forward step up and down 4. Side step up and down |
Who may qualify
- Ages
- 30 to 65 weeks
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (7 listed)
- Male and female participants
- Age between 30 and 65 years
- Referred by a neurologist
- Diagnosed case of stroke with one-sided hemiparesis
- Functional ambulatory capacity (Functional Ambulation Category ≥ 2)
Key exclusion criteria (3 listed)
- Participants with any musculoskeletal condition such as osteoarthritis or ligament laxity
- Significant cognitive, communicative, perceptual, or sensory problems that hinder understanding and/or following verbal commands
- Pregnant individuals
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Open and closed kinetic chain exercisesOpen Kinetic Chain (OKC): The hand or foot is free to move. These exercises usually involve one joint and target specific muscles. Examples: Leg extension, hamstring curl, biceps curl, straight leg raise. Closed Kinetic Chain (CKC): The hand or foot is fixed on a surface. These exercises involve multiple joints and muscle groups, improving stability and functional movement. Examples: Squats, lunges, push-ups, step-ups. | Other | Closed Kinetic Chain Exercises, Open Kinetic Chain Exercises |
Primary outcome
Knee hyperextension with Goniometer
Time frame: Assessment takes approximately 2-5 minutes per knee and may be performed at baseline and after the intervention period (e.g., 6-8 weeks) to evaluate changes in knee alignment and range of motion.
Knee hyperextension is measured using a universal goniometer to determine the degree to which the knee extends beyond the neutral anatomical position (0°). The patient lies in a supine position with the lower limb fully supported. The fulcrum of the goniometer is placed over the lateral epicondyle of the femur, the stationary arm is aligned with the greater trochanter of the femur, and the movable arm is aligned with the lateral malleolus of the fibula. The patient actively or passively extends the knee to its maximum range. Any extension beyond 0° is recorded as hyperextension (e.g., 5°, 10°, or 15° hyperextension).
Muscle Strength with dynamometer
Time frame: The assessment requires approximately 5-10 minutes to complete and can be performed at baseline and after the intervention period (e.g., 6-8 weeks) to evaluate changes in muscle strength.
The dynamometer is an objective and reliable tool used to measure muscle strength by quantifying the force generated during a muscle contraction. During testing, the participant performs a maximal voluntary isometric contraction against the dynamometer. Dynamometers are commonly used to assess the strength of various muscle groups, including the quadriceps, hamstrings, hip muscles, and upper limb muscles. Higher values indicate greater muscle strength. Dynamometry is widely used in clinical practice and research to evaluate baseline strength, monitor rehabilitation progress, and assess treatment outcomes.
3 secondary outcomes
Barthel Index (BI)
Time frame: The Barthel Index will be assessed at baseline and after 4 weeks of intervention to measure changes in activities of daily living and functional independence
Gait Dynamic Index
Time frame: The Dynamic Gait Index takes approximately 10-15 minutes to administer and can be assessed at baseline and after the intervention period (4 weeks) to evaluate changes in dynamic balance and gait performance.
Berg Balance Scale
Time frame: he Berg Balance Scale takes approximately 15-20 minutes to administer and can be assessed at baseline and after the intervention period (4 weeks) to evaluate changes in balance performance
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2026.
- Background: PubMed 35341230Lobo AA, Joshua AM, Nayak A, Mithra P P, Misri Z, Pai S. Effect of Compelled Body Weight Shift (CBWS) Therapy in Comparison to ProprioceptiveTraining on Functional Balance, Gait, andMuscle Strength Among Acute Stroke Subjects. Ann Neurosci. 2021 Jul;28(3-4):162-169. doi: 10.1177/09727531211063132. Epub 2022 Jan 28.
- Background: PubMed 33484541Ain QU, Imran M, Bashir A, Malik AN. Progressive resistance training improving gait performance and mobility in acute and chronic stroke patients. J Pak Med Assoc. 2021 Jan;71(1(A)):140-142. doi: 10.47391/JPMA.612.
- Background: PubMed 34695721Geerars M, Minnaar-van der Feen N, Huisstede BMA. Treatment of knee hyperextension in post-stroke gait. A systematic review. Gait Posture. 2022 Jan;91:137-148. doi: 10.1016/j.gaitpost.2021.08.016. Epub 2021 Aug 24.
- Background: PubMed 38820765Okada K, Haruyama K, Okuyama K, Tsuzuki K, Nakamura T, Kawakami M. Categorizing knee hyperextension patterns in hemiparetic gait and examining associated impairments in patients with chronic stroke. Gait Posture. 2024 Sep;113:18-25. doi: 10.1016/j.gaitpost.2024.05.025. Epub 2024 May 23.
- Background: PubMed 38540725Salaudeen MA, Bello N, Danraka RN, Ammani ML. Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones. Biomolecules. 2024 Mar 4;14(3):305. doi: 10.3390/biom14030305.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Open and closed kinetic chain exercises in people with Cerebrovascular Accident (Stroke) and Knee Hyperextension, run by Dow University of Health Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 2 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knee hyperextension with Goniometer (time frame: Assessment takes approximately 2-5 minutes per knee and may be performed at baseline and after the intervention period (e.g., 6-8 weeks) to evaluate changes in knee alignment and range of motion.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07670728, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2026.