ColonoscopyNCT07608120
Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation
A study testing PEG With Water, PEG With Low-dose Electrolyte Beverage and PEG With Medium-dose Electrolyte Beverage in people with Colonoscopy and Bowel Preparation Solutions, run by Nanfang Hospital, Southern Medical University at 1 site in China.
Trial summary
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Colonoscopy, Bowel Preparation Solutions, Colorectal Cancer Screening
- What is being tested?
- PEG With Water, PEG With Low-dose Electrolyte Beverage and PEG With Medium-dose Electrolyte Beverage
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 405 participants
- Where
- 1 siteChina
- Study dates
- 18 May 2026to 31 May 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 18-75 years scheduled to undergo elective colonoscopy
- Meet the standard clinical indications for colonoscopy;
- Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
- Able to comply with study-related data collection and follow-up;
- Provide written informed consent voluntarily.
Who cannot join
- Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
- Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
- Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
- Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
- Pregnant or breastfeeding women;
- Any other condition considered by the investigators to make the participant unsuitable for the study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong
Aimin Li, +86 13580317630, lam0725@163.com
About this study
Official title: Randomized Controlled Trial of Different Ratios of Electrolyte Beverage and Water Combined With Polyethylene Glycol on Bowel Preparation Quality and Ingestion Rhythm Before Colonoscopy
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.
- Being tested
- PEG With Water, PEG With Low-dose Electrolyte Beverage, PEG With Medium-dose Electrolyte Beverage
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PEG With WaterOther
Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.
PEG With Low-dose Electrolyte BeverageOther
Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.
PEG With Medium-dose Electrolyte BeverageOther
Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.
| Study group | Role | What they receive |
|---|---|---|
| Water Group | Active comparator | Participants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy. Receives: Other: PEG With Water |
| Low-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy. Receives: Other: PEG With Low-dose Electrolyte Beverage |
| Medium-dose Electrolyte Beverage Group | Experimental | Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy. Receives: Other: PEG With Medium-dose Electrolyte Beverage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adequate Bowel Preparation Rate
Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.
Measured: At the time of colonoscopy on Day 1
Secondary outcomes (3)
Total Boston Bowel Preparation Scale Score
Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy.
Measured: At the time of colonoscopy on Day 1
Bowel Preparation Completion Rate
Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.
Measured: During bowel preparation within 1 hour before colonoscopy on Day 1
Adverse Event Rate
Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue.
Measured: During bowel preparation within 1 hour before colonoscopy on Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 May 2026
- Study start18 May 2026
- Primary completion31 Jan 2027 (estimated)
- Study completion31 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ColonoscopyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 405 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nanfang Hospital, Southern Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07608120
- Sponsor's protocol ID
- NFEC-2026-307
- Status last verified
- May 2026
- First submitted
- 18 May 2026
- Last updated
- 27 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No