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Depression and Anxiety SymptomsNCT07611253

The Effect of Loving-Kindness Meditation on Mood and Anxiety Symptoms, Interpersonal Relationships, and Emotions: An Initial Randomized Controlled Trial With a Non-Clinical Sample of Undergraduate Women

A study testing Loving-Kindness Meditation and Visualization in people with Depression and Anxiety Symptoms, run by Luis Flores at 1 site in Canada.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this clinical trial was to examine the effects of Loving-Kindness Meditation (LKM) on anhedonic depressivity, interpersonal relationships (other inclusive self-concept, willingness to sacrifice, interaction quality) and emotions (positive affect, negative affect). Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Depression and Anxiety Symptoms
What is being tested?
Loving-Kindness Meditation and Visualization
Could I receive a placebo?
No, everyone receives an active treatment
How many people
240 participants
Where
1 siteCanada
Study dates
13 Jan 2021to 11 Apr 2021
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Participants must be enrolled as an undergraduate student
  • Each Participant had to self-identify as a woman.
  • Participants had to be age 18 or older.
  • Participants had to have at least one close female platonic friend.

Who cannot join

  • Participants did not complete at least three of seven daily meditations.

Trial locations and contacts

1 site in 1 country.

Canada1 site
  • Queen's University

    Kingston, Ontario

Other trials in Canada

About this study

Official title: The Effect of Loving-Kindness Meditation on Anhedonic Depressivity, Interpersonal Relationships, and Emotions.

The goal of this clinical trial was to examine the effects of Loving-Kindness Meditation (LKM) on anhedonic depressivity, interpersonal relationships (other inclusive self-concept, willingness to sacrifice, interaction quality) and emotions (positive affect, negative affect).

The second aim was to conduct exploratory analyses investigating potential mediators that help explain changes in anhedonic depressivity over the course of short-term targeted LKM.

Participants were randomly assigned to receive one week of ~5-minute daily audio recordings of Loving-Kindness Meditation or a visualization meditation, both of which were focused on a same-gender close friend. Participants completed baseline and follow-up questionnaires measuring psychological, social, and emotional variables; participants also completed daily questionnaires.

Read the detailed description

Undergraduate women were recruited via the Queen's University psychology department's subject pool (n = 222) and online advertisements (i.e., Facebook; n = 18) in 2021; written informed consent was obtained from all participants prior to any data collection.

We randomly assigned participants-via Microsoft Excel random number generation-to engage in one-week of either a targeted form of Loving-Kindness Meditation or a visualization meditation. Participants identified a specific close friend at the beginning of the study to be the target of their meditation practice. They completed baseline and one-week follow-up measures.

Audio instructions for the LKM and visualization meditation conditions were developed for this study based on those used by Seppala et al. (2014). Recordings were delivered via email. Descriptions of the conditions can be found in the Arms and Interventions sections.

Being tested
Loving-Kindness Meditation, Visualization
Keywords
Meditation, Anhedonic Depression, Social Relationships, Positive Affect, Inclusion of the Other in the Self Scale, Loving-Kindness Meditation, Willingness to Sacrifice, Negative Affect, Rochester Interaction Record
Medical subject headings
Depression, Anxiety Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Loving-Kindness MeditationBehavioural

    Participants received a ~5 minute audio recording of Loving-Kindness Meditation Instructions everday for one week. Recordings were delivered via email. Meditators in both conditions were instructed to find a comfortable position, either sitting or lying down, and were then guided through some initial deep breathing. Once relaxed, meditators in the LKM condition were asked to imagine receiving love and wishes of well-being from a close other; they were then asked to direct feelings of love and wishes of wellness to their target close friend. After approximately 5 minutes, meditators were guided back to relaxation.

  • VisualizationBehavioural

    Participants received a ~5 minute audio recording of visualization Instructions everday for one week. Recordings were delivered via email. Meditators in both conditions were instructed to find a comfortable position, either sitting or lying down, and were then guided through some initial deep breathing. Meditators in the visualization condition were asked to visualize specific details of their target close friend's appearance. After approximately 5 minutes, meditators were guided back to relaxation.

Study groups in NCT07611253
Study groupRoleWhat they receive
Loving-Kindness MeditationExperimentalParticipants randomly assigned (via Microsoft Excel) to receive the Loving-Kindness Meditation intervention.
Receives: Behavioral: Loving-Kindness Meditation
Visualization MeditationActive comparatorParticipants randomly assigned (via Microsoft Excel) to receive the Visualization Meditation active comparator condition.
Receives: Behavioral: Visualization

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Anhedonic Depressivity

    The anhedonic depression scale of the Mood and Anxiety Symptom Questionnaire (MASQ; Clark \& Watson, 1991) was used to measure anhedonic depressivity. Participants rated items of the MASQ (Clark \& Watson, 1991) on a scale from 1-5 (1 = Not at All; 5 = Extremely) based on how they felt over the past week. The anhedonic depression subscale includes 22 items (e.g., "Felt like there wasn't anything interesting or fun to do"). A mean score was calculated, with higher scores indicating more anhedonic depressivity.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

