Narrow Alveolar RidgeCGFNCT07534787
Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge
A study testing Ridge splitting, Dental implant placement and Concentrated Growth Factor (CGF) in people with Narrow Alveolar Ridge and CGF Concentrated Growth Factor, run by Cairo University at 2 sites in Egypt.
Trial summary
This study aims to evaluate the tissue biotype and bone density around dental implants in patients with narrow alveolar ridge. Ridge splitting with simultaneous implant placement covered with concentrated growth factor (CGF) membranes will be performed. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Narrow Alveolar Ridge, CGF Concentrated Growth Factor, Postoperative Pain
- What is being tested?
- Ridge splitting, Dental implant placement and Concentrated Growth Factor (CGF)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 2 sitesEgypt
- Study dates
- 1 May 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- -
- Patients with narrow alveolar ridge indicated for implant placement Age between 20 and 50 years Good general health Patients with adequate oral hygiene
Who cannot join
- Patients with systemic diseases affecting bone healing Smokers Pregnant or lactating females Patients with poor oral hygiene Patients with history of radiation therapy in the head and neck region
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Tasneem Farrag Ayoub, Master contact
Egypt2 sites
Cairo university
Cairo
Tasneem Farrag Ayoub, Master, +201125888659, tasneem.farrag@dentistry.cu.edu.eg
Faculty of Dentistry, Cairo University
Cairo
Tasneem Farrag Badran, Master, 01146245469, tasneem.farrag@dentistry.cu.edu.eg
About this study
Official title: Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge (Case Series).
This study aims to evaluate the tissue biotype and bone density around dental implants in patients with narrow alveolar ridge. Ridge splitting with simultaneous implant placement covered with concentrated growth factor (CGF) membranes will be performed. Clinical and radiographic evaluation will be done using periodontal probe and CBCT. Pain will also be assessed using visual analogue scale (VAS) during follow-up period.
Read the detailed description
This study is a case series conducted at the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. It aims to evaluate the tissue biotype and bone density around dental implants in adult patients with narrow alveolar ridge.
Alveolar ridge resorption and soft tissue shrinkage after tooth extraction represent a major problem affecting both aesthetics and function. Therefore, preserving alveolar bone and improving soft tissue conditions are essential for successful implant placement. The use of concentrated growth factor (CGF) membranes combined with ridge splitting and simultaneous implant placement may enhance healing, reduce postoperative pain, and improve tissue biotype and bone density.
All patients will undergo clinical and radiographic assessment before the procedure. Preoperative CBCT will be used for surgical planning. Tissue thickness will be measured using a periodontal probe. During surgery, ridge splitting will be performed followed by implant placement, and CGF membranes will be applied over the grafted area. Autologous bone chips will be used for augmentation.
Postoperative evaluation will include assessment of tissue biotype, bone density using CBCT, and pain using visual analogue scale (VAS). Follow-up will be carried out immediately after surgery and up to 4 months postoperatively.
- Conditions
- Narrow Alveolar Ridge, CGF Concentrated Growth Factor, Postoperative Pain, Implant Placement
- Being tested
- Ridge splitting, Dental implant placement, Concentrated Growth Factor (CGF)
- Keywords
- Ridge splitting, Dental implants, Concentrated growth factor (CGF), Bone density, Tissue biotype
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ridge splittingProcedure or surgery
Patients with narrow alveolar ridge will undergo ridge splitting procedure using chisel to allow implant placement.
Dental implant placementProcedure or surgery
Intervention Description:
Dental implants will be inserted simultaneously after ridge splitting in the prepared alveolar ridge.
Concentrated Growth Factor (CGF)Biological
CGF membranes will be prepared from patient venous blood and placed over the grafted area to enhance healing and tissue regeneration.
| Study group | Role | What they receive |
|---|---|---|
| Ridge Splitting with Simultaneous Implant Placement and CGF | Experimental | Patients with narrow alveolar ridge will undergo ridge splitting with simultaneous implant placement. Concentrated growth factor (CGF) membranes will be prepared from the patient's blood and placed over the grafted area. Autologous bone chips will be used for augmentation. Clinical and radiographic evaluation will be performed to assess tissue biotype, bone density, and pain during follow-up period. Receives: Procedure: Ridge splitting; Procedure: Dental implant placement; Biological: Concentrated Growth Factor (CGF) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain (VAS score)
Pain will be assessed using Visual Analogue Scale (VAS) ranging from 0 to 10.
Measured: 1st day and 3rd day postoperative
Secondary outcomes (1)
Tissue biotype thickness
Tissue biotype will be assessed using a periodontal probe and measured in millimeters.
Measured: Immediately postoperative and after 4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Apr 2026
- Study start1 May 2026 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Narrow Alveolar RidgeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tasneem farrag abdelkader ayoup, Cairo University
- Investigators
- Hesham Said Said, Professor, Study chair, Cairo UniversityAbdelmoez Mohamed El-Sharkawy, Associate professor, Study director, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07534787
- Sponsor's protocol ID
- Omfs 3-3-18.
