Dentin HypersensitivityNCT07669324
Effect of Chemical and Light Bleaching Techniques on Color Change, Dentin Hypersensitivity and Patient Satisfaction
A study testing Light activated bleaching and Chemically activated bleaching in people with Dentin Hypersensitivity, run by Nahda University at 1 site in Egypt.
Trial summary
Aim of The Study This study aims is to evaluate color change, dentin hypersensitivity and patient satisfaction after different bleaching techniques at different time intervals. Materials(subjects)\& Methods Chemically activated bleaching kit. Light activated bleaching kit. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Dentin Hypersensitivity
- What is being tested?
- Light activated bleaching and Chemically activated bleaching
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 15 Feb 2025to 13 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Presence of six sound maxillary anterior teeth.
- Patient having brown or yellowish stains.
- Good oral health maintained by routine brushing.
- Generalized tooth staining ranging from A2 or darker according to the value-oriented shade guide (Vita easy shade).
- Patient is willing to sign a consent form and can attend all recall visits.
Who cannot join
- Existing anterior crowns or any restorations on anterior teeth that will interfere with the bleaching process.
- Smoker or alcoholic patient.
- Patients suffering from active periodontal diseases and exposed roots.
- Patient who undergone previous whitening procedure.
- Pregnant and lactating women.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Evaluation of the Effect of Chemical and Light Activated Bleaching Techniques on Color Change, Dentin Hypersensitivity and Patient Satisfaction. (In-vivo Study)
Aim of The Study This study aims is to evaluate color change, dentin hypersensitivity and patient satisfaction after different bleaching techniques at different time intervals.
Materials(subjects)\& Methods
Read more
- Chemically activated bleaching kit.
- Light activated bleaching kit. This will be a randomized single-blind clinical trial, patients attending the faculty. Thirty-two patients will be selected for the study. Oral hygiene steps will be taken at the first visit, as well as scaling and polishing of the teeth. Patients will be divided into two groups according to the bleaching technique used. Group 1: chemical bleaching, Group 2: light activated bleaching.
Color change measurements:
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The whiteness index will be also calculated to verify the perceived bleaching effect.
Dentin hypersensitivity will be evaluated at baseline D0, immediately after bleaching treatment D1, 1 week (D2) and 3 month (D3) after bleaching using Visual Analogue Scale VAS numbered from 0 (no pain) to 10 (maximum extreme pain).
At the end of the study (3 months) a questionnaire was given to the patients to assess their satisfaction with bleaching treatment.
Read the detailed description
patients attending the faculty clinic will be screened and selected for the study according to the following inclusion criteria and exclusion criteria, inclusion criteria;
- Patients must be between 18 and 45 years old to avoid hypersensitivity resulting from the immature pulp in young populations, or the apparent yellowish color of dentin resulting from enamel wear in older populations.
- Presence of six sound maxillary anterior teeth.
- Patient having brown or yellowish stains.
- Good oral health maintained by routine brushing.
- Generalized tooth staining ranging from A2 or darker according to the value-oriented shade guide (Vita easy shade).
- Patient is willing to sign a consent form and can attend all recall visits.
Exclusion criteria:
- Existing anterior crowns or any restorations on anterior teeth that will interfere with the bleaching process.
- Smoker or alcoholic patient.
- Patients suffering from active periodontal diseases and exposed roots.
- Patient who undergone previous whitening procedure.
- Pregnant and lactating women. Thirty-two patients will be selected for the study. Oral hygiene steps will be taken at the first visit, as well as scaling and polishing of the teeth. Patients will be divided into two groups according to the bleaching technique used. Group 1: chemical bleaching, Group 2: light activated bleaching.
Bleaching techniques:
- Chemically activated bleaching: the patient's lips will be covered in Vaseline for protection, a cheek retractor is used to pull the lips and cheeks away from the teeth to shield them from the bleaching gel and to prevent gel leakage, the gingiva is properly dried, and a gingival protector liquid dam is added to all exposed gingiva and cured according to the manufacturer's instructions. Bleaching gel is uniformly added to the teeth and bleaching procedure will be conducted according to the manufacturer's instructions in one session for 20 min.
