Muscle Contractile PropertiesNCT07546851
Foot Progression Angle and Leg Press: Vastus Medialis Contractile Responses
A study testing Congruent Foot Position Leg Press and Incongruent Foot Position Leg Press in people with Muscle Contractile Properties and Resistance Exercise, run by Giresun University at 1 site in Turkey (Türkiye).
Trial summary
This study examined the interaction between rotational foot positioning during leg press and individuals' habitual foot progression angle (FPA) phenotype on the acute contractile response of the vastus medialis muscle Read more about this study
- Who is it for?
- Ages 20 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Contractile Properties, Resistance Exercise, Foot Progression Angle
- What is being tested?
- Congruent Foot Position Leg Press and Incongruent Foot Position Leg Press
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2026to 5 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 20 and 35 years
- Minimum five years of regular resistance training experience
- Currently active in training
- Foot progression angle measurements of both feet meeting the defined threshold values for group classification
Who cannot join
- History of lower extremity surgery or serious musculoskeletal injury within the past one year
- Congenital or acquired foot deformity
- History of neurological, cardiovascular, or metabolic disease
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Giresun University - Sports Science Faculty
Giresun, Centre, 28100
About this study
Official title: Foot Progression Angle Phenotype Modulates Acute Vastus Medialis Contractile Responses During Leg Press Exercise in Resistance-Trained Athletes
This study examined the interaction between rotational foot positioning during leg press and individuals' habitual foot progression angle (FPA) phenotype on the acute contractile response of the vastus medialis muscle
Read the detailed description
Participants A total of 24 male athletes (age: 27.5 ± 3.76 years) who were licensed and actively competing in bodybuilding with a minimum of five years of regular resistance training experience volunteered to participate. Prior to the study, participants were provided with detailed information regarding the research protocol and written informed consent was obtained.
Inclusion criteria were aged between 20 and 35 years, a minimum of five years of regular resistance training experience, and currently active participation in training. Additionally, measurements from both feet were required to meet the established threshold values for participants to be classified according to their FPA. Exclusion criteria were a history of lower extremity surgery or serious musculoskeletal injury within the past year, the presence of congenital or acquired foot deformity, and a history of neurological, cardiovascular, or metabolic disease.
Assessment of Demographic and Physical Characteristics A personal information form was used to obtain demographic data. Body height and mass were measured using standard procedures.
Assessment of Muscle Contractile Properties Muscle contractile properties were assessed using tensiomyography (TMG-BMC Ltd., Ljubljana, Slovenia) on the vastus medialis muscle of the dominant leg. Participants were positioned in supine with the knee supported at approximately 30° of flexion. The muscle belly was identified by palpation, and surface electrodes were placed proximal and distal to the motor point. The measurement probe was positioned perpendicular (90°) to the skin surface. Electrical stimulation was incrementally increased until maximal radial displacement of the muscle was obtained. Participants were instructed to keep their muscles fully relaxed throughout the measurements.
The following TMG parameters reflecting muscle contractile properties were analyzed: maximal radial deformation (Dm), contraction time (Tc), and delay time (Td). These parameters have been reported to demonstrate high relative reliability, with intraclass correlation coefficients of 0.97 for Dm, 0.92 for Tc, and 0.86 for Td, along with low measurement error (CV ≈ 2.7-4.7%) (Loturco et al., 2016; Tous-Fajardo et al., 2010). All measurements were performed before the exercise protocol and within 90 seconds following completion of the final repetition.
TMG Measurement Reliability Prior to the main experimental sessions, test-retest measurements were performed on 12 participants with a 48-hour interval. Reliability was assessed using the intraclass correlation coefficient [ICC(3,1)] calculated with a two-way mixed-effects model. ICC values for TMG parameters were 0.91 for Dm, 0.88 for Tc, and 0.83 for Td, indicating high reliability. The standard error of measurement (SEM) and minimal detectable change (MDC95) were calculated to quantify measurement error. SEM and MDC95 values were 0.31 mm and 0.86 mm for Dm, 0.49 ms and 1.36 ms for Tc, and 1.17 ms and 3.24 ms for Td, respectively.
Assessment of Foot Progression Angle Habitual FPA values were assessed during dynamic gait analysis using a baropodometric walkway platform (BTS P-Walk, BTS Bioengineering, Italy; 2.4 m). The system has been reported to be reliable for the assessment of gait parameters. Measurements were performed under standardized laboratory conditions. Participants were instructed to walk across the platform at their natural walking speed, and data collection was initiated without prior notification to preserve the naturalness of the gait pattern. Data recording began before the participant fully stepped onto the platform. FPA values were automatically calculated by the device's integrated software as the angle between the longitudinal axis of the foot and the direction of progression during gait. FPA values for both feet were obtained separately and the values provided by the device were used in analyses. A minimum of three valid walking trials were collected per participant, and mean FPA values across trials were used in analyses.
