Knee Phenotype Changes After THATHA-KPNCT07597538
Change of Knee Phenotype After Total Hip Arthroplasty
An observational study of Knee Phenotype Changes After THA and Coronal Plane Alignment of the Knee, run by Nader Ahmed Sayed Abdelhamed at 1 site in Egypt.
Trial summary
this study evaluates changes in knee phenotype after total hip arthroplasty using radiographic assessment of coronal alignment in a prospective cohort of patients Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Knee Phenotype Changes After THA, Coronal Plane Alignment of the Knee
- How many people
- 500 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Feb 2026to 1 Aug 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: the study population will include any patient undergoing primary unilateral total hip arthroplasty for hip joint pathology .patient will be recruited consecutively from the orthopedic surgery department . all eligible patients will be assessed preoperatively and followed postoperatively with full length lower limb radiographs to evaluate changes in knee phenotype and coronal alignment
Who may be able to join
- patients scheduled for primary unilateral total hip arthroplasty
- patient with hip joint pathology indicated for THA ( osteoarthritis )
- ability to provide informed consent
- availability for pre and post- operative radiographic follow-up
Who cannot join
- refusal to participate or withdraw consent
- incomplete radiographic data or loss to follow up
- previous surgery on the ipsilateral hip or knee
- patients with neuromuscular disorders affecting alignment
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Department of orthopedic surgery faculty of medicine assiut university
Asyut, Asyut Governorate, 71515
nader ahmed sayed, resident, +201029975354, Nader.17289651@med.aun.edu.eg
About this study
Official title: Evaluation of Knee Phenotype Following Total Hip Arthroplasty :A Prospective Cohort Study
this study evaluates changes in knee phenotype after total hip arthroplasty using radiographic assessment of coronal alignment in a prospective cohort of patients
Read the detailed description
this prospective cohort study evaluates the effect of total hip arthroplasty on knee phenotype using pre and post operative full-length radiographic assessment coronal alignment parameters will be measured to assess changes in knee biomechanics following THA
- Keywords
- knee phenotype, full length radiograph, CPAk
What is being measured
The primary outcome is the main question the study is designed to answer.
knee phenotype change following total hip arthroplasty
knee phenotype change will be assessed using full-length radiographs by comparing coronal alignment parameters before and after total hip arthroplasty
Measured: Immediately postoperatively"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 May 2026
- Study start1 Feb 2026
- Primary completion1 Feb 2028 (estimated)
- Study completion1 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee Phenotype Changes After THAStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nader Ahmed Sayed Abdelhamed
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Nader Ahmed Sayed Abdelhamed, Assiut University
- Investigators
- mohamed kamal abdelnasser, MD professor orthopedic, Principal investigator, faculty of medicine assiut univerisitymohamed anter ali, MD Doctor orthopedic surgery, Principal investigator, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07597538
- Sponsor's protocol ID
- THA-Knee-phenotype-2026
- Acronym
- THA-KP
- Status last verified
- May 2026
- First submitted
- 10 Apr 2026
- Last updated
- 19 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 19 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Knee Phenotype Following Total Hip Arthroplasty :A Prospective Cohort Study
- ClinicalTrials.gov ID
- NCT07597538
- Acronym / sponsor ID
- THA-KP / THA-Knee-phenotype-2026
- Keywords
- knee phenotype, full length radiograph, CPAk
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- Nader Ahmed Sayed AbdelhamedUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 1 Feb 2028 (estimated)
- Study completion
- 1 Aug 2028 (estimated)
- First posted
- 19 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
this study evaluates changes in knee phenotype after total hip arthroplasty using radiographic assessment of coronal alignment in a prospective cohort of patients
Detailed description
this prospective cohort study evaluates the effect of total hip arthroplasty on knee phenotype using pre and post operative full-length radiographic assessment coronal alignment parameters will be measured to assess changes in knee biomechanics following THA
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- the study population will include any patient undergoing primary unilateral total hip arthroplasty for hip joint pathology .patient will be recruited consecutively from the orthopedic surgery department . all eligible patients will be assessed preoperatively and followed postoperatively with full length lower limb radiographs to evaluate changes in knee phenotype and coronal alignment
Key inclusion criteria (4 listed)
- patients scheduled for primary unilateral total hip arthroplasty
- patient with hip joint pathology indicated for THA ( osteoarthritis )
- ability to provide informed consent
- availability for pre and post- operative radiographic follow-up
Key exclusion criteria (4 listed)
- refusal to participate or withdraw consent
- incomplete radiographic data or loss to follow up
- previous surgery on the ipsilateral hip or knee
- patients with neuromuscular disorders affecting alignment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
knee phenotype change following total hip arthroplasty
Time frame: Immediately postoperatively"
knee phenotype change will be assessed using full-length radiographs by comparing coronal alignment parameters before and after total hip arthroplasty
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 May 2026.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
mohamed kamal abdelnasser, MD professor orthopedic principal investigator
faculty of medicine assiut univerisity
mohamed anter ali, MD Doctor orthopedic surgery principal investigator
Assiut University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Knee Phenotype Changes After THA and Coronal Plane Alignment of the Knee, run by Nader Ahmed Sayed Abdelhamed at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact nader ahmed sayed, MD (resident) (+201029975354, Nader.17289651@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
knee phenotype change following total hip arthroplasty (time frame: Immediately postoperatively"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 May 2026.