Postoperative PainNCT07547618
Analgesic Consumption in the Early Postoperative Period: A Prospective Observational PACU Study
An observational study of Postoperative Pain and Analgesic Consumption, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Postoperative Pain, Analgesic Consumption, Pain Management
- What is being tested?
- Observational Assessment
- How many people
- 254 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Apr 2026to 20 Jul 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients undergoing elective surgical procedures and admitted to the post-anesthesia care unit (PACU) in a tertiary oncology hospital. The study population represents a heterogeneous surgical cohort managed under routine perioperative care conditions.
Who may be able to join
- Adults aged 18 years and older
- Undergoing elective surgical procedures
- Admitted to the post-anesthesia care unit (PACU) after surgery
- Receiving general and/or regional anesthesia
- Able to provide informed consent
Who cannot join
- Patients younger than 18 years
- Emergency surgical procedures
- Patients transferred directly to the intensive care unit postoperatively
- PACU stay shorter than 30 minutes
- Patients unable to communicate or assess pain
- Incomplete clinical records
- Refusal to participate in the study
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Rea
Ankara, Yenimahalle, 06200
Mustafa Kemal SAHIN, Dr, +905075800976, mksahin@msn.com
About this study
Official title: Factors Influencing Analgesic Consumption in the Early Postoperative Period: A Prospective Observational Study in the Post-Anesthesia Care Unit
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic pain. The post-anesthesia care unit (PACU) represents a critical phase in which pain is actively assessed and managed, and analgesic consumption during this period serves as an objective indicator of analgesic requirements and effectiveness of perioperative pain strategies.
This prospective observational study aims to identify patient-related, surgical, and anesthesia-related factors influencing analgesic consumption in the early postoperative period among adult patients admitted to the PACU following elective surgery. No additional interventions will be performed, and all perioperative management will follow routine clinical practice. Data will be collected prospectively from clinical records, anesthesia charts, and PACU monitoring forms.
Read more
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity assessed using a standardized pain scale at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements and to support the development of individualized pain management strategies, ultimately improving perioperative care quality and patient outcomes.
Read the detailed description
Postoperative pain is a major clinical concern that significantly affects recovery, patient satisfaction, and overall perioperative outcomes. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic postoperative pain. Therefore, early identification of factors influencing analgesic requirements is essential for optimizing individualized pain management strategies.
The post-anesthesia care unit (PACU) represents a critical period during which patients are closely monitored following surgery, and pain management is actively adjusted. Analgesic consumption during this phase provides an objective and clinically relevant measure of pain management adequacy. However, analgesic requirements may vary widely depending on patient-related factors (such as age, sex, and body mass index), surgical characteristics (type and duration of surgery), and anesthesia-related variables (anesthetic technique, intraoperative analgesic administration, and use of regional anesthesia).
This study is designed as a single-center, prospective observational study conducted in the post-anesthesia care unit of a tertiary oncology hospital. Adult patients undergoing elective surgical procedures will be included. No additional interventions will be performed, and all perioperative care will be administered according to routine clinical practice. Data will be collected prospectively from anesthesia records, PACU monitoring forms, and hospital electronic systems.
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements in the early postoperative period. These results may support the development of individualized and more effective pain management strategies and improve overall perioperative care quality.
- Conditions
- Postoperative Pain, Analgesic Consumption, Pain Management
- Being tested
- Observational Assessment
- Medical subject headings
- Pain, Postoperative, Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Observational AssessmentOther
This is a non-interventional observational study. No experimental intervention is applied. All patients receive routine perioperative care according to institutional clinical practice. The study involves prospective collection and analysis of clinical data related to analgesic consumption and associated factors during the early postoperative period in the post-anesthesia care unit (PACU).
| Study group | Role | What they receive |
|---|---|---|
| PACU Observational Cohort | This study consists of a single observational cohort of adult patients undergoing elective surgery and subsequently monitored in the post-anesthesia care unit (PACU). No intervention is applied as part of the study. All patients receive standard perioperative care according to institutional clinical practice. Data on analgesic consumption, pain scores, and perioperative variables are collected prospectively to evaluate factors influencing analgesic requirements in the early postoperative period. Receives: Other: Observational Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total Analgesic Consumption in the PACU
Total amount of analgesic medications administered to patients during their stay in the post-anesthesia care unit (PACU). Analgesic consumption will be recorded and standardized (e.g., converted to morphine equivalents if applicable) to allow comparison across patients.
