Lower Extremity Explosive Power DeficitNCT07604948
Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period
A study testing Ischemic Preconditioning in people with Lower Extremity Explosive Power Deficit and Sports Recovery, run by Guangzhou Sport University at 1 site in China.
Trial summary
This study aimed to evaluate the effects of ischemic preconditioning on lower limb explosive power and post-exercise recovery in basketball players during a 6-week post-season recovery training period. Read more about this study
- Who is it for?
- Ages 18 to 25 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Lower Extremity Explosive Power Deficit, Sports Recovery, Basketball Performance
- What is being tested?
- Ischemic Preconditioning
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 34 participants
- Where
- 1 siteChina
- Study dates
- 22 May 2026to 15 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male basketball students at Guangzhou Sport University.
- Regular participants in basketball training/practice.
- Healthy adults without cardiovascular, hepatic, renal, digestive, neurological, or metabolic diseases.
- Blood pressure within normal range.
- No history of lower extremity musculoskeletal injury within the past 6 months.
- Not currently using any performance-enhancing substances or medications affecting hormones/metabolism.
- Voluntary participation with signed informed consent.
Who cannot join
- Presence of acute or chronic diseases affecting exercise performance.
- History of deep vein thrombosis or coagulation disorders.
- Presence of skin lesions or infections at the thigh cuff placement site.
- Participation in other concurrent lower extremity strength/power training programs outside the study.
- Use of dietary supplements known to affect muscle metabolism within 4 weeks prior to enrollment.
- Inability to complete the full 6-week intervention and testing protocol.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Guangzhou Sport University
Guangzhou, Guangdong, 510430
Ziyue Ou, PHD, 15626121623, 105852022100090@stu.gzsport.edu.cn
About this study
Official title: Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period: A Randomized Controlled Trial
This study aimed to evaluate the effects of ischemic preconditioning on lower limb explosive power and post-exercise recovery in basketball players during a 6-week post-season recovery training period. Thirty-four male collegiate basketball players were randomly assigned to either an IPC group or a placebo control group. Bilateral lower limb IPC intervention (3 cycles, each consisting of 5-minute ischemia at 220 mmHg and 5-minute reperfusion, twice per week for 6 weeks) was administered before routine basketball training sessions. Lower limb explosive power, as well as physiological, biochemical, and morphological indices, were assessed before and after the intervention.
Read the detailed description
Background: Lower limb explosive power is crucial for basketball performance, and effective recovery strategies are key to maintaining training quality. Ischemic preconditioning (IPC) is a non-invasive, economical, and safe method that triggers endogenous protective mechanisms through brief ischemia-reperfusion cycles, showing potential in enhancing athletic performance and metabolic efficiency. However, the effects of IPC on lower limb explosive power during post-match recovery in basketball players remain understudied. Objective: To investigate the effects of a 6-week repeated remote ischemic preconditioning on lower limb explosive power, phosphagen energy system capacity, and physical recovery in male college basketball players. Design: A randomized, parallel-group, placebo-controlled trial with concealed allocation. Participants were randomly assigned to either the IPC experimental group (n=17) or the placebo control group (n=17). Both groups participated in the same regular basketball sessions. The experimental group received bilateral thigh IPC intervention (3×5 minutes, 220 mmHg) before each training session, while the control group received a placebo intervention (3×5 minutes, 20 mmHg). The intervention was administered twice a week for 6 weeks (30 minutes per session). Secondary endpoints: Urinary creatinine coefficient, 10-second maximal load test (blood lactate increment, peak power, mean power), hematological parameters (red blood cell count, hemoglobin, hematocrit, white blood cell count), serum testosterone, cortisol, testosterone/cortisol ratio, body composition (body weight, body fat percentage, BMI), and training load monitoring (heart rate, RPE, urine protein).
- Conditions
- Lower Extremity Explosive Power Deficit, Sports Recovery, Basketball Performance, Muscle Fatigue
- Being tested
- Ischemic Preconditioning, Placebo Ischemic Preconditioning
- Keywords
- Ischemic preconditioning, Basketball, Lower extremity explosiveness, Physical recovery, Post-match recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ischemic PreconditioningDevice
Bilateral thigh compression was applied using a Theratools pneumatic cuff (T-bfr-0475). Three cycles, each consisting of 5 minutes of ischemia (pressure 220 mmHg) and 5 minutes of reperfusion (total 30 minutes), were performed before regular basketball training sessions. The intervention was conducted twice per week for 6 weeks. Cuff placement: at the inguinal crease of the thigh. Subject position: supine, alternating between left and right legs.
