StrokeNCT07576465
Effects of SBMT Combined With NMES on UL Functions in Post Stroke Patients
A study testing Synergy-based motor therapy, Neuromuscular electrical stimulation and Conventional therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
Trial summary
The aim of this study to evaluate the effects of synergy-based motor therapy combined with neuromuscular electric stimulation on upper limb function on post stroke patients Read more about this study
- Who is it for?
- Ages 50 to 65 months
- Conditions the study is for
- Stroke
- What is being tested?
- Synergy-based motor therapy, Neuromuscular electrical stimulation and Conventional therapy
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Apr 2026to Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 65 months
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- 1) Age :50 to 65 2) Both male and female 3) Ischemic Stroke onset among 3 to 6 months (sub-acute section) 4) Hemiplegia affected upper limb 5) The score of Modified ash worth scale rating <2 for upper limb 6) The score of Mini mental state score >25
Who cannot join
- 1) Recurrent stroke or bilateral involvement 2) Cognitive or conversation impairment 3) Presence of pacemaker or contraindications to NMES 4) Uncontrolled comorbid situation (e.g extreme cardiac diseases )
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
District Head Quarter Hospital , Jhang
Jhang, Punjab Province, 35200
Hira Jabeen, MS, 03234116506, hira.jabeen@riphah.edu.pk
Jasia Fatima, MS(NMPT)
About this study
Official title: Effects of Synergy-based Motor Therapy Combined With Neuromuscular Electrical Stimulation in Post Stroke Patients
The aim of this study to evaluate the effects of synergy-based motor therapy combined with neuromuscular electric stimulation on upper limb function on post stroke patients
Read the detailed description
Stroke is a serious medical condition that affects blood flow of brain due to ischemic stroke or hemorrhagic stroke. It because the long-term disabilities most commonly in older adults. The challenges face after stroke is weakness, loss of functions in upper limb.(1) Patients also feel difficulty in daily life activities like eating, dressing, writing, holding objects. In previous years, many therapeutic approaches have been developed to improve upper limb functions after stroke. There is most promising techniques like synergy-based motor therapy and NMES and these techniques helps patients in different ways. (2) Synergy-based motor therapy (SBMT) is a therapeutic approach designed to address unusual synergy patterns usually seen after stroke. Its purpose is to restore voluntary control and promote separate joint movements by returning motor routes.(3) Neuromuscular Electrical Stimulation (NMES) is a minor that distributes low-existing electrical impulses to stimulate muscle contractions in weak or paralyzed muscles, leading to muscle strength, motor learning and functional recovery.(4) More effective intervention can be offered by mixing SBMT with NMES together by addressing nerve control and muscle activity.
Synergy-based motor therapy is to focuses on retraining the brain to allow natural movements of the arm and hand. This therapy is based on how the brain learns and adapts (neuroplasticity)(5) It helps patients practice specific tasks and movements that target the upper limb joints, like shoulder abduction, elbow extension, and wrist control. Over time, this type of therapy can improve coordination, range of motion, and function of the affected arm.(6) The upper limb plays a vital role in daily living. Even simple actions like buttoning a shirt or brushing teeth require coordination between the hand, wrist, elbow, and shoulder. When stroke disrupts this system, the person becomes dependent on others. Synergy-based motor therapy directly targets the impaired patterns in the upper limb and helps the patient regain voluntary control. It also reduces muscle tightness (spasticity) and increases active participation of the limb in functional tasks.(7) Another important approach in stroke rehabilitation is neuromuscular electrical stimulation (NMES). In NMES, small electrical impulses are sent through the skin to activate the muscles that the brain can no longer control well. This causes the muscles to contract and helps in maintaining muscle strength, preventing muscle wasting, and encouraging active movement.(8) NMES can be especially helpful for patients who are unable to move their arm due to severe weakness in the early phase of recovery.NMES is not just about stimulating muscles; it also sends feedback to the brain, which can help rebuild the brain-muscle connection. It supports the patient's ability to relearn lost skills. Moreover, NMES can reduce pain, improve blood flow, and increase patient motivation by allowing them to see progress even when they cannot move the limb on their own. This makes it a very useful tool in stroke rehabilitation, especially when used in combination with task-specific exercises.(9) Both therapies have shown positive results individually, combining both therapies may offer even better outcome. Synergy based motor therapy works on retraining the brain and correcting the movement patterns while NMES can assist by strengthening the muscles. Most studies have looked these therapies separately and not focused on older adults which have slower recovery than young adults.(10) This research is important because it addresses a gap in the existing literature by focusing on a specific age group and combining the two effective techniques. The findings help physical therapists and rehabilitation professionals develop more effective, evidence-based treatment plan for post stroke patients to improve the quality of life and independence in daily life.(11) Incorporating synergy-based motor therapy and neuromuscular electrical stimulation (NMES) into routine stroke rehabilitation programs may promote long-term benefits such as enhanced motor recovery, improved functional performance, and greater independence in daily activities among post-stroke patients. These interventions work by activating normal muscle synergies, improving neuromuscular recruitment patterns, and facilitating motor relearning through targeted feedback mechanisms. NMES provides sensory and motor stimulation that helps improve voluntary muscle activation, while synergy-based therapy focuses on restoring coordinated limb movements disrupted by cortical damage. Although both techniques have individually demonstrated positive outcomes in upper limb rehabilitation, comparative studies remain limited. Understanding the combined effect of these therapies in older adults with post-stroke hemiparesis is crucial for evidence-based decision making. The findings may assist clinicians in refining post-stroke rehabilitation approaches and designing more tailored intervention protocols for upper limb recovery.
