Periodontal DiseaseNCT07574827
Candida Albicans in Syrian Patients With Periodontitis
An observational study of Periodontal Disease and Periodontal Diseases, run by Al-Hawash Private University at 1 site in Syria.
Trial summary
Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth. Recent research has indicated that Candida albicans, a common fungal pathogen, may play a role in the exacerbation of periodontal diseases. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Periodontal Disease, Periodontal Diseases, Periodontitis
- What is being tested?
- Periodontal Assessment and Sample Collection from Subgingival Pockets
- How many people
- 100 participants
- Where
- 1 siteSyria
- Study dates
- 7 Apr 2026to Sep 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Syrian patients with periodontitis at Al-Hawash Private University Dental Clinics
Who may be able to join
- Patients aged 18 years and older.
- Diagnosed with chronic periodontitis based on clinical examination (attachment loss, probing depth).
- Consent to participate in the study.
Who cannot join
- Patients with systemic diseases affecting oral health (e.g., diabetes, immunosuppressive conditions).
- Recent antibiotic or antifungal treatment within the last three months.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Syria1 site, 1 recruiting
- Recruiting
Al-Hawash Private University, Faculty of Dentistry
Homs
Ali Abou Sulaiman, PhD, +963956790836, dr.ali.abousulaiman@hpu.edu.sy
About this study
Official title: Prevalence and Impact of Candida Albicans in Syrian Patients With Periodontitis: A Cross-Sectional Study
Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth. Recent research has indicated that Candida albicans, a common fungal pathogen, may play a role in the exacerbation of periodontal diseases. This study aims to investigate the prevalence and impact of Candida albicans in Syrian patients diagnosed with periodontitis, contributing to a better understanding of its role in oral health within this population.
- Conditions
- Periodontal Disease, Periodontal Diseases, Periodontitis
- Being tested
- Periodontal Assessment and Sample Collection from Subgingival Pockets
- Keywords
- Candida Albicans, Candida, Periodontitis, Sabouraud Dextrose Agar, Culture
- Medical subject headings
- Periodontal Diseases, Periodontitis, Torulopsis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Periodontal Assessment and Sample Collection from Subgingival PocketsDiagnostic test
Clinical examination to assess periodontal status. Collection of subgingival plaque samples for microbiological analysis to identify Candida Albicans.
| Study group | Role | What they receive |
|---|---|---|
| Syrian Patients With Periodontitis | Not described Receives: Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets | |
| Syrian Individuals without Periodontal Disease | Not described Receives: Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets |
What is being measured
The primary outcome is the main question the study is designed to answer.
Detection of Candida Species in Subgingival Samples
Measured: At enrollment
Secondary outcomes (1)
Periodontal Screening and Recording Index
Periodontal parameters are measured using the WHO probe by dividing the mouth into six sextants (three upper, three lower). The highest score in each sextant is recorded. Scoring from 0-4 is based on pocket depth, gingival health, and calculus presence.
Scoring Criteria:
0: Healthy periodontium, black band visible.
- Bleeding on probing (BOP), black band visible.
- Calculus present, black band visible.
- Pocket depth 3.5-5.5 mm (black band partially submerged).
- Pocket depth > 5.5 mm (black band entirely hidden).
Measured: At enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2026
- Study start7 Apr 2026
- Primary completionMar 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontal DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Hawash Private University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ali Abou Sulaiman, Ph.D. in Periodontology, Principal investigator, Al-Hawash Private University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07574827
- Sponsor's protocol ID
- 06-05-2025
- Status last verified
- Oct 2026
- First submitted
- 22 Apr 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevalence and Impact of Candida Albicans in Syrian Patients With Periodontitis: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07574827
- Acronym / sponsor ID
- 06-05-2025
- Conditions
- Periodontal Disease, Periodontal Diseases, Periodontitis
- Keywords
- Candida Albicans, Candida, Periodontitis, Sabouraud Dextrose Agar, Culture
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Al-Hawash Private UniversityUniversity, hospital or other
- Study start
- 7 Apr 2026 (actual)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 8 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth. Recent research has indicated that Candida albicans, a common fungal pathogen, may play a role in the exacerbation of periodontal diseases. This study aims to investigate the prevalence and impact of Candida albicans in Syrian patients diagnosed with periodontitis, contributing to a better understanding of its role in oral health within this population.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Syrian Patients With Periodontitis | – | Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets |
| Syrian Individuals without Periodontal Disease | – | Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Syrian patients with periodontitis at Al-Hawash Private University Dental Clinics
Key inclusion criteria (3 listed)
- Patients aged 18 years and older.
- Diagnosed with chronic periodontitis based on clinical examination (attachment loss, probing depth).
- Consent to participate in the study.
Key exclusion criteria (2 listed)
- Patients with systemic diseases affecting oral health (e.g., diabetes, immunosuppressive conditions).
- Recent antibiotic or antifungal treatment within the last three months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Periodontal Assessment and Sample Collection from Subgingival PocketsClinical examination to assess periodontal status. Collection of subgingival plaque samples for microbiological analysis to identify Candida Albicans. | Diagnostic test | Syrian Individuals without Periodontal Disease, Syrian Patients With Periodontitis |
Primary outcome
Detection of Candida Species in Subgingival Samples
Time frame: At enrollment
1 secondary outcome
Periodontal Screening and Recording Index
Time frame: At enrollment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ali Abou Sulaiman, Ph.D. in Periodontology principal investigator
Al-Hawash Private University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontal Disease and Periodontal Diseases, run by Al-Hawash Private University at 1 site in Syria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Syria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ali Abou Sulaiman (+963956790836, dr.ali.abousulaiman@hpu.edu.sy), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Detection of Candida Species in Subgingival Samples (time frame: At enrollment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.