AzTrials
AzTrials

Cardiovascular DiseasesNCT07643571

Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children

A study testing WeChat Mini-program Based Heat Health Risk Early Warning Intervention in people with Cardiovascular Diseases and Respiratory Diseases, run by Centers for Disease Control and Prevention, China at 1 site in China.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age children. Six participating schools are randomly assigned to two parallel groups. Read more about this study

Who is it for?
Ages 9 to 11 yearsHealthy volunteers can take part
What is being tested?
WeChat Mini-program Based Heat Health Risk Early Warning Intervention
Could I receive a placebo?
No, everyone receives an active treatment
How many people
200 participants
Where
1 siteChina
Study dates
10 Jun 2026to 15 Sep 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 9 to 11 years
  • All sexes
  • Healthy volunteers accepted
  • Child

School inclusion criteria

  1. Willing to participate in the study.
  2. Possess adequate facilities and qualified teaching staff.
  3. The school and teachers maintain good cooperation.
  4. Class size is no less than 35 students.
  5. All participating classrooms are equipped with air conditioners.

Participant inclusion criteria

  1. Fourth-grade primary school students aged 9 to 11, of all genders.
  2. Voluntary participation by students and their parents, good compliance, and signed informed consent.
  3. At least one adult family member has an internet-enabled mobile device.
  4. Good general health with no history of severe physical or mental disorders.
  5. Local permanent residents with a residency of no less than 6 months.

Participant exclusion criteria

  1. Participants who are unable or refuse to complete required examinations.
  2. Students receiving psychological or psychiatric treatment that may confound the study results.
  3. Those currently enrolled in other interventional clinical studies that may affect outcome assessment.
  4. Any other conditions deemed ineligible by the research team. Any participant meeting any of the above exclusion criteria will be excluded from the study.

Trial locations and contacts

1 site in 1 country.

China1 site

  • Six primary schools in Chaoyang District

    Beijing, Beijing Municipality, 100020

Other trials in China

About this study

This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age children. Six participating schools are randomly assigned to two parallel groups. The intervention group receives tiered heat alerts and guided self-health monitoring via the mini-program. The control group follows standard daily school and family routines, with no dedicated digital high-temperature early-warning intervention. The primary outcome is children's executive function after a 2.5-month follow-up. A range of secondary indicators related to physical status, mental health and health behaviors are assessed concurrently to quantify the intervention's benefits in mitigating adverse health outcomes caused by high temperatures.

Read the detailed description

This pilot study is conducted in Beijing, with 6 primary schools selected as research sites. A stratified cluster randomized controlled design is adopted, with schools as the unit of randomization. Eligible primary schools are randomly assigned to the intervention group and the control group, with 3 schools in each group.

A total of 5 Wisconsin Card Sorting Tests (WCST), 2 health examinations, 2 children's high-temperature protection themed drawing activities, and 5 mini-program questionnaire surveys will be conducted in this study.

The intervention group receives a digital intervention of high-temperature health risk early warning. The research team uses a WeChat mini-program to release corresponding high-temperature health risk level information, health tips, protection science popularization information and other early warning content when the high-temperature health risk level reaches yellow, orange or red, and simultaneously pushes them to head teachers and parents.

The monitoring and survey schedule for the intervention group during the study period is as follows: at baseline and endpoint, unified offline WCST and health examinations will be conducted for children once each, accompanied by one online mini-program questionnaire survey each time. One children's high-temperature protection themed drawing activity will be organized at baseline and at the end of the 3rd month after the intervention, and the works will be uploaded to the mini-program for check-in. At the end of the 1st, 2nd and 3rd months after the intervention, one online follow-up questionnaire and WCST will be completed each month, together with check-in. Meanwhile, blood pressure will be monitored once a week, and daily blood pressure monitoring and check-in will be carried out after each high-temperature health risk early warning release. In addition, after the release of high-temperature health risk early warnings, the intervention group is required to complete check-in for reading and transmitting early warning information, health tips and protection science popularization content, as well as online mini-program surveys on children's awareness of high-temperature health risk early warning information and short-term behavioral patterns. The above WCST and questionnaire surveys will be completed by children with parental assistance; blood pressure monitoring and check-in are the responsibility of head teachers during non-summer vacations and parents during summer vacations.

The control group does not receive the high-temperature health risk early warning intervention and will only complete the corresponding WCST, health examinations, questionnaire surveys and blood pressure monitoring.

