Sports PerformanceTCP-SoccerNCT07604519
Multi-Ingredient Supplementation in Professional Football Players
A study testing taurine, Caffeine and Phosphatidylserine in people with Sports Performance and Cognitive Performance During Physical Activity, run by Vizja University in Warsaw at 5 sites in 3 countries.
Trial summary
This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite… Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Sports Performance, Cognitive Performance During Physical Activity, Fatigue
- What is being tested?
- taurine, Caffeine and Phosphatidylserine
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 97 participants
- Where
- 5 sitesin 3 countries
- Study dates
- 14 Jun 2026to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- -
- Professional male football players aged 18-35 years
- Regular participation in team training and competitive matches
- Clinically healthy status confirmed prior to participation
- Written informed consent provided
Who cannot join
- Current musculoskeletal injury or illness
- Chronic metabolic, cardiovascular, or neurological disease
- Regular medication use
- Current use of dietary supplements or ergogenic aids
- Smoking or excessive alcohol consumption
- Known hypersensitivity to any study supplement ingredient
- -
Trial locations and contacts
5 sites in 3 countries.
5 sites in 3 countries
Poland3 sites
Professional Football Training Center
Lodz
Professional Football Training Center
Warsaw
Professional Football Training Center
Wroclaw
About this study
Official title: Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players
This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.
Read the detailed description
The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.
Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.
Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.
The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.
- Conditions
- Sports Performance, Cognitive Performance During Physical Activity, Fatigue, Recovery, Football Players
- Being tested
- Placebo, taurine, Caffeine, Phosphatidylserine
- Keywords
- Soccer, Football, Supplementation, Exercise Performance, Recovery
- Medical subject headings
- Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PlaceboOther
Placebo capsules administered daily during the 14-day intervention period
taurineDietary supplement
Taurine supplementation administered daily during the 14-day intervention period.
CaffeineDietary supplement
Caffeine supplementation administered daily during the 14-day intervention period.
PhosphatidylserineDietary supplement
Phosphatidylserine supplementation administered daily during the 14-day intervention period.
| Study group | Role | What they receive |
|---|---|---|
| P | Placebo comparator | Participants will receive visually identical placebo capsules for 14 days. Receives: Other: Placebo |
| TC | Experimental | Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days. Receives: Dietary Supplement: taurine; Dietary Supplement: Caffeine |
| TCP-300 | Experimental | Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days. Receives: Dietary Supplement: taurine; Dietary Supplement: Caffeine; Dietary Supplement: Phosphatidylserine |
| TCP-600 | Experimental | Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days. Receives: Dietary Supplement: taurine; Dietary Supplement: Caffeine; Dietary Supplement: Phosphatidylserine |
What is being measured
The primary outcome is the main question the study is designed to answer.
30 m sprint time
Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis.
Unit of Measure: seconds
Measured: Baseline and after 14 days of supplementation
Secondary outcomes (17)
Change in sprint count between first and second half
Percentage decline in the number of sprints between the first and second half of the standardized football-specific training session. Sprint change will be calculated as: [(second half value - first half value) / first half value] × 100.
Unit of Measure: percent
Measured: After 14 days of supplementation, during the standardized football-specific training session
Visual reaction time
Mean response time to a visual stimulus, measured using a validated visual reaction time test.
Measured: Baseline and after 14 days of supplementation
Auditory reaction time
Mean response time to an auditory stimulus, measured using a computerized auditory reaction time test.
Measured: Baseline and after 14 days of supplementation
Total distance covered
Total distance covered during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:
meters
Measured: After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Distance covered per minute during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:
meters per minute
Measured: After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Description:
Distance covered at running speeds above 19.8 km/h during the standardized football-specific training session, measured using a 10-Hz GPS tracking system.
Unit of Measure: meters
Measured: After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Total number of sprint efforts performed during the standardized football-specific training session. Sprinting will be defined as running speed above 25.0 km/h and measured using a 10-Hz GPS tracking system.
Unit of Measure: number of sprints
Measured: After 14 days of supplementation, during the standardized football-specific training session
Player Load
External training load during the standardized football-specific training session, measured using triaxial accelerometry integrated with the GPS tracking system.
Unit of Measure: arbitrary units
Measured: After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Resting heart rate variability assessed in the morning using the root mean square of successive differences between normal heartbeats. HRV will be measured using a heart rate sensor or wearable device under standardized resting conditions. Unit of Measure: milliseconds
Measured: Daily during the 14-day supplementation period
Sleep duration
Total sleep duration assessed using wearable sleep monitoring. Unit of Measure: hours
Measured: Daily during the 14-day supplementation period
Sleep efficiency
Percentage of time in bed spent asleep, assessed using wearable sleep monitoring.
Unit of Measure: percent
Measured: Daily during the 14-day supplementation period
Subjective fatigue
Subjective fatigue assessed using the fatigue item of the Hooper Index questionnaire on a 1-7 scale, where higher values indicate greater fatigue. Unit of Measure: score on a scale
Measured: Daily during the 14-day supplementation period
Muscle soreness
Perceived lower-limb muscle soreness assessed using a 0-10 delayed onset muscle soreness scale, where higher values indicate greater soreness.
