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Cervical RadiculopathyNCT07628348

Effects of DRT on Neck Pain, ROM, and Chest Expansion in Patients With CR

A study testing Diaphragmatic Release Technique and Traditional Physical Therapy in people with Cervical Radiculopathy, run by Riphah International University at 1 site in Pakistan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This randomized controlled trial aims to determine the effects of the diaphragmatic release technique on neck pain, cervical range of motion, and chest expansion in patients with cervical radiculopathy. Participants will be randomized to either the baseline treatment or the experimental group for five weeks. Read more about this study

Who is it for?
Ages 35 to 55 years
Conditions the study is for
Cervical Radiculopathy
What is being tested?
Diaphragmatic Release Technique and Traditional Physical Therapy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
1 sitePakistan
Study dates
1 Jan 2026to 1 Aug 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 35 to 55 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Presence of unilateral neck pain and paresthesia symptoms for about 2 months
  • Presence of posterolateral disc herniation at the C4-C7 level.
  • A positive spurling test
  • Positive upper limb neural tension tests for the median and ulnar nerve
  • Cervical rotation towards the painful side of less than 60 degrees
  • Chest Expansion of less than 4 cm

Who cannot join

  • Any tumor
  • Fracture
  • Osteoporosis
  • Scoliosis
  • Cervical and shoulder instability
  • Diabetic neuropathy
  • History or presence of a respiratory disease

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Imran Amjad, phd contact

03324390125

imran.amjad@riphah.edu.pk

Pakistan1 site, 1 recruiting
  • Iffat Anwar Medical Complex

    Lahore, Punjab Province, 54600

    Saba Rafiq, 0303-4045433, saba.rafiq@riphah.edu.pk

    Maneeha Shafique, MSOMPT

    Recruiting

Other trials in Pakistan

About this study

Official title: Effects of Diaphragmatic Release Technique on Neck Pain, Range of Motion, and Chest Expansion in Patients With Cervical Radiculopathy

This randomized controlled trial aims to determine the effects of the diaphragmatic release technique on neck pain, cervical range of motion, and chest expansion in patients with cervical radiculopathy. Participants will be randomized to either the baseline treatment or the experimental group for five weeks.

Read the detailed description

A group of researchers conducted a randomized controlled trial to compare the effects of neural mobilization and conservative treatment on pain, range of motion, and disability in patients with cervical radiculopathy. Eighty-eight patients from the Mayo Hospital, Lahore, were allocated into two groups after meeting the inclusion criteria. Cervical isometrics and a hot pack were applied to the control group. In contrast, the neural mobilization technique of median nerve sliding, along with cervical isometrics and a hot pack, was given to the experimental group over twelve sessions within four weeks. The numeric pain rating scale was used to measure pain intensity, the Neck Disability Index for functional status, and an inclinometer was used to measure the cervical range of motion. The neural mobilization technique was considered more effective for the treatment of median nerve bias and cervical radiculopathy as compared to the conservative treatment of isometrics in managing pain and disability. No difference was seen in the range of motion of the cervical spine in both groups.

A randomized placebo-controlled trial was conducted (2025) to determine the effect of immediate diaphragmatic relaxation on mobility and pain threshold in smartphone users with non-specific cervical spine pain. Thirty-eight women with neck pain were allocated into two groups. Neck range of motion was assessed by a goniometer, and pressure pain threshold by an algometer in participants who were assigned to the therapy group or a placebo group. The intervention consisted of a single manual relaxation of the diaphragm in the supine position. Comparison of pressure pain threshold showed significant differences in the therapy group.

Researchers carried out a pilot randomized controlled trial (2025) to ascertain the effects of manual release of the diaphragm on pain, disability, and function of the diaphragm in patients with chronic neck pain. A total of thirty-three patients were divided into a diaphragmatic manual release group and a placebo release group. A visual analog scale was used to evaluate the intensity of cervical pain, the level of disability with the neck disability index, and the CROM device for the measurement of range of motion. An ultrasound was used to measure the diaphragm excursion, and chest expansion was assessed with a tape ruler. The results of the study showed that the manual release of the diaphragm can have favorable outcomes for patients with neck pain.