- Conditions
- Stroke
- Being tested
- Synergy-based motor therapy, Neuromuscular electrical stimulation, Conventional therapy
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Synergy-based motor therapyBehavioural
First do the 5 minutes warm up exercises(passive range of motion exercises for shoulder,elbow ,wrist and then synergy based motor therapy for 25 minutes in which the flexor synergy facilitation ( 10 rep,3 sets) and brushing and tapping for sensory cueing and then 5 minutes of cool down exercises(slow passive movements of upper limb)
Neuromuscular electrical stimulationDevice
NMES applied to wrist extensors .Frequency: 35Hz ,Pulse Width250 ,Duty cycle :10s on /20s off ,Duration : 25 minutes
Conventional therapyOther
The conventional therapy group will receive standard physiotherapy for the upper limb for 30-45 minutes per session, five days per week for 6-8 weeks. It will include gentle warm-up, range of motion exercises, light strengthening, and simple functional activities like reaching, grasping, and daily task practice. Each session will end with stretching and relaxation. This treatment aims to improve movement, strength, and function without using NMES or synergy-based training.
| Study group | Role | What they receive |
|---|---|---|
| Synergy-based motor therapy and NMES | Experimental | Participants will receive synergy-based motor therapy combined with neuromuscular electrical stimulation (NMES) for upper limb rehabilitation following stroke. Treatment will focus on improving motor control, functional movement, and muscle activation. Receives: Behavioral: Synergy-based motor therapy; Device: Neuromuscular electrical stimulation; Other: Conventional therapy |
| Conventional therapy | Active comparator | Participants will receive conventional physiotherapy for upper limb rehabilitation following stroke, including standard exercises aimed at improving strength, range of motion, and functional ability. Receives: Behavioral: Synergy-based motor therapy; Device: Neuromuscular electrical stimulation; Other: Conventional therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fugl-Meyer Assesssment _Upper Extremity
The Fugl-Meyer Assessment for Upper Extremity (FMA-UE) is a standardized tool used to evaluate motor function in the upper limb of post-stroke patients. It assesses movement, coordination, and reflex activity of the shoulder, elbow, forearm, wrist, and hand. The scale includes 33 items, scored on a 3-point scale (0 = cannot perform, 1 = performs partially, 2 = performs fully), with a maximum score of 66 indicating normal function. It helps classify the severity of motor impairment: scores between 0-22 suggest severe, 23-44 moderate, and 45-66 mild impairment. The FMA-UE is based on Brunnstrom's stages of motor recovery and is widely recognized for its high validity and excellent reliability, with inter-rater and intra-rater reliability scores above 0.95. It is considered one of the most reliable clinical tools for evaluating motor recovery in stroke rehabilitation
Measured: 8th week
Secondary outcomes (1)
Modified Ashworth Scale (MAS)
The Modified Ashworth Scale (MAS) is a clinical tool used to measure spasticity in patients with neurological conditions such as stroke. The scale ranges from 0 to 4, with an additional 1+ grade, where 0 indicates no increase in muscle tone, and 4 indicates the affected part is rigid in flexion or extension. The scores reflect the severity of spasticity: higher scores represent greater resistance and spasticity
Measured: 8th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2026
- Study start1 Apr 2026
- Primary completionJul 2026 (estimated)
- Study completionJul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aruba Saeed, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07576465
- Sponsor's protocol ID
- REC/RCR&AHS/25/0237
- Status last verified
- May 2026
- First submitted
- 4 May 2026
- Last updated
- 8 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Wang C, Peng L, Hou ZG, Li J, Zhang T, Zhao J. Quantitative Assessment of Upper-Limb Motor Function for Post-Stroke Rehabilitation Based on Motor Synergy Analysis and Multi-Modality Fusion. IEEE Trans Neural Syst Rehabil Eng. 2020 Apr;28(4):943-952. doi: 10.1109/TNSRE.2020.2978273. Epub 2020 Mar 4.