Secondary outcomes (9)
  1. Positive Affect

    The Positive Affect Negative Affect Schedule (PANAS; Watson et al., 1988) was used to measure positive affect. The PANAS consists of 20 emotion words divided into two subscales (10 positive words and 10 negative words). Participants rate each emotion word on a scale from 1-5 (1 = Very Slightly or Not at All; 5 = Extremely) corresponding to how they have been feeling over the past week. The positive affect subscale contains emotion words such as: "Interested," "Excited," and "Inspired." A mean score was calculated for use in data analyses, with higher scores indicating greater positive affect.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  2. Willingness to Sacrifice

    The willingness to sacrifice scale is a two-item measure adapted from the Marburg Attitude Inventory for Styles of Loving (Bierhoff et al., 1993). Participants are asked to respond to the following questions on a scale from 1-10 (1 = Not at all; 10 = Entirely): "To what extent would you be willing to sacrifice your own desires for your close friend's desires?"; and "To what extent would you leave everything else aside for your close friend?". At baseline and follow-up, participants responded to these questions based on the previous week. For each administration, a mean score was calculated for use in data analyses.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  3. Other-Inclusive Self Concept

    The Inclusion of the Other in the Self Scale (IOS; Aron et al., 1992) is a one item measure composed of seven images of two increasingly overlapping circles labeled "self" and "other". Other-inclusive self-concept was measured with a modified IOS by asking participants to think about their relationship with their chosen close friend over the past week and to indicate the diagram that best matched their perceived connection. The IOS has convergent validity (Aron et al., 1992; Gächter et al., 2015) and discriminant validity (Aron et al., 1992) in relation to other established interpersonal closeness measures.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  4. Interaction Quality

    A modified version of the Rochester Interaction Record (M-RIR; based on Wheeler \& Reis, 1991) was used to measure interaction quality. The M-RIR asks participants to rate, from 1-7, the degree to which their interactions with their close other: 1) were intimate (1 = superficial; 7 = meaningful); 2) included self/other disclosure (1 = very little; 7 = a great deal); 3) were satisfying (1 = very unsatisfying; 7 = very satisfying); 4) were loving (1 = not at all loving; 7 = very loving); 5) were supportive (1 = not at all supportive; 7 = very supportive); and 6) were stressful (1 = not at all stressful; 7 = very stressful; reverse coded). At baseline and follow-up, participants completed the M-RIR for the past week. A mean score was calculated for use in data analyses, with higher scores indicating greater interaction quality.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  5. Anxious Arousal

    The anxious arousal subscale of the Mood and Anxiety Symptom Questionnaire (MASQ; Clark \& Watson, 1991) was used to measure anxious arousal.

    Participants rated items of the MASQ (Clark \& Watson, 1991) on a scale from 1-5 (1 = Not at All; 5 = Extremely) based on how they felt over the past week. The anxious arousal subscale includes 17 items (e.g., "Was trembling or shaking"). For each subscale, a mean score was calculated, with higher scores indicating more anxious arousal.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  6. Negative Affect

    The Positive Affect Negative Affect Schedule (PANAS; Watson et al., 1988) was used to measure negative affect. The PANAS consists of 20 emotion words divided into two subscales (10 positive words and 10 negative words). Participants rate each emotion word on a scale from 1-5 (1 = Very Slightly or Not at All; 5 = Extremely) corresponding to how they have been feeling over the past week. The negative affect subscale contains emotion words such as "Hostile", "Irritable", and "Ashamed'". A mean score was calculated for use in data analyses, with higher scores indicating greater negative affect.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  7. Emotional Closeness

    Emotional closeness was measured using a modified 10-item version of the Emotional Closeness Questionnaire (ECQ; Flores \& Berenbaum, 2012, 2014). The ECQ presents participants with 10 statements that reflect aspects of emotional closeness (e.g., "my friend gave me emotional support", "I shared my personal thoughts or feelings with my friend"). Respondents rate the degree each of these statements happened over the past week on a scale of 1 (not at all) to 5 (extremely). Scores from each question are averaged to create an overall score with higher scores indicating higher levels of emotional closeness (Flores \& Berenbaum, 2012, 2014). This questionnaire was modified to ask respondents to specifically consider the close other they chose at the beginning of the study.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  8. Desired Emotional Closeness

