AzTrials
AzTrials

Tooth Extraction Site HealingSPADNCT07608289

Socket Preservation Using Autogenous Dentin

A study testing Tooth extraction left to heal spontaneously, Tooth extraction plus collagen sponge and Tooth extraction plus tricalcium phosphate in people with Tooth Extraction Site Healing, run by University of Ostrava at 1 site in Czechia.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining… Read more about this study

Who is it for?
Ages 18 to 70 years
Conditions the study is for
Tooth Extraction Site Healing
What is being tested?
Tooth extraction left to heal spontaneously, Tooth extraction plus collagen sponge and Tooth extraction plus tricalcium phosphate
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
80 participants
Where
1 siteCzechia
Study dates
1 Jan 2025to 31 Dec 2028
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 70 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • 18-70 years
  • no active periodontitis
  • signed informed consent with participation in the study
  • need for extraction of teeth other than third molars
  • patients requesting only standard/reimbursed care

Who cannot join

  • drug or alcohol abuse
  • ongoing chemotherapy
  • ongoing radiotherapy
  • pregnancy
  • ongoing treatment of osteoporosis or other biological treatment with MRONJ risk
  • low compliance
  • patients asking for premium care

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Petr Jalůvka, MDDr. contact

+420 596 623 518

petr.jaluvka@osu.cz

Czechia1 site, 1 recruiting

  • University Hospital Ostrava

    Ostrava, 70852

    Martin Starosta, Assoc. Prof. MUDr., Ph.D., martin.starosta@osu.cz

    Petr Jalůvka, MDDr.

    Recruiting

Other trials in Czechia

About this study

Official title: Socket Preservation After Tooth Extraction Using Autogenous Dentin in Comparison With Other Techniques

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.

Read the detailed description

The study evaluates four different approaches to alveolar ridge preservation after tooth extraction. Eligible patients aged 18-70 years will undergo minimally traumatic extraction. Four treatment modalities will be compared: 1) Spontaneous healing secured with a stitch (control group), 2) Application of collagen sponge (Parasorb Cone, Resorba, Germany) secured with a stitch, 3) Application of a tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic) covered with a collagen sponge (Parasorb Cone) and secured with a stitch. 4) Application of autogenous dentin, covered with a collagen sponge (Parasorb Cone) and secured with a stitch. Alveolar ridge dimensions will be measured on CBCT before extraction and again after six months. Primary outcomes include the absolute and relative change in ridge width and height at 1 mm, 3 mm, and 5 mm below the highest point of the alveolar bone as per Del Canto-Díaz, 2019. Patient factors (periodontal biotype, soft tissue phenotype, and vestibular thickness of the alveolar bone) will be recorded to allow subgroup analysis.

Being tested
Tooth extraction left to heal spontaneously, Tooth extraction plus collagen sponge, Tooth extraction plus tricalcium phosphate, Tooth extraction plus autogenous dentin
Keywords
Socket preservation, autogenous dentin, tooth extraction, alveolar ridge augmentation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Tooth extraction left to heal spontaneouslyProcedure or surgery

    Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material.

  • Tooth extraction plus collagen spongeProcedure or surgery

    Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.

  • Tooth extraction plus tricalcium phosphateProcedure or surgery

    Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

  • Tooth extraction plus autogenous dentinProcedure or surgery

    Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Study groups in NCT07608289
Study groupRoleWhat they receive
Spontaneous healing secured with a stitch (control group)Active comparatorWound after the tooth extraction will be secured with a stitch without addition of any augmentation material.
Receives: Procedure: Tooth extraction left to heal spontaneously
Colagen spongeExperimentalWound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.
Receives: Procedure: Tooth extraction plus collagen sponge
Tricalcium phosphate xenograftExperimentalWound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.
Receives: Procedure: Tooth extraction plus tricalcium phosphate
Autogenous dentinExperimentalWound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.
Receives: Procedure: Tooth extraction plus autogenous dentin

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Alveolar bone width

    Absolute and relative change in the alveolar bone width at 1 mm, 3 mm, and 5 mm below the alveolar crest measured from CBCT imagery.

    Measured: 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 May 2026
  2. Study start1 Jan 2025
  3. Primary completion31 Dec 2027 (estimated)
  4. Study completion31 Dec 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
80 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07608289
Sponsor's protocol ID
SPAD
Acronym
SPAD
Status last verified
May 2026
First submitted
30 Apr 2026
Last updated
27 May 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Yuceer-Cetiner E, Ozkan N, Onger ME. Effect of Autogenous Dentin Graft on New Bone Formation. J Craniofac Surg. 2021 Jun 1;32(4):1354-1360. doi: 10.1097/SCS.0000000000007403.

    PubMed 33405453

  • Lopez Sacristan H, Del Canto Pingarron M, Alobera Gracia MA, de Elio Oliveros J, Diaz Pedrero R, Seco-Calvo J. Use of autologous tooth-derived material as a graft in the post-extraction socket. Split-mouth study with radiological and histological analysis. BMC Oral Health. 2024 Jul 23;24(1):832. doi: 10.1186/s12903-024-04576-0.

    PubMed 39044178

  • Isola G, Santonocito S, Di Tommasi S, Torrisi S, Iorio-Siciliano V, Caltabiano R, Ramaglia L, Torrisi P. Use of Autogenous Tooth-Derived Mineralized Dentin Matrix in the Alveolar Ridge Preservation Technique: Clinical and Histologic Evaluation. Int J Periodontics Restorative Dent. 2022 Jul-Aug;42(4):497-504. doi: 10.11607/prd.6170.

    PubMed 35830314

  • Yang F, Ruan Y, Bai X, Li Q, Tang X, Chen J, Chen Y, Wang L. Alveolar ridge preservation in sockets with severe periodontal destruction using autogenous partially demineralized dentin matrix: A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Dec;25(6):1019-1032. doi: 10.1111/cid.13247. Epub 2023 Jul 16.

    PubMed 37455372

  • Hussain AA, Al-Quisi AF, Abdulkareem AA. Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial. Biomed Res Int. 2023 Dec 27;2023:7932432. doi: 10.1155/2023/7932432. eCollection 2023.

    PubMed 38179035

  • Del Canto-Diaz A, de Elio-Oliveros J, Del Canto-Diaz M, Alobera-Gracia MA, Del Canto-Pingarron M, Martinez-Gonzalez JM. Use of autologous tooth-derived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e53-e60. doi: 10.4317/medoral.22536.

    PubMed 30573707

Questions about this trial

What is this clinical trial studying?

A study testing Tooth extraction left to heal spontaneously, Tooth extraction plus collagen sponge and Tooth extraction plus tricalcium phosphate in people with Tooth Extraction Site Healing, run by University of Ostrava at 1 site in Czechia.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Czechia. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Petr Jalůvka, MDDr. (+420 596 623 518, petr.jaluvka@osu.cz), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Alveolar bone width (time frame: 6 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07608289, which also lists 6 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026; AzTrials last refreshed its copy on 27 Oct 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in