Other Endosseous Dental Implant FailureImplantsNCT07601347
Effect of Immediate Placement and Loading of Compressive Versus Conventional Implants
A study testing Immediate implant placement and loading in people with Other Endosseous Dental Implant Failure, run by Ahmed Nagi Alghandour at 1 site in Egypt.
Trial summary
The current study aims to compare immediate placement and loading of compressive versus conventional dental implants after atraumatic extraction regarding the effectiveness, bone resorption and survival of each of them. Read more about this study
- Who is it for?
- Ages 20 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Other Endosseous Dental Implant Failure
- What is being tested?
- Immediate implant placement and loading
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Medically free patient
- Males and females
- Non-smoker patients
- Age ranging from 20-40 years
- Badly destructed upper premolar teeth that require implants, bone covering 2/3 of the root and of sufficient bone volume.
Who cannot join
- Patients with systemic conditions known to affect the periodontal status and healing such as uncontrolled diabetes and osteoporosis
- Heavy smokers
- Unfavorable position of the tooth or remaining roots
- Vitamin D deficiency,
- Periapical lesion/ periodontal affection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Beni-suef university
Banī Suwayf
ahmed Beni-suef university, phd
About this study
Official title: Effect of Immediate Placement and Loading of Compressive Versus Conventional Implants After Atraumatic Extraction Extraction (A Randomized Controlled Clinical Trial)
The current study aims to compare immediate placement and loading of compressive versus conventional dental implants after atraumatic extraction regarding the effectiveness, bone resorption and survival of each of them.
Read the detailed description
Oral health and oral health care are crucial for maintaining good chewing, digestion, speaking, attractiveness, and psychological well-being. The absence of one or more teeth, regardless of the cause, can have a negative impact on oral health. The most significant consequence for the patient is the compromised look, which is often the main motivation for seeking prosthodontic treatment. Tooth loss can result from various factors, such as congenital absence, trauma, dental disorders (such as caries or periodontal disease), and mechanical failure. Tooth loss can also happen as a result of associated several systemic disorders such cancer, cardiovascular disease, diabetes mellitus, and osteoporosis. Hence, it is crucial to uphold not just optimal dental hygiene, but also general well-being.
Patients may experience actual or perceived adverse consequences after the loss of one or more teeth. The psychological impacts can vary from modest to neuroticism. Tooth loss leads to a decrease in self-assurance, a tendency to avoid laughing in public, and a reluctance to establish intimate connections, particularly when the front teeth are absent.
Extensive research and clinical practice over the past few decades have unequivocally proven the effectiveness of implant dentistry. Traditionally, implants were placed in sockets that had already healed and loaded in a typical (delayed) manner.
The extraction of a tooth results in fast resorption of the alveolar ridge in both vertical and horizontal dimensions during the initial months post-extraction. In anterior teeth, reduced tissue impairs cosmetic modifications that obstruct prosthetic rehabilitation. The reduction in edge thickness, alteration of gingival contour, and loss of dental papilla, accompanied by the emergence of black gaps, are observed in these instances. Atraumatic extractions, the insertion of implants in the alveoli of excised teeth, and quick provisionalization have been suggested as alternatives to preserve tissue volume and contour, while reducing expenses and treatment duration.
Traditionally, dental implants have been submerged for a period of 3-6 months during osseointegration in order to minimize the risk of implant failure due to movements at the implant interface, as noted by Adell et al. Concerns were raised regarding the extended duration of this interval, prompting the suggestion of quick loading with a partial restoration during surgery. Nevertheless, there were significant instances of implant failure attributed to the fibrous encapsulation of the implants. Subsequent advancements in surgical technique, implant structure, and masticatory forces have provided evidence supporting the efficacy of quick loading treatments.
The concept of "Immediate loading" was introduced in the early 1990s. Today, over 15 years of clinical and histological research have proven its merits (13). The anterior mandible has been extensively researched, with a focus on immediate function, which is now considered a common operation. Nevertheless, subsequent research has indicated that this idea may be applicable to additional areas of the jaw, as long as the implant is initially stable (14, 15).
