Metabolic SyndromeBITENCT07620886
Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome
A study testing Postprandial walking and Brief resistance exercise snacks in people with Metabolic Syndrome and Prediabetes, run by Seoul National University.
Trial summary
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes. Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief… Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Metabolic Syndrome, Prediabetes
- What is being tested?
- Postprandial walking and Brief resistance exercise snacks
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 15 Jun 2026to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 40 to 65 years
- Presence of metabolic syndrome
- Fasting glucose of 100 mg/dL or higher or HbA1c of 5.7% or higher
- Not regularly engaged in structured exercise training, defined as less than 150 minutes per week during the past year
- Able to consume the standardized study meals
- Able to wear a continuous glucose monitor and a chest strap heart rate monitor
- Able to provide written informed consent
Who cannot join
- History of major cardiovascular, cerebrovascular, respiratory, renal, hepatic, neurological, or other severe medical conditions that may affect study participation.
- Uncontrolled hypertension, defined as systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg.
- Current use of medications associated with a high risk of hypoglycemia, such as insulin or sulfonylureas.
- Initiation or dose change of insulin or oral glucose-lowering medications within the past 3 months.
- Initiation or dose change of medications for hypertension, dyslipidemia, or diabetes within the past 3 months.
- Musculoskeletal, neurological, or orthopedic conditions that limit safe participation in walking or body-weight resistance exercise, including severe knee, hip, back, or ankle pain.
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- Regular participation in moderate-to-vigorous exercise of 150 minutes or more per week during the past year.
- Difficulty consuming the standardized study meals, including food allergy, dietary restrictions, or severe gastrointestinal symptoms.
- Difficulty wearing a continuous glucose monitor or history of severe skin irritation or allergy to adhesive sensors.
- Difficulty wearing a chest strap heart rate monitor or skin problems at the chest strap site.
- Pregnancy or planned pregnancy.
- Acute illness, infection, surgery, or hospitalization within the past month.
- Current participation in another interventional study.
- Any condition judged by the investigator to make participation unsafe or inappropriate.
- -
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Postprandial Walking and Brief Resistance Exercise Snacks on Continuous Glucose and Heart Rate Variability Responses in Adults With Metabolic Syndrome and Prediabetes: A Randomized Crossover Trial
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks consisting of squats and calf raises performed every 20 minutes during the postprandial period. Continuous glucose monitoring will be used to assess 24-hour glucose responses, and heart rate variability will be measured during the 2-hour postprandial period to evaluate acute autonomic responses.
The main outcome is 24-hour mean glucose derived from continuous glucose monitoring.
Read the detailed description
Metabolic syndrome and prediabetes are associated with impaired glucose regulation and increased cardiometabolic risk. Light physical activity after meals may help reduce postprandial glucose excursions and improve overall daily glucose control. However, it remains unclear whether brief resistance exercise snacks can provide glucose benefits comparable to postprandial walking under standardized meal conditions.
This study is a randomized crossover trial in adults aged 40 to 65 years with metabolic syndrome and prediabetes. Each participant will complete three experimental conditions in a randomized order: prolonged sitting, 15 minutes of walking after a standardized meal, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. The resistance exercise snacks will consist of simple body-weight exercises, including squats and calf raises.
Glucose responses will be assessed using continuous glucose monitoring. The primary outcome will be 24-hour mean glucose after each experimental condition. Key secondary glycemic outcomes will include 2-hour postprandial glucose incremental area under the curve, 2-hour mean glucose, peak glucose, time to peak glucose, nocturnal mean glucose, and glycemic variability indices. Heart rate variability will be assessed during the 2-hour postprandial period using RR interval data collected with a chest strap heart rate monitor to evaluate acute autonomic responses to each condition.
The purpose of this study is to determine whether brief resistance exercise snacks can improve 24-hour glucose regulation and postprandial glucose responses compared with uninterrupted sitting, and whether these responses are comparable to postprandial walking.
- Conditions
- Metabolic Syndrome, Prediabetes
- Being tested
- Postprandial walking, Brief resistance exercise snacks
- Keywords
- Continuous glucose monitoring, Postprandial glucose, Exercise snack, Resistance exercise, Heart rate variability, Prediabetes, Metabolic syndrome
- Medical subject headings
- Metabolic Syndrome, Prediabetic State
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Postprandial walkingBehavioural
Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Walking intensity will be monitored using heart rate and rating of perceived exertion.
Brief resistance exercise snacksBehavioural
Participants will perform 3-minute bouts of body-weight resistance exercises every 20 minutes during the postprandial period after consuming a standardized meal. The exercise bouts will include squats and calf raises.
| Study group | Role | What they receive |
|---|---|---|
| Prolonged Sitting | No intervention | Participants will remain seated during the 2-hour postprandial period after consuming a standardized meal. |
| Postprandial Walking | Experimental | Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Receives: Behavioral: Postprandial walking |
| Brief Resistance Exercise Snacks | Experimental | Participants will perform 3-minute bouts of body-weight resistance exercises, including squats and calf raises, every 20 minutes during the postprandial period after consuming a standardized meal. Receives: Behavioral: Brief resistance exercise snacks |
What is being measured
The primary outcome is the main question the study is designed to answer.
24-hour mean glucose
Mean glucose over 24 hours after each experimental condition, derived from continuous glucose monitoring.
Measured: 24 hours after each experimental condition
Secondary outcomes (2)
2-hour postprandial glucose incremental area under the curve
The 2-hour postprandial glucose incremental area under the curve will be calculated from continuous glucose monitoring data after the standardized meal.