Placebo Ischemic PreconditioningDevice
Identical procedure to IPC group except cuff pressure maintained at 20 mmHg (non-ischemic), applied before regular basketball training. Twice weekly for 6 weeks.
| Study group | Role | What they receive |
|---|---|---|
| IPC Group | Experimental | Bilateral thigh compression was applied using a Theratools pneumatic cuff (T-bfr-0475). Three cycles, each consisting of 5 minutes of ischemia (pressure 220 mmHg) and 5 minutes of reperfusion (total 30 minutes), were performed before regular basketball training sessions. The intervention was conducted twice per week for 6 weeks. Cuff placement: at the inguinal crease of the thigh. Subject position: supine, alternating between left and right legs. Receives: Device: Ischemic Preconditioning |
| Sham Control Group | Active comparator | Identical procedure to IPC group except cuff pressure maintained at 20 mmHg (non-ischemic), applied before regular basketball training. Twice weekly for 6 weeks. Receives: Device: Placebo Ischemic Preconditioning |
What is being measured
The primary outcome is the main question the study is designed to answer.
Squat Jump (SJ) height
Change from baseline in lower extremity concentric explosive power measured by Smart Jump portable contact mat (cm).
Measured: Baseline (Week 0) and Post-intervention (Week 8)
Countermovement Jump (CMJ) height
Change from baseline in lower extremity reactive explosive power without arm swing (cm).
Measured: Baseline and Week 8
Reactive Strength Index (RSI)
Change from baseline in RSI derived from 30cm drop jump using Smart Jump system (m/s). The RSI was calculated as jump height divided by ground contact time, with higher values indicating better reactive strength capacity in athletes (i.e., shorter ground contact times and greater jump heights). The observed range of RSI in the present study was [minimum value]-[maximum value] m/s.
Measured: Baseline and Week 8
Standing Long Jump
Change from baseline in lower extremity horizontal explosive power (cm).
Measured: Baseline and Week 8
T-Test (T-run)
Change from baseline in multi-directional agility performance (seconds).
Measured: Baseline and Week 8
3/4 Court Sprint
Change from baseline in linear sprint speed over 3/4 basketball court distance (~21m, seconds).
Measured: Baseline and Week 8
Secondary outcomes (4)
Blood Lactate Accumulation
Change in blood lactate accumulation during 10-second maximal load test (mmol/L).
Measured: Baseline and Week 8
Peak Power (10s Test)
Change from baseline in peak power output during 10-second maximal load test on Monark 828E cycle ergometer (Watts).
Measured: Baseline and Week 8
Mean Power (10s Test)
Change from baseline in mean power output during 10-second maximal load test (Watts).
Measured: Baseline and Week 8
Testosterone/Cortisol Ratio
Change from baseline in T/C ratio (×10-²).
Measured: Baseline and Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start22 May 2026
- Primary completion15 Jul 2026 (estimated)
- Study completion15 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Lower Extremity Explosive Power DeficitStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 34 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Guangzhou Sport University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ziyue Ou, Guangzhou Sport University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07604948
- Sponsor's protocol ID
- GZSU-IPC-BB-2024
- Status last verified
- May 2026
- First submitted
- 17 May 2026
- Last updated
- 26 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: The data have not been publicly released yet, and contributions may be considered after they are published.
Publications
Ou Z, Yang L, Zhu H, Weng X, Xu G. Ischemic preconditioning enhances autonomic nervous system modulation during frequency speed of kick test in taekwondo athletes: a randomized crossover study. BMC Sports Sci Med Rehabil. 2026 Feb 12;18(1):136. doi: 10.1186/s13102-026-01602-2.
PubMed 41680854Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, Redington AN. Remote preconditioning improves maximal performance in highly trained athletes. Med Sci Sports Exerc. 2011 Jul;43(7):1280-6. doi: 10.1249/MSS.0b013e318206845d.
PubMed 21131871Cheng CF, Kuo YH, Hsu WC, Chen C, Pan CH. Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes. Int J Environ Res Public Health. 2021 Oct 12;18(20):10653. doi: 10.3390/ijerph182010653.
PubMed 34682399Chen Y, Yang J, Muradov O, Li X, Lee JKW, Qiu J. Effect of ischemic preconditioning on maximum accumulated oxygen deficit in 400-meter runners. Eur J Sport Sci. 2023 May;23(5):789-796. doi: 10.1080/17461391.2022.2064769. Epub 2022 Apr 25.
PubMed 35400298Carvalho L, Barroso R. Ischemic Preconditioning Improves Strength Endurance Performance. J Strength Cond Res. 2019 Dec;33(12):3332-3337. doi: 10.1519/JSC.0000000000002846.
