Immediate Dental Implant PlacementADMNCT07573020
Influence of Acellular Dermal Matrix on Peri-implant Soft Tissue Phenotype and Marginal Bone Loss
A study testing Polytetrafluoroethylene coverage and Acellular Dermal Matrix in people with Immediate Dental Implant Placement and Dental Implant, run by Mansoura University at 1 site in Egypt.
Trial summary
To evaluate soft tissue augmentation using acellular dermal matrix (ADM) over immediately placed dental implants in anterior maxilla. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Immediate Dental Implant Placement, Dental Implant, Acellular Dermal Matrix
- What is being tested?
- Polytetrafluoroethylene coverage and Acellular Dermal Matrix
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Apr 2025to 1 Mar 2026
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients with non-restorable maxillary anterior tooth/teeth.
- Good oral hygiene.
- Patients' cooperation and fully capable to comply with the study protocol.
- Age ranges from 18 to 45 years.
- Free from history of parafunctional habits e.g. clenching and bruxism
- Sufficient inter- arch space.
Who cannot join
- Any local pathological condition that contraindicates implant placement.
- Pregnancy.
- Medication that affects bone healing.
- Psychological problems.
- Patient had undergone radiation therapy to the head and neck area in the past 12 months.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Influence of Acellular Dermal Matrix on Peri-implant Soft Tissue Phenotype and Marginal Bone Loss Following Immediate Implant Placement in Anterior Maxilla: A Randomized Controlled Clinical Trial
To evaluate soft tissue augmentation using acellular dermal matrix (ADM) over immediately placed dental implants in anterior maxilla.
Read the detailed description
This randomized clinical trial was designed to evaluate and compare the efficacy of ADM versus d-PTFE membranes in the preservation of the peri-implant hard and soft tissues in the setting of immediate implant placement on the anterior maxilla.
- Conditions
- Immediate Dental Implant Placement, Dental Implant, Acellular Dermal Matrix, Polytetrafluoroethylene, Soft Tissue Augmentation at Dental Implants
- Being tested
- Polytetrafluoroethylene coverage, Acellular Dermal Matrix
- Keywords
- Acellular Dermal Matrix, Immediate Dental Implants, Soft-tissue augmentation, Tissue Phenotype, d-PTFE
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Polytetrafluoroethylene coverageProcedure or surgery
The socket with immediately placed dental implant was covered with a d-PTFE membrane cut to fit the surgical site
Acellular Dermal MatrixProcedure or surgery
The socket with immediately placed dental implant was covered with ADM that was inserted into facial and palatal split thickness pouches.
| Study group | Role | What they receive |
|---|---|---|
| Control Group | Experimental | Immediately placed dental implants with high-density polytetrafluorethylene membrane coverage Receives: Procedure: Polytetrafluoroethylene coverage |
| Test Group | Experimental | Immediately placed dental implants with acellular dermal matrix allograft coverage Receives: Procedure: Acellular Dermal Matrix |
What is being measured
The primary outcome is the main question the study is designed to answer.
Peri-implant soft-tissue phenotype
A standardized periodontal probe was used to clinically measure the keratinized mucosal width, supracrestal tissue height, and mucosal thickness. They were measured in millimeters (mm)
Measured: Six months following implant placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 May 2026
- Study start1 Apr 2025
- Primary completion1 Dec 2025
- Study completion1 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Immediate Dental Implant PlacementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07573020
- Sponsor's protocol ID
- R.26.04.114
- Acronym
- ADM
- Status last verified
- May 2026
- First submitted
- 1 May 2026
- Last updated
- 7 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No