Cognitive ReserveNCT07667985
Cognitive Reserve and Post-Fatigue Recovery in Older Adults
An observational study of Cognitive Reserve and Aging, run by Uşak University at 1 site in Turkey (Türkiye).
Trial summary
As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life. Read more about this study
- Who is it for?
- Ages 65 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Cognitive Reserve, Aging, Mental Fatigue
- How many people
- 696 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Jun 2026to 24 Aug 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 90 years
- All sexes
- Healthy volunteers accepted
- Older adult
Study population: The study population consists of community-dwelling older adults aged 65 and over.The sample will include individuals who are independently mobile, able to perform activities of daily living, and free of severe cognitive impairments or acute medical conditions that would prevent them from understanding the research protocol or reporting their perception of fatigue and recovery.
Who may be able to join
- being 65 years of age or older,
- not having any neurological, psychiatric, or systemic disease that would affect one's mental state, and not using any medication for these conditions.
Who cannot join
- Being younger than 65 years old,
- having an illness or taking medication that affects mental health, or being
- unable to complete the questionnaires.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Determining the Post-Physical and Mental Fatigue Recovery Perspectives of Older Adults Based on Their Cognitive Reserves
As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life.
"Cognitive reserve" is a term that describes the brain's built-in resilience. Built over a lifetime through education, work, and social activities, a higher cognitive reserve acts like a buffer, helping the brain adapt to stress and aging. While research shows that a high cognitive reserve protects against conditions like dementia, we still do not fully understand how it helps older adults bounce back from normal, everyday physical and mental exhaustion.
Read more
The goal of this study is to investigate how cognitive reserve levels influence how individuals aged 65 and older perceive their recovery after experiencing physical and mental fatigue.
What the Study Involves
The researchers will evaluate participants aged 65 and older to measure their baseline cognitive reserve levels. The study will look closely at how these levels affect the participants':
Ability to cope with daily physical and mental fatigue. Need for rest and rest patterns. Time and ability to return to normal daily activities. Overall perception of their mental and physical recovery. Expected Outcome By understanding this relationship, the study aims to fill a gap in medical literature and help healthcare providers design better, more personalized rehabilitation and lifestyle support programs to improve the quality of life for older adults.
Read the detailed description
The aim of this study is to evaluate the perception of cognitive reserve level and recovery after physical and mental fatigue in individuals aged 65 and over. It also aims to examine the effect of cognitive reserve level on individuals' ability to cope with fatigue, need for rest, return to daily activities, and perception of mental recovery.
With the aging process, individuals may experience a decrease in physical endurance, a decline in cognitive functions, and changes in their capacity for recovery after fatigue. Especially in the elderly, physical and mental fatigue are among the factors that significantly affect daily living activities and quality of life.
Cognitive reserve refers to the capacity that individuals develop throughout their lives through education, professional experience, and mental-social activities, enabling them to maintain their cognitive functions despite brain damage. It has been shown that individuals with high cognitive reserve levels are more resilient to neurological and psychological stressors and can better maintain their cognitive performance. Although cognitive reserve is known in the literature to play a protective role, especially in dementia, age-related cognitive decline, and neurological diseases, its effect on fatigue and recovery processes encountered in daily life has not been sufficiently studied. However, it has been reported that mental fatigue affects attention, executive functions, and decision-making processes, and that these effects may vary among individuals. The recovery process after physical and mental fatigue is affected by numerous factors such as sleep quality, psychological state, chronic diseases, and lifestyle. It is thought that cognitive reserve may play an indirect role in this process through the individual's ability to cope with stress, mental flexibility, and adaptation capacity. However, in the current literature, studies that directly examine the relationship between cognitive reserve and the perception of recovery after physical and mental fatigue, especially in individuals aged 65 and over, are limited. Therefore, this study aims to contribute to the literature by revealing the effect of the level of cognitive reserve on the recovery perspective in elderly individuals.
- Conditions
- Cognitive Reserve, Aging, Mental Fatigue, Fatigue, Recovery of Function
- Keywords
- aging, cognitive reserve, fatigue, Post-Fatigue Recovery
- Medical subject headings
- Mental Fatigue, Fatigue
What is being measured
The primary outcome is the main question the study is designed to answer.
Cognitive Reserve Level
Cognitive Reserve Index questionnaire (CRIq):It assesses an individual's cognitive reserve by compiling information about that individual's entire adult life. The assessment will be conducted with the aid of a guide containing guidelines.