A clinical researcher (2024) presented a case report of a sixty-four year old Japanese male diagnosed with bilateral diaphragmatic nerve paralysis secondary to cervical spondylosis. The blood gas analysis showed type 2 respiratory failure. Chest X-ray showed no movement of the diaphragm with respiration. MRI of the cervical spine was done, which showed stenosis at the level of C3-C4 and C4-C5. This case indicated the importance of considering diaphragmatic paralysis as a manifestation of cervical radiculopathy. If left untreated, the radiculopathy at the C3-C4 and C4-C5 levels can cause a time delay in the distal motor response of the phrenic nerve that would ultimately affect the function of the diaphragm, leading to respiratory problems A group of researchers conducted a prospective parallel randomized controlled study (2023) to assess the effect of diaphragmatic release on neck pain and chest expansion in patients with upper crossed syndrome. Thirty patients with upper crossed syndrome aged twenty to twenty-six years were divided into two equal groups. The control group received postural correction exercises. The experimental group received the aforementioned plan as well as the diaphragmatic release exercise. Pain was assessed by a visual analog scale, craniovertebral angle by the photogrammetric method, and chest expansion by tape measurement. The study demonstrated that the diaphragmatic release technique improved chest expansion and neck pain in the upper crossed syndrome.

A group of researchers (2023) performed a cross-sectional study to compare breathing patterns and diaphragmatic movement in patients with cervical radiculopathy and in the asymptomatic group. Twenty-five patients with unilateral cervical radiculopathy were placed in one group, and twenty-five asymptomatic individuals were placed in another group. Diaphragmatic motion was assessed with the help of manual assessment of respiratory motion (MARM), breathing pattern by fluoroscopy, cervical range of motion with the cervical range of motion device, and kinesiophobia by the Tampa scale of kinesiophobia. The results of this study showed an abnormal breathing pattern and a reduction in diaphragmatic excursion on the side of radiculopathy in patients with cervical radiculopathy.

A randomized controlled trial was conducted (2021) to determine the effectiveness of standard physical therapy interventions and manual release of the diaphragm in patients with chronic neck pain. Forty patients were randomly allocated to receive three treatment sessions of baseline treatment and diaphragm manual release in the experimental group and placebo diaphragm technique in the control group. The primary outcome of pain intensity was assessed by the Numeric Pain Rating Scale (NPRS), active range of motion (AROM) by inclinometer, pressure pain threshold by Lizard AHI-O-meter algometer, and disability by the Neck Disability Index (NDI). The inclusion of manual diaphragm techniques in standard cervical treatment gave a better outcome in chronic neck pain patients.

A case-control study was conducted (2020) to evaluate the effect of forward head posture on the excursion of the diaphragm in patients with chronic neck pain. The study took place in the physical therapy department of Cairo University, Egypt. Thirty diagnosed patients with chronic neck pain were distributed into two groups. One group included patients with forward head posture, and another group included patients with no postural changes. The cranio-vertebral angle was evaluated with the bio-photogrammetry method, and the excursion of the diaphragm was measured with ultrasonography. The result of the study showed that patients with forward head posture can have decreased excursion of the diaphragm.

A group of clinical researchers (2017) performed a single-blind, randomized, repeated measures within subject crossover study over seventeen asymptomatic subjects. Pressure-induced pain threshold was evaluated using an algometer on both sides of the paraspinal muscles at the fourth cervical vertebral level, the lateral ends of the clavicle, and the tibialis anterior muscle before and after applying the manual release technique of the diaphragm. The results of the study showed that this intervention could yield a prompt statistical and clinically meaningful analgesic effect on the fourth segment of the cervical spine because of its direct relation with the phrenic nerve.

While there is a growing body of research indicating that physical therapy treatments play an important role in alleviating the signs and symptoms of cervical radiculopathy, neural mobilization, cervical isometrics, and other such methods concentrate more on the cervical problems themselves without considering the effects of respiratory dysfunction. Although previous research has established that diaphragm dysfunction may present itself as a consequence of cervical radiculopathy, as well as emphasized the significance of using a diaphragmatic approach for treating various other conditions, there is no research to date examining the effectiveness of this intervention in cases of cervical radiculopathy.

