Autism DisorderNCT07634965
Achilles Tendon and Ankle Characterization in Adults With Autism
An observational study of Autism Disorder, run by University of Haifa.
Trial summary
This study aims to identify ankle structural and functional profiles associated with sensory responsiveness and toe walking in adults with ASD. Expected outcomes include detecting group differences between adults with ASD and matched controls and identifying associations among sensory responsiveness, toe-walking… Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Autism Disorder
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 10 Aug 2026to 1 Aug 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: diagnosis of ASD, or with another diagnosis that includes features of ASD and healthy adult
Who may be able to join
- a diagnosis of ASD, or with another diagnosis that includes features of ASD (such as fragile x),
- independent in daily activities,
- live alone,
- have a moderate-high level of functioning.
- Ability to understand basic instructions for performing the tests, signing an informed consent form or having a guardian sign an informed consent form
Who cannot join
- other neurological diseases (e.g., CP, multiple sclerosis),
- significant orthopedic injuries to the lower limb in the past year,
- previous ankle or Achilles tendon surgeries,
- additional diseases that may affect the structure of the Achilles tendon and ankle,
- who have not signed an informed consent form or are not interested in participating in the study
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
This study aims to identify ankle structural and functional profiles associated with sensory responsiveness and toe walking in adults with ASD. Expected outcomes include detecting group differences between adults with ASD and matched controls and identifying associations among sensory responsiveness, toe-walking status, and objective ankle measures.
Read the detailed description
This study aims to examine ankle musculoskeletal characteristics in adults with Autism Spectrum Disorder.
A cross-sectional, community-based comparative study will enroll 80 adults aged 18-40, including 40 adults with ASD recruited in partnership with a supported residential community and 40 age- and sex-matched controls. Participants will complete a single assessment session evaluating ankle musculoskeletal characteristics, including tendon structure using ultrasonographic tissue characterization (UTC), ankle strength and range of motion, proprioceptive discrimination using the AMEDA apparatus, and assessment of current and past toe walking, alongside quantitative evaluation of sensory responsiveness using a validated questionnaire (Sensory Responsiveness Questionnaire - SQR). Group comparisons will evaluate differences in ankle structure and function, and association analyses will evaluate relationships among sensory responsiveness, toe-walking status, and ankle measures within the ASD group. Findings will inform the identification of preliminary clinical indicators to support the development of future community-based screening and physiotherapy interventions.
- Conditions
- Autism Disorder
- Keywords
- ankle, ASD, screening, Achilles tendon
- Medical subject headings
- Autistic Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Autism | Adult with Autism | |
| healthy control | healthy adult |
What is being measured
The primary outcome is the main question the study is designed to answer.
Achilles tendon
Achilles tendon structure via an ultrasound tissue characterization device
Measured: baseline
Secondary outcomes (4)
sensory responsiveness
Sensory Responsiveness Questionnaire. scale from 58-290 when higher score represent increased responsiveness
Measured: baseline
ankle joint range of motion
range of motion measured by goniometer in degrees
Measured: baseline
ankle joint muscle strength
ankle joint muscle strength measured by hand held dynamometer (in KgF)
Measured: baseline
toe walking
The presence of toe walking via observation on gait (presence / absence)
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jun 2026
- Study start10 Aug 2026 (estimated)
- Primary completion1 Aug 2027 (estimated)
- Study completion1 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Autism DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Haifa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gali Dar, University of Haifa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07634965
- Sponsor's protocol ID
- 235/26
- Status last verified
- Jun 2026
- First submitted
- 3 Jun 2026
- Last updated
- 11 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Achilles Tendon and Ankle Characterization in Adults With Autism
- ClinicalTrials.gov ID
- NCT07634965
- Acronym / sponsor ID
- 235/26
- Conditions
- Autism Disorder
- Keywords
- ankle, ASD, screening, Achilles tendon
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University of HaifaUniversity, hospital or other
- Study start
- 10 Aug 2026 (estimated)
- Primary completion
- 1 Aug 2027 (estimated)
- Study completion
- 1 Aug 2027 (estimated)
- First posted
- 9 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to identify ankle structural and functional profiles associated with sensory responsiveness and toe walking in adults with ASD. Expected outcomes include detecting group differences between adults with ASD and matched controls and identifying associations among sensory responsiveness, toe-walking status, and objective ankle measures.
Detailed description
This study aims to examine ankle musculoskeletal characteristics in adults with Autism Spectrum Disorder.
A cross-sectional, community-based comparative study will enroll 80 adults aged 18-40, including 40 adults with ASD recruited in partnership with a supported residential community and 40 age- and sex-matched controls. Participants will complete a single assessment session evaluating ankle musculoskeletal characteristics, including tendon structure using ultrasonographic tissue characterization (UTC), ankle strength and range of motion, proprioceptive discrimination using the AMEDA apparatus, and assessment of current and past toe walking, alongside quantitative evaluation of sensory responsiveness using a validated questionnaire (Sensory Responsiveness Questionnaire - SQR). Group comparisons will evaluate differences in ankle structure and function, and association analyses will evaluate relationships among sensory responsiveness, toe-walking status, and ankle measures within the ASD group. Findings will inform the identification of preliminary clinical indicators to support the development of future community-based screening and physiotherapy interventions.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Autism | – | –Adult with Autism |
| healthy control | – | –healthy adult |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- diagnosis of ASD, or with another diagnosis that includes features of ASD and healthy adult
Key inclusion criteria (5 listed)
- a diagnosis of ASD, or with another diagnosis that includes features of ASD (such as fragile x),
- independent in daily activities,
- live alone,
- have a moderate-high level of functioning.
- Ability to understand basic instructions for performing the tests, signing an informed consent form or having a guardian sign an informed consent form
Key exclusion criteria (5 listed)
- other neurological diseases (e.g., CP, multiple sclerosis),
- significant orthopedic injuries to the lower limb in the past year,
- previous ankle or Achilles tendon surgeries,
- additional diseases that may affect the structure of the Achilles tendon and ankle,
- who have not signed an informed consent form or are not interested in participating in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Achilles tendon
Time frame: baseline
Achilles tendon structure via an ultrasound tissue characterization device
4 secondary outcomes
sensory responsiveness
Time frame: baseline
ankle joint range of motion
Time frame: baseline
ankle joint muscle strength
Time frame: baseline
toe walking
Time frame: baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Autism Disorder, run by University of Haifa.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Gali Dar, PhD (+972505662054, gdar@univ.haifa.ac.il), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Achilles tendon (time frame: baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026.