    Desired emotional closeness was measured using a modified 10-item version of the Emotional Closeness Questionnaire (ECQ; Flores \& Berenbaum, 2012, 2014). The D-ECQ presents participants with 5 statements that reflect aspects of emotional closeness (e.g., "my friend gives me emotional support", "I share my personal thoughts or feelings with my friend"). Respondents rate the degree to which they would have liked each of these statements to have happened over the past week on a scale of 1 (not at all) to 5 (extremely). Scores from each question are averaged to create an overall score with higher scores indicating a higher desire for emotional closeness (Flores \& Berenbaum, 2012, 2014). This questionnaire was modified to ask respondents to specifically consider the close other they chose at the beginning of the study.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

  9. Worry

    The Penn State Worry Questionnaire (PSWQ; Meyer et al., 1990) was used to measure worry. The PSWQ asks participants to rate the degree to which 16 statements related to worry are typical or characteristic of them (e.g., "My worries overwhelm me", "Once I start worrying, I can't stop"). Respondents rate each item on a scale from 1 (not at all typical) to 5 (very typical; Meyer et al., 1990). A mean score was generated for each participant with higher scores indicating higher levels of worry.

    Measured: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted28 May 2026
  2. Study start13 Jan 2021
  3. Primary completion11 Apr 2021
  4. Study completion11 Apr 2021

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
240 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07611253
Sponsor's protocol ID
rf#1025416
Status last verified
May 2026
First submitted
1 May 2026
Last updated
28 May 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Deidentified participant data will be shared on Open Science Framework. Only IPD used in the results publication will be shared.

Publications

  • Flores Jr, L. E., & Berenbaum, H. (2014). Desired emotional closeness moderates the prospective relations between levels of perceived emotional closeness and psychological distress. Journal of Social and Clinical Psychology, 33(8), 673-700. https://doi.org/10.1521/jscp.2014.33.8.673

  • Flores Jr, L. E., & Berenbaum, H. (2012). Desire for emotional closeness moderates the effectiveness of the social regulation of emotion. Personality and Individual Differences, 53(8), 952-957. https://doi.org/10.1016/j.paid.2012.07.009

  • Meyer TJ, Miller ML, Metzger RL, Borkovec TD. Development and validation of the Penn State Worry Questionnaire. Behav Res Ther. 1990;28(6):487-95. doi: 10.1016/0005-7967(90)90135-6.

    PubMed 2076086
  • Hayes, A. F. (2018). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach (2nd ed.) Guilford publications.

  • Hayes, A. F. (2012). PROCESS: A versatile computational tool for observed variable mediation, moderation, and conditional process modeling [White paper]. Retrieved from http://www.afhayes.com/public/process2012.pdf

  • Trautwein FM, Naranjo JR, Schmidt S. Decentering the Self? Reduced Bias in Self- vs. Other-Related Processing in Long-Term Practitioners of Loving-Kindness Meditation. Front Psychol. 2016 Nov 21;7:1785. doi: 10.3389/fpsyg.2016.01785. eCollection 2016.

    PubMed 27917136
  • Bierhoff, H. W., Grau, I., & Ludwig, A. (1993). Marburger Einstellungsinventar zu Liebesstilen (MEIL). Hogrefe.

  • Wheeler, L., & Reis, H. T., (1991). Self-recording of everyday life events: Origins, types, and uses. Journal of Personality, 59, 339-354. doi:10.1111/j.1467-6494.1991.tb00252.x

  • Aron, A., Aron, E. N., & Smollan, D. (1992). Inclusion of the other in the self scale and the structure of interpersonal closeness. Journal of Personality and Social Psychology, 63(4), 596-612. https://doi.org/10.1037/0022-3514.63.4.596

  • Seppala, E.M., Hutcherson, C.A., Nguyen, D.T., Hutcheson, C. A., & Gross, J. J. (2014). Loving-kindness meditation: A tool to improve healthcare provider compassion, resilience, and patient care. Journal of Compassionate Health Care, 1(1), 1-9. https://doi.org/10.1186/s40639-014-0005-9

  • Gachter S, Starmer C, Tufano F. Measuring the Closeness of Relationships: A Comprehensive Evaluation of the 'Inclusion of the Other in the Self' Scale. PLoS One. 2015 Jun 12;10(6):e0129478. doi: 10.1371/journal.pone.0129478. eCollection 2015.

    PubMed 26068873
  • Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988 Jun;54(6):1063-70. doi: 10.1037//0022-3514.54.6.1063.

    PubMed 3397865
  • Clark LA, Watson D. Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. J Abnorm Psychol. 1991 Aug;100(3):316-36. doi: 10.1037//0021-843x.100.3.316.

    PubMed 1918611

Questions about this trial

What is this clinical trial studying?

A study testing Loving-Kindness Meditation and Visualization in people with Depression and Anxiety Symptoms, run by Luis Flores at 1 site in Canada.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 28 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Anhedonic Depressivity (time frame: Assessed once at baseline (Day 0) and once at follow-up after the intervention (follow up sent on Day 8).). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07611253, which also lists 13 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2026.

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