Alcohol Use Disorder (AUD)EVIMETALNCT07593664
Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder
A study testing Multiple Errand Test (MET) and Virtual MET in people with Alcohol Use Disorder (AUD), run by Hôpital le Vinatier at 2 sites in France.
Trial summary
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD). More specifically, the project aims to: 1. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Alcohol Use Disorder (AUD)
- What is being tested?
- Multiple Errand Test (MET) and Virtual MET
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 2 sitesFrance
- Study dates
- May 2026to Jun 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- written consent
- Normal or corrected vision and hearing
- Membership or entitlement to a social security plan
- spoken and written French
- third party liability insurance
- for patients only :
- at least 6 criteria for AUD based on the Diagnostic and statistical manual of mental disorders
- At the end of withdrawal: treatment with a diazepam equivalent of ≤ 20 mg/day
Who cannot join
- under tutorship/ judicial protection
- Sensory or motor impairment (impeding the use of virtual reality and/or mobility)
- Severe neurological disorder (such as dementia or Korsakoff's syndrome)
- Photosensitive epilepsy (contraindication for the use of virtual reality)
- Any other condition deemed incompatible with the study, at the investigator's discretion
- Montreal Cognitive Assessment (MoCA) score < 10 (severe cognitive impairment)
Show all 12Show fewer
- Breastfeeding or pregnant women
- Familiarity with the supermarket visited during the MET test
- For controls only :
- History of alcohol use disorder
- score ≥ 8 on the Alcohol Use Disorders Identification Test
- Score on the Frontal Assessment Battery < 16 (or < 15 if education is below secondary level)
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France2 sites
CH Le Vinatier
Bron, 69500
Hôpital de la Croix Rousse
Lyon, 69004
Louis-Ferdinand LESPINE, PhD, 0033437915514, Louis-ferdinand.LESPINE@ch-le-vinatier.fr
About this study
Official title: Evaluation of a Virtual Reality-based Version of the Multiple Errands Test for the Assessment of Executive Functions in Alcohol Use Disorder
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD).
More specifically, the project aims to:
Read more
- evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD.
- establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit.
All participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment).
Performance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.
Read the detailed description
The project aims to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive function in patients with alcohol use disorder (AUD), in comparison to the original test (MET), by:
- establishing the ecological validity of the V-MET: a high correlation between performance on the MET and performance on the V-MET (total number of errors) in patients with TUAL and executive dysfunction.
- establishing the sensitivity of the V-MET (to executive dysfunction): significant difference between V-MET performance in patients with an AUD and executive dysfunction versus (a) patients without executive dysfunction and (b) "healthy" volunteers
- Conditions
- Alcohol Use Disorder (AUD)
- Being tested
- Multiple Errand Test (MET), Virtual MET
- Keywords
- Multiple Errands Test, Executive functions, Virtual reality, Alcohol Use Disorder
- Medical subject headings
- Alcoholism
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multiple Errand Test (MET)Behavioural
The test takes place in a real supermarket. Participants must complete a list of tasks (e.g., purchasing certain items, collecting some information) while adhering to rules (e.g., not visiting the same place twice, etc).
Virtual METBehavioural
The test takes place in a virtual supermarket, developed on the C2Neuro app by C2CARE®.
Participants must complete a similar list of tasks to the MET (e.g., purchasing certain items, collecting some information) and adhere to similar to rules (e.g., not visiting the same place twice, etc) .
| Study group | Role | What they receive |
|---|---|---|
| AUD group with executive function deficit | Experimental | Group of patients with alcohol use disorder and a deficit in executive functions as assessed by the Frontal Assessment Battery Receives: Behavioral: Multiple Errand Test (MET); Behavioral: Virtual MET |
| AUD group without executive function deficit | Active comparator | Group of patients with alcohol use disorder but without a deficit in executive functions as assessed by the Frontal Assessment Battery Receives: Behavioral: Multiple Errand Test (MET); Behavioral: Virtual MET |
| Control group | Active comparator | Group of healthy volunteers Receives: Behavioral: Multiple Errand Test (MET); Behavioral: Virtual MET |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total number of errors on the test
Total number of errors on the MET and the V-MET.
Errors include:
- Inefficiencies (a more effective action could have been made)
- Rule breaks: a specific rule is broken
- Interpretation failure (the task is misunderstood or misinterpreted)
- Task failure: not carried out or not completely completed
Measured: Baseline
Secondary outcomes (4)
Inefficiencies on the test
Inefficiencies on the MET/V-MET : a more effective action could have been made Can be infinite
Measured: Baseline
Rule breaks on the test
Rule breaks on the MET / V-MET : a specific rule is broken
Measured: Baseline
Interpretation failures on the test
Interpretation failures on the MET/V-MET : the task is misunderstood or misinterpreted
Measured: Baseline
Task failures on the test
Task failures on the MET / V-MET : task not carried out or not completely completed
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 May 2026
- Study startMay 2026 (estimated)
- Primary completionJun 2028 (estimated)
- Study completionJun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol Use Disorder (AUD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hôpital le Vinatier
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Christophe ICARD, MD, Principal investigator, CH Le Vinatier
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07593664
- Sponsor's protocol ID
- 2025-A00421-48
- Acronym
- EVIMETAL
- Status last verified
- May 2026
- First submitted
- 12 May 2026
- Last updated
- 20 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Individual participant data (IPD) underlying the results reported in this study might be shared, including de-identified demographic data, baseline characteristics, outcome measures, and variables necessary to reproduce the analyses. All data will be fully anonymized to protect participant confidentiality. A data dictionary and relevant metadata might also be provided to facilitate interpretation and reuse. The analytic code will be provided at the time of publication of the primary study results. De-identified IPD will be shared via an open science repository such as Open Science Framework and may also be made available upon request.
