Predictors of Transmural Non-Occlusive Mesenteric Ischemia in ICU Patients With Suspected Acute Mesenteric Ischemia

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

• Ages 18 years and older
• All sexes
• No healthy volunteers
• Adult, Older adult

Study population: All adult patients who develop suspicion of acute mesenteric ischemia during their ICU stay will be included in the study. The study will take place in the ICUs of the two largest hospitals in Estonia: Tartu University Hospital and North Estonian Medical Centre.

Trial locations and contacts

2 sites in 1 country. Contact the study team or a site near you to ask about taking part.

About this study

Official title: Mesenteric Ischemia in the ICU: A Prospective Observational Study Across Estonian Regional Hospitals

Conditions

Non-Occlusive Mesenteric Ischaemia (NOMI), Acute Mesenteric Ischemia

Being tested

Observation

Keywords

Acute mesenteric ischemia, non-occlusive mesenteric ischemia, transmural necrosis, predictors

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

• ObservationOther

  This is a prospective observational study on ICU patients with the suspicion of acute mesenteric ischemia. No intervention is done.

What is being measured

The primary outcome is the main question the study is designed to answer.

1. Predictors of transmural necrosis in NOMI - age-adjusted Charlson comorbidity index

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • age-adjusted Charlson comorbidity index (Range 0 - 37 points). A higher score indicates a higher chance of 10-year mortality.

   Measured: Baseline

2. Predictors of transmural necrosis in NOMI patients - SOFA score

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Sequential Organ Failure Assessment (SOFA) score (Range 0 - 24 points). Higher scores indicate more severe organ dysfunction.

   Measured: Baseline

3. Predictors of transmural necrosis in NOMI patients - GRV

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Gastric residual volume (GRV) greater than 500 ml at any point within the 48 hours prior to the suspicion of acute mesenteric ischemia (AMI) will be recorded as a Yes or No variable. A high GRV indicates feeding intolerance, which may suggest non-occlusive mesenteric ischemia. This is a retrospective variable. After a patient is enrolled in the study, the patient's ICU datasheet will be retrospectively analyzed to determine if there was a GRV above 500 ml. If such an event occurred within the 48 hours prior to inclusion, the variable will be considered positive (Yes); if not, it will be considered negative (No).

   Measured: Baseline

4. Predictors of transmural ischemia in NOMI patients - bloody stool.

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Presence of bloody stool. Yes or No variable. Bloody stool might indicate gastrointestinal ischemia.

   Measured: Baseline

5. Predictors of transmural ischemia in NOMI patients - cardiac arrest.

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Cardiac arrest. Yes or No variable. If the patient was hospitalised due to cardiac arrest, then Yes, if not, then No. Cardiac arrest is a risk factor for developing NOMI.

   Measured: Baseline

6. Predictors of transmural ischemia in NOMI patients - RRT

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Need for renal replacement therapy (RRT) prior to suspicion of AMI. The variable is a Yes or No question. Once a patient is enrolled in the study, a retrospective analysis of their data sheet will be conducted to determine if the patient received renal replacement therapy (RRT) during their hospital stay prior to their inclusion in the study. RRT is a risk factor for developing non-occlusive mesenteric ischemia.

   Measured: Baseline

7. Predictors of transmural ischemia in NOMI patients - WBC.

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Highest White blood cell (WBC) levels within 72 hours prior to suspicion of acute mesenteric ischemia. Units: 10*12 /L. The highest WBC value within the 72 hours prior to suspicion of AMI will be recorded. Higher values indicate a more severe inflammatory response.

   Measured: Baseline

8. Predictors of transmural ischemia in NOMI patients - CRP

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • C-reactive protein (CRP). Units: mg/L. The highest CRP value within the 72 hours prior to suspicion of AMI will be recorded. Higher values indicate a severe inflammatory response.

   Measured: Baseline

9. Predictors of transmural ischemia in NOMI patients - lactate

   To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

   Variable:

   • Highest lactate value. Units: mmol/L. The highest lactate value within the 12 hours prior to suspicion of AMI will be recorded. Higher values indicate worse tissue perfusion.

   Measured: Baseline

10. Predictors of transmural ischemia in NOMI patients - pneumatosis intestinalis

    To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

    Variable:

    • Pneumatosis intestinalis. Yes or No variable.In patients suspected of acute mesenteric ischemia, the presence of pneumatosis intestinalis observed on computed tomography will be documented. The presence of pneumatosis intestinalis can indicate mesenteric ischemia.

    Measured: Baseline

11. Predictors of transmural ischemia in NOMI patients - bowel wall enhancement

    To identify independent predictors of transmural necrosis in patients with non-occlusive mesenteric ischemia.

    Variable:

    • Decreased bowel wall enhancement on the computed tomography. Yes or No variable. In patients suspected of acute mesenteric ischemia, the decrease in bowel wall enhancement observed on computed tomography will be documented. The decrease in bowel wall enhancement on CT can indicate mesenteric ischemia.

    Measured: Baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1. First posted28 May 2026
2. Study start6 Jun 2022
3. Primary completion5 Jun 2026 (estimated)
4. Study completion5 Sep 2026 (estimated)

Resources

• Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
• Other trials for Non-Occlusive Mesenteric Ischaemia (NOMI)Studies of the same condition, open and under way.
• What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.