PubMed 30844989Caru M, Levesque A, Lalonde F, Curnier D. An overview of ischemic preconditioning in exercise performance: A systematic review. J Sport Health Sci. 2019 Jul;8(4):355-369. doi: 10.1016/j.jshs.2019.01.008. Epub 2019 Jan 23.
PubMed 31333890Bailey TG, Jones H, Gregson W, Atkinson G, Cable NT, Thijssen DH. Effect of ischemic preconditioning on lactate accumulation and running performance. Med Sci Sports Exerc. 2012 Nov;44(11):2084-9. doi: 10.1249/MSS.0b013e318262cb17.
PubMed 22843115
Study at a glance
From the registry record, last updated by the sponsor on 26 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07604948
- Acronym / sponsor ID
- GZSU-IPC-BB-2024
- Conditions
- Lower Extremity Explosive Power Deficit, Sports Recovery, Basketball Performance, Muscle Fatigue
- Keywords
- Ischemic preconditioning, Basketball, Lower extremity explosiveness, Physical recovery, Post-match recovery
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 34 participants (estimated)
- Lead sponsor
- Guangzhou Sport UniversityUniversity, hospital or other
- Study start
- 22 May 2026 (actual)
- Primary completion
- 15 Jul 2026 (estimated)
- Study completion
- 15 Jul 2026 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to evaluate the effects of ischemic preconditioning on lower limb explosive power and post-exercise recovery in basketball players during a 6-week post-season recovery training period. Thirty-four male collegiate basketball players were randomly assigned to either an IPC group or a placebo control group. Bilateral lower limb IPC intervention (3 cycles, each consisting of 5-minute ischemia at 220 mmHg and 5-minute reperfusion, twice per week for 6 weeks) was administered before routine basketball training sessions. Lower limb explosive power, as well as physiological, biochemical, and morphological indices, were assessed before and after the intervention.
Detailed description
Background: Lower limb explosive power is crucial for basketball performance, and effective recovery strategies are key to maintaining training quality. Ischemic preconditioning (IPC) is a non-invasive, economical, and safe method that triggers endogenous protective mechanisms through brief ischemia-reperfusion cycles, showing potential in enhancing athletic performance and metabolic efficiency. However, the effects of IPC on lower limb explosive power during post-match recovery in basketball players remain understudied. Objective: To investigate the effects of a 6-week repeated remote ischemic preconditioning on lower limb explosive power, phosphagen energy system capacity, and physical recovery in male college basketball players. Design: A randomized, parallel-group, placebo-controlled trial with concealed allocation. Participants were randomly assigned to either the IPC experimental group (n=17) or the placebo control group (n=17). Both groups participated in the same regular basketball sessions. The experimental group received bilateral thigh IPC intervention (3×5 minutes, 220 mmHg) before each training session, while the control group received a placebo intervention (3×5 minutes, 20 mmHg). The intervention was administered twice a week for 6 weeks (30 minutes per session). Secondary endpoints: Urinary creatinine coefficient, 10-second maximal load test (blood lactate increment, peak power, mean power), hematological parameters (red blood cell count, hemoglobin, hematocrit, white blood cell count), serum testosterone, cortisol, testosterone/cortisol ratio, body composition (body weight, body fat percentage, BMI), and training load monitoring (heart rate, RPE, urine protein).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| IPC Group | Experimental | Device: Ischemic PreconditioningBilateral thigh compression was applied using a Theratools pneumatic cuff (T-bfr-0475). Three cycles, each consisting of 5 minutes of ischemia (pressure 220 mmHg) and 5 minutes of reperfusion (total 30 minutes), were performed before regular basketball training sessions. The intervention was conducted twice per week for 6 weeks. Cuff placement: at the inguinal crease of the thigh. Subject position: supine, alternating between left and right legs. |
| Sham Control Group | Active comparator | Device: Placebo Ischemic PreconditioningIdentical procedure to IPC group except cuff pressure maintained at 20 mmHg (non-ischemic), applied before regular basketball training. Twice weekly for 6 weeks. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Male basketball students at Guangzhou Sport University.
- Regular participants in basketball training/practice.
- Healthy adults without cardiovascular, hepatic, renal, digestive, neurological, or metabolic diseases.
- Blood pressure within normal range.
- No history of lower extremity musculoskeletal injury within the past 6 months.
Key exclusion criteria (6 listed)
- Presence of acute or chronic diseases affecting exercise performance.
- History of deep vein thrombosis or coagulation disorders.
- Presence of skin lesions or infections at the thigh cuff placement site.
- Participation in other concurrent lower extremity strength/power training programs outside the study.
