Neuromuscular Fatigue, Soccer, Recovery MonitoringNCT07623343
Neuromuscular Fatigue Assessment in Youth Soccer
A study testing T-SAFT90 Protocol in people with Neuromuscular Fatigue, Soccer, Recovery Monitoring, run by Istanbul Gelisim University at 1 site in Turkey (Türkiye).
Trial summary
This clinical trial investigates neuromuscular fatigue and recovery responses following a standardized soccer-specific fatigue protocol in trained young male soccer players. The study compares the sensitivity of different neuromuscular performance assessments, including the countermovement jump (CMJ), isometric… Read more about this study
- Who is it for?
- Ages 18 to 22 years, men only
- Conditions the study is for
- Neuromuscular Fatigue, Soccer, Recovery Monitoring
- What is being tested?
- T-SAFT90 Protocol
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jun 2025to 30 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 22 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Male soccer players aged 18-22 years Minimum of 3 years of active licensed soccer experience Minimum of 2 years of resistance training experience Classified as trained/development-level athletes Free from current musculoskeletal injury at the time of participation
Who cannot join
- History of lower-extremity injury resulting in absence from training for longer than 1 month within the previous 3 months Use of caffeine, alcohol, or nutritional supplements during the study period Participation in heavy physical activity outside the experimental protocol during the study period Failure to maintain regular training routines during the study period
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
İstanbul Gelisim University
Istanbul, Yeşilköy Mahallesi, 34140
About this study
Official title: Differential Neuromuscular Fatigue Responses in Multi- and Single-Joint Force Following a Simulated Soccer Protocol in Youth Players: Evidence for Divergent Assessment Sensitivity
This clinical trial investigates neuromuscular fatigue and recovery responses following a standardized soccer-specific fatigue protocol in trained young male soccer players. The study compares the sensitivity of different neuromuscular performance assessments, including the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), and isometric hamstring 90-90 (IH90-90) tests, for detecting fatigue and recovery over time.
The main questions the study aims to answer are:
Read more
- Which neuromuscular assessment is most sensitive for detecting fatigue following soccer-specific activity?
- How do force production characteristics change immediately after exercise and during recovery?
- Do single-joint and multi-joint isometric assessments demonstrate different recovery patterns?
Participants complete a standardized soccer simulation fatigue protocol and perform neuromuscular performance tests before exercise, immediately after exercise, and 24 and 48 hours following the protocol.
The findings may help improve fatigue monitoring strategies during congested training and match schedules in soccer players and support approaches aimed at reducing injury risk.
Read the detailed description
Neuromuscular fatigue monitoring is widely used in soccer to evaluate recovery status, optimize training load, and reduce injury risk during congested training and match schedules. However, different neuromuscular assessments may reflect distinct aspects of fatigue and recovery, and the time-dependent sensitivity of commonly used force-based assessments remains unclear.
The purpose of this randomized crossover trial is to compare the time-course sensitivity of the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), and isometric hamstring 90-90 (IH90-90) tests for detecting neuromuscular fatigue following a standardized soccer-specific fatigue protocol (T-SAFT90) in trained young male soccer players.
Eighteen trained male soccer players participate in the study. Neuromuscular performance is assessed before exercise, immediately after exercise, and at 24 and 48 hours following the fatigue protocol. The study evaluates changes in peak force and rapid force production characteristics obtained from single-joint and multi-joint isometric assessments, together with CMJ performance variables.
Participants complete the T-SAFT90 protocol designed to simulate the physiological and mechanical demands of competitive soccer activity. Following the protocol, participants perform a series of neuromuscular performance assessments across multiple recovery time points.
The study aims to determine which assessments are most sensitive for detecting acute and residual fatigue and whether single-joint and multi-joint force assessments demonstrate different recovery profiles. The findings may contribute to improved fatigue-monitoring strategies in soccer and assist practitioners in managing recovery and injury risk during periods of high training and match density.
- Being tested
- T-SAFT90 Protocol
- Keywords
- Football; countermovement jump; isometric mid-thigh pull; isometric hamstring; force plate; monitoring
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
T-SAFT90 ProtocolBehavioural
A standardized soccer-specific fatigue protocol designed to simulate the physiological and mechanical demands of competitive soccer activity.
| Study group | Role | What they receive |
|---|---|---|
| T-SAFT90 Fatigue Protocol | Experimental | Participants completed a standardized soccer-specific fatigue protocol followed by neuromuscular performance assessments performed before exercise, immediately post-exercise, and 24 and 48 hours after exercise. Receives: Behavioral: T-SAFT90 Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hamstring Peak Force IMTP Peak Force CMJ parametres (Jump Height, time to take off)
Peak forces measured during the isometric hamstring 90-90 and IMTP (isometric mid-thigh pull)test following a standardized soccer-specific fatigue protocol.
Measured: Baseline, immediately post-exercise, 24 hours post-exercise, and 48 hours post-exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2026
- Study start15 Jun 2025
- Primary completion30 Aug 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Neuromuscular Fatigue, Soccer, Recovery MonitoringStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants complete all testing conditions in a randomized crossover design. Neuromuscular performance assessments are performed before, immediately after, and 24 and 48 hours following the standardized soccer-specific fatigue protocol.
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Gelisim University
- Sponsor type
- University, hospital or other
- Collaborators
- Kırıkkale University
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07623343
- Sponsor's protocol ID
- 2025.04.31
- Status last verified
- Jun 2025
- First submitted
- 29 May 2026
- Last updated
- 3 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Individual participant data may be shared upon reasonable request to the corresponding author, in accordance with institutional policies and participant confidentiality requirements.