PubMed 32149692Zhou HX, Hu J, Yun RS, Zhao ZZ, Lai MH, Sun LH, Luo KL. Synergy-based functional electrical stimulation and robotic-assisted for retraining reach-to-grasp in stroke: a study protocol for a randomized controlled trial. BMC Neurol. 2023 Sep 12;23(1):324. doi: 10.1186/s12883-023-03369-2.
PubMed 37700225Niu CM, Chou CH, Bao Y, Wang T, Gu L, Zhang X, Cui L, Xuan Z, Zhuang C, Li S, Chen Z, Lan N, Xie Q. A pilot study of synergy-based FES for upper-extremity poststroke rehabilitation. Neurosci Lett. 2022 May 29;780:136621. doi: 10.1016/j.neulet.2022.136621. Epub 2022 Apr 5.
PubMed 35395324Wang T, Bao Y, Hao H, Zhang X, Li S, Xie Q, Lan N, Niu CM. Customization of Synergy-Based FES for Post-Stroke Rehabilitation of Upper-Limb Motor Functions. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:3541-3544. doi: 10.1109/EMBC.2018.8513083.
PubMed 30441143Sorimachi Y, Akaida H, Kutsuzawa K, Owaki D, Hayashibe M. Synergy-Based Evaluation of Hand Motor Function in Object Handling Using Virtual and Mixed Realities. Sensors (Basel). 2025 Mar 26;25(7):2080. doi: 10.3390/s25072080.
PubMed 40218597Niu CM, Bao Y, Zhuang C, Li S, Wang T, Cui L, Xie Q, Lan N. Synergy-Based FES for Post-Stroke Rehabilitation of Upper-Limb Motor Functions. IEEE Trans Neural Syst Rehabil Eng. 2019 Feb;27(2):256-264. doi: 10.1109/TNSRE.2019.2891004.
PubMed 30763238Pandian S, Arya KN, Kumar V, Joshi AK. Synergy-Based Motor Therapy Inducing Favorable Changes in Motor Function Components among Poststroke Subjects: A Single-Group Study. J Neurosci Rural Pract. 2022 Mar 8;13(2):261-269. doi: 10.1055/s-0042-1743458. eCollection 2022 Apr.
PubMed 35694074Bolognini N, Russo C, Edwards DJ. The sensory side of post-stroke motor rehabilitation. Restor Neurol Neurosci. 2016 Apr 11;34(4):571-86. doi: 10.3233/RNN-150606.
PubMed 27080070
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Synergy-based Motor Therapy Combined With Neuromuscular Electrical Stimulation in Post Stroke Patients
- ClinicalTrials.gov ID
- NCT07576465
- Acronym / sponsor ID
- REC/RCR&AHS/25/0237
- Conditions
- Stroke
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- Jul 2026 (estimated)
- Study completion
- Jul 2026 (estimated)
- First posted
- 8 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study to evaluate the effects of synergy-based motor therapy combined with neuromuscular electric stimulation on upper limb function on post stroke patients
Detailed description
Stroke is a serious medical condition that affects blood flow of brain due to ischemic stroke or hemorrhagic stroke. It because the long-term disabilities most commonly in older adults. The challenges face after stroke is weakness, loss of functions in upper limb.(1) Patients also feel difficulty in daily life activities like eating, dressing, writing, holding objects. In previous years, many therapeutic approaches have been developed to improve upper limb functions after stroke. There is most promising techniques like synergy-based motor therapy and NMES and these techniques helps patients in different ways. (2) Synergy-based motor therapy (SBMT) is a therapeutic approach designed to address unusual synergy patterns usually seen after stroke. Its purpose is to restore voluntary control and promote separate joint movements by returning motor routes.(3) Neuromuscular Electrical Stimulation (NMES) is a minor that distributes low-existing electrical impulses to stimulate muscle contractions in weak or paralyzed muscles, leading to muscle strength, motor learning and functional recovery.(4) More effective intervention can be offered by mixing SBMT with NMES together by addressing nerve control and muscle activity.