Unit of Measure: score on a scale
Measured: Daily during the 14-day supplementation period
Stroop task reaction time
Mean response time during a modified computerized Stroop task assessing cognitive fatigue, inhibitory control, sustained attention, and information processing speed. Unit of Measure: seconds
Measured: Baseline and after 14 days of supplementation
Stroop task accuracy
Percentage of correct responses during a modified computerized Stroop task. Unit of Measure: percent
Measured: Baseline and after 14 days of supplementation
Stroop task error rate
Number of incorrect responses during a modified computerized Stroop task. Unit of Measure: number of errors
Measured: Baseline and after 14 days of supplementation
Perceived mental fatigue
Subjective perceived mental fatigue assessed using a 0-10 visual analogue scale, where higher values indicate greater perceived mental fatigue. Unit of Measure: score on a 0-10 scale
Measured: Baseline and after 14 days of supplementation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start14 Jun 2026
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sports PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to parallel study groups receiving either placebo or multi-ingredient supplementation during the intervention period.
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 97 participants (actual)
Sponsor and investigators
- Lead sponsor
- Vizja University in Warsaw
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Krzysztof Mizera, Vizja University in Warsaw
- Investigators
- Krzysztof Maciej MIZERA, PhD, Principal investigator, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07604519
- Sponsor's protocol ID
- MIZERA-FOOTBALL-2026
- Acronym
- TCP-Soccer
- Status last verified
- Jun 2026
- First submitted
- 13 May 2026
- Last updated
- 2 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Data sharing plans have not yet been finalized.
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players
- ClinicalTrials.gov ID
- NCT07604519
- Acronym / sponsor ID
- TCP-Soccer / MIZERA-FOOTBALL-2026
- Conditions
- Sports Performance, Cognitive Performance During Physical Activity, Fatigue, Recovery, Football Players
- Keywords
- Soccer, Football, Supplementation, Exercise Performance, Recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 97 participants (actual)
- Lead sponsor
- Vizja University in WarsawUniversity, hospital or other
- Study start
- 14 Jun 2026 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.
Detailed description
The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.
Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.
Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.
The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 4
- Model description
- Participants will be randomly assigned to parallel study groups receiving either placebo or multi-ingredient supplementation during the intervention period.
| Arm | Type | Receives |
|---|---|---|
| P | Placebo comparator | Other: PlaceboParticipants will receive visually identical placebo capsules for 14 days. |
| TC | Experimental | Dietary Supplement: taurine, Dietary Supplement: CaffeineParticipants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days. |
| TCP-300 | Experimental | Dietary Supplement: taurine, Dietary Supplement: Caffeine, Dietary Supplement: PhosphatidylserineParticipants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days. |
| TCP-600 | Experimental | Dietary Supplement: taurine, Dietary Supplement: Caffeine, Dietary Supplement: PhosphatidylserineParticipants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- -
- Professional male football players aged 18-35 years
- Regular participation in team training and competitive matches
- Clinically healthy status confirmed prior to participation
- Written informed consent provided
Key exclusion criteria (7 listed)
- Current musculoskeletal injury or illness
- Chronic metabolic, cardiovascular, or neurological disease
- Regular medication use
- Current use of dietary supplements or ergogenic aids
- Smoking or excessive alcohol consumption
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PlaceboPlacebo capsules administered daily during the 14-day intervention period | Other | P |
| taurineTaurine supplementation administered daily during the 14-day intervention period. | Dietary supplement | TC, TCP-300, TCP-600 |
| CaffeineCaffeine supplementation administered daily during the 14-day intervention period. | Dietary supplement | TC, TCP-300, TCP-600 |
| PhosphatidylserinePhosphatidylserine supplementation administered daily during the 14-day intervention period. | Dietary supplement | TCP-300, TCP-600 |
Primary outcome
30 m sprint time
Time frame: Baseline and after 14 days of supplementation
Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis. Unit of Measure: seconds
17 secondary outcomes
Change in sprint count between first and second half
Time frame: After 14 days of supplementation, during the standardized football-specific training session
Visual reaction time
Time frame: Baseline and after 14 days of supplementation
Auditory reaction time
Time frame: Baseline and after 14 days of supplementation
Total distance covered
Time frame: After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Time frame: After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Time frame: After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Time frame: After 14 days of supplementation, during the standardized football-specific training session
Player Load
Time frame: After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Time frame: Daily during the 14-day supplementation period
Sleep duration
Time frame: Daily during the 14-day supplementation period
Sleep efficiency
Time frame: Daily during the 14-day supplementation period
Subjective fatigue
Time frame: Daily during the 14-day supplementation period
Muscle soreness
Time frame: Daily during the 14-day supplementation period
Stroop task reaction time
Time frame: Baseline and after 14 days of supplementation
Stroop task accuracy
Time frame: Baseline and after 14 days of supplementation
Stroop task error rate
Time frame: Baseline and after 14 days of supplementation
Perceived mental fatigue
Time frame: Baseline and after 14 days of supplementation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2026.
- Individual participant dataSharing planned: Undecided. Data sharing plans have not yet been finalized.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Krzysztof Maciej MIZERA, PhD principal investigator
1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland
5 sites in 3 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing taurine, Caffeine and Phosphatidylserine in people with Sports Performance and Cognitive Performance During Physical Activity, run by Vizja University in Warsaw at 5 sites in 3 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in Poland, Hungary, Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30 m sprint time (time frame: Baseline and after 14 days of supplementation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2026.