Study at a glance
From the registry record, last updated by the sponsor on 20 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of a Virtual Reality-based Version of the Multiple Errands Test for the Assessment of Executive Functions in Alcohol Use Disorder
- ClinicalTrials.gov ID
- NCT07593664
- Acronym / sponsor ID
- EVIMETAL / 2025-A00421-48
- Conditions
- Alcohol Use Disorder (AUD)
- Keywords
- Multiple Errands Test, Executive functions, Virtual reality, Alcohol Use Disorder
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Hôpital le VinatierUniversity, hospital or other
- Study start
- May 2026 (estimated)
- Primary completion
- Jun 2028 (estimated)
- Study completion
- Jun 2028 (estimated)
- First posted
- 18 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD).
More specifically, the project aims to:
- evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD.
- establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit.
All participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment).
Performance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.
Detailed description
The project aims to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive function in patients with alcohol use disorder (AUD), in comparison to the original test (MET), by:
- establishing the ecological validity of the V-MET: a high correlation between performance on the MET and performance on the V-MET (total number of errors) in patients with TUAL and executive dysfunction.
- establishing the sensitivity of the V-MET (to executive dysfunction): significant difference between V-MET performance in patients with an AUD and executive dysfunction versus (a) patients without executive dysfunction and (b) "healthy" volunteers
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| AUD group with executive function deficit | Experimental | Behavioral: Multiple Errand Test (MET), Behavioral: Virtual METGroup of patients with alcohol use disorder and a deficit in executive functions as assessed by the Frontal Assessment Battery |
| AUD group without executive function deficit | Active comparator | Behavioral: Multiple Errand Test (MET), Behavioral: Virtual METGroup of patients with alcohol use disorder but without a deficit in executive functions as assessed by the Frontal Assessment Battery |
| Control group | Active comparator | Behavioral: Multiple Errand Test (MET), Behavioral: Virtual METGroup of healthy volunteers |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- written consent
- Normal or corrected vision and hearing
- Membership or entitlement to a social security plan
- spoken and written French
- third party liability insurance
Key exclusion criteria (12 listed)
- under tutorship/ judicial protection
- Sensory or motor impairment (impeding the use of virtual reality and/or mobility)
- Severe neurological disorder (such as dementia or Korsakoff's syndrome)
- Photosensitive epilepsy (contraindication for the use of virtual reality)
- Any other condition deemed incompatible with the study, at the investigator's discretion
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multiple Errand Test (MET)The test takes place in a real supermarket. Participants must complete a list of tasks (e.g., purchasing certain items, collecting some information) while adhering to rules (e.g., not visiting the same place twice, etc). | Behavioural | AUD group with executive function deficit, AUD group without executive function deficit, Control group |
| Virtual METThe test takes place in a virtual supermarket, developed on the C2Neuro app by C2CARE®. Participants must complete a similar list of tasks to the MET (e.g., purchasing certain items, collecting some information) and adhere to similar to rules (e.g., not visiting the same place twice, etc) . | Behavioural | AUD group with executive function deficit, AUD group without executive function deficit, Control group |
Primary outcome
Total number of errors on the test
Time frame: Baseline
Total number of errors on the MET and the V-MET. Errors include: * Inefficiencies (a more effective action could have been made) * Rule breaks: a specific rule is broken * Interpretation failure (the task is misunderstood or misinterpreted) * Task failure: not carried out or not completely completed
4 secondary outcomes
Inefficiencies on the test
Time frame: Baseline
Rule breaks on the test
Time frame: Baseline
Interpretation failures on the test
Time frame: Baseline
Task failures on the test
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 May 2026.
- Individual participant dataSharing planned: Yes. Individual participant data (IPD) underlying the results reported in this study might be shared, including de-identified demographic data, baseline characteristics, outcome measures, and variables necessary to reproduce the analyses. All data will be fully anonymized to protect participant confidentiality. A data dictionary and relevant metadata might also be provided to facilitate interpretation and reuse. The analytic code will be provided at the time of publication of the primary study results. De-identified IPD will be shared via an open science repository such as Open Science Framework and may also be made available upon request.
Related trials for Alcohol Use Disorder (AUD)
RecruitingPhase 2
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD)
RecruitingPhase 1/2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy Volunteers, Alcohol Use Disorder (AUD)
Recruiting
High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study
Alcohol Use Disorder (AUD)
Not yet recruitingObservational study
Disease Intervention Specialist (DIS) for SUD
Substance Use Disorder (SUD), Opioid Use Disorder
RecruitingPhase 2
Suvorexant for Treatment of AUD and PTSD
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Christophe ICARD, MD principal investigator
CH Le Vinatier
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multiple Errand Test (MET) and Virtual MET in people with Alcohol Use Disorder (AUD), run by Hôpital le Vinatier at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Louis-Ferdinand LESPINE, PhD (+33437915155, Louis-ferdinand.LESPINE@ch-le-vinatier.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total number of errors on the test (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 May 2026; AzTrials last refreshed its copy on 26 Oct 2026.