Cerebral PalsyCLT-PHYSIO-CPNCT07651995
Effect of Coordinative Locomotor Training in Children With Cerebral Palsy
A study testing Coordinative Locomotor Training and Conventional Physiotherapy in people with Cerebral Palsy and Hemiplegia, run by University of Faisalabad at 1 site in Pakistan.
Trial summary
Cerebral palsy is a brain disorder that affects how children move their bodies. Children with spastic hemiplegic CP have stiffness on one side of the body, making it hard to walk and balance. This study will test a special exercise program called Coordinative Locomotor Training (CLT). Read more about this study
- Who is it for?
- Ages 8 to 12 years
- Conditions the study is for
- Cerebral Palsy, Hemiplegia, Spastic cp
- What is being tested?
- Coordinative Locomotor Training and Conventional Physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Feb 2026to 10 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Children aged 8 to 12 years.
- Diagnosed with spastic hemiplegic cerebral palsy.
- GMFCS Level I or II.
- Ability to follow simple verbal instructions.
- Medically stable with no changes in anti-spastic medication in the last 3 months.
Who cannot join
- Orthopedic surgery or Botulinum toxin injection in the last 6 months.
- Severe cognitive impairment preventing cooperation.
- Visual or vestibular deficits affecting balance.
- Uncontrolled seizures.
- Other neurological or musculoskeletal disorders unrelated to CP.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
The University of Faisalabad
Faisalābad, Punjab Province, 3800
About this study
Official title: Effect of Coordinative Locomotor Training as Compared to Conventional Physio Therapy in Improving Interlimb Coordination and Dynamic Balance Among Children With Spastic Hemiplegic Cerebral Palsy
Cerebral palsy is a brain disorder that affects how children move their bodies. Children with spastic hemiplegic CP have stiffness on one side of the body, making it hard to walk and balance. This study will test a special exercise program called Coordinative Locomotor Training (CLT). CLT uses running and skating movements to train both arms and legs to work together. The investigator want to see if CLT works better than regular physiotherapy for improving coordination and balance in participants. Half of the children will do CLT, and the other half will do regular exercises. The investogar will measure their balance and walking ability before and after 4 weeks of training.
Read the detailed description
This is a double-blinded, parallel-group, randomized controlled trial conducted at the Department of Rehabilitation Sciences, The University of Faisalabad. A total of 38 children diagnosed with spastic hemiplegic cerebral palsy (GMFCS Level I-II), aged 8 to 12 years, will be recruited from pediatric physiotherapy centers. Participants will be randomly assigned (1:1 ratio) using a computer-generated randomization list to either the Experimental Group (CLT) or the Control Group (CPT). The Experimental Group (n=19) will receive Coordinative Locomotor Training based on Proprioceptive Neuromuscular Facilitation (PNF) sprinter and skater patterns. The intervention will be delivered in three postures (supine, sitting, and single-leg stand) for 3 sets of 5 repetitions with a 10-second hold and 10-second rest, lasting 30 minutes per session, 3 times per week for 4 weeks (total 12 sessions). The Control Group (n=19) will receive conventional physiotherapy consisting of hot pack application for 10 minutes, rotational exercises for 5 minutes, followed by stretching and resistance training for 15 minutes, lasting 30 minutes per session, 3 times per week for 4 weeks (total 12 sessions). The primary outcome measures are interlimb coordination (assessed via 1-step time asymmetry and stride time variability) and dynamic balance (Pediatric Balance Scale). Secondary outcomes include functional gait (TUG and 10MWT) and static balance (one-leg stand test).Participants will not know whether they are in experiment or control group. A blinded assessor will evaluate all participants at baseline (Week 0) and post-intervention (Week 8). Data will be analyzed using SPSS version 23.
- Conditions
- Cerebral Palsy, Hemiplegia, Spastic cp
- Being tested
- Coordinative Locomotor Training, Conventional Physiotherapy
- Keywords
- Coordinative Locomotor Training, Spastic Hemiplegia, PNF, Pediatric Balance, Physiotherapy
- Medical subject headings
- Cerebral Palsy, Hemiplegia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Coordinative Locomotor TrainingOther
Participants perform PNF sprinter pattern (flexion/adduction/external rotation on one side with extension/abduction/internal rotation on the opposite side) and skater pattern (reciprocal upper and lower limb movements). Exercises are done for 3 sets of 5 reps, 10-sec holds, 30 min/session, 3x/week for 4 weeks.
Conventional PhysiotherapyOther
rotational exercises (5 min), then passive stretching of hamstrings, quadriceps, and ankle plantarflexors combined with resistance training using elastic bands (15 min).
| Study group | Role | What they receive |
|---|---|---|
| Coordinative Locomotor Training (CLT) | Experimental | PNF-based sprinter and skater patterns in supine, sitting, and standing. Receives: Other: Coordinative Locomotor Training |
| Conventional Physiotherapy (CPT) | Active comparator | ROM exercises, stretching, and resistance training. Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Interlimb Coordination
Measured by 1-step time asymmetry (NAI) during gait analysis.
Measured: Baseline (Week 0) and Post-intervention (Week 8)
Change in Dynamic Balance
Measured by the Pediatric Balance Scale (PBS). A 14-item scale scoring from 0 to 56. Higher scores indicate better balance.