Synergy-based motor therapy is to focuses on retraining the brain to allow natural movements of the arm and hand. This therapy is based on how the brain learns and adapts (neuroplasticity)(5) It helps patients practice specific tasks and movements that target the upper limb joints, like shoulder abduction, elbow extension, and wrist control. Over time, this type of therapy can improve coordination, range of motion, and function of the affected arm.(6) The upper limb plays a vital role in daily living. Even simple actions like buttoning a shirt or brushing teeth require coordination between the hand, wrist, elbow, and shoulder. When stroke disrupts this system, the person becomes dependent on others. Synergy-based motor therapy directly targets the impaired patterns in the upper limb and helps the patient regain voluntary control. It also reduces muscle tightness (spasticity) and increases active participation of the limb in functional tasks.(7) Another important approach in stroke rehabilitation is neuromuscular electrical stimulation (NMES). In NMES, small electrical impulses are sent through the skin to activate the muscles that the brain can no longer control well. This causes the muscles to contract and helps in maintaining muscle strength, preventing muscle wasting, and encouraging active movement.(8) NMES can be especially helpful for patients who are unable to move their arm due to severe weakness in the early phase of recovery.NMES is not just about stimulating muscles; it also sends feedback to the brain, which can help rebuild the brain-muscle connection. It supports the patient's ability to relearn lost skills. Moreover, NMES can reduce pain, improve blood flow, and increase patient motivation by allowing them to see progress even when they cannot move the limb on their own. This makes it a very useful tool in stroke rehabilitation, especially when used in combination with task-specific exercises.(9) Both therapies have shown positive results individually, combining both therapies may offer even better outcome. Synergy based motor therapy works on retraining the brain and correcting the movement patterns while NMES can assist by strengthening the muscles. Most studies have looked these therapies separately and not focused on older adults which have slower recovery than young adults.(10) This research is important because it addresses a gap in the existing literature by focusing on a specific age group and combining the two effective techniques. The findings help physical therapists and rehabilitation professionals develop more effective, evidence-based treatment plan for post stroke patients to improve the quality of life and independence in daily life.(11) Incorporating synergy-based motor therapy and neuromuscular electrical stimulation (NMES) into routine stroke rehabilitation programs may promote long-term benefits such as enhanced motor recovery, improved functional performance, and greater independence in daily activities among post-stroke patients. These interventions work by activating normal muscle synergies, improving neuromuscular recruitment patterns, and facilitating motor relearning through targeted feedback mechanisms. NMES provides sensory and motor stimulation that helps improve voluntary muscle activation, while synergy-based therapy focuses on restoring coordinated limb movements disrupted by cortical damage. Although both techniques have individually demonstrated positive outcomes in upper limb rehabilitation, comparative studies remain limited. Understanding the combined effect of these therapies in older adults with post-stroke hemiparesis is crucial for evidence-based decision making. The findings may assist clinicians in refining post-stroke rehabilitation approaches and designing more tailored intervention protocols for upper limb recovery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Synergy-based motor therapy and NMES | Experimental | Behavioral: Synergy-based motor therapy, Device: Neuromuscular electrical stimulation, Other: Conventional therapyParticipants will receive synergy-based motor therapy combined with neuromuscular electrical stimulation (NMES) for upper limb rehabilitation following stroke. Treatment will focus on improving motor control, functional movement, and muscle activation. |
| Conventional therapy | Active comparator | Behavioral: Synergy-based motor therapy, Device: Neuromuscular electrical stimulation, Other: Conventional therapyParticipants will receive conventional physiotherapy for upper limb rehabilitation following stroke, including standard exercises aimed at improving strength, range of motion, and functional ability. |
Who may qualify
- Ages
- 50 to 65 months
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (1 listed)
- 1) Age :50 to 65 2) Both male and female 3) Ischemic Stroke onset among 3 to 6 months (sub-acute section) 4) Hemiplegia affected upper limb 5) The score of Modified ash worth scale rating <2 for upper limb 6) The score of Mini mental state score >25
Key exclusion criteria (1 listed)
- 1) Recurrent stroke or bilateral involvement 2) Cognitive or conversation impairment 3) Presence of pacemaker or contraindications to NMES 4) Uncontrolled comorbid situation (e.g extreme cardiac diseases )