The "Compressive" implant is a singular implant featuring compressive threads. It is utilized for both single and multiple restorations with immediate loading in the maxilla and mandible, provided there is sufficient bone tissue. Implants can be positioned using either a flap or flapless technique, with the implants put subcrestally. Implant implantation is feasible immediately after tooth extraction, provided there is adequate bone tissue. It may be utilized in conjunction with Basal implants. The abutment direction may be modified by up to 15° in relation to the implant axis. Abutment of the implant specifically engineered for cement-retained prostheses.
Scientific evidence is increasingly demonstrating that osseointegration can occur in implants placed directly into recently extracted sockets. Implant dentistry has made another significant advancement with the potential for immediately loading implants into recently removed tooth sockets. Research has demonstrated that using both a bone graft and a membrane in cases where there is a bone deficiency in the area of implant placement leads to a higher quality and quantity of regenerated bone compared to using only a bone graft or a membrane alone.
An immediate implant placement refers to the placement of a dental implant directly into a socket that has just been created by the extraction of a tooth. Immediate loading refers to the process of attaching the prosthesis to the implant on the same day the implant is inserted, applying a certain amount of pressure during biting in a centered position.
Implants can be placed in fresh extraction sockets which means they can be inserted during the same visit as the tooth extraction. This approach has several benefits: it reduces complications, shortens the overall treatment time by minimizing surgical procedures, improves the patient's psychological experience, and can improve the appearance of the implant. Moreover, the timely insertion of an implant following tooth extraction can assist in preserving the bone crest and achieving optimal implant placement from a prosthetic perspective.
Existing literature indicates that the short-term survival rates for implants implanted immediately, early, delayed, or late are comparable and roughly 95%. Immediate implant insertion can be successfully performed in all areas of the jaws, however, it is more difficult to replace implants in the molar regions. Immediate implant placement can still be considered even in cases of chronic infection, as it is not an absolute contraindication.
- Conditions
- Other Endosseous Dental Implant Failure
- Being tested
- Immediate implant placement and loading
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate implant placement and loadingProcedure or surgery
- Preoperative Cone beam
- Articaine 4% local anesthesia in two sides
- Piezoelectric device used around the badly decay tooth
- Ensuring the preservation of the associated gingiva and papillae.
- Following the elevation of the flap, atraumatic extraction by using piezoelectric device:
- The teeth will be retrieved without stress. B. The Conventional dental implant will be put directly into the alveolar bone c. Placement of healing abutment in conventional implant and measurement d. Stability measured using AnyCheck or periotest device of both implants and crestal bone level by periodontal probe postoperatively.
- Suturing f. Cone beam xray postoperatively g. Postoperative instructions and medications h. after one week immediate loading by placement of temporary pmma crown
Immediate implant placement and loadingProcedure or surgery
- Preoperative Cone beam
- Articaine 4% local anesthesia in two sides
- Piezoelectric device used around the badly decay tooth
- Ensuring the preservation of the associated gingiva and papillae.
- Following the elevation of the flap, atraumatic extraction by using piezoelectric device:
- The teeth will be retrieved without stress. B. The Compressive dental implant will be put directly into the alveolar bone c. Stability measured using AnyCheck or periotest device of both implants and crestal bone level by periodontal probe postoperatively.
- Suturing e. Cone beam xray postoperatively f. Postoperative instructions and medications g. after one week immediate loading by placement of temporary pmma crown
| Study group | Role | What they receive |
|---|---|---|
| Immediate placement of conventional endosteal implants | Active comparator | Removal of non restorable tooth then immediate placement of conventional implants then immediate loading Receives: Procedure: Immediate implant placement and loading |
| Immediate placement of compressive implants | Active comparator | Removal of non restorable tooth then immediate placement of compressive implants then immediate loading Receives: Procedure: Immediate implant placement and loading |
What is being measured
The primary outcome is the main question the study is designed to answer.
stability
using AnyCheck Device from 1 to 100
Measured: 6 months
Pain after the surgery
using visual analogue scale from 1 to 10
Measured: 6 months
Crestal Bone resorption and deposition
using cone beam computed tomography .