- Use of dietary supplements known to affect muscle metabolism within 4 weeks prior to enrollment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ischemic PreconditioningBilateral thigh compression was applied using a Theratools pneumatic cuff (T-bfr-0475). Three cycles, each consisting of 5 minutes of ischemia (pressure 220 mmHg) and 5 minutes of reperfusion (total 30 minutes), were performed before regular basketball training sessions. The intervention was conducted twice per week for 6 weeks. Cuff placement: at the inguinal crease of the thigh. Subject position: supine, alternating between left and right legs. | Device | IPC Group |
| Placebo Ischemic PreconditioningIdentical procedure to IPC group except cuff pressure maintained at 20 mmHg (non-ischemic), applied before regular basketball training. Twice weekly for 6 weeks. | Device | Sham Control Group |
Primary outcome
Squat Jump (SJ) height
Time frame: Baseline (Week 0) and Post-intervention (Week 8)
Change from baseline in lower extremity concentric explosive power measured by Smart Jump portable contact mat (cm).
Countermovement Jump (CMJ) height
Time frame: Baseline and Week 8
Change from baseline in lower extremity reactive explosive power without arm swing (cm).
Reactive Strength Index (RSI)
Time frame: Baseline and Week 8
Change from baseline in RSI derived from 30cm drop jump using Smart Jump system (m/s). The RSI was calculated as jump height divided by ground contact time, with higher values indicating better reactive strength capacity in athletes (i.e., shorter ground contact times and greater jump heights). The observed range of RSI in the present study was [minimum value]-[maximum value] m/s.
Standing Long Jump
Time frame: Baseline and Week 8
Change from baseline in lower extremity horizontal explosive power (cm).
T-Test (T-run)
Time frame: Baseline and Week 8
Change from baseline in multi-directional agility performance (seconds).
3/4 Court Sprint
Time frame: Baseline and Week 8
Change from baseline in linear sprint speed over 3/4 basketball court distance (~21m, seconds).
4 secondary outcomes
Blood Lactate Accumulation
Time frame: Baseline and Week 8
Peak Power (10s Test)
Time frame: Baseline and Week 8
Mean Power (10s Test)
Time frame: Baseline and Week 8
Testosterone/Cortisol Ratio
Time frame: Baseline and Week 8
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 May 2026.
- Background: PubMed 41680854Ou Z, Yang L, Zhu H, Weng X, Xu G. Ischemic preconditioning enhances autonomic nervous system modulation during frequency speed of kick test in taekwondo athletes: a randomized crossover study. BMC Sports Sci Med Rehabil. 2026 Feb 12;18(1):136. doi: 10.1186/s13102-026-01602-2.
- Background: PubMed 21131871Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, Redington AN. Remote preconditioning improves maximal performance in highly trained athletes. Med Sci Sports Exerc. 2011 Jul;43(7):1280-6. doi: 10.1249/MSS.0b013e318206845d.
- Background: PubMed 34682399Cheng CF, Kuo YH, Hsu WC, Chen C, Pan CH. Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes. Int J Environ Res Public Health. 2021 Oct 12;18(20):10653. doi: 10.3390/ijerph182010653.
- Background: PubMed 35400298Chen Y, Yang J, Muradov O, Li X, Lee JKW, Qiu J. Effect of ischemic preconditioning on maximum accumulated oxygen deficit in 400-meter runners. Eur J Sport Sci. 2023 May;23(5):789-796. doi: 10.1080/17461391.2022.2064769. Epub 2022 Apr 25.
- Background: PubMed 30844989Carvalho L, Barroso R. Ischemic Preconditioning Improves Strength Endurance Performance. J Strength Cond Res. 2019 Dec;33(12):3332-3337. doi: 10.1519/JSC.0000000000002846.
- Background: PubMed 31333890Caru M, Levesque A, Lalonde F, Curnier D. An overview of ischemic preconditioning in exercise performance: A systematic review. J Sport Health Sci. 2019 Jul;8(4):355-369. doi: 10.1016/j.jshs.2019.01.008. Epub 2019 Jan 23.
- Background: PubMed 22843115Bailey TG, Jones H, Gregson W, Atkinson G, Cable NT, Thijssen DH. Effect of ischemic preconditioning on lactate accumulation and running performance. Med Sci Sports Exerc. 2012 Nov;44(11):2084-9. doi: 10.1249/MSS.0b013e318262cb17.
- Individual participant dataSharing planned: Undecided. The data have not been publicly released yet, and contributions may be considered after they are published.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ischemic Preconditioning in people with Lower Extremity Explosive Power Deficit and Sports Recovery, run by Guangzhou Sport University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ziyue Ou, PHD (+8615626121623, 105852022100090@stu.gzsport.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Squat Jump (SJ) height (time frame: Baseline (Week 0) and Post-intervention (Week 8)). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07604948, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2026.