FPA Measurement Reliability Test-retest reliability of FPA measurements was assessed in 12 participants with a 48-hour interval. The two-way mixed model intraclass correlation coefficient (ICC 3,1) was 0.92. The minimal detectable change (MDC95) was calculated as 1.8°.
Leg Press Foot Positioning and Exercise Protocol In the neutral protocol, participants' feet were placed on the platform at shoulder-width apart with foot rotation in a neutral (0°) position. In the toe-out protocol (30°), feet were placed at the same shoulder-width distance with the forefoot rotated 30° outward. Foot positions were measured using a standard goniometer at each session and verified by angle markings drawn on the footplate.
All procedures were performed on a 45° inclined leg press machine (Technogym, Italy). Range of motion was restricted from 90° of knee flexion to full extension. One-repetition maximum (1RM) values were determined 48 hours prior to the experimental sessions. The 1RM was defined as the maximum load the participant could complete with technically correct form through the full range of motion.
In the experimental session, participants performed the leg press exercise following a standardized general warm-up. The exercise protocol consisted of 2 × 15 repetitions at 40% 1RM followed by 4 × 10 repetitions at 75-80% 1RM. Inter-set rest was standardized at 2 minutes. Tempo was controlled using a metronome with a 2-second eccentric phase and 1-second concentric phase, and technical compliance was monitored by an experienced coach. Participants were required to complete all repetitions; sets were terminated in the event of technical breakdown or failure to complete a repetition.
- Being tested
- Congruent Foot Position Leg Press, Incongruent Foot Position Leg Press
- Keywords
- Foot progression angle, Leg press, Tensiomyography, Vastus medialis, Muscle contractile properties, Resistance training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Congruent Foot Position Leg PressBehavioural
Leg press exercise performed with foot rotation position congruent with the participant's habitual foot progression angle phenotype. HFPA group: 30° toe-out; NFPA group: 0° neutral. Protocol: 2×15 repetitions at 40% 1RM followed by 4×10 repetitions at 75-80% 1RM.
Incongruent Foot Position Leg PressBehavioural
Leg press exercise performed with foot rotation position incongruent with the participant's habitual foot progression angle phenotype. HFPA group: 0° neutral; NFPA group: 30° toe-out. Protocol: 2×15 repetitions at 40% 1RM followed by 4×10 repetitions at 75-80% 1RM.
| Study group | Role | What they receive |
|---|---|---|
| Congruent Foot Position | Experimental | Participants performed leg press exercise with a foot rotation position congruent with their habitual foot progression angle phenotype. For HFPA group: 30° toe-out; for NFPA group: 0° neutral. Receives: Behavioral: Congruent Foot Position Leg Press |
| Incongruent Foot Position | Experimental | Participants performed leg press exercise with a foot rotation position incongruent with their habitual foot progression angle phenotype. For HFPA group: 0° neutral; for NFPA group: 30° toe-out. Receives: Behavioral: Incongruent Foot Position Leg Press |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Maximal Radial Deformation (Dm) of Vastus Medialis
Dm reflects the maximal radial displacement of the muscle belly in response to electrical stimulation, assessed via tensiomyography (TMG). Pre-to-post exercise change in Dm was compared between congruent and incongruent foot rotation conditions.
Measured: Immediately before and within 90 seconds after completion of the exercise protocol
Change in Contraction Time (Tc) of Vastus Medialis
Tc reflects the time required for the muscle to contract from 10% to 90% of maximal radial displacement, assessed via tensiomyography (TMG). Pre-to-post exercise change in Tc was compared between congruent and incongruent foot rotation conditions.
Measured: Immediately before and within 90 seconds after completion of the exercise protocol
Secondary outcomes (1)
Change in Delay Time (Td) of Vastus Medialis
Td reflects the time from electrical stimulation to the onset of muscle contraction (10% of maximal radial displacement), assessed via tensiomyography (TMG). Pre-to-post exercise change in Td was compared between congruent and incongruent foot rotation conditions.
Measured: Immediately before and within 90 seconds after completion of the exercise protocol
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Apr 2026
- Study start1 Jan 2026
- Primary completion18 Jan 2026
- Study completion5 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle Contractile PropertiesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Model description
- Each participant performed leg press exercise under both congruent and incongruent foot rotation conditions in a crossover design, with a 48-hour washout period between sessions.