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Synergy-based motor therapyFirst do the 5 minutes warm up exercises(passive range of motion exercises for shoulder,elbow ,wrist and then synergy based motor therapy for 25 minutes in which the flexor synergy facilitation ( 10 rep,3 sets) and brushing and tapping for sensory cueing and then 5 minutes of cool down exercises(slow passive movements of upper limb) | Behavioural | Conventional therapy, Synergy-based motor therapy and NMES |
| Neuromuscular electrical stimulationNMES applied to wrist extensors .Frequency: 35Hz ,Pulse Width250 ,Duty cycle :10s on /20s off ,Duration : 25 minutes | Device | Conventional therapy, Synergy-based motor therapy and NMES |
| Conventional therapyThe conventional therapy group will receive standard physiotherapy for the upper limb for 30-45 minutes per session, five days per week for 6-8 weeks. It will include gentle warm-up, range of motion exercises, light strengthening, and simple functional activities like reaching, grasping, and daily task practice. Each session will end with stretching and relaxation. This treatment aims to improve movement, strength, and function without using NMES or synergy-based training. | Other | Conventional therapy, Synergy-based motor therapy and NMES |
Primary outcome
Fugl-Meyer Assesssment _Upper Extremity
Time frame: 8th week
The Fugl-Meyer Assessment for Upper Extremity (FMA-UE) is a standardized tool used to evaluate motor function in the upper limb of post-stroke patients. It assesses movement, coordination, and reflex activity of the shoulder, elbow, forearm, wrist, and hand. The scale includes 33 items, scored on a 3-point scale (0 = cannot perform, 1 = performs partially, 2 = performs fully), with a maximum score of 66 indicating normal function. It helps classify the severity of motor impairment: scores between 0-22 suggest severe, 23-44 moderate, and 45-66 mild impairment. The FMA-UE is based on Brunnstrom's stages of motor recovery and is widely recognized for its high validity and excellent reliability, with inter-rater and intra-rater reliability scores above 0.95. It is considered one of the most reliable clinical tools for evaluating motor recovery in stroke rehabilitation
1 secondary outcome
Modified Ashworth Scale (MAS)
Time frame: 8th week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
- Background: PubMed 32149692Wang C, Peng L, Hou ZG, Li J, Zhang T, Zhao J. Quantitative Assessment of Upper-Limb Motor Function for Post-Stroke Rehabilitation Based on Motor Synergy Analysis and Multi-Modality Fusion. IEEE Trans Neural Syst Rehabil Eng. 2020 Apr;28(4):943-952. doi: 10.1109/TNSRE.2020.2978273. Epub 2020 Mar 4.
- Background: PubMed 37700225Zhou HX, Hu J, Yun RS, Zhao ZZ, Lai MH, Sun LH, Luo KL. Synergy-based functional electrical stimulation and robotic-assisted for retraining reach-to-grasp in stroke: a study protocol for a randomized controlled trial. BMC Neurol. 2023 Sep 12;23(1):324. doi: 10.1186/s12883-023-03369-2.
- Background: PubMed 35395324Niu CM, Chou CH, Bao Y, Wang T, Gu L, Zhang X, Cui L, Xuan Z, Zhuang C, Li S, Chen Z, Lan N, Xie Q. A pilot study of synergy-based FES for upper-extremity poststroke rehabilitation. Neurosci Lett. 2022 May 29;780:136621. doi: 10.1016/j.neulet.2022.136621. Epub 2022 Apr 5.
- Background: PubMed 30441143Wang T, Bao Y, Hao H, Zhang X, Li S, Xie Q, Lan N, Niu CM. Customization of Synergy-Based FES for Post-Stroke Rehabilitation of Upper-Limb Motor Functions. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:3541-3544. doi: 10.1109/EMBC.2018.8513083.
- Background: PubMed 40218597Sorimachi Y, Akaida H, Kutsuzawa K, Owaki D, Hayashibe M. Synergy-Based Evaluation of Hand Motor Function in Object Handling Using Virtual and Mixed Realities. Sensors (Basel). 2025 Mar 26;25(7):2080. doi: 10.3390/s25072080.
- Background: PubMed 30763238Niu CM, Bao Y, Zhuang C, Li S, Wang T, Cui L, Xie Q, Lan N. Synergy-Based FES for Post-Stroke Rehabilitation of Upper-Limb Motor Functions. IEEE Trans Neural Syst Rehabil Eng. 2019 Feb;27(2):256-264. doi: 10.1109/TNSRE.2019.2891004.
- Background: PubMed 35694074Pandian S, Arya KN, Kumar V, Joshi AK. Synergy-Based Motor Therapy Inducing Favorable Changes in Motor Function Components among Poststroke Subjects: A Single-Group Study. J Neurosci Rural Pract. 2022 Mar 8;13(2):261-269. doi: 10.1055/s-0042-1743458. eCollection 2022 Apr.
- Background: PubMed 27080070Bolognini N, Russo C, Edwards DJ. The sensory side of post-stroke motor rehabilitation. Restor Neurol Neurosci. 2016 Apr 11;34(4):571-86. doi: 10.3233/RNN-150606.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aruba Saeed principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Synergy-based motor therapy, Neuromuscular electrical stimulation and Conventional therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Imran Amjad (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fugl-Meyer Assesssment _Upper Extremity (time frame: 8th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07576465, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.