Being tested
WeChat Mini-program Based Heat Health Risk Early Warning Intervention
Keywords
Heat stress, heat early warning, digital intervention, WeChat mini-program, school-age children, executive function, Wisconsin Card Sorting Test, cognitive function, cluster randomized controlled trial, children's physical health, heat-related disease, climate change
Medical subject headings
Cardiovascular Diseases, Respiratory Tract Diseases, Heat Stress Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • WeChat Mini-program Based Heat Health Risk Early Warning InterventionOther

    This study implements a digital early warning intervention targeting children's high-temperature health risks. During the intervention period, when the high-temperature health risk level reaches yellow, orange or red, relevant risk information, health tips and heat protection education materials are released to parents and head teachers via the WeChat mini-program. Parents or teachers pass on the warning information to participating children. During non-summer periods, Beijing's high-temperature early warning information is pushed to head teachers and parents via the WeChat mini-program; during summer vacation, location-specific early warning information is sent to parents. All recipients are required to pass on the information to children promptly upon receipt.

Study groups in NCT07643571
Study groupRoleWhat they receive
Control GroupNo interventionThe control group does not receive the mini-program-based high-temperature health risk early warning intervention.
WeChat Mini-program Heat Health Early Warning Intervention GroupExperimentalParticipants receive tiered yellow, orange and red heat risk alerts and heat protection guidance via the WeChat Mini Program once alerts are issued due to high temperatures. Teachers and parents share health promotion tips with enrolled children. Mandatory mini-program check-ins and routine health monitoring are implemented throughout the 2.5-month intervention.
Receives: Other: WeChat Mini-program Based Heat Health Risk Early Warning Intervention

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. The primary outcome is the comprehensive total score of children's executive function constructed based on the Wisconsin Card Sorting Test (WCST)

    The only primary outcome of this study is the composite score of cognitive executive function derived from the Wisconsin Card Sorting Test (WCST) via the TOPSIS method. All WCST absolute indicators and sub-dimensions are sub-indicators instead of independent outcomes. The WCST indicators are grouped into three sub-dimensions: conceptual thinking (Total Correct, Total Errors, Nonperseverative Errors, Conceptual Level Responses, Categories Completed), perseveration (Perseverative Responses, Perseverative Errors), and set maintenance (Failure to Maintain Set). Negative indicators are converted using the formula (x' = Max(x) - x). After Z-score normalization, the decision matrix is established, positive and negative ideal solutions are identified, and Euclidean distances and relative closeness are computed. The resulting relative closeness value is taken as the final composite score of cognitive executive function, the single primary outcome of this study.

    Measured: at 2.5 months of intervention.

Secondary outcomes (30)

  1. Systolic Blood Pressure

    Systolic Blood Pressure measured in mmHg

    Measured: at 2.5 months of intervention

  2. Diastolic Blood Pressure

    Diastolic blood pressure measured in mmHg

    Measured: at 2.5 months of intervention

  3. Heart Rate

    Resting heart rate measured in beats per minute (bpm)

    Measured: at 2.5 months of intervention

  4. Forced Expiratory Volume in 1 second (FEV1)

    Pulmonary function indicator measured in liters (L)

    Measured: at 2.5 months of intervention

  5. Forced Vital Capacity (FVC)

    Pulmonary function indicator measured in liters (L)

    Measured: at 2.5 months of intervention

  6. Peak Expiratory Flow (PEF)

    Pulmonary function indicator measured in liters per second (L/s)

    Measured: at 2.5 months of intervention

  7. Forced Expiratory Flow 25-75% (FEF25-75%)

    Mid-expiratory flow measured in liters per second (L/s)

    Measured: at 2.5 months of intervention

  8. Fractional Exhaled Nitric Oxide (FeNO50)

    Exhaled nitric oxide level at 50 mL/s flow rate, measured in parts per billion (ppb)

    Measured: at 2.5 months of intervention

  9. Fractional Exhaled Nitric Oxide (FeNO200)

    Exhaled nitric oxide level at 200 mL/s flow rate, measured in parts per billion (ppb)

    Measured: at 2.5 months of intervention

  10. Calcium Nitric Oxide (CaNO)

    Airway nitric oxide parameter measured in ppb

    Measured: at 2.5 months of intervention

  11. Fractional Expiratory Carbon Monoxide (FeCO)

    Exhaled carbon monoxide level measured in parts per million (ppm)

    Measured: at 2.5 months of intervention

  12. Body Fat Percentage

    Body fat percentage measured by bioelectrical impedance analysis

    Measured: at 2.5 months of intervention

  13. Total Body Water

    Total body water measured in liters (L)