Measured: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Secondary outcomes (5)
Pain Intensity at PACU Admission
Pain intensity assessed at admission to the post-anesthesia care unit (PACU) using a standardized pain scale (e.g., Visual Analog Scale or Numeric Rating Scale, 0-10, where 0 indicates no pain and 10 indicates worst imaginable pain).
Measured: At PACU admission (within the immediate postoperative period)
Pain Intensity at PACU Discharge
Pain intensity assessed at discharge from the post-anesthesia care unit (PACU) using a standardized pain scale (e.g., Visual Analog Scale or Numeric Rating Scale, 0-10).
Measured: At PACU discharge (within approximately 0-4 hours postoperatively)
Requirement for Rescue Analgesia in the PACU
Need for additional rescue analgesic treatment during PACU stay, recorded as whether rescue analgesia was required.
Measured: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Incidence of Postoperative Nausea and Vomiting in the PACU
Occurrence of postoperative nausea and/or vomiting during PACU stay, recorded based on routine clinical assessment.
Measured: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Length of Stay in the PACU
Duration of time spent in the post-anesthesia care unit, measured in minutes from PACU admission to discharge.
Measured: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Apr 2026
- Study start5 Apr 2026
- Primary completion1 Jul 2026 (estimated)
- Study completion20 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Postoperative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 254 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mustafa Kemal ŞAHİN, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07547618
- Sponsor's protocol ID
- 2026-04/75
- Status last verified
- Apr 2026
- First submitted
- 17 Apr 2026
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared due to institutional data protection policies and the need to maintain patient confidentiality. All data collected in this study will be anonymized and used solely for the purposes of this research.
Publications
Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003 Dec 6;362(9399):1921-8. doi: 10.1016/S0140-6736(03)14966-5.
PubMed 14667752Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramer MR; Society for Ambulatory Anesthesia. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014 Jan;118(1):85-113. doi: 10.1213/ANE.0000000000000002.
PubMed 24356162Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003 Aug;97(2):534-540. doi: 10.1213/01.ANE.0000068822.10113.9E.
PubMed 12873949
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Factors Influencing Analgesic Consumption in the Early Postoperative Period: A Prospective Observational Study in the Post-Anesthesia Care Unit
- ClinicalTrials.gov ID
- NCT07547618
- Acronym / sponsor ID
- 2026-04/75
- Conditions
- Postoperative Pain, Analgesic Consumption, Pain Management
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 254 participants (estimated)
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalUniversity, hospital or other
- Study start
- 5 Apr 2026 (actual)
- Primary completion
- 1 Jul 2026 (estimated)
- Study completion
- 20 Jul 2026 (estimated)
- First posted
- 23 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic pain. The post-anesthesia care unit (PACU) represents a critical phase in which pain is actively assessed and managed, and analgesic consumption during this period serves as an objective indicator of analgesic requirements and effectiveness of perioperative pain strategies.
This prospective observational study aims to identify patient-related, surgical, and anesthesia-related factors influencing analgesic consumption in the early postoperative period among adult patients admitted to the PACU following elective surgery. No additional interventions will be performed, and all perioperative management will follow routine clinical practice. Data will be collected prospectively from clinical records, anesthesia charts, and PACU monitoring forms.
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity assessed using a standardized pain scale at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements and to support the development of individualized pain management strategies, ultimately improving perioperative care quality and patient outcomes.
Detailed description
Postoperative pain is a major clinical concern that significantly affects recovery, patient satisfaction, and overall perioperative outcomes. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic postoperative pain. Therefore, early identification of factors influencing analgesic requirements is essential for optimizing individualized pain management strategies.