- Acronym
- CGF
- Status last verified
- Mar 2026
- First submitted
- 10 Apr 2026
- Last updated
- 16 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Radiographic Evaluation of Ridge Splitting With Simultaneous Implant Placement Covered With Concentrated Growth Factor Membranes in Narrow Alveolar Ridge (Case Series).
- ClinicalTrials.gov ID
- NCT07534787
- Acronym / sponsor ID
- CGF / Omfs 3-3-18.
- Conditions
- Narrow Alveolar Ridge, CGF Concentrated Growth Factor, Postoperative Pain, Implant Placement
- Keywords
- Ridge splitting, Dental implants, Concentrated growth factor (CGF), Bone density, Tissue biotype
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 16 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the tissue biotype and bone density around dental implants in patients with narrow alveolar ridge. Ridge splitting with simultaneous implant placement covered with concentrated growth factor (CGF) membranes will be performed. Clinical and radiographic evaluation will be done using periodontal probe and CBCT. Pain will also be assessed using visual analogue scale (VAS) during follow-up period.
Detailed description
This study is a case series conducted at the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. It aims to evaluate the tissue biotype and bone density around dental implants in adult patients with narrow alveolar ridge.
Alveolar ridge resorption and soft tissue shrinkage after tooth extraction represent a major problem affecting both aesthetics and function. Therefore, preserving alveolar bone and improving soft tissue conditions are essential for successful implant placement. The use of concentrated growth factor (CGF) membranes combined with ridge splitting and simultaneous implant placement may enhance healing, reduce postoperative pain, and improve tissue biotype and bone density.
All patients will undergo clinical and radiographic assessment before the procedure. Preoperative CBCT will be used for surgical planning. Tissue thickness will be measured using a periodontal probe. During surgery, ridge splitting will be performed followed by implant placement, and CGF membranes will be applied over the grafted area. Autologous bone chips will be used for augmentation.
Postoperative evaluation will include assessment of tissue biotype, bone density using CBCT, and pain using visual analogue scale (VAS). Follow-up will be carried out immediately after surgery and up to 4 months postoperatively.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Ridge Splitting with Simultaneous Implant Placement and CGF | Experimental | Procedure: Ridge splitting, Procedure: Dental implant placement, Biological: Concentrated Growth Factor (CGF)Patients with narrow alveolar ridge will undergo ridge splitting with simultaneous implant placement. Concentrated growth factor (CGF) membranes will be prepared from the patient's blood and placed over the grafted area. Autologous bone chips will be used for augmentation. Clinical and radiographic evaluation will be performed to assess tissue biotype, bone density, and pain during follow-up period. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- -
- Patients with narrow alveolar ridge indicated for implant placement Age between 20 and 50 years Good general health Patients with adequate oral hygiene
Key exclusion criteria (1 listed)
- Patients with systemic diseases affecting bone healing Smokers Pregnant or lactating females Patients with poor oral hygiene Patients with history of radiation therapy in the head and neck region
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ridge splittingPatients with narrow alveolar ridge will undergo ridge splitting procedure using chisel to allow implant placement. | Procedure or surgery | Ridge Splitting with Simultaneous Implant Placement and CGF |
| Dental implant placementIntervention Description: Dental implants will be inserted simultaneously after ridge splitting in the prepared alveolar ridge. | Procedure or surgery | Ridge Splitting with Simultaneous Implant Placement and CGF |
| Concentrated Growth Factor (CGF)CGF membranes will be prepared from patient venous blood and placed over the grafted area to enhance healing and tissue regeneration. | Biological | Ridge Splitting with Simultaneous Implant Placement and CGF |
Primary outcome
Pain (VAS score)
Time frame: 1st day and 3rd day postoperative
Pain will be assessed using Visual Analogue Scale (VAS) ranging from 0 to 10.
1 secondary outcome
Tissue biotype thickness
Time frame: Immediately postoperative and after 4 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Narrow Alveolar Ridge
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Osseodensification for Narrow Alveolar Ridge Expansion
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Recruiting
Crestal Bone Loss Around Narrow Diameter Implants Versus Standard Diameter Implants With Bone Augmentation in Horizontally Deficient Posterior Mandibular Sites.
Horizontal Atrophy of Edentulous Alveolar Ridge
Active, not recruiting
Narrow Dental Implants in Multiple Fixed Prosthesis: A Controlled Clinical Trial
Edentulous Alveolar Ridge
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Tasneem Farrag Ayoub, Master contact
Hesham Said Said, Professor study chair
Cairo University
Abdelmoez Mohamed El-Sharkawy, Associate professor study director
Cairo University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ridge splitting, Dental implant placement and Concentrated Growth Factor (CGF) in people with Narrow Alveolar Ridge and CGF Concentrated Growth Factor, run by Cairo University at 2 sites in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 16 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tasneem Farrag Ayoub, Master (+201125888649 ext. +201146245469, tasneem.farrag@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain (VAS score) (time frame: 1st day and 3rd day postoperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Apr 2026.