HealthyITSNCT07623811
Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support
A study testing Cognitive Support System in people with Healthy, run by dōTERRA International at 1 site in United States.
Trial summary
This study will evaluate whether the InTune product system may help support attention, memory, focus, and other thinking skills in healthy adults ages 18-64. Participants will be randomly assigned to receive either the InTune products or placebo products that look and feel the same but do not contain active… Read more about this study
- Who is it for?
- Ages 18 to 64 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Cognitive Support System
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 313 participants
- Where
- 1 siteUnited States
- Study dates
- 10 Jun 2026to 23 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 64 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Able to read and understand English, willing to attend one study visit at the doTERRA campus in Pleasant Grove, UT
Who cannot join
- Regular use (topical, aromatic, or internal) of rosemary, copaiba, cedarwood, peppermint, wild orange, Spanish sage, lime peel, marjoram, litsea, agarwood, vetiver, hiba wood, elderberry extract, or vanilla essential oil in the past month
- Allergy or sensitivity to rosemary, copaiba, cedarwood, peppermint, wild orange, Spanish sage, lime peel, marjoram, litsea, agarwood, vetiver, hiba wood, elderberry extract, or vanilla essential oil
- Use of recreational drugs within the past month
- Color blindness
- Pregnancy, either currently or within the last 3 months
- Participation in a clinical trial within the past 30 days
- Medical conditions, medications, or allergies that could compromise safety or data integrity, as determined by the medical reviewer or principal investigator
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support. A Double-Blind, Placebo-Controlled, Parallel, Adaptive Trial.
This study will evaluate whether the InTune product system may help support attention, memory, focus, and other thinking skills in healthy adults ages 18-64. Participants will be randomly assigned to receive either the InTune products or placebo products that look and feel the same but do not contain active ingredients. Participants will use the products throughout their participation in the study and complete a series of cognitive tests and questionnaires at the beginning and end of the study. Researchers will compare changes in memory performance, self-reported mental clarity and focus, product experiences, and any side effects between the two groups.
Read the detailed description
Cognitive performance in adolescents and young to mid-adults directly influences academic success, workplace productivity, decision-making, and daily functioning. Although cognitive decline is typically studied in older populations, attention, working memory, executive function, and mental fatigue are highly relevant in individuals aged 18-64, particularly under conditions of academic, occupational, and digital demands. Neural plasticity remains active throughout this period, making cognitive function potentially modifiable. Despite strong consumer interest in products marketed for focus and mental clarity, well-controlled trials in healthy young and mid-adult populations remain limited. This study aims to address that gap by rigorously evaluating a non-pharmaceutical cognitive support system together with cognitive training in an actively performing population.
InTune is a proprietary essential oil blend. Many of the study product components are widely used for cognitive support. Human clinical data are needed on this specific system, justifying an exploratory, adaptive clinical trial.
- Conditions
- Healthy
- Being tested
- Placebo, Cognitive Support System
- Keywords
- neural plasticity, executive function, working memory, Immediate and Delayed Recall, Raven's Matrices, PROMIS Cognitive Scale
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PlaceboOther
Aromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The placebo aroma stick will contain 5 drops of benzaldehyde diluted to 1% in fractionated coconut oil on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick is a moisturizing base (similar to deodorant).
Cognitive Support SystemOther
InTune is a product system including an essential oil blend and active botanicals delivered in a liquid form for aromatic application and a solid stick for topical application. Aromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The aroma stick will contain 5 drops of InTune essential oil blend on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick includes a moisturizing base and 25% InTune essential oil blend plus hiba wood oil and elderberry extract. Placebo is the moisturizing base only.
| Study group | Role | What they receive |
|---|---|---|
| InTune system | Experimental | Aromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The aroma stick will contain 5 drops of InTune essential oil blend on a cotton wick inside a hard plastic casing with a lid.
Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick includes a moisturizing base and 25% InTune essential oil blend plus hiba wood oil and elderberry extract. Placebo is the moisturizing base only. Receives: Other: Cognitive Support System |
| Placebo | Placebo comparator | Aromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The placebo aroma stick will contain 5 drops of benzaldehyde diluted to 1% in fractionated coconut oil on a cotton wick inside a hard plastic casing with a lid.
Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick is a moisturizing base (similar to deodorant). Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Composite Z-Score
Within- and between-treatment changes to composite z-score comprised of Stroop, Backward Digit Span, Immediate and Delayed Recall, and Raven's Matrices tests from baseline to completion will be the primary outcome. A higher composite z-score indicates better overall cognitive performance (e.g., improved attention, memory, processing speed, and reasoning). Lower composite z-scores indicate poorer cognitive performance.
Measured: 1 study visit, 90 minutes
Secondary outcomes (8)
PROMIS Cognitive Scale
The Patient-Reported Outcome Measurement Information System (PROMIS) Cognitive subjective survey assesses patient-perceived cognitive deficits. Aspects include mental acuity, concentration, verbal fluency, verbal and nonverbal memory, and perceived changes in cognitive functions. Participants report their answers on a scale of 1 to 5. A higher score indicates a more positive perception of cognition. A lower score indicates a poorer perception of one's cognitive abilities.
Measured: 1 study visit, 90 minutes
VAS Scales (test difficulty)
A Visual Analog Scale (VAS) is a measurement tool with a scale of 0 to 100. For test difficulty, a score of 0 indicates a lower perception of difficulty, while a high score of 100 indicates a higher perception of difficulty.
Measured: 1 study visit, 90 minutes.
VAS Scale (mental clarity)
The Visual Analog Scale (VAS) for mental clarity assesses perception of mental clarity on a scale of 0 to 100. Higher scores indicate a perception of greater mental clarity.
Measured: 1 study visit, 90 minutes.
VAS Scale (focus)
The Visual Analog Scale (VAS) for focus assesses perception of one's ability to focus, on a scale of 0 to 100. Higher scores indicate a perception of greater ability to focus.
Measured: 1 study visit, 90 minutes
VAS Scale (mental energy)
The Visual Analog Scale (VAS) for mental energy assesses perception of mental energy on a scale of 0 to 100. Higher scores indicate a perception of greater mental energy.
Measured: 1 study visit, 90 minutes
VAS Scale (calmness)
The Visual Analog Scale (VAS) for calmness assesses perception of calmness on a scale of 0 to 100. Higher scores indicate a perception of greater calmness.
Measured: 1 study visit, 90 minutes
Incidence of Adverse Events
Number and severity of participant-reported adverse events occurring during the study visit.
Measured: 1 study visit, 90 minutes
Product feedback
Feedback on the aroma of the topical product and aromatic product, and sensations felt during the application and use of the study products.
Measured: 1 study visit, 90 minutes.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2026
- Study start10 Jun 2026
- Primary completion23 Sep 2026
- Study completion23 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 313 participants (actual)
Sponsor and investigators
- Lead sponsor
- dōTERRA International
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Nicole Stevens, PhD, Principal investigator, doTERRA International LLC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07623811
- Sponsor's protocol ID
- DO-126058-ITS
- Acronym
- ITS
- Status last verified
- Oct 2026
- First submitted
- 29 May 2026
- Last updated
- 15 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support. A Double-Blind, Placebo-Controlled, Parallel, Adaptive Trial.
- ClinicalTrials.gov ID
- NCT07623811
- Acronym / sponsor ID
- ITS / DO-126058-ITS
- Conditions
- Healthy
- Keywords
- neural plasticity, executive function, working memory, Immediate and Delayed Recall, Raven's Matrices, PROMIS Cognitive Scale
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 313 participants (actual)
- Lead sponsor
- dōTERRA InternationalIndustry (pharma, biotech, devices)
- Study start
- 10 Jun 2026 (actual)
- Primary completion
- 23 Sep 2026 (actual)
- Study completion
- 23 Sep 2026 (actual)
- First posted
- 3 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will evaluate whether the InTune product system may help support attention, memory, focus, and other thinking skills in healthy adults ages 18-64. Participants will be randomly assigned to receive either the InTune products or placebo products that look and feel the same but do not contain active ingredients. Participants will use the products throughout their participation in the study and complete a series of cognitive tests and questionnaires at the beginning and end of the study. Researchers will compare changes in memory performance, self-reported mental clarity and focus, product experiences, and any side effects between the two groups.