Measured: 6 months
Crestal bone loss
using periodontal probe
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2026
- Study start1 Dec 2025
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Other Endosseous Dental Implant FailureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ahmed Nagi Alghandour
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ahmed Nagi Alghandour, Beni-Suef University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07601347
- Sponsor's protocol ID
- 202626
- Acronym
- Implants
- Status last verified
- May 2026
- First submitted
- 30 Apr 2026
- Last updated
- 22 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Immediate Placement and Loading of Compressive Versus Conventional Implants After Atraumatic Extraction Extraction (A Randomized Controlled Clinical Trial)
- ClinicalTrials.gov ID
- NCT07601347
- Acronym / sponsor ID
- Implants / 202626
- Conditions
- Other Endosseous Dental Implant Failure
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Ahmed Nagi AlghandourUniversity, hospital or other
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 22 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The current study aims to compare immediate placement and loading of compressive versus conventional dental implants after atraumatic extraction regarding the effectiveness, bone resorption and survival of each of them.
Detailed description
Oral health and oral health care are crucial for maintaining good chewing, digestion, speaking, attractiveness, and psychological well-being. The absence of one or more teeth, regardless of the cause, can have a negative impact on oral health. The most significant consequence for the patient is the compromised look, which is often the main motivation for seeking prosthodontic treatment. Tooth loss can result from various factors, such as congenital absence, trauma, dental disorders (such as caries or periodontal disease), and mechanical failure. Tooth loss can also happen as a result of associated several systemic disorders such cancer, cardiovascular disease, diabetes mellitus, and osteoporosis. Hence, it is crucial to uphold not just optimal dental hygiene, but also general well-being.
Patients may experience actual or perceived adverse consequences after the loss of one or more teeth. The psychological impacts can vary from modest to neuroticism. Tooth loss leads to a decrease in self-assurance, a tendency to avoid laughing in public, and a reluctance to establish intimate connections, particularly when the front teeth are absent.
Extensive research and clinical practice over the past few decades have unequivocally proven the effectiveness of implant dentistry. Traditionally, implants were placed in sockets that had already healed and loaded in a typical (delayed) manner.
The extraction of a tooth results in fast resorption of the alveolar ridge in both vertical and horizontal dimensions during the initial months post-extraction. In anterior teeth, reduced tissue impairs cosmetic modifications that obstruct prosthetic rehabilitation. The reduction in edge thickness, alteration of gingival contour, and loss of dental papilla, accompanied by the emergence of black gaps, are observed in these instances. Atraumatic extractions, the insertion of implants in the alveoli of excised teeth, and quick provisionalization have been suggested as alternatives to preserve tissue volume and contour, while reducing expenses and treatment duration.
Traditionally, dental implants have been submerged for a period of 3-6 months during osseointegration in order to minimize the risk of implant failure due to movements at the implant interface, as noted by Adell et al. Concerns were raised regarding the extended duration of this interval, prompting the suggestion of quick loading with a partial restoration during surgery. Nevertheless, there were significant instances of implant failure attributed to the fibrous encapsulation of the implants. Subsequent advancements in surgical technique, implant structure, and masticatory forces have provided evidence supporting the efficacy of quick loading treatments.
The concept of "Immediate loading" was introduced in the early 1990s. Today, over 15 years of clinical and histological research have proven its merits (13). The anterior mandible has been extensively researched, with a focus on immediate function, which is now considered a common operation. Nevertheless, subsequent research has indicated that this idea may be applicable to additional areas of the jaw, as long as the implant is initially stable (14, 15).
The "Compressive" implant is a singular implant featuring compressive threads. It is utilized for both single and multiple restorations with immediate loading in the maxilla and mandible, provided there is sufficient bone tissue. Implants can be positioned using either a flap or flapless technique, with the implants put subcrestally. Implant implantation is feasible immediately after tooth extraction, provided there is adequate bone tissue. It may be utilized in conjunction with Basal implants. The abutment direction may be modified by up to 15° in relation to the implant axis. Abutment of the implant specifically engineered for cement-retained prostheses.
Scientific evidence is increasingly demonstrating that osseointegration can occur in implants placed directly into recently extracted sockets. Implant dentistry has made another significant advancement with the potential for immediately loading implants into recently removed tooth sockets. Research has demonstrated that using both a bone graft and a membrane in cases where there is a bone deficiency in the area of implant placement leads to a higher quality and quantity of regenerated bone compared to using only a bone graft or a membrane alone.