Publications
Topuz O, Dogan AA, Senturk D, Ripley NJ. Differential neuromuscular fatigue responses in multi- and single-joint force following a simulated soccer protocol in youth players: evidence for divergent assessment sensitivity. BMC Sports Sci Med Rehabil. 2026 Sep 26;18(1):559. doi: 10.1186/s13102-026-02105-w.
PubMed 42983890
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differential Neuromuscular Fatigue Responses in Multi- and Single-Joint Force Following a Simulated Soccer Protocol in Youth Players: Evidence for Divergent Assessment Sensitivity
- ClinicalTrials.gov ID
- NCT07623343
- Acronym / sponsor ID
- 2025.04.31
- Keywords
- Football; countermovement jump; isometric mid-thigh pull; isometric hamstring; force plate; monitoring
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Istanbul Gelisim UniversityUniversity, hospital or other
- Collaborators
- Kırıkkale University
- Study start
- 15 Jun 2025 (actual)
- Primary completion
- 30 Aug 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 3 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial investigates neuromuscular fatigue and recovery responses following a standardized soccer-specific fatigue protocol in trained young male soccer players. The study compares the sensitivity of different neuromuscular performance assessments, including the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), and isometric hamstring 90-90 (IH90-90) tests, for detecting fatigue and recovery over time.
The main questions the study aims to answer are:
- Which neuromuscular assessment is most sensitive for detecting fatigue following soccer-specific activity?
- How do force production characteristics change immediately after exercise and during recovery?
- Do single-joint and multi-joint isometric assessments demonstrate different recovery patterns?
Participants complete a standardized soccer simulation fatigue protocol and perform neuromuscular performance tests before exercise, immediately after exercise, and 24 and 48 hours following the protocol.
The findings may help improve fatigue monitoring strategies during congested training and match schedules in soccer players and support approaches aimed at reducing injury risk.
Detailed description
Neuromuscular fatigue monitoring is widely used in soccer to evaluate recovery status, optimize training load, and reduce injury risk during congested training and match schedules. However, different neuromuscular assessments may reflect distinct aspects of fatigue and recovery, and the time-dependent sensitivity of commonly used force-based assessments remains unclear.
The purpose of this randomized crossover trial is to compare the time-course sensitivity of the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), and isometric hamstring 90-90 (IH90-90) tests for detecting neuromuscular fatigue following a standardized soccer-specific fatigue protocol (T-SAFT90) in trained young male soccer players.
Eighteen trained male soccer players participate in the study. Neuromuscular performance is assessed before exercise, immediately after exercise, and at 24 and 48 hours following the fatigue protocol. The study evaluates changes in peak force and rapid force production characteristics obtained from single-joint and multi-joint isometric assessments, together with CMJ performance variables.
Participants complete the T-SAFT90 protocol designed to simulate the physiological and mechanical demands of competitive soccer activity. Following the protocol, participants perform a series of neuromuscular performance assessments across multiple recovery time points.
The study aims to determine which assessments are most sensitive for detecting acute and residual fatigue and whether single-joint and multi-joint force assessments demonstrate different recovery profiles. The findings may contribute to improved fatigue-monitoring strategies in soccer and assist practitioners in managing recovery and injury risk during periods of high training and match density.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants complete all testing conditions in a randomized crossover design. Neuromuscular performance assessments are performed before, immediately after, and 24 and 48 hours following the standardized soccer-specific fatigue protocol.
| Arm | Type | Receives |
|---|---|---|
| T-SAFT90 Fatigue Protocol | Experimental | Behavioral: T-SAFT90 ProtocolParticipants completed a standardized soccer-specific fatigue protocol followed by neuromuscular performance assessments performed before exercise, immediately post-exercise, and 24 and 48 hours after exercise. |
Who may qualify
- Ages
- 18 to 22 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Male soccer players aged 18-22 years Minimum of 3 years of active licensed soccer experience Minimum of 2 years of resistance training experience Classified as trained/development-level athletes Free from current musculoskeletal injury at the time of participation
Key exclusion criteria (1 listed)
- History of lower-extremity injury resulting in absence from training for longer than 1 month within the previous 3 months Use of caffeine, alcohol, or nutritional supplements during the study period Participation in heavy physical activity outside the experimental protocol during the study period Failure to maintain regular training routines during the study period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| T-SAFT90 ProtocolA standardized soccer-specific fatigue protocol designed to simulate the physiological and mechanical demands of competitive soccer activity. | Behavioural | T-SAFT90 Fatigue Protocol |
Primary outcome
Hamstring Peak Force IMTP Peak Force CMJ parametres (Jump Height, time to take off)
Time frame: Baseline, immediately post-exercise, 24 hours post-exercise, and 48 hours post-exercise
Peak forces measured during the isometric hamstring 90-90 and IMTP (isometric mid-thigh pull)test following a standardized soccer-specific fatigue protocol.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2026.
- Derived from this study: PubMed 42983890Topuz O, Dogan AA, Senturk D, Ripley NJ. Differential neuromuscular fatigue responses in multi- and single-joint force following a simulated soccer protocol in youth players: evidence for divergent assessment sensitivity. BMC Sports Sci Med Rehabil. 2026 Sep 26;18(1):559. doi: 10.1186/s13102-026-02105-w.
- Individual participant dataSharing planned: Undecided. Individual participant data may be shared upon reasonable request to the corresponding author, in accordance with institutional policies and participant confidentiality requirements.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing T-SAFT90 Protocol in people with Neuromuscular Fatigue, Soccer, Recovery Monitoring, run by Istanbul Gelisim University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hamstring Peak Force IMTP Peak Force CMJ parametres (Jump Height, time to take off) (time frame: Baseline, immediately post-exercise, 24 hours post-exercise, and 48 hours post-exercise). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07623343, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2026.