Detailed description
Cognitive performance in adolescents and young to mid-adults directly influences academic success, workplace productivity, decision-making, and daily functioning. Although cognitive decline is typically studied in older populations, attention, working memory, executive function, and mental fatigue are highly relevant in individuals aged 18-64, particularly under conditions of academic, occupational, and digital demands. Neural plasticity remains active throughout this period, making cognitive function potentially modifiable. Despite strong consumer interest in products marketed for focus and mental clarity, well-controlled trials in healthy young and mid-adult populations remain limited. This study aims to address that gap by rigorously evaluating a non-pharmaceutical cognitive support system together with cognitive training in an actively performing population.
InTune is a proprietary essential oil blend. Many of the study product components are widely used for cognitive support. Human clinical data are needed on this specific system, justifying an exploratory, adaptive clinical trial.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| InTune system | Experimental | Other: Cognitive Support SystemAromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The aroma stick will contain 5 drops of InTune essential oil blend on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick includes a moisturizing base and 25% InTune essential oil blend plus hiba wood oil and elderberry extract. Placebo is the moisturizing base only. |
| Placebo | Placebo comparator | Other: PlaceboAromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The placebo aroma stick will contain 5 drops of benzaldehyde diluted to 1% in fractionated coconut oil on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick is a moisturizing base (similar to deodorant). |
Who may qualify
- Ages
- 18 to 64 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Able to read and understand English, willing to attend one study visit at the doTERRA campus in Pleasant Grove, UT
Key exclusion criteria (7 listed)
- Regular use (topical, aromatic, or internal) of rosemary, copaiba, cedarwood, peppermint, wild orange, Spanish sage, lime peel, marjoram, litsea, agarwood, vetiver, hiba wood, elderberry extract, or vanilla essential oil in the past month
- Allergy or sensitivity to rosemary, copaiba, cedarwood, peppermint, wild orange, Spanish sage, lime peel, marjoram, litsea, agarwood, vetiver, hiba wood, elderberry extract, or vanilla essential oil
- Use of recreational drugs within the past month
- Color blindness
- Pregnancy, either currently or within the last 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PlaceboAromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The placebo aroma stick will contain 5 drops of benzaldehyde diluted to 1% in fractionated coconut oil on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick is a moisturizing base (similar to deodorant). | Other | Placebo |
| Cognitive Support SystemInTune is a product system including an essential oil blend and active botanicals delivered in a liquid form for aromatic application and a solid stick for topical application. Aromatic use will entail breathing from a passive nasal aroma stick several times during cognitive testing, as directed by the survey and study staff. The aroma stick will contain 5 drops of InTune essential oil blend on a cotton wick inside a hard plastic casing with a lid. Topical use will entail applying a solid stick to inner arms and chest directly before daily cognitive training. The stick includes a moisturizing base and 25% InTune essential oil blend plus hiba wood oil and elderberry extract. Placebo is the moisturizing base only. | Other | InTune system |
Primary outcome
Composite Z-Score
Time frame: 1 study visit, 90 minutes
Within- and between-treatment changes to composite z-score comprised of Stroop, Backward Digit Span, Immediate and Delayed Recall, and Raven's Matrices tests from baseline to completion will be the primary outcome. A higher composite z-score indicates better overall cognitive performance (e.g., improved attention, memory, processing speed, and reasoning). Lower composite z-scores indicate poorer cognitive performance.
8 secondary outcomes
PROMIS Cognitive Scale
Time frame: 1 study visit, 90 minutes
VAS Scales (test difficulty)
Time frame: 1 study visit, 90 minutes.
VAS Scale (mental clarity)
Time frame: 1 study visit, 90 minutes.
VAS Scale (focus)
Time frame: 1 study visit, 90 minutes
VAS Scale (mental energy)
Time frame: 1 study visit, 90 minutes
VAS Scale (calmness)
Time frame: 1 study visit, 90 minutes
Incidence of Adverse Events
Time frame: 1 study visit, 90 minutes
Product feedback
Time frame: 1 study visit, 90 minutes.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nicole Stevens, PhD principal investigator
doTERRA International LLC
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive Support System in people with Healthy, run by dōTERRA International at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Composite Z-Score (time frame: 1 study visit, 90 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.