High Flow Nasal CanulaNCT07575776
Effect of High-Flow Nasal Oxygen on Laryngoscopic View
An observational study of High Flow Nasal Canula and Laryngoscopy, run by Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s..
Trial summary
This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- High Flow Nasal Canula, Laryngoscopy, Airway Anesthesia
- What is being tested?
- HFNO flow 0, HFNO flow 40 and HFNO 60
- Type of treatment
- Medical device
- How many people
- 150 participants
- Where
- No sites listed yet
- Study dates
- 1 Sep 2026to 1 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients undergoing elective surgical procedures requiring endotracheal intubation under general anesthesia.
Who may be able to join
- Age ≥18 years
- Scheduled for endotracheal intubation under general anesthesia
- Use of videolaryngoscopy
Who cannot join
- Anticipated difficult airway
- Emergency intubation
- Contraindications to HFNO
- Inability to obtain adequate video recording
About this study
Official title: Effect of Different Flows Using High-Flow Nasal Oxygen (HFNO) on Laryngoscopic View Quality During Videolaryngoscopy
This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L/min). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.
Read the detailed description
Anaesthetic management Anaesthesia induction and airway management will be standardized as far as clinically feasible. Standard monitoring will be applied according to institutional practice. Preoxygenation will be performed using high-flow nasal oxygen (HFNO). General anaesthesia will be induced using standard intravenous agents, followed by administration of neuromuscular blockade to facilitate laryngoscopy. Mask ventilation will be performed as clinically indicated.
Videolaryngoscopy will be performed using a standardized device and blade type whenever possible. All procedures will be performed by anesthesiologists experienced in videolaryngoscopy.
Study procedure
After induction of anaesthesia and achievement of adequate conditions for laryngoscopy, videolaryngoscopy will be performed. During a single laryngoscopic sequence, images of the laryngeal view will be obtained under three predefined HFNO flow conditions:
- 0 L/min
- 40 L/min
- 60 L/min At each flow level, once a stable laryngeal view will be achieved, a still image will be captured using the videolaryngoscope recording system. The laryngoscope position will be maintained as stable as possible during acquisition of all three images. No attempt at tracheal intubation will be made during image acquisition.
After completion of the image capture protocol, tracheal intubation will be performed according to standard clinical practice.
All images will be anonymized and stored for subsequent offline analysis. Image assessment Captured images will be evaluated offline by an independent anesthesiologist blinded to HFNO flow rates and patient identity. Where applicable, evaluation will be performed by more than one assessor to allow assessment of inter-rater agreement.
Each image will be assessed using predefined objective and subjective measures (Percentage of Glottic Opening, Likert scale).
- Conditions
- High Flow Nasal Canula, Laryngoscopy, Airway Anesthesia, Airway Complication of Anaesthesia, Difficult Airway, Difficult / Failed Intubation
- Being tested
- HFNO flow 0, HFNO flow 40, HFNO 60
- Keywords
- high flow nasal canula, thrive, difficult airway, airway management, anaesthesia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
HFNO flow 0Device
Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will be 0 l/min. During these flows images will be captured using videolaryngoscope.
HFNO flow 40Device
Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 40 l/min. During these flows images will be captured using videolaryngoscope.
HFNO 60Device
Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 60 l/min. During these flows images will be captured using videolaryngoscope.
| Study group | Role | What they receive |
|---|---|---|
| Group HFNO | Adult patients with HFNO support for airway management Receives: Device: HFNO flow 0; Device: HFNO flow 40; Device: HFNO 60 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality of view
Percentage of glottic opening (POGO score) assessed from recorded videolaryngoscopic images.
Measured: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Secondary outcomes (2)
Cormack-Lehane classification
Ordinal grading of glottic view using Cormack- Lehane classification.
