Resting Metabolic RateNCT07628764
Within-Individual Variability of Resting Metabolic Rate Over 12 Weeks
An observational study of Resting Metabolic Rate and Energy Metabolism, run by Tel Aviv University at 1 site in Israel.
Trial summary
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Resting Metabolic Rate, Energy Metabolism
- What is being tested?
- Repeated Measurement of Resting Metabolic Rate
- How many people
- 30 participants
- Where
- 1 siteIsrael
- Study dates
- 1 Jul 2026to Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Healthy adult men and women from the community, aged 18-65 years, who are clinically healthy and able to participate in repeated metabolic measurements under standardized laboratory conditions.
Who may be able to join
- Adults aged 18-65 years
- Clinically healthy individuals
- Stable body weight (±2 kg) over the past 3 months
- Ability and willingness to attend morning measurements three times per week for 12 weeks
- Ability to provide informed consent
Who cannot join
- Known uncontrolled endocrine or metabolic disease
- Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy)
- Acute illness within 14 days prior to enrollment
- Pregnancy or lactation
- Any medical condition that, in the opinion of the investigators, may interfere with safe participation
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Lien Bruck contact
Israel1 site, 1 recruiting
- Recruiting
Sylvan Adams Sport Science Institute
Tel Aviv, 6428607
Yftach Prof. Gepner, 050-682-8501, gepner@tauex.tau.ac.il
0587487431, lienbruck@tauex.tau.ac.il
About this study
Official title: Within-Individual Variability of Resting Metabolic Rate Assessed Repeatedly Over 12 Weeks Using Whole-Room Calorimetry
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry.
The study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.
Read the detailed description
Resting metabolic rate (RMR) is a major component of total daily energy expenditure and is widely used in metabolic research. However, most studies rely on single or infrequent measurements, assuming RMR is stable within individuals.
Emerging evidence suggests that RMR exhibits measurable within-individual variability, but the temporal structure and magnitude of this variability remain poorly characterized.
This study will implement a high-frequency repeated-measures design, with RMR measured three times per week over 12 weeks using whole-room indirect calorimetry under standardized conditions. This approach will allow detailed characterization of short-term variability and provide estimates for within-subject variability, measurement error, and minimal detectable change.
The findings will inform interpretation of longitudinal metabolic studies and improve study design in future research.
- Conditions
- Resting Metabolic Rate, Energy Metabolism
- Being tested
- Repeated Measurement of Resting Metabolic Rate
- Keywords
- Resting Metabolic Rate, Energy Expenditure, Metabolism, Indirect Calorimetry, Variability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Repeated Measurement of Resting Metabolic RateOther
Repeated assessment of resting metabolic rate under standardized conditions; no intervention is administered.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Adults | Healthy adult participants undergoing repeated measurements of resting metabolic rate (RMR) three times per week over a 12-week period under standardized conditions. No intervention is applied. Receives: Other: Repeated Measurement of Resting Metabolic Rate |
What is being measured
The primary outcome is the main question the study is designed to answer.
Within-Individual Variability in Resting Metabolic Rate (RMR)
Within-individual variability in resting metabolic rate (RMR) assessed using repeated measurements under standardized conditions. Variability will be quantified using mean, standard deviation (SD), and coefficient of variation (CV%) across repeated measurements.
Measured: 12 weeks
Secondary outcomes (3)
Minimal Detectable Change (MDC) in RMR
The minimal detectable change in resting metabolic rate required to distinguish true physiological change from measurement variability.
Measured: 12 weeks
Between-Individual Variability in RMR
Assessment of variability in resting metabolic rate between participants based on repeated measurements.
Measured: 12 weeks
Temporal Trends in RMR
Assessment of systematic changes in resting metabolic rate over time using repeated measurements across the study period.
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2026
- Study start1 Jul 2026
- Primary completionDec 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Resting Metabolic RateStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tel Aviv University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gepner Yftach, Tel Aviv University
- Investigators
- Yftach Prof. Gepner, Principal investigator, Tel Aviv University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07628764
- Sponsor's protocol ID
- 0012137-2
- Status last verified
- Oct 2026
- First submitted
- 1 Jun 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Within-Individual Variability of Resting Metabolic Rate Assessed Repeatedly Over 12 Weeks Using Whole-Room Calorimetry
- ClinicalTrials.gov ID
- NCT07628764
- Acronym / sponsor ID
- 0012137-2
- Conditions
- Resting Metabolic Rate, Energy Metabolism
- Keywords
- Resting Metabolic Rate, Energy Expenditure, Metabolism, Indirect Calorimetry, Variability
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Tel Aviv UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (actual)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- Dec 2027 (estimated)
- First posted
- 5 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry.
The study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.
Detailed description
Resting metabolic rate (RMR) is a major component of total daily energy expenditure and is widely used in metabolic research. However, most studies rely on single or infrequent measurements, assuming RMR is stable within individuals.
Emerging evidence suggests that RMR exhibits measurable within-individual variability, but the temporal structure and magnitude of this variability remain poorly characterized.
This study will implement a high-frequency repeated-measures design, with RMR measured three times per week over 12 weeks using whole-room indirect calorimetry under standardized conditions. This approach will allow detailed characterization of short-term variability and provide estimates for within-subject variability, measurement error, and minimal detectable change.
The findings will inform interpretation of longitudinal metabolic studies and improve study design in future research.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy Adults | – | Other: Repeated Measurement of Resting Metabolic RateHealthy adult participants undergoing repeated measurements of resting metabolic rate (RMR) three times per week over a 12-week period under standardized conditions. No intervention is applied. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Healthy adult men and women from the community, aged 18-65 years, who are clinically healthy and able to participate in repeated metabolic measurements under standardized laboratory conditions.
Key inclusion criteria (5 listed)
- Adults aged 18-65 years
- Clinically healthy individuals
- Stable body weight (±2 kg) over the past 3 months
- Ability and willingness to attend morning measurements three times per week for 12 weeks
- Ability to provide informed consent
Key exclusion criteria (5 listed)
- Known uncontrolled endocrine or metabolic disease
- Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy)
- Acute illness within 14 days prior to enrollment
- Pregnancy or lactation
- Any medical condition that, in the opinion of the investigators, may interfere with safe participation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Repeated Measurement of Resting Metabolic RateRepeated assessment of resting metabolic rate under standardized conditions; no intervention is administered. | Other | Healthy Adults |
Primary outcome
Within-Individual Variability in Resting Metabolic Rate (RMR)
Time frame: 12 weeks
Within-individual variability in resting metabolic rate (RMR) assessed using repeated measurements under standardized conditions. Variability will be quantified using mean, standard deviation (SD), and coefficient of variation (CV%) across repeated measurements.
3 secondary outcomes
Minimal Detectable Change (MDC) in RMR
Time frame: 12 weeks
Between-Individual Variability in RMR
Time frame: 12 weeks
Temporal Trends in RMR
Time frame: 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Lien Bruck contact
Yftach Prof. Gepner principal investigator
Tel Aviv University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Resting Metabolic Rate and Energy Metabolism, run by Tel Aviv University at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yftach Prof. Gepner (+972 50-682-8501, gepner@tauex.tau.ac.il), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Within-Individual Variability in Resting Metabolic Rate (RMR) (time frame: 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.