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Giresun University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nihat Sarıalioğlu, Giresun University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07546851
- Sponsor's protocol ID
- GRU-SBF-NS-04
- Status last verified
- Apr 2026
- First submitted
- 7 Apr 2026
- Last updated
- 23 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to ethical restrictions and participant confidentiality agreements.
Study at a glance
From the registry record, last updated by the sponsor on 23 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Foot Progression Angle Phenotype Modulates Acute Vastus Medialis Contractile Responses During Leg Press Exercise in Resistance-Trained Athletes
- ClinicalTrials.gov ID
- NCT07546851
- Acronym / sponsor ID
- GRU-SBF-NS-04
- Keywords
- Foot progression angle, Leg press, Tensiomyography, Vastus medialis, Muscle contractile properties, Resistance training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Giresun UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 18 Jan 2026 (actual)
- Study completion
- 5 Apr 2026 (actual)
- First posted
- 23 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examined the interaction between rotational foot positioning during leg press and individuals' habitual foot progression angle (FPA) phenotype on the acute contractile response of the vastus medialis muscle
Detailed description
Participants A total of 24 male athletes (age: 27.5 ± 3.76 years) who were licensed and actively competing in bodybuilding with a minimum of five years of regular resistance training experience volunteered to participate. Prior to the study, participants were provided with detailed information regarding the research protocol and written informed consent was obtained.
Inclusion criteria were aged between 20 and 35 years, a minimum of five years of regular resistance training experience, and currently active participation in training. Additionally, measurements from both feet were required to meet the established threshold values for participants to be classified according to their FPA. Exclusion criteria were a history of lower extremity surgery or serious musculoskeletal injury within the past year, the presence of congenital or acquired foot deformity, and a history of neurological, cardiovascular, or metabolic disease.
Assessment of Demographic and Physical Characteristics A personal information form was used to obtain demographic data. Body height and mass were measured using standard procedures.
Assessment of Muscle Contractile Properties Muscle contractile properties were assessed using tensiomyography (TMG-BMC Ltd., Ljubljana, Slovenia) on the vastus medialis muscle of the dominant leg. Participants were positioned in supine with the knee supported at approximately 30° of flexion. The muscle belly was identified by palpation, and surface electrodes were placed proximal and distal to the motor point. The measurement probe was positioned perpendicular (90°) to the skin surface. Electrical stimulation was incrementally increased until maximal radial displacement of the muscle was obtained. Participants were instructed to keep their muscles fully relaxed throughout the measurements.
The following TMG parameters reflecting muscle contractile properties were analyzed: maximal radial deformation (Dm), contraction time (Tc), and delay time (Td). These parameters have been reported to demonstrate high relative reliability, with intraclass correlation coefficients of 0.97 for Dm, 0.92 for Tc, and 0.86 for Td, along with low measurement error (CV ≈ 2.7-4.7%) (Loturco et al., 2016; Tous-Fajardo et al., 2010). All measurements were performed before the exercise protocol and within 90 seconds following completion of the final repetition.
TMG Measurement Reliability Prior to the main experimental sessions, test-retest measurements were performed on 12 participants with a 48-hour interval. Reliability was assessed using the intraclass correlation coefficient [ICC(3,1)] calculated with a two-way mixed-effects model. ICC values for TMG parameters were 0.91 for Dm, 0.88 for Tc, and 0.83 for Td, indicating high reliability. The standard error of measurement (SEM) and minimal detectable change (MDC95) were calculated to quantify measurement error. SEM and MDC95 values were 0.31 mm and 0.86 mm for Dm, 0.49 ms and 1.36 ms for Tc, and 1.17 ms and 3.24 ms for Td, respectively.
Assessment of Foot Progression Angle Habitual FPA values were assessed during dynamic gait analysis using a baropodometric walkway platform (BTS P-Walk, BTS Bioengineering, Italy; 2.4 m). The system has been reported to be reliable for the assessment of gait parameters. Measurements were performed under standardized laboratory conditions. Participants were instructed to walk across the platform at their natural walking speed, and data collection was initiated without prior notification to preserve the naturalness of the gait pattern. Data recording began before the participant fully stepped onto the platform. FPA values were automatically calculated by the device's integrated software as the angle between the longitudinal axis of the foot and the direction of progression during gait. FPA values for both feet were obtained separately and the values provided by the device were used in analyses. A minimum of three valid walking trials were collected per participant, and mean FPA values across trials were used in analyses.
