Tooth Loss in the Esthetic Zone Requiring Immediate Implant PlacementSA-TCP ImplantNCT07613320

Silicate-Added Beta-TCP in Fully Guided Immediate Implants in the Esthetic Zone

A study testing Silicate-added β-TCP putty for jumping gap grafting and Conventional healing/ No graft in people with Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement and Bone Grafting, run by Mansoura University at 1 site in Egypt.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This study aims to evaluate bone and soft tissue changes clinically and digitally after using a customized healing Abutment with or without silicate-added beta-tricalcium phosphate (Si-β-TCP) putty. Read more about this study

Who is it for?: Ages 18 to 50 years
Conditions the study is for: Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Bone Grafting, Customized Healing Abutment
What is being tested?: Silicate-added β-TCP putty for jumping gap grafting and Conventional healing/ No graft
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 72 participants
Where: 1 siteEgypt
Study dates: 1 Dec 2025to 30 Jul 2026
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 50 years
All sexes
No healthy volunteers
Adult

Who may be able to join

Patients with non-restorable teeth in maxillary esthetic zone requiring dental extraction.
Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
Jumping gap more than 2mm.
Patients with good oral hygiene.
Patients willing to participate in the study's follow-up intervals.

Who cannot join

Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site impaired the immediate implant placement.
Alcohol or drug abuse.
Smokers.
Patients with systemic diseases that absolutely contraindicate implant placement (bleeding disorders, immunosuppression,…etc.)
Pregnancy.
Patients with para-functional habits (bruxism and clenching).
Lack of motivation or inability to maintain good oral hygiene.
-

Trial locations and contacts

1 site in 1 country.

Egypt1 site

Faculty of Dentistry Mansoura University
Al Mansurah, Dakahlia Governorate

Other trials in Egypt

About this study

Official title: Evaluation of Silicate-Added Beta-Tricalcium Phosphate Putty in Fully-Guided Immediate Implants in the Esthetic Zone Using Customized Healing Abutment

This study aims to evaluate bone and soft tissue changes clinically and digitally after using a customized healing Abutment with or without silicate-added beta-tricalcium phosphate (Si-β-TCP) putty.

Read the detailed description

Fully guided immediate implant placement in the esthetic zone presents challenges related to soft tissue closure, jumping gap management, and peri-implant stability. The use of silicate-added β-TCP putty with customized healing abutments has been proposed to improve soft tissue healing and maintain peri-implant architecture.

Conditions: Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Bone Grafting, Customized Healing Abutment, Immediate Dental Implant Placement
Being tested: Silicate-added β-TCP putty for jumping gap grafting, Conventional healing/ No graft
Keywords: Immediate implant placement, Fully-guided surgery, Esthetic zone, Customized healing abutment, Si-β-TCP putty

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Silicate-added β-TCP putty for jumping gap graftingProcedure or surgery
Application of silicate-added beta-tricalcium phosphate putty in the jumping gap around fully-guided immediate implants placed in the esthetic zone, combined with provisional crown as a customized healing abutment to enhance peri-implant soft tissue healing and ridge preservation.
Conventional healing/ No graftProcedure or surgery
Standard fully-guided implant placement protocol without the use of bone graft material allowing natural healing of the jumping gap around immediately placed implants in the esthetic zone.

Study groups in NCT07613320
Study group	Role	What they receive
Control group	Experimental	Immediate implant placement with customized healing abutment without Si-β-TCP putty in the esthetic zone. Receives: Procedure: Conventional healing/ No graft
Study group (Si-β-TCP Putty Group)	Experimental	Immediate implant placement with silicate-added beta-tricalcium phosphate putty and customized healing abutment in the esthetic zone. Receives: Procedure: Silicate-added β-TCP putty for jumping gap grafting

What is being measured

The primary outcome is the main question the study is designed to answer.

Implant stability
Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).
Measured: Immediate post-operative, 3 months, and 6 months.
Hard Tissue (Peri-implant bone)
Marginal bone loss will be assessed using CBCT measured in mm.
Measured: - Immediately after implant placement - 6 months after implant placement

Secondary outcomes (1)

Soft Tissue
Soft tissue contour and peri-implant tissue condition will be assessed using digital intraoral scanning (STL files) using superimposition and modified sulcus bleeding index (mSBI).
Measured: Baseline, 1 month, 3 months, and 6 months.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Dec 202530 Jul 2026

First posted29 May 2026
Study start1 Dec 2025
Primary completion30 Jun 2026
Study completion30 Jul 2026

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Tooth Loss in the Esthetic Zone Requiring Immediate Implant PlacementStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Double blind
Who is masked: Participant, Outcomes assessor
Enrolment: 72 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07613320
Sponsor's protocol ID: MS.26.01.119
Acronym: SA-TCP Implant
Status last verified: Sep 2026
First submitted: 22 May 2026
Last updated: 22 Sep 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Not yet recruiting
Immediate vs Conventional Loading With Different Crown Materials on Immediately Placed Single Implants
Partial Edentulism, Dental Implant

All Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement trials