Chronic UrticariaNUHISTRANCT07611032
A Single-Arm Exploratory Study of NatureU Hista Dissolve on Chronic Urticaria Symptoms
A study testing NatureU Histra Disslove in people with Chronic Urticaria and Urticaria, run by OmniSolutions Laboratory Holdings Limited at 1 site in China.
Trial summary
This was a single-center, open-label, single-arm, exploratory self-controlled study evaluating NatureU Histra Disslove in adults with chronic urticaria symptoms. Twenty-four participants were screened, 19 participants were enrolled, and 19 participants completed the study and were included in the effectiveness… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Chronic Urticaria, Urticaria, Angioedema
- What is being tested?
- NatureU Histra Disslove
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 19 participants
- Where
- 1 siteChina
- Study dates
- 4 Oct 2024to 1 Nov 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants who signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
- Adults diagnosed with chronic urticaria by a dermatologist based on clinical symptoms and medical history.
- Age 18 to 65 years.
- Participants with typical wheals with itching and/or angioedema symptoms of chronic urticaria and either a Urticaria Activity Score 7 of at least 7 or a Urticaria Control Test score below 12.
- Participants willing to maintain normal healthy routines during the study, avoid alcohol, and avoid foods likely to trigger allergic reactions.
Who cannot join
- Severe internal organ disease, including heart disease, kidney disease, or other serious disease that could affect product metabolism.
- Known allergy or intolerance to any ingredient of the study product.
- Other skin disease or systemic disease that could affect urticaria manifestations.
- Participation in another clinical trial or use of prohibited drug treatment.
- Heavy smoking, alcohol abuse, or other lifestyle factors that could affect study results.
- Severe psychological disorder or cognitive impairment that could affect compliance.
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- Inability to follow study dietary restrictions or requirements because of religious or personal reasons.
- Abnormal blood routine, liver function, kidney function, or other laboratory test results outside the normal range.
- Population for whom the product was contraindicated, including minors, participants planning pregnancy, pregnant or lactating participants, participants with liver or kidney disease history, and participants taking long-term medication.
- Any other factor judged by the investigator to make participation inappropriate.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Single-Center, Open-Label, Single-Arm Exploratory Self-Controlled Study of NatureU Histra Disslove on Urticaria Control, Urticaria Activity, and Dermatology Quality of Life in Adults With Chronic Urticaria Symptoms
This was a single-center, open-label, single-arm, exploratory self-controlled study evaluating NatureU Histra Disslove in adults with chronic urticaria symptoms. Twenty-four participants were screened, 19 participants were enrolled, and 19 participants completed the study and were included in the effectiveness analysis. Participants took one tablet of the study product orally once daily, 20 minutes before a main meal, for 28 consecutive days. Urticaria Control Test, Urticaria Activity Score 7, and Dermatology Life Quality Index assessments were performed at baseline, Day 14, and Day 28. Safety was monitored during the study.
Read the detailed description
The study was designed as an exploratory human evaluation of a food product containing active diamine oxidase (DAO). Screening was conducted from August 29, 2024 through October 4, 2024. After investigator review of the inclusion and exclusion criteria, 19 adults with chronic urticaria symptoms were enrolled on October 4, 2024. Participants received NatureU Histra Disslove at the study center on Day 0 and took the product continuously for 28 days through Day 28. The protocol specified oral intake of one tablet 20 minutes before a main meal, preferably dinner. Outcome assessments included the Urticaria Control Test (UCT), Urticaria Activity Score 7 (UAS7), and Dermatology Life Quality Index (DLQI) at Day 0, Day 14, and Day 28. Safety monitoring included adverse event collection and laboratory safety assessment. The study was open-label, single-arm, and self-controlled, with no placebo or parallel control group. Analyses were based on participants who completed the study assessments.
- Conditions
- Chronic Urticaria, Urticaria, Angioedema
- Being tested
- NatureU Histra Disslove
- Keywords
- NatureU Histra Disslove, NatureU Yan, diamine oxidase, DAO, chronic urticaria, Urticaria Control Test, Urticaria Activity Score 7, Dermatology Life Quality Index
- Medical subject headings
- Chronic Urticaria, Urticaria, Angioedema
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NatureU Histra DissloveDietary supplement
NatureU Histra Disslove is a food product containing active diamine oxidase (DAO). Participants took one tablet orally once daily, 20 minutes before a main meal, preferably dinner, for 28 consecutive days.
| Study group | Role | What they receive |
|---|---|---|
| NatureU Histra Disslove | Experimental | Participants received NatureU Histra Disslove, one tablet orally once daily 20 minutes before a main meal for 28 consecutive days. Receives: Dietary Supplement: NatureU Histra Disslove |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change From Baseline in Urticaria Control Test Score
The Urticaria Control Test (UCT) was used to assess urticaria control. UCT ranges from 0 to 16, with higher scores indicating better urticaria control. The primary endpoint was within-participant change from baseline after 28 days of product intake.
Measured: Baseline, Day 14, and Day 28
Secondary outcomes (2)
Change From Baseline in Urticaria Activity Score 7
Urticaria Activity Score 7 (UAS7) was calculated from daily wheal and itch scores over 7 consecutive days. The total score ranges from 0 to 42, with lower scores indicating lower urticaria activity. The secondary endpoint was within-participant change from baseline after 28 days of product intake.
Measured: Baseline, Day 14, and Day 28
Change From Baseline in Dermatology Life Quality Index
The Dermatology Life Quality Index (DLQI) was used to assess skin-disease-related quality of life. The total score ranges from 0 to 30, with higher scores indicating worse quality of life. The secondary endpoint was within-participant change from baseline after 28 days of product intake.