- Light activated bleaching: same protection protocol is used in addition to protective eye wear for both patient and operator. Bleaching gel is uniformly added to the teeth and light bleaching procedure will be conducted according to the manufacturer's instructions in one session for 20 min.
Color change measurements:
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The measured values will be recorded in the units of CIELab color space. CIE L* parameter shows the degree of lightness, a* is indicative of redness/greenness, and b* indicates yellowness/blueness. Variations in L*, a*, and b* axes and chromatic alteration will be performed at each period and compared to baseline using the following calculation: ΔE* = [(ΔL*)2 + (Δa*)2 + (Δb*)2]1/2.
Whiteness index (WID):
The whiteness index will be also calculated to verify the perceived bleaching effect. The WID is a simple linear formulation that uses the CIELab chromatic coordinate values, in which the higher the values obtained, the greater the bleaching effect provided by a given procedure. WID will be calculated using the following formula: WID = (0.511 × L ∗) - (2.324 × a ∗) - (1.100 × b ∗).
Evaluation of postoperative dentin hypersensitivity:
Dentin hypersensitivity will be evaluated at baseline D0, immediately after bleaching treatment D1, 1 week (D2) and 3 month (D3) after bleaching using Visual Analogue Scale VAS numbered from 0 (no pain) to 10 (maximum extreme pain).
Evaluation of patient satisfaction:
At the end of the study (3 months) a questionnaire was given to the patients to assess their satisfaction with bleaching treatment. Multi-item measure of satisfaction will be used to evaluate patients' perceptions of importance and performance of four characteristics of a bleaching treatment; final tooth color, color stability, length of treatment and comfort during treatment. Patients will be asked to rate the perceived importance of each characteristic on a 7-point Likert scale anchored by 1='Not at all important' and 7='Very important'. The perceived performance of each characteristic will be assessed on a scale anchored by 1='Very bad' and 7='Excellent'. Difference between performance and importance scores of individual service characteristics will be then calculated to form a third variable, the gap score, which will be used as an indicator of patient satisfaction. Also, the overall satisfaction of patients with the bleaching service will be measured separately on a 7-point scale anchored by 1='Not at all satisfied' and 7='Very satisfied'.
- Conditions
- Dentin Hypersensitivity
- Being tested
- Light activated bleaching, Chemically activated bleaching
- Keywords
- chemical bleaching, light activated bleaching, dentin hypersensitivity, color change
- Medical subject headings
- Dentin Sensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Light activated bleachingOther
bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.protective eye wear for both patient and operator was used,d, the bleaching gel was applied, and agitated, and then light activation was used for the period of the session.
Chemically activated bleachingOther
The bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.the bleaching gel was applied and agitated and then left on tooth surface for the period of the session
| Study group | Role | What they receive |
|---|---|---|
| light-activated bleaching | Experimental | bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.protective eye wear for both patient and operator was used,d, the bleaching gel was applied, and agitated, and then light activation was used for the period of the session. Receives: Other: Light activated bleaching |
| Chemically activated bleaching | Experimental | The bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.the bleaching gel was applied and agitated and then left on tooth surface for the period of the session Receives: Other: Chemically activated bleaching |
What is being measured
The primary outcome is the main question the study is designed to answer.
color change measurement
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The measured values will be recorded in the units of CIELab color space. CIE L* parameter shows the degree of lightness, a* is indicative of redness/greenness, and b* indicates yellowness/blueness. Variations in L*, a*, and b* axes and chromatic alteration will be performed at each period and compared to baseline using the following calculation: ΔE* = [(ΔL*)2 + (Δa*)2 + (Δb*)2]1/2.
Measured: three months
Secondary outcomes (2)
dentin hypersensitivity
Dentin hypersensitivity will be evaluated at baseline D0, immediately after bleaching treatment D1, 1 week (D2) and 3 month (D3) after bleaching using Visual Analogue Scale VAS numbered from 0 (no pain) to 10 (maximum extreme pain).