    Measured: at 2.5 months of intervention

  14. Inorganic Salts

    Inorganic salt content measured in kilograms (kg)

    Measured: at 2.5 months of intervention

  15. Basal Metabolic Rate (BMR)

    Basal metabolic rate measured in kilocalories per day (kcal/day)

    Measured: at 2.5 months of intervention

  16. Body Weight

    Body weight measured in kilograms (kg)

    Measured: at 2.5 months of intervention

  17. High-Temperature Health KAP Score

    Knowledge, Attitude, and Practice (KAP) score on high-temperature health

    Measured: at 2.5 months of intervention

  18. High-Temperature Health Cognition and Protection Behavior Drawing Score

    Drawing-based score of children's cognition and protective behaviors for high-temperature health

    Measured: at 2.5 months of intervention

  19. Short-Term Behavioral Pattern Score

    Score of children's short-term behavioral patterns related to heat health

    Measured: at 2.5 months of intervention

  20. SAS Anxiety Scale Score

    Self-rating Anxiety Scale (SAS) score for children's anxiety symptoms

    Measured: at 2.5 months of intervention

  21. CDI Children's Depression Scale Score

    Children's Depression Inventory (CDI) score for depressive symptoms

    Measured: at 2.5 months of intervention

  22. SGRQ Respiratory Symptom Scale Score

    St. George's Respiratory Questionnaire (SGRQ) score for respiratory symptoms

    Measured: at 2.5 months of intervention

  23. School Absenteeism Days

    Number of school absenteeism days during the study period

    Measured: at 2.5 months of intervention

  24. Academic Performance

    Scores of children's academic examinations

    Measured: at 2.5 months of intervention

  25. Heat-Related Illness Incidence

    Occurrence frequency of heat-related illnesses in children

    Measured: at 2.5 months of intervention

  26. Gastrointestinal Diseases Incidence

    Occurrence frequency of gastrointestinal diseases in children

    Measured: at 2.5 months of intervention

  27. Respiratory Diseases Incidence

    Occurrence frequency of respiratory diseases in children

    Measured: at 2.5 months of intervention

  28. Allergies Incidence

    Occurrence frequency of allergies in children

    Measured: at 2.5 months of intervention

  29. Accidental Injuries Incidence

    Occurrence frequency of accidental injuries in children

    Measured: at 2.5 months of intervention

  30. Early Warning Information Check-in Rate

    Check-in rate of early warning information received by the intervention group

    Measured: at 2.5 months of intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Jun 2026
  2. Study start10 Jun 2026
  3. Primary completion15 Sep 2026
  4. Study completion15 Sep 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Investigator, Outcomes assessor
Enrolment
200 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07643571
Sponsor's protocol ID
NIEH202643
Status last verified
Oct 2026
First submitted
3 Jun 2026
Last updated
26 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Lei J, Sun Q, Chen R, Zhu Y, Zhou L, Xue X, Fang J, Du Y, Wang Y, Li T, Kan H. Respiratory Benefits of Multisetting Air Purification in Children: A Cluster Randomized Crossover Trial. JAMA Pediatr. 2025 Feb 1;179(2):122-128. doi: 10.1001/jamapediatrics.2024.5049.

    PubMed 39621320

  • Wang Y, Sun Y, Ban J, Fang J, Sun Q, Du Y, Liu Y, Dong H, Wang Q, Chen C, Zhang Y, Ma R, Chen R, Kan H, Li T. Cognitive benefits of air purification among schoolchildren: A randomized, double-blind, crossover trial. Innovation (Camb). 2026 Feb 5;7(5):101304. doi: 10.1016/j.xinn.2026.101304. eCollection 2026 May 4.

    PubMed 42100097

  • Pan CY, Tsai CL, Chu CH, Sung MC, Huang CY, Ma WY. Effects of Physical Exercise Intervention on Motor Skills and Executive Functions in Children With ADHD: A Pilot Study. J Atten Disord. 2019 Feb;23(4):384-397. doi: 10.1177/1087054715569282. Epub 2015 Feb 2.

    PubMed 25646023

  • Assari S, Zare H. Extreme Heat Exposure is Associated with Lower Learning, General Cognitive Ability, and Memory among US Children. Open J Neurosci. 2025;3(1):10-22. doi: 10.31586/ojn.2025.1277. Epub 2025 Jan 10.