Being tested
Diaphragmatic Release Technique, Traditional Physical Therapy
Keywords
Neck Pain, Radiculopathy, Range of Motion, Diaphragm, Musculoskeletal Manipulation
Medical subject headings
Radiculopathy, Neck Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Diaphragmatic Release TechniqueOther

    The experimental group will be given the diaphragmatic release technique for 5 mins along with cervical distraction. 10 repetitions x 1 set and 10 sec hold for 3 days/week, and cervical isometrics (flexion, extension, lateral flexion, and rotation) 10 reps x 3 sets for 3 days/week, along with neurodynamic mobilization of the median and ulnar nerve 10 reps x 3sets for 3 days/week each session will be of 40 mins for a total of 4 weeks

  • Traditional Physical TherapyOther

    cervical distraction. 10 repetitions x 1 set and 10 sec hold for 3 days/week, and cervical isometrics (flexion, extension, lateral flexion, and rotation) 10 reps x 3 sets for 3 days/week, along with neurodynamic mobilization of the median and ulnar nerve 10 reps x 3sets for 3 days/week each session will be of 40 mins for a total of 4 weeks

Study groups in NCT07628348
Study groupRoleWhat they receive
Diaphragmatic Release TechniqueExperimentalDiaphragmatic release technique along with cervical distraction, cervical isometrics, and neurodynamic mobilization.
Receives: Other: Diaphragmatic Release Technique
Traditional Physical TherapyActive comparatorCervical distraction, cervical isometrics, and neurodynamic mobilization.
Receives: Other: Traditional Physical Therapy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Numeric Pain Rating scale

    Change from baseline in neck pain intensity will be measured using the Numeric Pain Rating Scale (NPRS). NPRS is scored from 0 to 10, where 0 indicates no pain and 10 indicates worst imaginable pain.

    Measured: 4th week

  2. ROM Cervical Spine (Flexion)

    Change from baseline range of motion in cervical flexion will be measured using a universal goniometer.

    Measured: 4th week

  3. ROM Cervical Spine (Extension)

    Change from baseline range of motion in cervical extension will be measured using a universal goniometer.

    Measured: 4th week

  4. ROM Cervical Spine (Lateral Flexion)

    Change from baseline range of motion in cervical lateral flexion will be measured using a universal goniometer.

    Measured: 4th week

  5. ROM Cervical Spine (Rotation)

    Change from baseline range of motion in cervical rotation will be measured using a universal goniometer.

    Measured: 4th week

  6. Chest Expansion

    Change from baseline in chest expansion will be measured using a measuring tape at the axillary level. Normal chest expansion is 4-7 cm.

    Measured: 4th week

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted5 Jun 2026
  2. Study start1 Jan 2026
  3. Primary completion1 Jul 2026 (estimated)
  4. Study completion1 Aug 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
40 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07628348
Sponsor's protocol ID
REC/RCR & AHS/25/0131
Status last verified
Jun 2026
First submitted
1 Jun 2026
Last updated
5 Jun 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Rafiq S, Zafar H, Gillani SA, Waqas MS, Zia A, Liaqat S, Rafiq Y. Comparison of neural mobilization and conservative treatment on pain, range of motion, and disability in cervical radiculopathy: A randomized controlled trial. PLoS One. 2022 Dec 6;17(12):e0278177. doi: 10.1371/journal.pone.0278177. eCollection 2022.

    PubMed 36472990
  • Cheng KC, Hii EYX, Lin YN, Kuo YL, Tsai YJ. Effects of manual diaphragm release on pain, disability and diaphragm function in patients with chronic neck pain: a pilot randomized controlled trial. BMC Complement Med Ther. 2025 Oct 1;25(1):349. doi: 10.1186/s12906-025-05090-8.

    PubMed 41034882
  • Yousefiyan R, Kordi Yoosefinejad A, Jalli R, Rezaei I. Comparison of breathing pattern and diaphragmatic motion in patients with unilateral cervical radiculopathy and asymptomatic group. BMC Pulm Med. 2023 Dec 9;23(1):498. doi: 10.1186/s12890-023-02804-x.

    PubMed 38071289
  • Anwar S, Arsalan A, Zafar H, Ahmad A, Hanif A. Effects of breathing reeducation on cervical and pulmonary outcomes in patients with non specific chronic neck pain: A double blind randomized controlled trial. PLoS One. 2022 Aug 25;17(8):e0273471. doi: 10.1371/journal.pone.0273471. eCollection 2022.

    PubMed 36006997
  • Kawabata T, Tobino K. Bilateral Diaphragmatic Nerve Paralysis Secondary to Cervical Spondylosis: A Rare Case. Cureus. 2024 Oct 20;16(10):e71904. doi: 10.7759/cureus.71904. eCollection 2024 Oct.