Measured: three months
Whiteness index WID
whiteness index was also calculated to verify the perceived bleaching effect. The WIDis a simple linear formulation that uses the CIELab chromatic coordinate values, in which the higher the values obtained, the greater the bleaching effect provided by a given procedure. WID will be calculated using the following formula WID = (0.511 × L*) - (2.324 × a*) - (1.100 × b*)
Measured: 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jun 2026
- Study start15 Feb 2025
- Primary completion22 Apr 2025
- Study completion13 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dentin HypersensitivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Nahda University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sarah Mohsen Mohamed, Nahda University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07669324
- Sponsor's protocol ID
- (00A-1-25-1)
- Status last verified
- Jan 2025
- First submitted
- 19 Feb 2026
- Last updated
- 25 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of the Effect of Chemical and Light Activated Bleaching Techniques on Color Change, Dentin Hypersensitivity and Patient Satisfaction. (In-vivo Study)
- ClinicalTrials.gov ID
- NCT07669324
- Acronym / sponsor ID
- (00A-1-25-1)
- Conditions
- Dentin Hypersensitivity
- Keywords
- chemical bleaching, light activated bleaching, dentin hypersensitivity, color change
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Nahda UniversityUniversity, hospital or other
- Study start
- 15 Feb 2025 (actual)
- Primary completion
- 22 Apr 2025 (actual)
- Study completion
- 13 May 2025 (actual)
- First posted
- 25 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aim of The Study This study aims is to evaluate color change, dentin hypersensitivity and patient satisfaction after different bleaching techniques at different time intervals.
Materials(subjects)\& Methods
- Chemically activated bleaching kit.
- Light activated bleaching kit. This will be a randomized single-blind clinical trial, patients attending the faculty. Thirty-two patients will be selected for the study. Oral hygiene steps will be taken at the first visit, as well as scaling and polishing of the teeth. Patients will be divided into two groups according to the bleaching technique used. Group 1: chemical bleaching, Group 2: light activated bleaching.
Color change measurements:
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The whiteness index will be also calculated to verify the perceived bleaching effect.
Dentin hypersensitivity will be evaluated at baseline D0, immediately after bleaching treatment D1, 1 week (D2) and 3 month (D3) after bleaching using Visual Analogue Scale VAS numbered from 0 (no pain) to 10 (maximum extreme pain).
At the end of the study (3 months) a questionnaire was given to the patients to assess their satisfaction with bleaching treatment.
Detailed description
patients attending the faculty clinic will be screened and selected for the study according to the following inclusion criteria and exclusion criteria, inclusion criteria;
- Patients must be between 18 and 45 years old to avoid hypersensitivity resulting from the immature pulp in young populations, or the apparent yellowish color of dentin resulting from enamel wear in older populations.
- Presence of six sound maxillary anterior teeth.
- Patient having brown or yellowish stains.
- Good oral health maintained by routine brushing.
- Generalized tooth staining ranging from A2 or darker according to the value-oriented shade guide (Vita easy shade).
- Patient is willing to sign a consent form and can attend all recall visits.
Exclusion criteria:
- Existing anterior crowns or any restorations on anterior teeth that will interfere with the bleaching process.
- Smoker or alcoholic patient.
- Patients suffering from active periodontal diseases and exposed roots.
- Patient who undergone previous whitening procedure.
- Pregnant and lactating women. Thirty-two patients will be selected for the study. Oral hygiene steps will be taken at the first visit, as well as scaling and polishing of the teeth. Patients will be divided into two groups according to the bleaching technique used. Group 1: chemical bleaching, Group 2: light activated bleaching.
Bleaching techniques:
- Chemically activated bleaching: the patient's lips will be covered in Vaseline for protection, a cheek retractor is used to pull the lips and cheeks away from the teeth to shield them from the bleaching gel and to prevent gel leakage, the gingiva is properly dried, and a gingival protector liquid dam is added to all exposed gingiva and cured according to the manufacturer's instructions. Bleaching gel is uniformly added to the teeth and bleaching procedure will be conducted according to the manufacturer's instructions in one session for 20 min.
- Light activated bleaching: same protection protocol is used in addition to protective eye wear for both patient and operator. Bleaching gel is uniformly added to the teeth and light bleaching procedure will be conducted according to the manufacturer's instructions in one session for 20 min.
Color change measurements:
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The measured values will be recorded in the units of CIELab color space. CIE L* parameter shows the degree of lightness, a* is indicative of redness/greenness, and b* indicates yellowness/blueness. Variations in L*, a*, and b* axes and chromatic alteration will be performed at each period and compared to baseline using the following calculation: ΔE* = [(ΔL*)2 + (Δa*)2 + (Δb*)2]1/2.