    PubMed 40027445

  • Perera F, Nadeau K. Climate Change, Fossil-Fuel Pollution, and Children's Health. N Engl J Med. 2022 Jun 16;386(24):2303-2314. doi: 10.1056/NEJMra2117706. No abstract available.

    PubMed 35704482

  • Romanello M, Napoli CD, Green C, Kennard H, Lampard P, Scamman D, Walawender M, Ali Z, Ameli N, Ayeb-Karlsson S, Beggs PJ, Belesova K, Berrang Ford L, Bowen K, Cai W, Callaghan M, Campbell-Lendrum D, Chambers J, Cross TJ, van Daalen KR, Dalin C, Dasandi N, Dasgupta S, Davies M, Dominguez-Salas P, Dubrow R, Ebi KL, Eckelman M, Ekins P, Freyberg C, Gasparyan O, Gordon-Strachan G, Graham H, Gunther SH, Hamilton I, Hang Y, Hanninen R, Hartinger S, He K, Heidecke J, Hess JJ, Hsu SC, Jamart L, Jankin S, Jay O, Kelman I, Kiesewetter G, Kinney P, Kniveton D, Kouznetsov R, Larosa F, Lee JKW, Lemke B, Liu Y, Liu Z, Lott M, Lotto Batista M, Lowe R, Odhiambo Sewe M, Martinez-Urtaza J, Maslin M, McAllister L, McMichael C, Mi Z, Milner J, Minor K, Minx JC, Mohajeri N, Momen NC, Moradi-Lakeh M, Morrissey K, Munzert S, Murray KA, Neville T, Nilsson M, Obradovich N, O'Hare MB, Oliveira C, Oreszczyn T, Otto M, Owfi F, Pearman O, Pega F, Pershing A, Rabbaniha M, Rickman J, Robinson EJZ, Rocklov J, Salas RN, Semenza JC, Sherman JD, Shumake-Guillemot J, Silbert G, Sofiev M, Springmann M, Stowell JD, Tabatabaei M, Taylor J, Thompson R, Tonne C, Treskova M, Trinanes JA, Wagner F, Warnecke L, Whitcombe H, Winning M, Wyns A, Yglesias-Gonzalez M, Zhang S, Zhang Y, Zhu Q, Gong P, Montgomery H, Costello A. The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms. Lancet. 2023 Dec 16;402(10419):2346-2394. doi: 10.1016/S0140-6736(23)01859-7. Epub 2023 Nov 14.

    PubMed 37977174

  • Ebi KL, Capon A, Berry P, Broderick C, de Dear R, Havenith G, Honda Y, Kovats RS, Ma W, Malik A, Morris NB, Nybo L, Seneviratne SI, Vanos J, Jay O. Hot weather and heat extremes: health risks. Lancet. 2021 Aug 21;398(10301):698-708. doi: 10.1016/S0140-6736(21)01208-3.

    PubMed 34419205

  • He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, Smith W, Rose K, Morgan IG. Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China: A Randomized Clinical Trial. JAMA. 2015 Sep 15;314(11):1142-8. doi: 10.1001/jama.2015.10803.

    PubMed 26372583

  • Liu Z, Gao P, Gao AY, Lin Y, Feng XX, Zhang F, Xu LQ, Niu WY, Fang H, Zhou S, Li WH, Yuan JH, Xu CX, Wu N, Li HJ, Wen LM, Patton GC, Wang HJ, Wu YF. Effectiveness of a Multifaceted Intervention for Prevention of Obesity in Primary School Children in China: A Cluster Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 1;176(1):e214375. doi: 10.1001/jamapediatrics.2021.4375. Epub 2022 Jan 4.

    PubMed 34747972

  • Shinde S, Weiss HA, Varghese B, Khandeparkar P, Pereira B, Sharma A, Gupta R, Ross DA, Patton G, Patel V. Promoting school climate and health outcomes with the SEHER multi-component secondary school intervention in Bihar, India: a cluster-randomised controlled trial. Lancet. 2018 Dec 8;392(10163):2465-2477. doi: 10.1016/S0140-6736(18)31615-5. Epub 2018 Nov 22.

    PubMed 30473365

Questions about this trial

What is this clinical trial studying?

A study testing WeChat Mini-program Based Heat Health Risk Early Warning Intervention in people with Cardiovascular Diseases and Respiratory Diseases, run by Centers for Disease Control and Prevention, China at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

The primary outcome is the comprehensive total score of children's executive function constructed based on the Wisconsin Card Sorting Test (WCST) (time frame: at 2.5 months of intervention.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07643571, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in