Ankle SprainNCT07655973
Foot Intensive Rehabilitation With Perturbation Based Training in Ankle Sprain Patients
A study testing Foot-Intensive Rehabilitation and Foot-Intensive Rehabilitation + Perturbation-Based Training in people with Ankle Sprain, run by University of Lahore at 1 site in Pakistan.
Trial summary
To determine the foot-intensive rehabilitation with and without perturbation-based training on pain reduction, range of motion improvement, balance enhancement, and functional instability in patients recovering from ankle sprains NULL HYPOTHESIS There will be no significant difference in the effectiveness of… Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Ankle Sprain
- What is being tested?
- Foot-Intensive Rehabilitation and Foot-Intensive Rehabilitation + Perturbation-Based Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 sitePakistan
- Study dates
- 27 Dec 2025to 27 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • Gender: male /female
- Participants aged 18 to 35 years old.
- Diagnosis of an ankle sprain (within 4 weeks of injury).
- No prior history of severe ankle fractures or surgeries(Hoch et al., 2023)
Who cannot join
- Presence of severe or complex ankle fractures requiring surgical intervention.
- Conditions other than ankle sprain like neuropathy that affect balance or cutaneous sensation.
- Neurological disorders impacting balance or proprioception.
- Pregnancy or planning to become pregnant during the study period(Hoch et al., 2023)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Foot Intensive Rehabilitation With & Without Perturbation Based Training in Patients With Ankle Sprain
To determine the foot-intensive rehabilitation with and without perturbation-based training on pain reduction, range of motion improvement, balance enhancement, and functional instability in patients recovering from ankle sprains NULL HYPOTHESIS There will be no significant difference in the effectiveness of foot-intensive rehabilitation with perturbation-based training compared to foot-intensive rehabilitation alone in reducing pain, improving range of motion, enhancing balance, or reducing functional instability among patients recovering from ankle sprains.
ALTERNATE HYPOTHESIS There will be a significant difference in pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability between patients undergoing foot- intensive rehabilitation with perturbation-based training compared to those undergoing foot-intensive rehabilitation.
Read more
Study Design:
It will be a Randomized Clinical Trial
Study Population:
Ankle Sprain Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals. The interventions will aim to address pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability among participants recovering from ankle sprains.
Read the detailed description
Group A: Foot-Intensive Rehabilitation with Perturbation-Based Training
Foot-Intensive Rehabilitation:
Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments. This program will typically include:
- Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs.
- Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release.
- Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing.
- Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.
Perturbation-Based Training: In addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions:
- Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control.
- Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies.
- Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.
Group B: Foot-Intensive Rehabilitation without Perturbation-Based Training
Foot-Intensive Rehabilitation:
Participants in Group B will receive the same structured rehabilitation program focusing on foot- intensive exercises as in Group A. This program includes similar components such as therapeutic exercises, manual therapy, modalities, and functional training targeting ankle sprain recovery and foot-specific impairments.
Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals
- Conditions
- Ankle Sprain
- Being tested
- Foot-Intensive Rehabilitation, Foot-Intensive Rehabilitation + Perturbation-Based Training
- Keywords
- Foot Perturbation, Foot Intensive Rehabilitation, Ankle Sprain
- Medical subject headings
- Ankle Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Foot-Intensive RehabilitationOther
Foot-Intensive Rehabilitation
This program will typically include:
- Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs.
- Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release.
- Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing.
- Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.
Foot-Intensive Rehabilitation + Perturbation-Based TrainingOther
In addition to the foot-intensive rehabilitation program, participants in experimental group will undergo perturbation-based training sessions:
- Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control.
- Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies.
- Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.
| Study group | Role | What they receive |
|---|---|---|
| Foot-Intensive Rehabilitation | Active comparator | Foot-Intensive Rehabilitation:
Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments Receives: Other: Foot-Intensive Rehabilitation |
| Foot-Intensive Rehabilitation + Perturbation-Based Training | Experimental | In addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions Receives: Other: Foot-Intensive Rehabilitation + Perturbation-Based Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric pain rate scale (NPRS)
Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain" (Riley et al., 2019)
Measured: 6 weeks (Baseline, 3rd week, 6th week)
Range of Motion (ROM) Measurement
Goniometer: To measure dorsiflexion, plantarflexion, inversion, and eversion of the ankle joint(Rome \& Cowieson, 1996).
Measured: 6 weeks (Baseline, 3rd week, 6th week)
Balance Assessment:
Star Excursion Balance Test (SEBT): Measures reach distances in multiple directions to assess dynamic balance and reach symmetry.(Coughlan et al., 2012)
Measured: 6 weeks (Baseline, 3rd week, 6th week)
Functional Instability Measurement
Cumberland Ankle Instability Tool (CAIT): A questionnaire to assess the severity of functional ankle instability.(ALEXANDRE et al., 2024)
Measured: 6 weeks (Baseline, 3rd week, 6th week)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2026
- Study start27 Dec 2025
- Primary completion12 Mar 2026
- Study completion27 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ankle SprainStudies of the same condition, open and under way.
- More trials run by University of LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Sana Akram, MSOMPT, Principal investigator, University of Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07655973
- Sponsor's protocol ID
- UOL/IREB/25/15/03/10
- Status last verified
- Dec 2025
- First submitted
- 13 Jun 2026
- Last updated
- 30 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Foot Intensive Rehabilitation With & Without Perturbation Based Training in Patients With Ankle Sprain
- ClinicalTrials.gov ID
- NCT07655973
- Acronym / sponsor ID
- UOL/IREB/25/15/03/10
- Conditions
- Ankle Sprain
- Keywords
- Foot Perturbation, Foot Intensive Rehabilitation, Ankle Sprain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- University of LahoreUniversity, hospital or other
- Study start
- 27 Dec 2025 (actual)
- Primary completion
- 12 Mar 2026 (actual)
- Study completion
- 27 Apr 2026 (actual)
- First posted
- 18 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To determine the foot-intensive rehabilitation with and without perturbation-based training on pain reduction, range of motion improvement, balance enhancement, and functional instability in patients recovering from ankle sprains NULL HYPOTHESIS There will be no significant difference in the effectiveness of foot-intensive rehabilitation with perturbation-based training compared to foot-intensive rehabilitation alone in reducing pain, improving range of motion, enhancing balance, or reducing functional instability among patients recovering from ankle sprains.