Measured: 0 to 120 minutes after the standardized meal
Change in RMSSD
Change in the root mean square of successive differences from the pre-meal resting baseline during the 2-hour postprandial period. RMSSD will be calculated from RR interval data collected with a chest strap heart rate monitor.
Measured: 0 to 120 minutes after the standardized meal
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jun 2026
- Study start15 Jun 2026 (estimated)
- Primary completionSep 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Metabolic SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. Each participant will serve as his or her own control.
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Seoul National University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yunmin Han, Seoul National University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07620886
- Sponsor's protocol ID
- SNU-CGM-EX-2026
- Other IDs
- 2601/001-020
- Acronym
- BITE
- Status last verified
- May 2026
- First submitted
- 27 May 2026
- Last updated
- 2 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 2 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Postprandial Walking and Brief Resistance Exercise Snacks on Continuous Glucose and Heart Rate Variability Responses in Adults With Metabolic Syndrome and Prediabetes: A Randomized Crossover Trial
- ClinicalTrials.gov ID
- NCT07620886
- Acronym / sponsor ID
- BITE / SNU-CGM-EX-2026
- Conditions
- Metabolic Syndrome, Prediabetes
- Keywords
- Continuous glucose monitoring, Postprandial glucose, Exercise snack, Resistance exercise, Heart rate variability, Prediabetes, Metabolic syndrome
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Seoul National UniversityUniversity, hospital or other
- Study start
- 15 Jun 2026 (estimated)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 2 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks consisting of squats and calf raises performed every 20 minutes during the postprandial period. Continuous glucose monitoring will be used to assess 24-hour glucose responses, and heart rate variability will be measured during the 2-hour postprandial period to evaluate acute autonomic responses.
The main outcome is 24-hour mean glucose derived from continuous glucose monitoring.
Detailed description
Metabolic syndrome and prediabetes are associated with impaired glucose regulation and increased cardiometabolic risk. Light physical activity after meals may help reduce postprandial glucose excursions and improve overall daily glucose control. However, it remains unclear whether brief resistance exercise snacks can provide glucose benefits comparable to postprandial walking under standardized meal conditions.
This study is a randomized crossover trial in adults aged 40 to 65 years with metabolic syndrome and prediabetes. Each participant will complete three experimental conditions in a randomized order: prolonged sitting, 15 minutes of walking after a standardized meal, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. The resistance exercise snacks will consist of simple body-weight exercises, including squats and calf raises.
Glucose responses will be assessed using continuous glucose monitoring. The primary outcome will be 24-hour mean glucose after each experimental condition. Key secondary glycemic outcomes will include 2-hour postprandial glucose incremental area under the curve, 2-hour mean glucose, peak glucose, time to peak glucose, nocturnal mean glucose, and glycemic variability indices. Heart rate variability will be assessed during the 2-hour postprandial period using RR interval data collected with a chest strap heart rate monitor to evaluate acute autonomic responses to each condition.
The purpose of this study is to determine whether brief resistance exercise snacks can improve 24-hour glucose regulation and postprandial glucose responses compared with uninterrupted sitting, and whether these responses are comparable to postprandial walking.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. Each participant will serve as his or her own control.
| Arm | Type | Receives |
|---|---|---|
| Prolonged Sitting | No intervention | –Participants will remain seated during the 2-hour postprandial period after consuming a standardized meal. |
| Postprandial Walking | Experimental | Behavioral: Postprandial walkingParticipants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. |
| Brief Resistance Exercise Snacks | Experimental | Behavioral: Brief resistance exercise snacksParticipants will perform 3-minute bouts of body-weight resistance exercises, including squats and calf raises, every 20 minutes during the postprandial period after consuming a standardized meal. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Adults aged 40 to 65 years
- Presence of metabolic syndrome
- Fasting glucose of 100 mg/dL or higher or HbA1c of 5.7% or higher
- Not regularly engaged in structured exercise training, defined as less than 150 minutes per week during the past year
- Able to consume the standardized study meals
Key exclusion criteria (15 listed)
- History of major cardiovascular, cerebrovascular, respiratory, renal, hepatic, neurological, or other severe medical conditions that may affect study participation.
- Uncontrolled hypertension, defined as systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg.
- Current use of medications associated with a high risk of hypoglycemia, such as insulin or sulfonylureas.
- Initiation or dose change of insulin or oral glucose-lowering medications within the past 3 months.
- Initiation or dose change of medications for hypertension, dyslipidemia, or diabetes within the past 3 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Postprandial walkingParticipants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Walking intensity will be monitored using heart rate and rating of perceived exertion. | Behavioural | Postprandial Walking |
| Brief resistance exercise snacksParticipants will perform 3-minute bouts of body-weight resistance exercises every 20 minutes during the postprandial period after consuming a standardized meal. The exercise bouts will include squats and calf raises. | Behavioural | Brief Resistance Exercise Snacks |
Primary outcome
24-hour mean glucose
Time frame: 24 hours after each experimental condition
Mean glucose over 24 hours after each experimental condition, derived from continuous glucose monitoring.
2 secondary outcomes
2-hour postprandial glucose incremental area under the curve
Time frame: 0 to 120 minutes after the standardized meal
Change in RMSSD
Time frame: 0 to 120 minutes after the standardized meal
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jun 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Postprandial walking and Brief resistance exercise snacks in people with Metabolic Syndrome and Prediabetes, run by Seoul National University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yunmin Han (+82-10-3537-2339, hym224@snu.ac.kr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
24-hour mean glucose (time frame: 24 hours after each experimental condition). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jun 2026.