Measured: Baseline, Day 14, and Day 28
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 May 2026
- Study start4 Oct 2024
- Primary completion1 Nov 2024
- Study completion1 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic UrticariaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants received NatureU Histra Disslove for 28 consecutive days in a single-arm self-controlled exploratory design.
- Masking
- None (open label)
- Enrolment
- 19 participants (actual)
Sponsor and investigators
- Lead sponsor
- OmniSolutions Laboratory Holdings Limited
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07611032
- Sponsor's protocol ID
- SP-CTI-DX006
- Other IDs
- 2024080001
- Acronym
- NUHISTRA
- Status last verified
- Jul 2026
- First submitted
- 15 May 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Single-Center, Open-Label, Single-Arm Exploratory Self-Controlled Study of NatureU Histra Disslove on Urticaria Control, Urticaria Activity, and Dermatology Quality of Life in Adults With Chronic Urticaria Symptoms
- ClinicalTrials.gov ID
- NCT07611032
- Acronym / sponsor ID
- NUHISTRA / SP-CTI-DX006
- Conditions
- Chronic Urticaria, Urticaria, Angioedema
- Keywords
- NatureU Histra Disslove, NatureU Yan, diamine oxidase, DAO, chronic urticaria, Urticaria Control Test, Urticaria Activity Score 7, Dermatology Life Quality Index
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 19 participants (actual)
- Lead sponsor
- OmniSolutions Laboratory Holdings LimitedIndustry (pharma, biotech, devices)
- Study start
- 4 Oct 2024 (actual)
- Primary completion
- 1 Nov 2024 (actual)
- Study completion
- 1 Nov 2024 (actual)
- First posted
- 28 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This was a single-center, open-label, single-arm, exploratory self-controlled study evaluating NatureU Histra Disslove in adults with chronic urticaria symptoms. Twenty-four participants were screened, 19 participants were enrolled, and 19 participants completed the study and were included in the effectiveness analysis. Participants took one tablet of the study product orally once daily, 20 minutes before a main meal, for 28 consecutive days. Urticaria Control Test, Urticaria Activity Score 7, and Dermatology Life Quality Index assessments were performed at baseline, Day 14, and Day 28. Safety was monitored during the study.
Detailed description
The study was designed as an exploratory human evaluation of a food product containing active diamine oxidase (DAO). Screening was conducted from August 29, 2024 through October 4, 2024. After investigator review of the inclusion and exclusion criteria, 19 adults with chronic urticaria symptoms were enrolled on October 4, 2024. Participants received NatureU Histra Disslove at the study center on Day 0 and took the product continuously for 28 days through Day 28. The protocol specified oral intake of one tablet 20 minutes before a main meal, preferably dinner. Outcome assessments included the Urticaria Control Test (UCT), Urticaria Activity Score 7 (UAS7), and Dermatology Life Quality Index (DLQI) at Day 0, Day 14, and Day 28. Safety monitoring included adverse event collection and laboratory safety assessment. The study was open-label, single-arm, and self-controlled, with no placebo or parallel control group. Analyses were based on participants who completed the study assessments.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants received NatureU Histra Disslove for 28 consecutive days in a single-arm self-controlled exploratory design.
| Arm | Type | Receives |
|---|---|---|
| NatureU Histra Disslove | Experimental | Dietary Supplement: NatureU Histra DissloveParticipants received NatureU Histra Disslove, one tablet orally once daily 20 minutes before a main meal for 28 consecutive days. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Participants who signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
- Adults diagnosed with chronic urticaria by a dermatologist based on clinical symptoms and medical history.
- Age 18 to 65 years.
- Participants with typical wheals with itching and/or angioedema symptoms of chronic urticaria and either a Urticaria Activity Score 7 of at least 7 or a Urticaria Control Test score below 12.
- Participants willing to maintain normal healthy routines during the study, avoid alcohol, and avoid foods likely to trigger allergic reactions.
Key exclusion criteria (10 listed)
- Severe internal organ disease, including heart disease, kidney disease, or other serious disease that could affect product metabolism.
- Known allergy or intolerance to any ingredient of the study product.
- Other skin disease or systemic disease that could affect urticaria manifestations.
- Participation in another clinical trial or use of prohibited drug treatment.
- Heavy smoking, alcohol abuse, or other lifestyle factors that could affect study results.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NatureU Histra DissloveNatureU Histra Disslove is a food product containing active diamine oxidase (DAO). Participants took one tablet orally once daily, 20 minutes before a main meal, preferably dinner, for 28 consecutive days. | Dietary supplement | NatureU Histra Disslove |
Primary outcome
Change From Baseline in Urticaria Control Test Score
Time frame: Baseline, Day 14, and Day 28
The Urticaria Control Test (UCT) was used to assess urticaria control. UCT ranges from 0 to 16, with higher scores indicating better urticaria control. The primary endpoint was within-participant change from baseline after 28 days of product intake.
2 secondary outcomes
Change From Baseline in Urticaria Activity Score 7
Time frame: Baseline, Day 14, and Day 28
Change From Baseline in Dermatology Life Quality Index
Time frame: Baseline, Day 14, and Day 28
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NatureU Histra Disslove in people with Chronic Urticaria and Urticaria, run by OmniSolutions Laboratory Holdings Limited at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change From Baseline in Urticaria Control Test Score (time frame: Baseline, Day 14, and Day 28). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.