ALTERNATE HYPOTHESIS There will be a significant difference in pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability between patients undergoing foot- intensive rehabilitation with perturbation-based training compared to those undergoing foot-intensive rehabilitation.
Study Design:
It will be a Randomized Clinical Trial
Study Population:
Ankle Sprain Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals. The interventions will aim to address pain reduction, range of motion improvement, balance enhancement, and reduction in functional instability among participants recovering from ankle sprains.
Detailed description
Group A: Foot-Intensive Rehabilitation with Perturbation-Based Training
Foot-Intensive Rehabilitation:
Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments. This program will typically include:
- Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs.
- Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release.
- Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing.
- Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity.
Perturbation-Based Training: In addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions:
- Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control.
- Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies.
- Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement.
Group B: Foot-Intensive Rehabilitation without Perturbation-Based Training
Foot-Intensive Rehabilitation:
Participants in Group B will receive the same structured rehabilitation program focusing on foot- intensive exercises as in Group A. This program includes similar components such as therapeutic exercises, manual therapy, modalities, and functional training targeting ankle sprain recovery and foot-specific impairments.
Both groups will undergo the assigned interventions for the duration of 6 weeks under the supervision of trained physical therapists or healthcare professionals
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Foot-Intensive Rehabilitation | Active comparator | Other: Foot-Intensive RehabilitationFoot-Intensive Rehabilitation: Participants in Group A will undergo a structured rehabilitation program focused on addressing ankle sprains and improving foot-specific impairments |
| Foot-Intensive Rehabilitation + Perturbation-Based Training | Experimental | Other: Foot-Intensive Rehabilitation + Perturbation-Based TrainingIn addition to the foot-intensive rehabilitation program, participants will undergo perturbation-based training sessions |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- • Gender: male /female
Key exclusion criteria (4 listed)
- Presence of severe or complex ankle fractures requiring surgical intervention.
- Conditions other than ankle sprain like neuropathy that affect balance or cutaneous sensation.
- Neurological disorders impacting balance or proprioception.
- Pregnancy or planning to become pregnant during the study period(Hoch et al., 2023)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Foot-Intensive RehabilitationFoot-Intensive Rehabilitation This program will typically include: * Therapeutic Exercises: Range of motion exercises, strengthening exercises for foot and ankle muscles, proprioceptive training, and flexibility exercises tailored to individual needs. * Manual Therapy: Hands-on techniques performed by a physical therapist or trained personnel to address soft tissue restrictions, joint mobilization, and mayofascial release. * Modalities: Use of modalities like ice, heat, ultrasound, or electrical stimulation for pain relief and enhancing tissue healing. * Functional Training: Specific drills and activities mimicking daily tasks or sports- related movements to improve functional capacity. | Other | Foot-Intensive Rehabilitation |
| Foot-Intensive Rehabilitation + Perturbation-Based TrainingIn addition to the foot-intensive rehabilitation program, participants in experimental group will undergo perturbation-based training sessions: * Balance Challenges: Engaging in exercises on unstable surfaces (e.g., balance boards, foam pads) or using devices inducing controlled instability to challenge balance and neuro- muscular control. * Dynamic Movements: Performing controlled perturbations or sudden movements to elicit adaptive responses and improve reactive balance strategies. * Progression: Gradual progression of difficulty and complexity in perturbation-based exercises based on individual tolerance and improvement. | Other | Foot-Intensive Rehabilitation + Perturbation-Based Training |
Primary outcome
Numeric pain rate scale (NPRS)
Time frame: 6 weeks (Baseline, 3rd week, 6th week)
Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain" (Riley et al., 2019)
Range of Motion (ROM) Measurement
Time frame: 6 weeks (Baseline, 3rd week, 6th week)
Goniometer: To measure dorsiflexion, plantarflexion, inversion, and eversion of the ankle joint(Rome \& Cowieson, 1996).
Balance Assessment:
Time frame: 6 weeks (Baseline, 3rd week, 6th week)
Star Excursion Balance Test (SEBT): Measures reach distances in multiple directions to assess dynamic balance and reach symmetry.(Coughlan et al., 2012)
Functional Instability Measurement
Time frame: 6 weeks (Baseline, 3rd week, 6th week)
Cumberland Ankle Instability Tool (CAIT): A questionnaire to assess the severity of functional ankle instability.(ALEXANDRE et al., 2024)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jun 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Ankle Sprain
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Functional Recovery After a Recent Lateral Ankle Sprain With Early Initiation of Rehabilitation: Changes in the Ankle-GO Score and Its Association With Return to Sport and Recurrent Sprains.
Ankle Sprain
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Enovis High Ankle Sprain Brace Testing
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The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle Instability
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The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Chronic Ankle Instability
Ankle Sprains, Ankle Sprain Strain
Not yet recruiting
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Chronic Ankle Instability, Ankle Sprain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sana Akram, MSOMPT principal investigator
University of Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Foot-Intensive Rehabilitation and Foot-Intensive Rehabilitation + Perturbation-Based Training in people with Ankle Sprain, run by University of Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric pain rate scale (NPRS) (time frame: 6 weeks (Baseline, 3rd week, 6th week)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jun 2026.