The post-anesthesia care unit (PACU) represents a critical period during which patients are closely monitored following surgery, and pain management is actively adjusted. Analgesic consumption during this phase provides an objective and clinically relevant measure of pain management adequacy. However, analgesic requirements may vary widely depending on patient-related factors (such as age, sex, and body mass index), surgical characteristics (type and duration of surgery), and anesthesia-related variables (anesthetic technique, intraoperative analgesic administration, and use of regional anesthesia).
This study is designed as a single-center, prospective observational study conducted in the post-anesthesia care unit of a tertiary oncology hospital. Adult patients undergoing elective surgical procedures will be included. No additional interventions will be performed, and all perioperative care will be administered according to routine clinical practice. Data will be collected prospectively from anesthesia records, PACU monitoring forms, and hospital electronic systems.
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements in the early postoperative period. These results may support the development of individualized and more effective pain management strategies and improve overall perioperative care quality.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| PACU Observational Cohort | – | Other: Observational AssessmentThis study consists of a single observational cohort of adult patients undergoing elective surgery and subsequently monitored in the post-anesthesia care unit (PACU). No intervention is applied as part of the study. All patients receive standard perioperative care according to institutional clinical practice. Data on analgesic consumption, pain scores, and perioperative variables are collected prospectively to evaluate factors influencing analgesic requirements in the early postoperative period. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients undergoing elective surgical procedures and admitted to the post-anesthesia care unit (PACU) in a tertiary oncology hospital. The study population represents a heterogeneous surgical cohort managed under routine perioperative care conditions.
Key inclusion criteria (5 listed)
- Adults aged 18 years and older
- Undergoing elective surgical procedures
- Admitted to the post-anesthesia care unit (PACU) after surgery
- Receiving general and/or regional anesthesia
- Able to provide informed consent
Key exclusion criteria (7 listed)
- Patients younger than 18 years
- Emergency surgical procedures
- Patients transferred directly to the intensive care unit postoperatively
- PACU stay shorter than 30 minutes
- Patients unable to communicate or assess pain
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Observational AssessmentThis is a non-interventional observational study. No experimental intervention is applied. All patients receive routine perioperative care according to institutional clinical practice. The study involves prospective collection and analysis of clinical data related to analgesic consumption and associated factors during the early postoperative period in the post-anesthesia care unit (PACU). | Other | PACU Observational Cohort |
Primary outcome
Total Analgesic Consumption in the PACU
Time frame: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Total amount of analgesic medications administered to patients during their stay in the post-anesthesia care unit (PACU). Analgesic consumption will be recorded and standardized (e.g., converted to morphine equivalents if applicable) to allow comparison across patients.
5 secondary outcomes
Pain Intensity at PACU Admission
Time frame: At PACU admission (within the immediate postoperative period)
Pain Intensity at PACU Discharge
Time frame: At PACU discharge (within approximately 0-4 hours postoperatively)
Requirement for Rescue Analgesia in the PACU
Time frame: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Incidence of Postoperative Nausea and Vomiting in the PACU
Time frame: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Length of Stay in the PACU
Time frame: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Background: PubMed 14667752Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003 Dec 6;362(9399):1921-8. doi: 10.1016/S0140-6736(03)14966-5.
- Background: PubMed 24356162Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramer MR; Society for Ambulatory Anesthesia. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014 Jan;118(1):85-113. doi: 10.1213/ANE.0000000000000002.
- Background: PubMed 12873949Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003 Aug;97(2):534-540. doi: 10.1213/01.ANE.0000068822.10113.9E.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared due to institutional data protection policies and the need to maintain patient confidentiality. All data collected in this study will be anonymized and used solely for the purposes of this research.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Postoperative Pain and Analgesic Consumption, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mustafa Kemal Şahin (+905075800976, mksahin@msn.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total Analgesic Consumption in the PACU (time frame: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07547618, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.