Whiteness index (WID):
The whiteness index will be also calculated to verify the perceived bleaching effect. The WID is a simple linear formulation that uses the CIELab chromatic coordinate values, in which the higher the values obtained, the greater the bleaching effect provided by a given procedure. WID will be calculated using the following formula: WID = (0.511 × L ∗) - (2.324 × a ∗) - (1.100 × b ∗).
Evaluation of postoperative dentin hypersensitivity:
Dentin hypersensitivity will be evaluated at baseline D0, immediately after bleaching treatment D1, 1 week (D2) and 3 month (D3) after bleaching using Visual Analogue Scale VAS numbered from 0 (no pain) to 10 (maximum extreme pain).
Evaluation of patient satisfaction:
At the end of the study (3 months) a questionnaire was given to the patients to assess their satisfaction with bleaching treatment. Multi-item measure of satisfaction will be used to evaluate patients' perceptions of importance and performance of four characteristics of a bleaching treatment; final tooth color, color stability, length of treatment and comfort during treatment. Patients will be asked to rate the perceived importance of each characteristic on a 7-point Likert scale anchored by 1='Not at all important' and 7='Very important'. The perceived performance of each characteristic will be assessed on a scale anchored by 1='Very bad' and 7='Excellent'. Difference between performance and importance scores of individual service characteristics will be then calculated to form a third variable, the gap score, which will be used as an indicator of patient satisfaction. Also, the overall satisfaction of patients with the bleaching service will be measured separately on a 7-point scale anchored by 1='Not at all satisfied' and 7='Very satisfied'.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| light-activated bleaching | Experimental | Other: Light activated bleachingbleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.protective eye wear for both patient and operator was used,d, the bleaching gel was applied, and agitated, and then light activation was used for the period of the session. |
| Chemically activated bleaching | Experimental | Other: Chemically activated bleachingThe bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.the bleaching gel was applied and agitated and then left on tooth surface for the period of the session |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Presence of six sound maxillary anterior teeth.
- Patient having brown or yellowish stains.
- Good oral health maintained by routine brushing.
- Generalized tooth staining ranging from A2 or darker according to the value-oriented shade guide (Vita easy shade).
- Patient is willing to sign a consent form and can attend all recall visits.
Key exclusion criteria (5 listed)
- Existing anterior crowns or any restorations on anterior teeth that will interfere with the bleaching process.
- Smoker or alcoholic patient.
- Patients suffering from active periodontal diseases and exposed roots.
- Patient who undergone previous whitening procedure.
- Pregnant and lactating women.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Light activated bleachingbleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.protective eye wear for both patient and operator was used,d, the bleaching gel was applied, and agitated, and then light activation was used for the period of the session. | Other | light-activated bleaching |
| Chemically activated bleachingThe bleaching procedure was conducted according to the manufacturer's instructions. Retractor was set in place, the teeth were dried by air stream, the lips were lubricated with Vaseline, a cheek retractor was placed, and isolation was achieved using cotton rolls and the gingival soft tissues were isolated by protective Liquidam (Philips, Andover, MA), Labial surfaces of the teeth 11, 12, 21, 22 were then covered with whitening gel in about 1-2mm thick layer. one 20 min session was done.the bleaching gel was applied and agitated and then left on tooth surface for the period of the session | Other | Chemically activated bleaching |
Primary outcome
color change measurement
Time frame: three months
Tooth color measurements will be performed at baseline T0, immediately after bleaching treatment T1, 1-week T2 and 1-month T3 after bleaching using a spectrophotometer. The measured values will be recorded in the units of CIELab color space. CIE L* parameter shows the degree of lightness, a* is indicative of redness/greenness, and b* indicates yellowness/blueness. Variations in L*, a*, and b* axes and chromatic alteration will be performed at each period and compared to baseline using the following calculation: ΔE* = [(ΔL*)2 + (Δa*)2 + (Δb*)2]1/2.
2 secondary outcomes
dentin hypersensitivity
Time frame: three months
Whiteness index WID
Time frame: 1 month
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Light activated bleaching and Chemically activated bleaching in people with Dentin Hypersensitivity, run by Nahda University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
color change measurement (time frame: three months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Jun 2026.