An immediate implant placement refers to the placement of a dental implant directly into a socket that has just been created by the extraction of a tooth. Immediate loading refers to the process of attaching the prosthesis to the implant on the same day the implant is inserted, applying a certain amount of pressure during biting in a centered position.
Implants can be placed in fresh extraction sockets which means they can be inserted during the same visit as the tooth extraction. This approach has several benefits: it reduces complications, shortens the overall treatment time by minimizing surgical procedures, improves the patient's psychological experience, and can improve the appearance of the implant. Moreover, the timely insertion of an implant following tooth extraction can assist in preserving the bone crest and achieving optimal implant placement from a prosthetic perspective.
Existing literature indicates that the short-term survival rates for implants implanted immediately, early, delayed, or late are comparable and roughly 95%. Immediate implant insertion can be successfully performed in all areas of the jaws, however, it is more difficult to replace implants in the molar regions. Immediate implant placement can still be considered even in cases of chronic infection, as it is not an absolute contraindication.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Immediate placement of conventional endosteal implants | Active comparator | Procedure: Immediate implant placement and loadingRemoval of non restorable tooth then immediate placement of conventional implants then immediate loading |
| Immediate placement of compressive implants | Active comparator | Procedure: Immediate implant placement and loadingRemoval of non restorable tooth then immediate placement of compressive implants then immediate loading |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Medically free patient
- Males and females
- Non-smoker patients
- Age ranging from 20-40 years
- Badly destructed upper premolar teeth that require implants, bone covering 2/3 of the root and of sufficient bone volume.
Key exclusion criteria (5 listed)
- Patients with systemic conditions known to affect the periodontal status and healing such as uncontrolled diabetes and osteoporosis
- Heavy smokers
- Unfavorable position of the tooth or remaining roots
- Vitamin D deficiency,
- Periapical lesion/ periodontal affection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate implant placement and loading1. Preoperative Cone beam 2. Articaine 4% local anesthesia in two sides 3. Piezoelectric device used around the badly decay tooth 4. Ensuring the preservation of the associated gingiva and papillae. 5. Following the elevation of the flap, atraumatic extraction by using piezoelectric device: A. The teeth will be retrieved without stress. B. The Conventional dental implant will be put directly into the alveolar bone c. Placement of healing abutment in conventional implant and measurement d. Stability measured using AnyCheck or periotest device of both implants and crestal bone level by periodontal probe postoperatively. e. Suturing f. Cone beam xray postoperatively g. Postoperative instructions and medications h. after one week immediate loading by placement of temporary pmma crown | Procedure or surgery | Immediate placement of conventional endosteal implants |
| Immediate implant placement and loading1. Preoperative Cone beam 2. Articaine 4% local anesthesia in two sides 3. Piezoelectric device used around the badly decay tooth 4. Ensuring the preservation of the associated gingiva and papillae. 5. Following the elevation of the flap, atraumatic extraction by using piezoelectric device: A. The teeth will be retrieved without stress. B. The Compressive dental implant will be put directly into the alveolar bone c. Stability measured using AnyCheck or periotest device of both implants and crestal bone level by periodontal probe postoperatively. d. Suturing e. Cone beam xray postoperatively f. Postoperative instructions and medications g. after one week immediate loading by placement of temporary pmma crown | Procedure or surgery | Immediate placement of compressive implants |
Primary outcome
stability
Time frame: 6 months
using AnyCheck Device from 1 to 100
Pain after the surgery
Time frame: 6 months
using visual analogue scale from 1 to 10
Crestal Bone resorption and deposition
Time frame: 6 months
using cone beam computed tomography .
Crestal bone loss
Time frame: 6 months
using periodontal probe
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 May 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate implant placement and loading in people with Other Endosseous Dental Implant Failure, run by Ahmed Nagi Alghandour at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact ahmed alghandour, phd (01224567435 ext. 002, ahmed.nagi@dent.bsu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
stability (time frame: 6 months). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 May 2026.