Measured: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Subjective image quality (Likert scale)
Subjective assessment of laryngoscopic image quality rated on a 5-point Likert scale (1 = very poor, 5 = excellent) by independent evaluators blinded to HFNO flow conditions
Measured: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2026
- Study start1 Sep 2026 (estimated)
- Primary completion1 Sep 2027 (estimated)
- Study completion1 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for High Flow Nasal CanulaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Michal Kalina, Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07575776
- Sponsor's protocol ID
- HFNORCT
- Status last verified
- May 2026
- First submitted
- 4 May 2026
- Last updated
- 8 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Different Flows Using High-Flow Nasal Oxygen (HFNO) on Laryngoscopic View Quality During Videolaryngoscopy
- ClinicalTrials.gov ID
- NCT07575776
- Acronym / sponsor ID
- HFNORCT
- Conditions
- High Flow Nasal Canula, Laryngoscopy, Airway Anesthesia, Airway Complication of Anaesthesia, Difficult Airway, Difficult / Failed Intubation
- Keywords
- high flow nasal canula, thrive, difficult airway, airway management, anaesthesia
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.University, hospital or other
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 1 Sep 2027 (estimated)
- Study completion
- 1 Dec 2027 (estimated)
- First posted
- 8 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L/min). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.
Detailed description
Anaesthetic management Anaesthesia induction and airway management will be standardized as far as clinically feasible. Standard monitoring will be applied according to institutional practice. Preoxygenation will be performed using high-flow nasal oxygen (HFNO). General anaesthesia will be induced using standard intravenous agents, followed by administration of neuromuscular blockade to facilitate laryngoscopy. Mask ventilation will be performed as clinically indicated.
Videolaryngoscopy will be performed using a standardized device and blade type whenever possible. All procedures will be performed by anesthesiologists experienced in videolaryngoscopy.
Study procedure
After induction of anaesthesia and achievement of adequate conditions for laryngoscopy, videolaryngoscopy will be performed. During a single laryngoscopic sequence, images of the laryngeal view will be obtained under three predefined HFNO flow conditions:
- 0 L/min
- 40 L/min
- 60 L/min At each flow level, once a stable laryngeal view will be achieved, a still image will be captured using the videolaryngoscope recording system. The laryngoscope position will be maintained as stable as possible during acquisition of all three images. No attempt at tracheal intubation will be made during image acquisition.
After completion of the image capture protocol, tracheal intubation will be performed according to standard clinical practice.
All images will be anonymized and stored for subsequent offline analysis. Image assessment Captured images will be evaluated offline by an independent anesthesiologist blinded to HFNO flow rates and patient identity. Where applicable, evaluation will be performed by more than one assessor to allow assessment of inter-rater agreement.
Each image will be assessed using predefined objective and subjective measures (Percentage of Glottic Opening, Likert scale).
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Group HFNO | – | Device: HFNO flow 0, Device: HFNO flow 40, Device: HFNO 60Adult patients with HFNO support for airway management |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients undergoing elective surgical procedures requiring endotracheal intubation under general anesthesia.
Key inclusion criteria (3 listed)
- Age ≥18 years
- Scheduled for endotracheal intubation under general anesthesia
- Use of videolaryngoscopy
Key exclusion criteria (4 listed)
- Anticipated difficult airway
- Emergency intubation
- Contraindications to HFNO
- Inability to obtain adequate video recording
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| HFNO flow 0Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will be 0 l/min. During these flows images will be captured using videolaryngoscope. | Device | Group HFNO |
| HFNO flow 40Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 40 l/min. During these flows images will be captured using videolaryngoscope. | Device | Group HFNO |
| HFNO 60Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 60 l/min. During these flows images will be captured using videolaryngoscope. | Device | Group HFNO |
Primary outcome
Quality of view
Time frame: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Percentage of glottic opening (POGO score) assessed from recorded videolaryngoscopic images.
2 secondary outcomes
Cormack-Lehane classification
Time frame: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Subjective image quality (Likert scale)
Time frame: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
Related trials for High Flow Nasal Canula
Not yet recruiting
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
Deep Sedation, High Flow Nasal Canula
Active, not recruitingObservational study
Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula
Respiration Disorders
Recruiting
Non-invasive Ventilation Versus High Flow Oxygen
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Not yet recruiting
ADINA vs. High Flow Nasal Cannula Comparison Study
Respiratory Distress Neonatal
Active, not recruiting
Comparison of Different Oxygen Flow Rates During Preoxygenation Using High-Flow Nasal Oxygen
Airway Anesthesia, Preoxygenation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of High Flow Nasal Canula and Laryngoscopy, run by Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s..
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quality of view (time frame: From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.