Measured: Baseline (Week 0) and Post-intervention (Week 8)
Secondary outcomes (1)
Change in Functional Gait Speed
Measured by the Time Up and Go (TUG) test in seconds,
Measured: Baseline (Week 0) and Post-intervention (Week 8)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jun 2026
- Study start15 Feb 2026
- Primary completion15 Jun 2026
- Study completion10 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 38 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Faisalabad
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muhammad Muneeb Jafar, University of Faisalabad
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07651995
- Sponsor's protocol ID
- TUF/EIRB/ 199 /26
- Acronym
- CLT-PHYSIO-CP
- Status last verified
- Jun 2026
- First submitted
- 8 Jun 2026
- Last updated
- 23 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Coordinative Locomotor Training as Compared to Conventional Physio Therapy in Improving Interlimb Coordination and Dynamic Balance Among Children With Spastic Hemiplegic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07651995
- Acronym / sponsor ID
- CLT-PHYSIO-CP / TUF/EIRB/ 199 /26
- Conditions
- Cerebral Palsy, Hemiplegia, Spastic cp
- Keywords
- Coordinative Locomotor Training, Spastic Hemiplegia, PNF, Pediatric Balance, Physiotherapy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 38 participants (actual)
- Lead sponsor
- University of FaisalabadUniversity, hospital or other
- Study start
- 15 Feb 2026 (actual)
- Primary completion
- 15 Jun 2026 (actual)
- Study completion
- 10 Aug 2026 (estimated)
- First posted
- 16 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cerebral palsy is a brain disorder that affects how children move their bodies. Children with spastic hemiplegic CP have stiffness on one side of the body, making it hard to walk and balance. This study will test a special exercise program called Coordinative Locomotor Training (CLT). CLT uses running and skating movements to train both arms and legs to work together. The investigator want to see if CLT works better than regular physiotherapy for improving coordination and balance in participants. Half of the children will do CLT, and the other half will do regular exercises. The investogar will measure their balance and walking ability before and after 4 weeks of training.
Detailed description
This is a double-blinded, parallel-group, randomized controlled trial conducted at the Department of Rehabilitation Sciences, The University of Faisalabad. A total of 38 children diagnosed with spastic hemiplegic cerebral palsy (GMFCS Level I-II), aged 8 to 12 years, will be recruited from pediatric physiotherapy centers. Participants will be randomly assigned (1:1 ratio) using a computer-generated randomization list to either the Experimental Group (CLT) or the Control Group (CPT). The Experimental Group (n=19) will receive Coordinative Locomotor Training based on Proprioceptive Neuromuscular Facilitation (PNF) sprinter and skater patterns. The intervention will be delivered in three postures (supine, sitting, and single-leg stand) for 3 sets of 5 repetitions with a 10-second hold and 10-second rest, lasting 30 minutes per session, 3 times per week for 4 weeks (total 12 sessions). The Control Group (n=19) will receive conventional physiotherapy consisting of hot pack application for 10 minutes, rotational exercises for 5 minutes, followed by stretching and resistance training for 15 minutes, lasting 30 minutes per session, 3 times per week for 4 weeks (total 12 sessions). The primary outcome measures are interlimb coordination (assessed via 1-step time asymmetry and stride time variability) and dynamic balance (Pediatric Balance Scale). Secondary outcomes include functional gait (TUG and 10MWT) and static balance (one-leg stand test).Participants will not know whether they are in experiment or control group. A blinded assessor will evaluate all participants at baseline (Week 0) and post-intervention (Week 8). Data will be analyzed using SPSS version 23.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Coordinative Locomotor Training (CLT) | Experimental | Other: Coordinative Locomotor TrainingPNF-based sprinter and skater patterns in supine, sitting, and standing. |
| Conventional Physiotherapy (CPT) | Active comparator | Other: Conventional PhysiotherapyROM exercises, stretching, and resistance training. |
Who may qualify
- Ages
- 8 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (5 listed)
- Children aged 8 to 12 years.
- Diagnosed with spastic hemiplegic cerebral palsy.
- GMFCS Level I or II.
- Ability to follow simple verbal instructions.
- Medically stable with no changes in anti-spastic medication in the last 3 months.
Key exclusion criteria (5 listed)
- Orthopedic surgery or Botulinum toxin injection in the last 6 months.
- Severe cognitive impairment preventing cooperation.
- Visual or vestibular deficits affecting balance.
- Uncontrolled seizures.
- Other neurological or musculoskeletal disorders unrelated to CP.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Coordinative Locomotor TrainingParticipants perform PNF sprinter pattern (flexion/adduction/external rotation on one side with extension/abduction/internal rotation on the opposite side) and skater pattern (reciprocal upper and lower limb movements). Exercises are done for 3 sets of 5 reps, 10-sec holds, 30 min/session, 3x/week for 4 weeks. | Other | Coordinative Locomotor Training (CLT) |
| Conventional Physiotherapyrotational exercises (5 min), then passive stretching of hamstrings, quadriceps, and ankle plantarflexors combined with resistance training using elastic bands (15 min). | Other | Conventional Physiotherapy (CPT) |
Primary outcome
Change in Interlimb Coordination
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
Measured by 1-step time asymmetry (NAI) during gait analysis.
Change in Dynamic Balance
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
Measured by the Pediatric Balance Scale (PBS). A 14-item scale scoring from 0 to 56. Higher scores indicate better balance.
1 secondary outcome
Change in Functional Gait Speed
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Cerebral Palsy
Not yet recruiting
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral Palsy
Recruiting
Additional Effects on tDCS With AOT on Lower Limb Functions on Children With Diplegic CP
Diplegic Cerebral Palsy
Recruiting
Sensory Integration Therapy vs Conventional Physical Therapy in Children With Mixed Cerebral Palsy
Cerebral Palsy
Active, not recruiting
Functional Outcomes and Control Using Synchron BCI - Australia
Neurologic Disorder, Neurologic Diseases
Enrolling by invitationObservational study
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Coordinative Locomotor Training and Conventional Physiotherapy in people with Cerebral Palsy and Hemiplegia, run by University of Faisalabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 23 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Interlimb Coordination (time frame: Baseline (Week 0) and Post-intervention (Week 8)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2026.