    PubMed 39564008
  • McCoss CA, Johnston R, Edwards DJ, Millward C. Preliminary evidence of Regional Interdependent Inhibition, using a 'Diaphragm Release' to specifically induce an immediate hypoalgesic effect in the cervical spine. J Bodyw Mov Ther. 2017 Apr;21(2):362-374. doi: 10.1016/j.jbmt.2016.08.015. Epub 2016 Sep 9.

    PubMed 28532881
  • Sleijser-Koehorst MLS, Coppieters MW, Epping R, Rooker S, Verhagen AP, Scholten-Peeters GGM. Diagnostic accuracy of patient interview items and clinical tests for cervical radiculopathy. Physiotherapy. 2021 Jun;111:74-82. doi: 10.1016/j.physio.2020.07.007. Epub 2020 Jul 28.

    PubMed 33309074
  • Marco B, Evans D, Symonds N, Peolsson A, Coppieters MW, Jull G, Lofgren H, Zsigmond P, Falla D. Determining the level of cervical radiculopathy: Agreement between visual inspection of pain drawings and magnetic resonance imaging. Pain Pract. 2023 Jan;23(1):32-40. doi: 10.1111/papr.13147. Epub 2022 Jul 8.

    PubMed 35765137
  • Tatsios PI, Grammatopoulou E, Dimitriadis Z, Papandreou M, Paraskevopoulos E, Spanos S, Karakasidou P, Koumantakis GA. The Effectiveness of Spinal, Diaphragmatic, and Specific Stabilization Exercise Manual Therapy and Respiratory-Related Interventions in Patients with Chronic Nonspecific Neck Pain: Systematic Review and Meta-Analysis. Diagnostics (Basel). 2022 Jun 30;12(7):1598. doi: 10.3390/diagnostics12071598.

    PubMed 35885502
  • Jeong GH, Lee BH. Effects of Telerehabilitation Combining Diaphragmatic Breathing Re-Education and Shoulder Stabilization Exercises on Neck Pain, Posture, and Function in Young Adult Men with Upper Crossed Syndrome: A Randomized Controlled Trial. J Clin Med. 2024 Mar 11;13(6):1612. doi: 10.3390/jcm13061612.

    PubMed 38541838
  • Czepinska A, Zawadka M, Dabkowska I. Immediate diaphragmatic relaxation effect on mobility and pain threshold in smartphone users with non-specific cervical spine pain: a randomized placebo-controlled trial. Wiad Lek. 2025;78(3):522-530. doi: 10.36740/WLek/202427.

    PubMed 40219877
  • Sadeghi A, Rostami M, Ameri S, Karimi Moghaddam A, Karimi Moghaddam Z, Zeraatchi A. Effectiveness of isometric exercises on disability and pain of cervical spondylosis: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2022 Jun 16;14(1):108. doi: 10.1186/s13102-022-00500-7.

    PubMed 35710510
  • Zhou Y, Wang B, Pei Z, Yang J, Jiang C, Tian X, Qu X, Li L. Facet tropism: Association between cervical disc degeneration and cervical spondylotic radiculopathy in middle-aged patients. J Clin Neurosci. 2022 May;99:89-93. doi: 10.1016/j.jocn.2022.01.011. Epub 2022 Mar 9.

    PubMed 35278934
  • Alshami AM, Bamhair DA. Effect of manual therapy with exercise in patients with chronic cervical radiculopathy: a randomized clinical trial. Trials. 2021 Oct 18;22(1):716. doi: 10.1186/s13063-021-05690-y.

    PubMed 34663421
  • Lam KN, Rushton A, Thoomes E, Thoomes-de Graaf M, Heneghan NR, Falla D. Neck pain with radiculopathy: A systematic review of classification systems. Musculoskelet Sci Pract. 2021 Aug;54:102389. doi: 10.1016/j.msksp.2021.102389. Epub 2021 May 6.

    PubMed 33992884

Questions about this trial

What is this clinical trial studying?

A study testing Diaphragmatic Release Technique and Traditional Physical Therapy in people with Cervical Radiculopathy, run by Riphah International University at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 5 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Imran Amjad, phd (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Numeric Pain Rating scale (time frame: 4th week). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07628348, which also lists 18 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jun 2026.

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