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Sedentary BehaviorNCT07632911

The Effect of Aerobic and Resistance Training on the Immune System

A study testing Aerobic and resistance exercise in people with Sedentary Behavior, run by Inonu University at 1 site in Turkey (Türkiye).

Enrolling by invitation

Enrolling by invitation. The study team selects and invites participants, usually from an existing group of patients.

Sites and contacts
Official record
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Trial summary

Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. Read more about this study

Who is it for?
Ages 18 to 35 years, women onlyHealthy volunteers can take part
Conditions the study is for
Sedentary Behavior
What is being tested?
Aerobic and resistance exercise
Could I receive a placebo?
No, everyone receives an active treatment
How many people
36 participants
Where
1 siteTurkey (Türkiye)
Study dates
2 Jan 2025to 1 Dec 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 35 years
  • Women only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • University students aged 18-30
  • Individuals who have engaged in recreational exercise at least two days a week for the past three months
  • Those with low or no smoking or alcohol consumption who volunteer to participate in the study.

Who cannot join

  • Individuals who have had an infection or chronic illness in the last 6 months,
  • Those with a history of autoimmune disease,
  • Metabolic syndrome, or cardiovascular disease,
  • Those who have used antibiotics or anti-inflammatory drugs in the last 3 months,
  • Those who have suffered a serious injury during exercise or are unable to continue are not eligible.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Turkey (Türkiye)1 site

  • İnönu University

    Malatya

Other trials in Turkey (Türkiye)

About this study

Official title: Aerobic and Resistance Training Effects on Inflammatory and Immune Biomarkers in Young Sedentary Women

Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.

Read the detailed description

The effects of exercise on the immune system have been studied for many years. Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response. Regular exercise has been shown to increase individuals' physical fitness levels. Exercise is used in the prevention and treatment of various diseases. Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health. Regular exercise positively affects all systems of the organism, including the immune system. Changes in the immune system after acute and chronic exercise differ. The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals. While light to moderate exercise strengthens the immune system, intense exercise can suppress it. The effects of exercise on the immune system have been the subject of much research in recent years. However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood. Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system. In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response. This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation. Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels. The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.

Being tested
Aerobic and resistance exercise
Keywords
Aerobic exercise, resistance training, sedentary women, exercise immunology
Medical subject headings
Sedentary Behavior

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Aerobic and resistance exerciseBehavioural

    Because it was done on young girls who lead a sedentary lifestyle.

Study groups in NCT07632911
Study groupRoleWhat they receive
Resistance exercise groupExperimentalExercise group completed a 6-week supervised training program consisting of three sessions per week on non-consecutive days. Each session lasted 45-60 minutes and included a standardized warm-up, main exercise phase, and cool-down. Training stimulus was controlled using both internal and external load parameters. Internal load was monitored via heart rate (HR) and rating of perceived exertion (RPE), whereas external load was defined by exercise duration, intensity, and training volume.
Receives: Behavioral: Aerobic and resistance exercise
Aerobic GroupExperimentalThe aerobic training group performed continuous exercise on a treadmill or cycle ergometer at 60-75% of heart rate reserve (HRR), corresponding to moderate-to-vigorous intensity. Exercise intensity was continuously monitored using HR and verified with RPE (target: 12-15). A progressive overload approach was applied, with intensity increasing from 60% HRR in the initial weeks to 70-75% HRR in the final phase.
Receives: Behavioral: Aerobic and resistance exercise
Control groupExperimentalThe control group maintained habitual activities and refrained from structured exercise.
Receives: Behavioral: Aerobic and resistance exercise

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in C-Reactive Protein (CRP) Levels

    Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation. (Unit of measurement: mg/L)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  2. Change in Interleukin-6 (IL-6) Levels

    Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response. (Unit of measurement: pg/mL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  3. Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels

    Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity. (Unit of measurement: pg/mL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  4. Change in Salivary Immunoglobulin A (IgA) Levels

    Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response. (Unit of measurement: mg/dL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  5. Change in Immunoglobulin M (IgM) Levels

    Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response. (Unit of measurement: mg/dL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  6. Change in Immunoglobulin G (IgG) Levels

    Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response. (Unit of measurement: mg/dL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

  7. Change in Leukocyte (WBC) Count

    Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status. (Unit of measurement: cells/µL)

    Measured: Baseline (Week 0) and Post-intervention (Week 6)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Jun 2026
  2. Study start2 Jan 2025
  3. Primary completion15 Sep 2026 (estimated)
  4. Study completion1 Dec 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Participant
Enrolment
36 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07632911
Sponsor's protocol ID
11/03/2025-7252
Status last verified
Aug 2026
First submitted
21 May 2026
Last updated
31 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Nash D, Hughes MG, Butcher L, Aicheler R, Smith P, Cullen T, Webb R. IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Scand J Med Sci Sports. 2023 Jan;33(1):4-19. doi: 10.1111/sms.14241. Epub 2022 Oct 8.

    PubMed 36168944

  • Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, Leigh TM, Carter P, Davies MJ. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013 Oct 29;8(10):e78350. doi: 10.1371/journal.pone.0078350. eCollection 2013.

    PubMed 24205208

  • Coughlin GH, Antush MT, Vella CA. Associations of sedentary behavior and screen time with biomarkers of inflammation and insulin resistance. J Behav Med. 2024 Oct;47(5):828-838. doi: 10.1007/s10865-024-00498-y. Epub 2024 May 25.

    PubMed 38796664

  • Thomas NE, Williams DR. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008 Oct;18(5):543-56. doi: 10.1111/j.1600-0838.2008.00824.x. Epub 2008 Jul 9.

    PubMed 18627553

  • Dogra S, Wolf M, Jeffrey MP, Foley RCA, Logan-Sprenger H, Jones-Taggart H, Green-Johnson JM. Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults. BMC Sports Sci Med Rehabil. 2019 Oct 18;11:23. doi: 10.1186/s13102-019-0138-4. eCollection 2019.

    PubMed 31636910

Questions about this trial

What is this clinical trial studying?

A study testing Aerobic and resistance exercise in people with Sedentary Behavior, run by Inonu University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: enrolling by invitation, as of the sponsor's last update on 31 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in C-Reactive Protein (CRP) Levels (time frame: Baseline (Week 0) and Post-intervention (Week 6)). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07632911, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Aug 2026.

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