FPA Measurement Reliability Test-retest reliability of FPA measurements was assessed in 12 participants with a 48-hour interval. The two-way mixed model intraclass correlation coefficient (ICC 3,1) was 0.92. The minimal detectable change (MDC95) was calculated as 1.8°.
Leg Press Foot Positioning and Exercise Protocol In the neutral protocol, participants' feet were placed on the platform at shoulder-width apart with foot rotation in a neutral (0°) position. In the toe-out protocol (30°), feet were placed at the same shoulder-width distance with the forefoot rotated 30° outward. Foot positions were measured using a standard goniometer at each session and verified by angle markings drawn on the footplate.
All procedures were performed on a 45° inclined leg press machine (Technogym, Italy). Range of motion was restricted from 90° of knee flexion to full extension. One-repetition maximum (1RM) values were determined 48 hours prior to the experimental sessions. The 1RM was defined as the maximum load the participant could complete with technically correct form through the full range of motion.
In the experimental session, participants performed the leg press exercise following a standardized general warm-up. The exercise protocol consisted of 2 × 15 repetitions at 40% 1RM followed by 4 × 10 repetitions at 75-80% 1RM. Inter-set rest was standardized at 2 minutes. Tempo was controlled using a metronome with a 2-second eccentric phase and 1-second concentric phase, and technical compliance was monitored by an experienced coach. Participants were required to complete all repetitions; sets were terminated in the event of technical breakdown or failure to complete a repetition.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- Single blind (investigator)
- Number of arms
- 2
- Model description
- Each participant performed leg press exercise under both congruent and incongruent foot rotation conditions in a crossover design, with a 48-hour washout period between sessions.
| Arm | Type | Receives |
|---|---|---|
| Congruent Foot Position | Experimental | Behavioral: Congruent Foot Position Leg PressParticipants performed leg press exercise with a foot rotation position congruent with their habitual foot progression angle phenotype. For HFPA group: 30° toe-out; for NFPA group: 0° neutral. |
| Incongruent Foot Position | Experimental | Behavioral: Incongruent Foot Position Leg PressParticipants performed leg press exercise with a foot rotation position incongruent with their habitual foot progression angle phenotype. For HFPA group: 0° neutral; for NFPA group: 30° toe-out. |
Who may qualify
- Ages
- 20 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Age between 20 and 35 years
- Minimum five years of regular resistance training experience
- Currently active in training
- Foot progression angle measurements of both feet meeting the defined threshold values for group classification
Key exclusion criteria (3 listed)
- History of lower extremity surgery or serious musculoskeletal injury within the past one year
- Congenital or acquired foot deformity
- History of neurological, cardiovascular, or metabolic disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Congruent Foot Position Leg PressLeg press exercise performed with foot rotation position congruent with the participant's habitual foot progression angle phenotype. HFPA group: 30° toe-out; NFPA group: 0° neutral. Protocol: 2×15 repetitions at 40% 1RM followed by 4×10 repetitions at 75-80% 1RM. | Behavioural | Congruent Foot Position |
| Incongruent Foot Position Leg PressLeg press exercise performed with foot rotation position incongruent with the participant's habitual foot progression angle phenotype. HFPA group: 0° neutral; NFPA group: 30° toe-out. Protocol: 2×15 repetitions at 40% 1RM followed by 4×10 repetitions at 75-80% 1RM. | Behavioural | Incongruent Foot Position |
Primary outcome
Change in Maximal Radial Deformation (Dm) of Vastus Medialis
Time frame: Immediately before and within 90 seconds after completion of the exercise protocol
Dm reflects the maximal radial displacement of the muscle belly in response to electrical stimulation, assessed via tensiomyography (TMG). Pre-to-post exercise change in Dm was compared between congruent and incongruent foot rotation conditions.
Change in Contraction Time (Tc) of Vastus Medialis
Time frame: Immediately before and within 90 seconds after completion of the exercise protocol
Tc reflects the time required for the muscle to contract from 10% to 90% of maximal radial displacement, assessed via tensiomyography (TMG). Pre-to-post exercise change in Tc was compared between congruent and incongruent foot rotation conditions.
1 secondary outcome
Change in Delay Time (Td) of Vastus Medialis
Time frame: Immediately before and within 90 seconds after completion of the exercise protocol
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Apr 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to ethical restrictions and participant confidentiality agreements.
Related trials for Muscle Contractile Properties
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Congruent Foot Position Leg Press and Incongruent Foot Position Leg Press in people with Muscle Contractile Properties and Resistance Exercise, run by Giresun University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Maximal Radial Deformation (Dm) of Vastus Medialis (time frame: Immediately before and within 90 seconds after completion of the exercise protocol). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Apr 2026.