Measured: Baseline
Secondary outcomes (1)
Perception of Coping and Recovery After Mental and Physical Fatigue
The study will be evaluated using a 5-item multiple-choice questionnaire developed by researchers based on current literature. The questionnaire assesses individuals' perceptions of physical-mental fatigue, their ability to cope with physical/mental fatigue, their need for physical/mental rest, and their perspectives on returning to daily physical-mental activities. Participants will select up to 3 response options for each question or provide textual explanations. A higher frequency of selecting positive coping/recovery options indicates a more positive outlook on physical/mental recovery.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jun 2026
- Study start20 Jun 2026
- Primary completion24 Aug 2026
- Study completion24 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive ReserveStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 696 participants (actual)
Sponsor and investigators
- Lead sponsor
- Uşak University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kevser Gürsan, Uşak University
- Investigators
- Elif Tuncay, PhD, Principal investigator, Uşak UniversityKevser GÜRSAN, PhD, Study director, Uşak UniversityEmre Cengiz, PhD, Study chair, Uşak UniversityElif Gür Kabul, PhD, Study chair, Uşak University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07667985
- Sponsor's protocol ID
- 1280-1280-11
- Status last verified
- Jun 2026
- First submitted
- 19 Jun 2026
- Last updated
- 15 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Determining the Post-Physical and Mental Fatigue Recovery Perspectives of Older Adults Based on Their Cognitive Reserves
- ClinicalTrials.gov ID
- NCT07667985
- Acronym / sponsor ID
- 1280-1280-11
- Conditions
- Cognitive Reserve, Aging, Mental Fatigue, Fatigue, Recovery of Function
- Keywords
- aging, cognitive reserve, fatigue, Post-Fatigue Recovery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 696 participants (actual)
- Lead sponsor
- Uşak UniversityUniversity, hospital or other
- Study start
- 20 Jun 2026 (actual)
- Primary completion
- 24 Aug 2026 (actual)
- Study completion
- 24 Aug 2026 (actual)
- First posted
- 25 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life.
"Cognitive reserve" is a term that describes the brain's built-in resilience. Built over a lifetime through education, work, and social activities, a higher cognitive reserve acts like a buffer, helping the brain adapt to stress and aging. While research shows that a high cognitive reserve protects against conditions like dementia, we still do not fully understand how it helps older adults bounce back from normal, everyday physical and mental exhaustion.
The goal of this study is to investigate how cognitive reserve levels influence how individuals aged 65 and older perceive their recovery after experiencing physical and mental fatigue.
What the Study Involves
The researchers will evaluate participants aged 65 and older to measure their baseline cognitive reserve levels. The study will look closely at how these levels affect the participants':
Ability to cope with daily physical and mental fatigue. Need for rest and rest patterns. Time and ability to return to normal daily activities. Overall perception of their mental and physical recovery. Expected Outcome By understanding this relationship, the study aims to fill a gap in medical literature and help healthcare providers design better, more personalized rehabilitation and lifestyle support programs to improve the quality of life for older adults.
Detailed description
The aim of this study is to evaluate the perception of cognitive reserve level and recovery after physical and mental fatigue in individuals aged 65 and over. It also aims to examine the effect of cognitive reserve level on individuals' ability to cope with fatigue, need for rest, return to daily activities, and perception of mental recovery.
With the aging process, individuals may experience a decrease in physical endurance, a decline in cognitive functions, and changes in their capacity for recovery after fatigue. Especially in the elderly, physical and mental fatigue are among the factors that significantly affect daily living activities and quality of life.
Cognitive reserve refers to the capacity that individuals develop throughout their lives through education, professional experience, and mental-social activities, enabling them to maintain their cognitive functions despite brain damage. It has been shown that individuals with high cognitive reserve levels are more resilient to neurological and psychological stressors and can better maintain their cognitive performance. Although cognitive reserve is known in the literature to play a protective role, especially in dementia, age-related cognitive decline, and neurological diseases, its effect on fatigue and recovery processes encountered in daily life has not been sufficiently studied. However, it has been reported that mental fatigue affects attention, executive functions, and decision-making processes, and that these effects may vary among individuals. The recovery process after physical and mental fatigue is affected by numerous factors such as sleep quality, psychological state, chronic diseases, and lifestyle. It is thought that cognitive reserve may play an indirect role in this process through the individual's ability to cope with stress, mental flexibility, and adaptation capacity. However, in the current literature, studies that directly examine the relationship between cognitive reserve and the perception of recovery after physical and mental fatigue, especially in individuals aged 65 and over, are limited. Therefore, this study aims to contribute to the literature by revealing the effect of the level of cognitive reserve on the recovery perspective in elderly individuals.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 65 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
- Study population
- The study population consists of community-dwelling older adults aged 65 and over.The sample will include individuals who are independently mobile, able to perform activities of daily living, and free of severe cognitive impairments or acute medical conditions that would prevent them from understanding the research protocol or reporting their perception of fatigue and recovery.
Key inclusion criteria (2 listed)
- being 65 years of age or older,
- not having any neurological, psychiatric, or systemic disease that would affect one's mental state, and not using any medication for these conditions.
Key exclusion criteria (3 listed)
- Being younger than 65 years old,
- having an illness or taking medication that affects mental health, or being
- unable to complete the questionnaires.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Cognitive Reserve Level
Time frame: Baseline
Cognitive Reserve Index questionnaire (CRIq):It assesses an individual's cognitive reserve by compiling information about that individual's entire adult life. The assessment will be conducted with the aid of a guide containing guidelines.
1 secondary outcome
Perception of Coping and Recovery After Mental and Physical Fatigue
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Elif Tuncay, PhD principal investigator
Uşak University
Kevser GÜRSAN, PhD study director
Uşak University
Emre Cengiz, PhD study chair
Uşak University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cognitive Reserve and Aging, run by Uşak University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cognitive Reserve Level (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.